Discovery and Structure−Activity Relationships of Trisubstituted Pyrimidines/Pyridines as Novel Calcium-Sensing Receptor Antagonists
Yang, Wu, Ruan, Zheming, Wang, Yufeng, Van Kirk, Katy, Ma, Zhengping, Arey, Brian J, Cooper, Christopher B, Seethala, Ramakrishna, Feyen, Jean H. M, Dickson, John K
Published in Journal of medicinal chemistry (26.02.2009)
Published in Journal of medicinal chemistry (26.02.2009)
Get full text
Journal Article
Muraglitazar, a Novel Dual (α/γ) Peroxisome Proliferator–Activated Receptor Activator, Improves Diabetes and Other Metabolic Abnormalities and Preserves β-Cell Function in db/db Mice
HARRITY, Thomas, FARRELLY, Dennis, WEI WANG, HAO ZHANG, FENDERSON, William, CHEN, Sean, DEVASTHALE, Pratik, JEON, Yoon, SEETHALA, Ramakrishna, YANG, Wen-Pin, REN, Jimmy, MIN ZHOU, TIEMAN, Aaron, RYONO, Denis, BILLER, Scott, MOOKHTIAR, Kasim A, WETTERAU, John, GREGG, Richard, CHENG, Peter T, HARIHARAN, Narayanan, CUIXIA CHU, KUNSELMAN, Lori, LIQUN GU, PONTICIELLO, Randolph, CAP, Michael, FUCHENG QU, CHUNNING SHAO
Published in Diabetes (New York, N.Y.) (01.01.2006)
Published in Diabetes (New York, N.Y.) (01.01.2006)
Get full text
Journal Article
Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold
Sun, Chongqing, Robl, Jeffrey A, Wang, Tammy C, Huang, Yanting, Kuhns, Joyce E, Lupisella, John A, Beehler, Blake C, Golla, Rajasree, Sleph, Paul G, Seethala, Ramakrishna, Fura, Aberra, Krystek, Stanley R, An, Yongmi, Malley, Mary F, Sack, John S, Salvati, Mark E, Grover, Gary J, Ostrowski, Jacek, Hamann, Lawrence G
Published in Journal of medicinal chemistry (28.12.2006)
Published in Journal of medicinal chemistry (28.12.2006)
Get full text
Journal Article
Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications
Li, James J, Sutton, James C, Nirschl, Alexandra, Zou, Yan, Wang, Haixia, Sun, Chongqing, Pi, Zulan, Johnson, Rebecca, Krystek, Stanley R, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G, Beehler, Blake C, Grover, Gary J, Fura, Aberra, Vyas, Viral P, Li, Cindy Y, Gougoutas, Jack Z, Galella, Michael A, Zahler, Robert, Ostrowski, Jacek, Hamann, Lawrence G
Published in Journal of medicinal chemistry (28.06.2007)
Published in Journal of medicinal chemistry (28.06.2007)
Get full text
Journal Article
Cloning and Functional Expression of a cDNA Encoding a Human Type 2 Neuropeptide Y Receptor
Rose, P M, Fernandes, P, Lynch, J S, Frazier, S T, Fisher, S M, Kodukula, K, Kienzle, B, Seethala, R
Published in The Journal of biological chemistry (29.09.1995)
Published in The Journal of biological chemistry (29.09.1995)
Get full text
Journal Article
Acylation of Acylglycerols by Acyl Coenzyme A:Diacylglycerol Acyltransferase 1 (DGAT1)
Cheng, Dong, Iqbal, Jahangir, Devenny, James, Chu, Ching-Hsuen, Chen, Luping, Dong, Jessica, Seethala, Ramakrishna, Keim, William J., Azzara, Anthony V., Lawrence, R. Michael, Pelleymounter, Mary Ann, Hussain, M. Mahmood
Published in The Journal of biological chemistry (31.10.2008)
Published in The Journal of biological chemistry (31.10.2008)
Get full text
Journal Article
Characterization of a new class of selective nonsteroidal progesterone receptor agonists
Dong, Yu, Roberge, Jacques Y, Wang, Zhaoqing, Wang, Xiaodong, Tamasi, Joseph, Dell, Vanessa, Golla, Rajasree, Corte, James R, Liu, Yalei, Fang, Tianan, Anthony, Monique N, Schnur, Dora M, Agler, Michele L, Dickson, John K, Lawrence, R.Michael, Prack, Margaret M, Seethala, Ramakrishna, Feyen, Jean H.M
