Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class
Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Aristoff, Paul A, Johnson, Paul D, Skulnick, Harvey I, Dolak, Lester A, Seest, Eric P, Tomich, Paul K, Bohanon, Michael J, Horng, Miao-Miao, Lynn, Janet C, Chong, Kong-Teck, Hinshaw, Roger R, Watenpaugh, Keith D, Janakiraman, Musiri N, Thaisrivongs, Suvit
Published in Journal of medicinal chemistry (27.08.1998)
Published in Journal of medicinal chemistry (27.08.1998)
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(-)-6-chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor
Wishka, DG, Graber, DR, Kopta, LA, Olmsted, RA, Friis, JM, Hosley, JD, Adams, WJ, Seest, EP, Castle, TM, Dolak, LA, Keiser, BJ, Yagi, Y, Jeganathan, A, Schlachter, ST, Murphy, MJ, Cleek, GJ, Nugent, RA, Poppe, SM, Swaney, SM, Han, FS, Watt, W, White, WL, Poel, TJ, Thomas, RC, Voorman, RL, Stefanski, KJ, Stehle, RG, Tarpley, WG, Morris, J
Published in Journal of medicinal chemistry (23.04.1998)
Published in Journal of medicinal chemistry (23.04.1998)
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Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens
Barbachyn, Michael R, Cleek, Gary J, Dolak, Lester A, Garmon, Stuart A, Morris, Joel, Seest, Eric P, Thomas, Richard C, Toops, Dana S, Watt, William, Wishka, Donn G, Ford, Charles W, Zurenko, Gary E, Hamel, Judith C, Schaadt, Ronda D, Stapert, Douglas, Yagi, Betty H, Adams, Wade J, Friis, Janice M, Slatter, J. Gregory, Sams, James P, Oien, Nancee L, Zaya, Matthew J, Wienkers, Larry C, Wynalda, Michael A
Published in Journal of medicinal chemistry (16.01.2003)
Published in Journal of medicinal chemistry (16.01.2003)
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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors: The Sulfonamide-Substituted Cyclooctylpyranones
Skulnick, Harvey I, Johnson, Paul D, Aristoff, Paul A, Morris, Jeanette K, Lovasz, Kristine D, Howe, W. Jeffrey, Watenpaugh, Keith D, Janakiraman, Musiri N, Anderson, David J, Reischer, Robert J, Schwartz, Theresa M, Banitt, Lee S, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Dolak, Lester A, Seest, Eric P, Schwende, Francis J, Rush, Bob D, Howard, Gina M, Toth, Lisa N, Wilkinson, Karen R, Kakuk, Thomas J, Johnson, Carol W, Cole, Serena L, Zaya, Renee M, Zipp, Gail L, Possert, Peggy L, Dalga, Robert J, Zhong, Wei-Zhu, Williams, Marta G, Romines, Karen R
Published in Journal of medicinal chemistry (28.03.1997)
Published in Journal of medicinal chemistry (28.03.1997)
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Carbon–carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria
Lee, Chi Sing, Allwine, Debra A, Barbachyn, Michael R, Grega, Kevin C, Dolak, Lester A, Ford, Charles W, Jensen, Randy M, Seest, Eric P, Hamel, Judith C, Schaadt, Ronda D, Stapert, Douglas, Yagi, Betty H, Zurenko, Gary E, Genin, Michael J
Published in Bioorganic & medicinal chemistry (01.12.2001)
Published in Bioorganic & medicinal chemistry (01.12.2001)
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Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition
Thorarensen, Atli, Douglas, Jr, Martin R., Rohrer, Douglas C., Vosters, Anne F., Yem, Anthony W., Marshall, Vincent D., Lynn, Janet C., Bohanon, Michael J., Tomich, Paul K., Zurenko, Gary E., Sweeney, Michael T., Jensen, Randy M., Nielsen, James W., Seest, Eric P., Dolak, Lester A.
