Application of Crystallographic and Modeling Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors
RZMOVL, S. E, SUDHAKAR BABU, Y, BUGG, C. E, ERION, M. D, GUIDA, W. C, MONTGOMERY, J. A, SECRIST, J. A
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.1991)
Published in Proceedings of the National Academy of Sciences - PNAS (15.12.1991)
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Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugs
W B Parker, E L White, S C Shaddix, L J Ross, R W Buckheit, Jr, J M Germany, J A Secrist, 3rd, R Vince, W M Shannon
Published in The Journal of biological chemistry (25.01.1991)
Published in The Journal of biological chemistry (25.01.1991)
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Phosphorylation of the enantiomers of the carbocyclic analog of 2'-deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase
L L Bennett, Jr, W B Parker, P W Allan, L M Rose, Y F Shealy, J A Secrist, 3rd, J A Montgomery, G Arnett, R L Kirkman, W M Shannon
Published in Molecular pharmacology (01.12.1993)
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Published in Molecular pharmacology (01.12.1993)
Journal Article
Incorporation of the carbocyclic analog of 2'-deoxyguanosine into the DNA of herpes simplex virus and of HEp-2 cells infected with herpes simplex virus
W B Parker, S C Shaddix, P W Allan, G Arnett, L M Rose, W M Shannon, Y F Shealy, J A Montgomery, J A Secrist, 3rd, L L Bennett, Jr
Published in Molecular pharmacology (01.02.1992)
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Published in Molecular pharmacology (01.02.1992)
Journal Article
The Structural Basis for Substrate Specificity and Inhibition of Human S-Adenosylmethionine Decarboxylase
Tolbert, W. David, Ekstrom, Jennifer L, Mathews, Irimpan I, Secrist, John A, Kapoor, Preeti, Pegg, Anthony E, Ealick, Steven E
Published in Biochemistry (Easton) (14.08.2001)
Published in Biochemistry (Easton) (14.08.2001)
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Programs to facilitate tuberculosis drug discovery: the tuberculosis antimicrobial acquisition and coordinating facility
Goldman, R C, Laughon, B E, Reynolds, R C, Secrist, 3rd, J A, Maddry, J A, Guié, M-A, Poffenberger, A C, Kwong, C A, Ananthan, S
Published in Infectious disorders drug targets (01.06.2007)
Published in Infectious disorders drug targets (01.06.2007)
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Comparison of the Mechanism of Cytotoxicity of 2-Chloro-9-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)adenine, 2-Chloro-9-(2-deoxy-2-fluoro-β-d-ribofuranosyl)adenine, and 2-Chloro-9-(2-deoxy-2,2-difluoro-β-d-ribofuranosyl)adenine in CEM Cells
Parker, W B, Shaddix, S C, Rose, L M, Shewach, D S, Hertel, L W, Secrist, 3rd, J A, Montgomery, J A, Bennett, Jr, L L
Published in Molecular pharmacology (01.03.1999)
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Published in Molecular pharmacology (01.03.1999)
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In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase
Parker, W B, King, S A, Allan, P W, Bennett, Jr, L L, Secrist, 3rd, J A, Montgomery, J A, Gilbert, K S, Waud, W R, Wells, A H, Gillespie, G Y, Sorscher, E J
Published in Human gene therapy (20.09.1997)
Published in Human gene therapy (20.09.1997)
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Structure−Activity Relationships of Bisphosphate Nucleotide Derivatives as P2Y1 Receptor Antagonists and Partial Agonists
Nandanan, Erathodiyil, Camaioni, Emidio, Jang, Soo-Yeon, Kim, Yong-Chul, Cristalli, Gloria, Herdewijn, Piet, Secrist, John A, Tiwari, Kamal N, Mohanram, Arvind, Harden, T. Kendall, Boyer, José L, Jacobson, Kenneth A
Published in Journal of medicinal chemistry (06.05.1999)
Published in Journal of medicinal chemistry (06.05.1999)
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Metabolism of 4′-thio-β- d-arabinofuranosylcytosine in CEM cells
Parker, William B, Shaddix, Sue C, Rose, Lucy M, Waud, William R, Shewach, Donna S, Tiwari, Kamal N, Secrist, John A
Published in Biochemical pharmacology (15.12.2000)
Published in Biochemical pharmacology (15.12.2000)
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Bis(tBuSATE) phosphotriester prodrugs of 8-azaguanosine and 6-methylpurine riboside; bis(pom) phosphotriester prodrugs of 2'-deoxy-4'-thioadenosine and its corresponding 9alpha anomer
Rose, J D, Parker, W B, Secrist, 3rd, J A
Published in Nucleosides, nucleotides & nucleic acids (2005)
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Published in Nucleosides, nucleotides & nucleic acids (2005)
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Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides
Secrist, John A, Tiwari, Kamal N, Riordan, James M, Montgomery, John A
Published in Journal of medicinal chemistry (01.08.1991)
Published in Journal of medicinal chemistry (01.08.1991)
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Journal Article
Search for New Purine- and Ribose-Modified Adenosine Analogs as Selective Agonists and Antagonists at Adenosine Receptors
Siddiqi, Suhaib M, Jacobson, Kenneth A, Esker, John L, Olah, Mark E, Ji, Xiao-duo, Melman, Neli, Tiwari, Kamal N, Secrist, John A, Schneller, Stewart W
Published in Journal of medicinal chemistry (01.03.1995)
Published in Journal of medicinal chemistry (01.03.1995)
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Journal Article
Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(Arylmethyl) derivatives of 9-deazaguanine
Montgomery, John A., Niwas, Shri, Rose, Jerry D., Secrist, John A., Babu, Y. Sudhakar, Bugg, Charles E., Erion, Mark D., Guida, Wayne C., Ealick, Steven E.
Published in Journal of medicinal chemistry (1993)
Published in Journal of medicinal chemistry (1993)
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SYNTHESIS AND BIOLOGICAL ACTIVITY OF 2-FLUORO ADENINE AND 6-METHYL PURINE NUCLEOSIDE ANALOGS AS PRODRUGS FOR SUICIDE GENE THERAPY OF CANCER
Silamkoti, A. V., Allan, P. W., Hassan, A. E. A., Fowler, A. T., Sorscher, E. J., Parker, W. B., Secrist, J. A.
Published in Nucleosides, nucleotides & nucleic acids (01.01.2005)
Published in Nucleosides, nucleotides & nucleic acids (01.01.2005)
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Effects of 2-chloro-9-(3-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate
PARKER, W. B, SHADDIX, S. C, CHI-HSIUNG CHANG, WHITE, E. L, ROSE, L. M, BROCKMAN, R. W, SHORTNACY, A. T, MONTGOMERY, J. A, SECRIST, J. A, LEE BENNETT, L. JR
Published in Cancer research (Chicago, Ill.) (01.05.1991)
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Published in Cancer research (Chicago, Ill.) (01.05.1991)
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