Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
Siddiquee, Khandaker, Zhang, Shumin, Guida, Wayne C, Blaskovich, Michelle A, Greedy, Benjamin, Lawrence, Harshani R, Yip, M.L. Richard, Jove, Richard, McLaughlin, Mark M, Lawrence, Nicholas J, Sebti, Said M, Turkson, James
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.2007)
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Ral GTPase Down-regulation Stabilizes and Reactivates p53 to Inhibit Malignant Transformation
Tecleab, Awet, Zhang, Xiaolei, Sebti, Said M.
Published in The Journal of biological chemistry (07.11.2014)
Published in The Journal of biological chemistry (07.11.2014)
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MDMX Overexpression Prevents p53 Activation by the MDM2 Inhibitor Nutlin
Hu, Baoli, Gilkes, Daniele M., Farooqi, Bilal, Sebti, Said M., Chen, Jiandong
Published in The Journal of biological chemistry (03.11.2006)
Published in The Journal of biological chemistry (03.11.2006)
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Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation
Mahajan, Kiran, Coppola, Domenico, Challa, Sridevi, Fang, Bin, Chen, Y Ann, Zhu, Weiwei, Lopez, Alexis S, Koomen, John, Engelman, Robert W, Rivera, Charlene, Muraoka-Cook, Rebecca S, Cheng, Jin Q, Schönbrunn, Ernst, Sebti, Said M, Earp, H Shelton, Mahajan, Nupam P
Published in PloS one (19.03.2010)
Published in PloS one (19.03.2010)
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Phase II Study of the Mitogen-Activated Protein Kinase 1/2 Inhibitor Selumetinib in Patients With Advanced Hepatocellular Carcinoma
O'NEIL, Bert H, GOFF, Laura W, SEBTI, Said M, SULLIVAN, Daniel M, WOOK KAUH, John Sae, STROSBERG, Jonathan R, BEKAII-SAAB, Tanios S, LEE, Ruey-Min, KAZI, Aslamuzzaman, MOORE, Dominic T, LEAROYD, Maria, LUSH, Richard M
Published in Journal of clinical oncology (10.06.2011)
Published in Journal of clinical oncology (10.06.2011)
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Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine
Carbone, Michele, Amelio, Ivano, Affar, El Bachir, Brugarolas, James, Cannon-Albright, Lisa A, Cantley, Lewis C, Cavenee, Webster K, Chen, Zhijian, Croce, Carlo M, Andrea, Alan D', Gandara, David, Giorgi, Carlotta, Jia, Wei, Lan, Qing, Mak, Tak Wah, Manley, James L, Mikoshiba, Katsuhiko, Onuchic, Jose N, Pass, Harvey I, Pinton, Paolo, Prives, Carol, Rothman, Nathaniel, Sebti, Said M, Turkson, James, Wu, Xifeng, Yang, Haining, Yu, Herbert, Melino, Gerry
Published in Cell death and differentiation (01.11.2018)
Published in Cell death and differentiation (01.11.2018)
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Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway
NEFEDOVA, Yulia, NAGARAJ, Srinivas, ROSENBAUER, Amsler, MURO-CACHO, Carlos, SEBTI, Said M, GABRILOVICH, Dmitry I
Published in Cancer research (Chicago, Ill.) (15.10.2005)
Published in Cancer research (Chicago, Ill.) (15.10.2005)
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Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases
Schonbrunn, Ernst, Betzi, Stephane, Alam, Riazul, Martin, Mathew P, Becker, Andreas, Han, Huijong, Francis, Rawle, Chakrasali, Ramappa, Jakkaraj, Sudhakar, Kazi, Aslamuzzaman, Sebti, Said M, Cubitt, Christopher L, Gebhard, Anthony W, Hazlehurst, Lori A, Tash, Joseph S, Georg, Gunda I
Published in Journal of medicinal chemistry (23.05.2013)
Published in Journal of medicinal chemistry (23.05.2013)
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Discovery of a Novel Shp2 Protein Tyrosine Phosphatase Inhibitor
Chen, Liwei, Sung, Shen-Shu, Yip, M L Richard, Lawrence, Harshani R, Ren, Yuan, Guida, Wayne C, Sebti, Said M, Lawrence, Nicholas J, Wu, Jie
Published in Molecular pharmacology (01.08.2006)
Published in Molecular pharmacology (01.08.2006)
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Activation of Dendritic Cells via Inhibition of Jak2/STAT3 Signaling
Nefedova, Yulia, Cheng, Pingyan, Gilkes, Daniele, Blaskovich, Michelle, Beg, Amer A, Sebti, Said M, Gabrilovich, Dmitry I
Published in Journal of Immunology (01.10.2005)
Published in Journal of Immunology (01.10.2005)
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An Oxazole-Based Small-Molecule Stat3 Inhibitor Modulates Stat3 Stability and Processing and Induces Antitumor Cell Effects
Siddiquee, Khandaker A. Z, Gunning, Patrick T, Glenn, Matthew, Katt, William P, Zhang, Shumin, Schroeck, Christopher, Sebti, Said M, Jove, Richard, Hamilton, Andrew D, Turkson, James
Published in ACS chemical biology (01.12.2007)
Published in ACS chemical biology (01.12.2007)
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Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs
Francois, Rony A., Zhang, Anying, Husain, Kazim, Wang, Chen, Hutchinson, Sean, Kongnyuy, Michael, Batra, Surinder K., Coppola, Domenico, Sebti, Said M., Malafa, Mokenge P.
