Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis
Susanto, O, Stewart, S E, Voskoboinik, I, Brasacchio, D, Hagn, M, Ellis, S, Asquith, S, Sedelies, K A, Bird, P I, Waterhouse, N J, Trapani, J A
Published in Cell death and differentiation (01.09.2013)
Published in Cell death and differentiation (01.09.2013)
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Journal Article
The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress
Bird, C H, Christensen, M E, Mangan, M S J, Prakash, M D, Sedelies, K A, Smyth, M J, Harper, I, Waterhouse, N J, Bird, P I
Published in Cell death and differentiation (01.06.2014)
Published in Cell death and differentiation (01.06.2014)
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Journal Article
Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737
Sutton, V R, Sedelies, K, Dewson, G, Christensen, M E, Bird, P I, Johnstone, R W, Kluck, R M, Trapani, J A, Waterhouse, N J
Published in Cell death & disease (01.07.2012)
Published in Cell death & disease (01.07.2012)
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Journal Article
Functional dissociation of ΔΨm and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis
Waterhouse, N J, Sedelies, K A, Sutton, V R, Pinkoski, M J, Thia, K Y, Johnstone, R, Bird, P I, Green, D R, Trapani, J A
Published in Cell death and differentiation (01.04.2006)
Published in Cell death and differentiation (01.04.2006)
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Journal Article
Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity
Sedelies, K A, Ciccone, A, Clarke, C J P, Oliaro, J, Sutton, V R, Scott, F L, Silke, J, Susanto, O, Green, D R, Johnstone, R W, Bird, P I, Trapani, J A, Waterhouse, N J
Published in Cell death and differentiation (01.04.2008)
Published in Cell death and differentiation (01.04.2008)
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Journal Article
Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation
Sutton, V R, Davis, J E, Cancilla, M, Johnstone, R W, Ruefli, A A, Sedelies, K, Browne, K A, Trapani, J A
Published in The Journal of experimental medicine (20.11.2000)
Published in The Journal of experimental medicine (20.11.2000)
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Functional dissociation of [Delta][Psi]m and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis
Waterhouse, N J, Sedelies, K A, Sutton, V R, Pinkoski, M J, Thia, K Y, Johnstone, R, Bird, P I, Green, D R, Trapani, J A
Published in Cell death and differentiation (01.04.2006)
Published in Cell death and differentiation (01.04.2006)
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Journal Article
Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis
Waterhouse, N J, Sedelies, K A, Sutton, V R, Pinkoski, M J, Thia, K Y, Johnstone, R, Bird, P I, Green, D R, Trapani, J A
Published in Cell death and differentiation (01.04.2006)
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Published in Cell death and differentiation (01.04.2006)
Journal Article
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors
PEART, Melissa J, TAINTON, Kellie M, RUEFLI, Astrid A, DEAR, Anthony E, SEDELIES, Karin A, O'REILLY, Lorraine A, WATERHOUSE, Nigel J, TRAPANI, Joseph A, JOHNSTONE, Ricky W
Published in Cancer research (Chicago, Ill.) (01.08.2003)
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Published in Cancer research (Chicago, Ill.) (01.08.2003)
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Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis
Waterhouse, Nigel J, Sutton, Vivien R, Sedelies, Karin A, Ciccone, Annette, Jenkins, Misty, Turner, Stephen J, Bird, Phillip I, Trapani, Joseph A
Published in The Journal of cell biology (10.04.2006)
Published in The Journal of cell biology (10.04.2006)
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Journal Article
A Central Role for Bid in Granzyme B-induced Apoptosis
Waterhouse, Nigel J., Sedelies, Karin A., Browne, Kylie A., Wowk, Michelle E., Newbold, Andrea, Sutton, Vivien R., Clarke, Chris J. P, Oliaro, Jane, Lindemann, Ralph K., Bird, Phillip I., Johnstone, Ricky W., Trapani, Joseph A.
Published in The Journal of biological chemistry (11.02.2005)
Published in The Journal of biological chemistry (11.02.2005)
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hScrib is a functional homologue of the Drosophila tumour suppressor Scribble
DOW, Lukas E, BRUMBY, Anthony M, MURATORE, Rosa, COOMBE, Michelle L, SEDELIES, Karin A, TRAPANI, Joseph A, RUSSELL, Sarah M, RICHARDSON, Helena E, HUMBERT, Patrick O
Published in Oncogene (18.12.2003)
Published in Oncogene (18.12.2003)
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Discordant Regulation of Granzyme H and Granzyme B Expression in Human Lymphocytes
Sedelies, Karin A., Sayers, Thomas J., Edwards, Kirsten M., Chen, Weisan, Pellicci, Daniel G., Godfrey, Dale I., Trapani, Joseph A.
Published in The Journal of biological chemistry (18.06.2004)
Published in The Journal of biological chemistry (18.06.2004)
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Journal Article
Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis
Waterhouse, Nigel J, Sedelies, Karin A, Trapani, Joseph A
Published in Immunology and cell biology (01.02.2006)
Published in Immunology and cell biology (01.02.2006)
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Journal Article
Cytotoxic lymphocytes; instigators of dramatic target cell death
Waterhouse, Nigel J., Clarke, Chris J.P., Sedelies, Karin A., Teng, Michele W., Trapani, Joseph A.
Published in Biochemical pharmacology (15.09.2004)
Published in Biochemical pharmacology (15.09.2004)
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