Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
Segal, Joe M., Kent, Deniz, Wesche, Daniel J., Ng, Soon Seng, Serra, Maria, Oulès, Bénédicte, Kar, Gozde, Emerton, Guy, Blackford, Samuel J. I., Darmanis, Spyros, Miquel, Rosa, Luong, Tu Vinh, Yamamoto, Ryo, Bonham, Andrew, Jassem, Wayel, Heaton, Nigel, Vigilante, Alessandra, King, Aileen, Sancho, Rocio, Teichmann, Sarah, Quake, Stephen R., Nakauchi, Hiromitsu, Rashid, S. Tamir
Published in Nature communications (26.07.2019)
Published in Nature communications (26.07.2019)
Get full text
Journal Article
Validation of Current Good Manufacturing Practice Compliant Human Pluripotent Stem Cell‐Derived Hepatocytes for Cell‐Based Therapy
Blackford, Samuel J.I., Ng, Soon Seng, Segal, Joe M., King, Aileen J.F., Austin, Amazon L., Kent, Deniz, Moore, Jennifer, Sheldon, Michael, Ilic, Dusko, Dhawan, Anil, Mitry, Ragai R., Rashid, S. Tamir
Published in Stem cells translational medicine (01.02.2019)
Published in Stem cells translational medicine (01.02.2019)
Get full text
Journal Article
Novel Cell Lines Isolated From Mouse Embryonic Stem Cells Exhibiting De Novo Methylation of the E‐Cadherin Promoter
Hawkins, Kate, Keramari, Maria, Soncin, Francesca, Segal, Joe M., Mohamet, Lisa, Miazga, Natalie, Ritson, Sarah, Bobola, Nicoletta, Merry, Catherine L. R., Ward, Christopher M.
Published in Stem cells (Dayton, Ohio) (01.11.2014)
Published in Stem cells (Dayton, Ohio) (01.11.2014)
Get full text
Journal Article
Differential Expression of Insulin-Like Growth Factor 1 and Wnt Family Member 4 Correlates With Functional Heterogeneity of Human Dermal Fibroblasts
Culley, Oliver J, Louis, Blaise, Philippeos, Christina, Oulès, Bénédicte, Tihy, Matthieu, Segal, Joe M, Hyliands, Della, Jenkins, Gail, Bhogal, Ranjit K, Siow, Richard C, Watt, Fiona M
Published in Frontiers in cell and developmental biology (06.04.2021)
Published in Frontiers in cell and developmental biology (06.04.2021)
Get full text
Journal Article
Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold
Ng, Soon Seng, Saeb-Parsy, Kourosh, Blackford, Samuel J.I., Segal, Joe M., Serra, Maria Paola, Horcas-Lopez, Marta, No, Da Yoon, Mastoridis, Sotiris, Jassem, Wayel, Frank, Curtis W., Cho, Nam Joon, Nakauchi, Hiromitsu, Glenn, Jeffrey S., Rashid, S. Tamir
Published in Biomaterials (01.11.2018)
Published in Biomaterials (01.11.2018)
Get full text
Journal Article
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
Alsamman, Sarah, Christenson, Stephanie A, Yu, Amy, Ayad, Nadia M E, Mooring, Meghan S, Segal, Joe M, Hu, Jimmy Kuang-Hsien, Schaub, Johanna R, Ho, Steve S, Rao, Vikram, Marlow, Megan M, Turner, Scott M, Sedki, Mai, Pantano, Lorena, Ghoshal, Sarani, Ferreira, Diego Dos Santos, Ma, Hsiao-Yen, Duwaerts, Caroline C, Espanol-Suner, Regina, Wei, Lan, Newcomb, Benjamin, Mileva, Izolda, Canals, Daniel, Hannun, Yusuf A, Chung, Raymond T, Mattis, Aras N, Fuchs, Bryan C, Tager, Andrew M, Yimlamai, Dean, Weaver, Valerie M, Mullen, Alan C, Sheppard, Dean, Chen, Jennifer Y
Published in Science translational medicine (19.08.2020)
Published in Science translational medicine (19.08.2020)
Get more information
Journal Article
Small molecule screen employing patient-derived iPS hepatocytes identifies LRRK2 as a novel therapeutic target for Alpha1 Antitrypsin Deficiency
Kent, Deniz, Ng, Soon Seng, Khoshkenar, Payam, Syanda, Adam M, Li Chao Zheng, Zieger, Marina, Greer, Cindy, Hatch, Stephanie B, Segal, Joe M, Samuel Ji Blackford, Chowdary, Vivek, Taylor Ismali, Danovi, Davide, Sahdeo, Sunil, Ebner, Daniel, Mueller, Christian, S Tamir Rashid
Published in bioRxiv (17.09.2021)
Published in bioRxiv (17.09.2021)
Get full text
Paper
Validation of a library of cGMP-compliant human pluripotent stem cell lines for use in liver therapy
Blackford, Samuel J I, Ng, Soon Seng, Segal, Joe M, King, Aileen J F, Moore, Jennifer, Sheldon, Michael, Ilic, Dusko, Dhawan, Anil, Mitry, Ragai, S Tamir Rashid
Published in bioRxiv (10.04.2018)
Published in bioRxiv (10.04.2018)
Get full text
Paper
Conversion of iPS derived hepatic progenitors into scalable, functional and developmentally relevant human organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold engineered from collagen-coated pores of defined size
Ng, Soon Seng, Saeb-Parsy, Kourosh, Segal, Joe M, Serra, Maria Paola, Blackford, Samuel J I, Marta Horcas Lopez, Da Yoon No, Frank, Curtis W, Cho, Nam Joon, Nakauchi, Hiromitsu, Glenn, Jeffrey S, S Tamir Rashid
Published in bioRxiv (06.04.2018)
Published in bioRxiv (06.04.2018)
Get full text
Paper
Single-cell analysis identifies EpCAM+/CDH6+/TROP-2- cells as human liver progenitors
Segal, Joe M, Wesche, Daniel J, Serra, Maria Paola, B n dicte Oul s, Kent, Deniz, Ng, Soon Seng, Kar, Gozde, Emerton, Guy, Blackford, Samuel, Darmanis, Spyros, Rosa, Miquel, Tu Vinh, Yamamoto, Ryo, Bonham, Andrew, Vigilante, Alessandra, Teichmann, Sarah, Quake, Stephen R, Nakauchi, Hiromitsu, S Tamir Rashid
Published in bioRxiv (04.04.2018)
Published in bioRxiv (04.04.2018)
Get full text
Paper