Concepts for agonistic targeting of CD40 in immuno-oncology
Richards, David M., Sefrin, Julian P., Gieffers, Christian, Hill, Oliver, Merz, Christian
Published in Human vaccines & immunotherapeutics (01.02.2020)
Published in Human vaccines & immunotherapeutics (01.02.2020)
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Journal Article
Sensitization of Tumors for Attack by Virus-Specific CD8+ T-Cells Through Antibody-Mediated Delivery of Immunogenic T-Cell Epitopes
Sefrin, Julian P, Hillringhaus, Lars, Mundigl, Olaf, Mann, Karin, Ziegler-Landesberger, Doris, Seul, Heike, Tabares, Gloria, Knoblauch, Dominic, Leinenbach, Andreas, Friligou, Irene, Dziadek, Sebastian, Offringa, Rienk, Lifke, Valeria, Lifke, Alexander
Published in Frontiers in immunology (21.08.2019)
Published in Frontiers in immunology (21.08.2019)
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Journal Article
A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity
Thiemann, Meinolf, Richards, David M, Heinonen, Karl, Kluge, Michael, Marschall, Viola, Merz, Christian, Redondo Müller, Mauricio, Schnyder, Tim, Sefrin, Julian P, Sykora, Jaromir, Fricke, Harald, Gieffers, Christian, Hill, Oliver
Published in Frontiers in oncology (19.09.2018)
Published in Frontiers in oncology (19.09.2018)
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Journal Article
HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality
Richards, David M, Marschall, Viola, Billian-Frey, Katharina, Heinonen, Karl, Merz, Christian, Redondo Müller, Mauricio, Sefrin, Julian P, Schröder, Matthias, Sykora, Jaromir, Fricke, Harald, Hill, Oliver, Gieffers, Christian, Thiemann, Meinolf
Published in Journal for immunotherapy of cancer (19.07.2019)
Published in Journal for immunotherapy of cancer (19.07.2019)
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Journal Article
The Contained Self-Reactive Peripheral T Cell Repertoire: Size, Diversity, and Cellular Composition
Richards, David M, Ruggiero, Eliana, Hofer, Ann-Cathrin, Sefrin, Julian P, Schmidt, Manfred, von Kalle, Christof, Feuerer, Markus
Published in The Journal of immunology (1950) (01.09.2015)
Published in The Journal of immunology (1950) (01.09.2015)
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Journal Article
Abstract 1076: Hexavalent HERA-CD40L induces a productive T cell-mediated anti-tumor immune response and shows superior activity in comparison to benchmark CD40 agonistic antibodies
Gieffers, Christian, Richards, David M., Sykora, Jaromir, Merz, Christian, Sefrin, Julian P., Billian-Frey, Katharina, Heinonen, Karl, Müller, Mauricio Redondo, Schröder, Matthias, Thiemann, Meinolf, Hill, Oliver
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 4460: Novel bispecific molecules combining HERA-CD40L with anti-CEA or with anti-PD-L1 for targeting
Thiemann, Meinolf, Billian-Frey, Katharina, Schröder, Matthias, Merz, Christian, Sykora, Jaromir, Richards, David M., Müller, Mauricio Redondo, Sefrin, Julian P., Heinonen, Karl, Gieffers, Christian, Hill, Oliver
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 4143: The novel hexavalent human GITR agonist HERA-GITRL promotes anti-tumor efficacy independent of Fc-functionality and shows superior activity compared with the monoclonal anti-GITR antibody TRX518
Schröder, Matthias, Marshall, Viola, Thiemann, Meinolf, Richards, David M., Merz, Christian, Sykora, Jaromir, Sefrin, Julian P., Redondo-Müller, Mauricio, Heinonen, Karl, Billian-Frey, Katharina, Hill, Oliver, Gieffers, Christian
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 630: Novel hexavalent HVEM agonist HERA-LIGHT promotes T cell activation and expansion
Sefrin, Julian P., Richards, David M., Sykora, Jaromir, Thiemann, Meinolf, Merz, Christian, Marschall, Viola, Müller, Mauricio Redondo, Heinonen, Karl, Fricke, Harald, Gieffers, Christian, Hill, Oliver
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 3754: The novel hexavalent human CD137/4-1BB agonist HERA-CD137L promotes anti-cancer immunity by activating CD8 T cells while regulatory T cells are not affected
Thiemann, Meinolf, Sykora, Jaromir, Richards, David M., Merz, Christian, Marschall, Viola, Mueller, Mauricio Redondo, Sefrin, Julian P., Heinonen, Karl, Fricke, Harald, Gieffers, Christian, Hill, Oliver
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 4845: HERA-CD27L, a true CD27 agonist, is a hexavalent CD27 ligand that enhances T cell activation and induces potent anti-tumor immunity
Sefrin, Julian P., Richards, David M., Billian-Frey, Katharina, Heinonen, Karl, Marschall, Viola, Merz, Christian, Müller, Mauricio Redondo, Schröder, Matthias, Sykora, Jaromir, Thiemann, Meinolf, Fricke, Harald, Gieffers, Christian, Hill, Oliver
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article