Published in Cancer cell international (22.07.2019)
Published in Cancer cell international (22.07.2019)
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Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism
Hodul, Pamela J, Dong, Yanbin, Husain, Kazim, Pimiento, Jose M, Chen, Jiandong, Zhang, Anying, Francois, Rony, Pledger, Warren J, Coppola, Domenico, Sebti, Said M, Chen, Dung-Tsa, Malafa, Mokenge P
Published in PloS one (2013)
Published in PloS one (2013)
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Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors
Li, Rongshi, Martin, Mathew P, Liu, Yan, Wang, Binglin, Patel, Ronil A, Zhu, Jin-Yi, Sun, Nan, Pireddu, Roberta, Lawrence, Nicholas J, Li, Jiannong, Haura, Eric B, Sung, Shen-Shu, Guida, Wayne C, Schonbrunn, Ernst, Sebti, Said M
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104)
Gajewski, Thomas F, Salama, April K S, Niedzwiecki, Donna, Johnson, Jeffrey, Linette, Gerald, Bucher, Cynthia, Blaskovich, Michelle A, Sebti, Said M, Haluska, Frank
Published in Journal of translational medicine (10.12.2012)
Published in Journal of translational medicine (10.12.2012)
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A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A
Martin, Mathew P, Zhu, Jin-Yi, Lawrence, Harshani R, Pireddu, Roberta, Luo, Yunting, Alam, Riazul, Ozcan, Sevil, Sebti, Said M, Lawrence, Nicholas J, Schönbrunn, Ernst
Published in ACS chemical biology (20.04.2012)
Published in ACS chemical biology (20.04.2012)
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Phase I Trial of a Combination of the Multikinase Inhibitor Sorafenib and the Farnesyltransferase Inhibitor Tipifarnib in Advanced Malignancies
Hong, David S, Sebti, Said M, Newman, Robert A, Blaskovich, Michelle A, Ye, Lei, Gagel, Robert F, Moulder, Stacy, Wheler, Jennifer J, Naing, Aung, Tannir, Nizar M, Ng, Chaan S, Sherman, Steven I, El Naggar, Adel K, Khan, Rabia, Trent, Jon, Wright, John J, Kurzrock, Razelle
Published in Clinical cancer research (15.11.2009)
Published in Clinical cancer research (15.11.2009)
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A Small Molecule Inhibits Akt through Direct Binding to Akt and Preventing Akt Membrane Translocation
Kim, Donghwa, Sun, Mei, He, Lili, Zhou, Qing-Hua, Chen, Jun, Sun, Xia-Meng, Bepler, Gerold, Sebti, Said M., Cheng, Jin Q.
Published in The Journal of biological chemistry (12.03.2010)
Published in The Journal of biological chemistry (12.03.2010)
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Inhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic cancer cells in vitro and in vivo
Ucar, Deniz A, Magis, Andrew T, He, Di-Hua, Lawrence, Nicholas J, Sebti, Said M, Kurenova, Elena, Zajac-Kaye, Maria, Zhang, Jianliang, Hochwald, Steven N
Published in Anti-cancer agents in medicinal chemistry (01.05.2013)
Published in Anti-cancer agents in medicinal chemistry (01.05.2013)
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