Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design
Wyatt, Paul G, Woodhead, Andrew J, Berdini, Valerio, Boulstridge, John A, Carr, Maria G, Cross, David M, Davis, Deborah J, Devine, Lindsay A, Early, Theresa R, Feltell, Ruth E, Lewis, E. Jonathan, McMenamin, Rachel L, Navarro, Eva F, O’Brien, Michael A, O’Reilly, Marc, Reule, Matthias, Saxty, Gordon, Seavers, Lisa C. A, Smith, Donna-Michelle, Squires, Matt S, Trewartha, Gary, Walker, Margaret T, Woolford, Alison J.-A
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors
Howard, Nigel, Abell, Chris, Blakemore, Wendy, Chessari, Gianni, Congreve, Miles, Howard, Steven, Jhoti, Harren, Murray, Christopher W, Seavers, Lisa C. A, van Montfort, Rob L. M
Published in Journal of medicinal chemistry (23.02.2006)
Published in Journal of medicinal chemistry (23.02.2006)
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Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation
Gill, Adrian L, Frederickson, Martyn, Cleasby, Anne, Woodhead, Steven J, Carr, Maria G, Woodhead, Andrew J, Walker, Margaret T, Congreve, Miles S, Devine, Lindsay A, Tisi, Dominic, O'Reilly, Marc, Seavers, Lisa C. A, Davis, Deborah J, Curry, Jayne, Anthony, Rachel, Padova, Alessandro, Murray, Christopher W, Carr, Robin A. E, Jhoti, Harren
Published in Journal of medicinal chemistry (27.01.2005)
Published in Journal of medicinal chemistry (27.01.2005)
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AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth
Grimshaw, Kyla M, Hunter, Lisa-Jane K, Yap, Timothy A, Heaton, Simon P, Walton, Mike I, Woodhead, Steven J, Fazal, Lynsey, Reule, Matthias, Davies, Thomas G, Seavers, Lisa C, Lock, Victoria, Lyons, John F, Thompson, Neil T, Workman, Paul, Garrett, Michelle D
Published in Molecular cancer therapeutics (01.05.2010)
Published in Molecular cancer therapeutics (01.05.2010)
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Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B
Collins, Ian, Caldwell, John, Fonseca, Tatiana, Donald, Alastair, Bavetsias, Vassilios, Hunter, Lisa-Jane K., Garrett, Michelle D., Rowlands, Martin G., Aherne, G. Wynne, Davies, Thomas G., Berdini, Valerio, Woodhead, Steven J., Davis, Deborah, Seavers, Lisa C.A., Wyatt, Paul G., Workman, Paul, McDonald, Edward
Published in Bioorganic & medicinal chemistry (15.02.2006)
Published in Bioorganic & medicinal chemistry (15.02.2006)
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Feedback from the Science Café roundtables at the ninth European Bioanalysis Forum Young Scientist Symposium: optimizing the work-life balance in a bioanalytical laboratory
Hanckmann, Eva, Heads, Paul, Pineault, Kyriel, Szuster, Claire, Zeiser, Katja, Beecroft, James, Da Cunha, Mariana Carneiro, Dan, Brian, Heughebaert, Liesl, Hogan, Dean, Jacobs, Cathy, Schaar, Juel Maalouli, Marincich, Lorenzo, Minelli, Francesca, Noor, Bodrul, Reille-Seroussi, Marie, Roberts, Amelia, Seavers, Lisa, Spendal, Manca, Thomas, Harriet, Klooster, Joury Van't, Nuffel, Elien Van, Wolter, Lisa, Timmerman, Philip
Published in Bioanalysis (2024)
Published in Bioanalysis (2024)
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Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)
McHardy, Tatiana, Caldwell, John J, Cheung, Kwai-Ming, Hunter, Lisa J, Taylor, Kevin, Rowlands, Martin, Ruddle, Ruth, Henley, Alan, de Haven Brandon, Alexis, Valenti, Melanie, Davies, Thomas G, Fazal, Lynsey, Seavers, Lisa, Raynaud, Florence I, Eccles, Suzanne A, Aherne, G. Wynne, Garrett, Michelle D, Collins, Ian
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Identification of N -(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1 H -pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design
Wyatt, Paul G., Woodhead, Andrew J., Berdini, Valerio, Boulstridge, John A., Carr, Maria G., Cross, David M., Davis, Deborah J., Devine, Lindsay A., Early, Theresa R., Feltell, Ruth E., Lewis, E. Jonathan, McMenamin, Rachel L., Navarro, Eva F., O’Brien, Michael A., O’Reilly, Marc, Reule, Matthias, Saxty, Gordon, Seavers, Lisa C. A., Smith, Donna-Michelle, Squires, Matt S., Trewartha, Gary, Walker, Margaret T., Woolford, Alison J.-A.
Published in Journal of medicinal chemistry (01.08.2008)
Published in Journal of medicinal chemistry (01.08.2008)
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Journal Article
Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation
Gill, Adrian L, Frederickson, Martyn, Cleasby, Anne, Woodhead, Steven J, Carr, Maria G, Woodhead, Andrew J, Walker, Margaret T, Congreve, Miles S, Devine, Lindsay A, Tisi, Dominic, O'Reilly, Marc, Seavers, Lisa C A, Davis, Deborah J, Curry, Jayne, Anthony, Rachel, Padova, Alessandro, Murray, Christopher W, Carr, Robin A E, Jhoti, Harren
Published in Journal of medicinal chemistry (27.01.2005)
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Published in Journal of medicinal chemistry (27.01.2005)
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