Published in Steroids (01.03.2004)
Published in Steroids (01.03.2004)
Get full text
Journal Article
Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3 '-hydroxyazetidin-1-yl)ethanone [BMS-8163361, an Orally Active Novel Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor
Ye, Xiang-Yang, Chen, Stephanie Y., Wu, Shung, Yoon, David S., Wang, Haixia, Hong, Zhenqiu, O'Connor, Stephen P., Li, Jun, Li, James J., Kennedy, Lawrence J., Walker, Steven J., Nayeem, Akbar, Sheriff, Steven, Camac, Daniel M., Ramamurthy, Vidyhashankar, Morin, Paul E., Zebo, Rachel, Taylor, Joseph R., Morgan, Nathan N., Ponticiello, Randolph P., Harrity, Thomas, Apedo, Atsu, Golla, Rajasree, Seethala, Ramakrishna, Wang, Mengmeng, Harper, Timothy W., Sleczka, Bogdan G., He, Bin, Kirby, Mark, Leahy, David K., Li, Jianqing, Hanson, Ronald L., Guo, Zhiwei, Li, Yi-Xin, DiMarco, John D., Scaringe, Raymond, Maxwell, Brad, Moulin, Frederick, Barrish, Joel C., Gordon, David A., Robl, Jeffrey A.
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
Get full text
Journal Article
Acylation of Acylglycerols by Acyl Coenzyme A:Diacylglycerol Acyltransferase 1 (DGAT1): FUNCTIONAL IMPORTANCE OF DGAT1 IN THE INTESTINAL FAT ABSORPTION
Cheng, Dong, Iqbal, Jahangir, Devenny, James, Chu, Ching-Hsuen, Chen, Luping, Dong, Jessica, Seethala, Ramakrishna, Keim, William J, Azzara, Anthony V, Lawrence, R. Michael, Pelleymounter, Mary Ann, Hussain, M. Mahmood
Published in The Journal of biological chemistry (31.10.2008)
Published in The Journal of biological chemistry (31.10.2008)
Get full text
Journal Article
Discovery of Clinical Candidate 2‑((2S,6S)‑2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3′-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor
Ye, Xiang-Yang, Chen, Stephanie Y, Wu, Shung, Yoon, David S, Wang, Haixia, Hong, Zhenqiu, O’Connor, Stephen P, Li, Jun, Li, James J, Kennedy, Lawrence J, Walker, Steven J, Nayeem, Akbar, Sheriff, Steven, Camac, Daniel M, Ramamurthy, Vidyhashankar, Morin, Paul E, Zebo, Rachel, Taylor, Joseph R, Morgan, Nathan N, Ponticiello, Randolph P, Harrity, Thomas, Apedo, Atsu, Golla, Rajasree, Seethala, Ramakrishna, Wang, Mengmeng, Harper, Timothy W, Sleczka, Bogdan G, He, Bin, Kirby, Mark, Leahy, David K, Li, Jianqing, Hanson, Ronald L, Guo, Zhiwei, Li, Yi-Xin, DiMarco, John D, Scaringe, Raymond, Maxwell, Brad, Moulin, Frederick, Barrish, Joel C, Gordon, David A, Robl, Jeffrey A
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
Get full text
Journal Article
Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats
Ostrowski, Jacek, Kuhns, Joyce E, Lupisella, John A, Manfredi, Mark C, Beehler, Blake C, Krystek, Stanley R, Bi, Yingzhi, Sun, Chongqing, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G, Fura, Aberra, An, Yongmi, Kish, Kevin F, Sack, John S, Mookhtiar, Kasim A, Grover, Gary J, Hamann, Lawrence G
Published in Endocrinology (Philadelphia) (01.01.2007)
Published in Endocrinology (Philadelphia) (01.01.2007)
Get full text
Journal Article
Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors for the treatment of metabolic disorders
Yoon, David S., Wu, Shung C., Seethala, Ramakrishna, Golla, Rajasree, Nayeem, Akbar, Everlof, John G., Gordon, David A., Hamann, Lawrence G., Robl, Jeffrey A.