Published in Bioorganic & medicinal chemistry letters (04.06.2001)
Published in Bioorganic & medicinal chemistry letters (04.06.2001)
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Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors
Thaisrivongs, Suvit, Skulnick, Harvey I, Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Johnson, Paul D, Aristoff, Paul A, Judge, Thomas M, Gammill, Ronald B, Morris, Jeanette K, Romines, Karen R, Chrusciel, Robert A, Hinshaw, Roger R, Chong, Kong-Teck, Tarpley, W. Gary, Poppe, Susan M, Slade, David E, Lynn, Janet C, Horng, Miao-Miao, Tomich, Paul K, Seest, Eric P, Dolak, Lester A, Howe, W. Jeffrey, Howard, Gina M, Schwende, Francis J, Toth, Lisa N, Padbury, Guy E, Wilson, Grace J, Shiou, Lihua, Zipp, Gail L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J, Koeplinger, Kenneth A, Zhao, Zhiyang, Cole, Serena, Zaya, Renee M, Kakuk, Thomas J, Janakiraman, Musiri N, Watenpaugh, Keith D
Published in Journal of medicinal chemistry (25.10.1996)
Published in Journal of medicinal chemistry (25.10.1996)
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Stereoselective Synthesis of Furo[2,3-c]pyridine Pyrimidine Thioethers, A New Class of Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors
Wishka, Donn G, Graber, David R, Seest, Eric P, Dolak, Lester A, Han, Fusen, Watt, William, Morris, Joel
Published in Journal of organic chemistry (30.10.1998)
Published in Journal of organic chemistry (30.10.1998)
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The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones
Ciske, Fred L, Barbachyn, Michael R, Genin, Michael J, Grega, Kevin C, Lee, Chi Sing, Dolak, Lester A, Seest, Eric P, Watt, William, Adams, Wade J, Friis, Janice M, Ford, Charles W, Zurenko, Gary E
Published in Bioorganic & medicinal chemistry letters (01.12.2003)
Published in Bioorganic & medicinal chemistry letters (01.12.2003)
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(-)-6-Chloro-2-[(1-furo[2,3-c] pyridin-5-yl-ethyl)thio]-4-p yrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor
Wishka, D G, Graber, DR, Kopta, LA, Olmsted, R A, Friis, J M, Hosley, J D, Adams, W J, Seest, E P, Castle, T M, Dolak, LA, Keiser, B J, Yagi, Yoshihiko, Jeganathan, A, Schlachter, ST
Published in Journal of medicinal chemistry (01.04.1998)
Published in Journal of medicinal chemistry (01.04.1998)
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Journal Article
Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones
Skulnick, H I, Johnson, P D, Aristoff, P A, Morris, J K, Lovasz, K D, Howe, W J, Watenpaugh, K D, Janakiraman, M N, Anderson, D J, Reischer, R J, Schwartz, T M, Banitt, L S, Tomich, P K, Lynn, J C, Horng, M M, Chong, K T, Hinshaw, R R, Dolak, L A, Seest, E P, Schwende, F J, Rush, B D, Howard, G M, Toth, L N, Wilkinson, K R, Romines, K R
Published in Journal of medicinal chemistry (28.03.1997)
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Published in Journal of medicinal chemistry (28.03.1997)
Journal Article
(−)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor
Wishka, Donn G, Graber, David R, Kopta, Laurice A, Olmsted, Robert A, Friis, Janice M, Hosley, John D, Adams, Wade J, Seest, Eric P, Castle, Thomas M, Dolak, Lester A, Keiser, Barbara J, Yagi, Yoshihiko, Jeganathan, Azhwarsamy, Schlachter, Stephen T, Murphy, Michael J, Cleek, Gary J, Nugent, Richard A, Poppe, Susan M, Swaney, Steven M, Han, Fusen, Watt, William, White, Wendy L, Poel, Toni-Jo, Thomas, Richard C, Voorman, Richard L, Stefanski, Kevin J, Stehle, Randall G, Tarpley, W. Gary, Morris, Joel
Published in Journal of medicinal chemistry (23.04.1998)
Published in Journal of medicinal chemistry (23.04.1998)
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A Facile Asymmetric Synthesis of 1,2,3-Substituted Indenes
Romines, Karen R, Lovasz, Kristine D, Mizsak, Stephen A, Morris, Jeanette K, Seest, Eric P, Han, Fusen, Tulinsky, John, Judge, Thomas M, Gammill, Ronald B
Published in Journal of organic chemistry (05.03.1999)
Published in Journal of organic chemistry (05.03.1999)
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Isolation and 1H and 13C NMR of Ammiol and Khellol Glucosides
Tjarks, Larry W, Spencer, Gayland F, Seest, Eric P
Published in Journal of natural products (Washington, D.C.) (01.05.1989)
Published in Journal of natural products (Washington, D.C.) (01.05.1989)
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Asymmetric Synthesis of an HIV Protease Inhibitor via a Novel .alpha.-Oxoketene/Ketene [4 + 2] Cycloaddition Reaction
Gammill, Ronald B, Judge, Thomas M, Phillips, Gillian, Zhang, Qingwei, Sowell, C. Gregory, Cheney, B. Vernon, Mizsak, Stephen A, Dolak, Lester A, Seest, Eric P
Published in Journal of the American Chemical Society (01.12.1994)
Published in Journal of the American Chemical Society (01.12.1994)
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