Published in Bioorganic & medicinal chemistry letters (01.11.2014)
Published in Bioorganic & medicinal chemistry letters (01.11.2014)
Get full text
Journal Article
BMS-192548, a Tetracyclic Binding Inhibitor of Neuropeptide Y Receptors, from Aspergillus niger WB2346: I. Taxonomy, Fermentation, Isolation and Biological Activity
KODUKULA, KRISHNA, ARCURI, MAREDITH, CUTRONE, JINGFANG QIAN, HUGILL, ROBERT M., LOWE, SUSAN E., PIRNIK, DOLORES M., SHU, YUE-ZHONG, FERNANDES, PRABHAVATHI B., SEETHALA, RAMAKRISHNA
Published in Journal of antibiotics (1995)
Published in Journal of antibiotics (1995)
Get full text
Journal Article
Synthesis and structure–activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
Ye, Xiang-Yang, Yoon, David, Chen, Stephanie Y., Nayeem, Akbar, Golla, Rajasree, Seethala, Ramakrishna, Wang, Mengmeng, Harper, Timothy, Sleczka, Bogdan G., Apedo, Atsu, Li, Yi-Xin, He, Bin, Kirby, Mark, Gordon, David A., Robl, Jeffrey A.
Published in Bioorganic & medicinal chemistry letters (15.01.2014)
Published in Bioorganic & medicinal chemistry letters (15.01.2014)
Get full text
Journal Article
Eleven Amino Acid Glucagon-like Peptide-1 Receptor Agonists with Antidiabetic Activity
Mapelli, Claudio, Natarajan, Sesha I, Meyer, Jean-Philippe, Bastos, Margarita M, Bernatowicz, Michael S, Lee, Ving G, Pluscec, Jelka, Riexinger, Douglas J, Sieber-McMaster, Ellen S, Constantine, Keith L, Smith-Monroy, Constance A, Golla, Rajasree, Ma, Zhengping, Longhi, Daniel A, Shi, Dan, Xin, Li, Taylor, Joseph R, Koplowitz, Barry, Chi, Cecilia L, Khanna, Ashish, Robinson, Gordon W, Seethala, Ramakrishna, Antal-Zimanyi, Ildiko A, Stoffel, Robert H, Han, Songping, Whaley, Jean M, Huang, Christine S, Krupinski, John, Ewing, William R
Published in Journal of medicinal chemistry (10.12.2009)
Published in Journal of medicinal chemistry (10.12.2009)
Get full text
Journal Article
Generation of 3,8-substituted 1,2,4-triazolopyridines as potent inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1)
Wang, Haixia, Robl, Jeffrey A., Hamann, Lawrence G., Simpkins, Ligaya, Golla, Rajasree, Li, Yi-Xin, Seethala, Ramakrishna, Zvyaga, Tatyana, Gordon, David A., Li, James J.
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
Published in Bioorganic & medicinal chemistry letters (15.07.2011)
Get full text
Journal Article
Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)
Li, Jun, Kennedy, Lawrence J, Walker, Steven J, Wang, Haixia, Li, James J, Hong, Zhenqiu, O’Connor, Stephen P, Ye, Xiang-yang, Chen, Stephanie, Wu, Shung, Yoon, David S, Nayeem, Akbar, Camac, Daniel M, Ramamurthy, Vidhyashankar, Morin, Paul E, Sheriff, Steven, Wang, Mengmeng, Harper, Timothy W, Golla, Rajasree, Seethala, Ramakrishna, Harrity, Thomas, Ponticiello, Randolph P, Morgan, Nathan N, Taylor, Joseph R, Zebo, Rachel, Maxwell, Brad, Moulin, Frederick, Gordon, David A, Robl, Jeffrey A
Published in ACS medicinal chemistry letters (13.12.2018)
Published in ACS medicinal chemistry letters (13.12.2018)
Get full text
Journal Article
Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11I2-hydroxysteroid dehydrogenase type 1 (11I2-HSD1)
Ye, Xiang-Yang, Yoon, David, Chen, Stephanie, Nayeem, Akbar, Golla, Rajasree, Seethala, Ramakrishna, Wang, Mengmeng, Harper, Timothy, Sleczka, Bogdan, Apedo, Atsu, Li, Yi-Xin, He, Bin, Kirby, Mark, Gordon, David, Robl, Jeffrey
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
Get full text
Journal Article