FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis
Turunen, S. Pauliina, von Nandelstadh, Pernilla, Öhman, Tiina, Gucciardo, Erika, Seashore-Ludlow, Brinton, Martins, Beatriz, Rantanen, Ville, Li, Huini, Höpfner, Katrin, Östling, Päivi, Varjosalo, Markku, Lehti, Kaisa
Published in Cell death and differentiation (01.12.2019)
Published in Cell death and differentiation (01.12.2019)
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Journal Article
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors
Azimi, Alireza, Caramuta, Stefano, Seashore‐Ludlow, Brinton, Boström, Johan, Robinson, Jonathan L, Edfors, Fredrik, Tuominen, Rainer, Kemper, Kristel, Krijgsman, Oscar, Peeper, Daniel S, Nielsen, Jens, Hansson, Johan, Egyhazi Brage, Suzanne, Altun, Mikael, Uhlen, Mathias, Maddalo, Gianluca
Published in Molecular systems biology (05.03.2018)
Published in Molecular systems biology (05.03.2018)
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Journal Article
High‐content screening of drug combinations of an mPGES‐1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance
Zaghmi, Ahlem, Aybay, Erdem, Jiang, Long, Shang, Mingmei, Steinmetz‐Späh, Julia, Wermeling, Fredrik, Kogner, Per, Korotkova, Marina, Östling, Päivi, Jakobsson, Per‐Johan, Seashore‐Ludlow, Brinton, Larsson, Karin
Published in Molecular oncology (01.02.2024)
Published in Molecular oncology (01.02.2024)
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Journal Article
Domino Carbopalladation-Carbonylation: Investigation of Substrate Scope
Seashore-Ludlow, Brinton, Danielsson, Jakob, Somfai, Peter
Published in Advanced synthesis & catalysis (01.01.2012)
Published in Advanced synthesis & catalysis (01.01.2012)
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Journal Article
The transcriptome‐wide landscape of molecular subtype‐specific mRNA expression profiles in acute myeloid leukemia
Mou, Tian, Pawitan, Yudi, Stahl, Matthias, Vesterlund, Mattias, Deng, Wenjiang, Jafari, Rozbeh, Bohlin, Anna, Österroos, Albin, Siavelis, Loannis, Bäckvall, Helena, Erkers, Tom, Kiviluoto, Santeri, Seashore‐Ludlow, Brinton, Östling, Päivi, Orre, Lukas M., Kallioniemi, Olli, Lehmann, Sören, Lehtiö, Janne, Vu, Trung Nghia
Published in American journal of hematology (01.05.2021)
Published in American journal of hematology (01.05.2021)
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Journal Article
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
Viswanathan, Vasanthi S., Ryan, Matthew J., Dhruv, Harshil D., Gill, Shubhroz, Eichhoff, Ossia M., Seashore-Ludlow, Brinton, Kaffenberger, Samuel D., Eaton, John K., Shimada, Kenichi, Aguirre, Andrew J., Viswanathan, Srinivas R., Chattopadhyay, Shrikanta, Tamayo, Pablo, Yang, Wan Seok, Rees, Matthew G., Chen, Sixun, Boskovic, Zarko V., Javaid, Sarah, Huang, Cherrie, Wu, Xiaoyun, Tseng, Yuen-Yi, Roider, Elisabeth M., Gao, Dong, Cleary, James M., Wolpin, Brian M., Mesirov, Jill P., Haber, Daniel A., Engelman, Jeffrey A., Boehm, Jesse S., Kotz, Joanne D., Hon, Cindy S., Chen, Yu, Hahn, William C., Levesque, Mitchell P., Doench, John G., Berens, Michael E., Shamji, Alykhan F., Clemons, Paul A., Stockwell, Brent R., Schreiber, Stuart L.
Published in Nature (London) (27.07.2017)
Published in Nature (London) (27.07.2017)
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Journal Article
Correlating chemical sensitivity and basal gene expression reveals mechanism of action
Rees, Matthew G, Seashore-Ludlow, Brinton, Cheah, Jaime H, Adams, Drew J, Price, Edmund V, Gill, Shubhroz, Javaid, Sarah, Coletti, Matthew E, Jones, Victor L, Bodycombe, Nicole E, Soule, Christian K, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Haber, Daniel A, Clish, Clary B, Bittker, Joshua A, Palmer, Michelle, Wagner, Bridget K, Clemons, Paul A, Shamji, Alykhan F, Schreiber, Stuart L
Published in Nature chemical biology (01.02.2016)
Published in Nature chemical biology (01.02.2016)
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Journal Article
Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality
Jerby-Arnon, Livnat, Pfetzer, Nadja, Waldman, Yedael Y., McGarry, Lynn, James, Daniel, Shanks, Emma, Seashore-Ludlow, Brinton, Weinstock, Adam, Geiger, Tamar, Clemons, Paul A., Gottlieb, Eyal, Ruppin, Eytan
Published in Cell (28.08.2014)
Published in Cell (28.08.2014)
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Journal Article
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
Seashore-Ludlow, Brinton, Rees, Matthew G, Cheah, Jaime H, Cokol, Murat, Price, Edmund V, Coletti, Matthew E, Jones, Victor, Bodycombe, Nicole E, Soule, Christian K, Gould, Joshua, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Wawer, Mathias J, Kuru, Nurdan, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Bittker, Joshua A, Palmer, Michelle, Bradner, James E, Shamji, Alykhan F, Clemons, Paul A, Schreiber, Stuart L
Published in Cancer discovery (01.11.2015)
Published in Cancer discovery (01.11.2015)
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Journal Article
Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery
Mateus, André, Gordon, Laurie J., Wayne, Gareth J., Almqvist, Helena, Axelsson, Hanna, Seashore-Ludlow, Brinton, Treyer, Andrea, Matsson, Pär, Lundbäck, Thomas, West, Andy, Hann, Michael M., Artursson, Per
Published in Proceedings of the National Academy of Sciences - PNAS (25.07.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (25.07.2017)
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Journal Article
Targeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia
Bwanika, Henri Colyn, Leo, Isabelle Rose, Struyf, Nona, Talanti, Asimina, Aswad, Luay, Konnur, Aishwarya, Björklund, Ann-Charlotte, Heyman, Mats, Rassidakis, Georgios, Erkers, Tom, Seashore-Ludlow, Brinton, Jafari, Rozbeh, Pokrovskaja Tamm, Katja
Published in Scientific reports (18.02.2024)
Published in Scientific reports (18.02.2024)
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Journal Article
Multiomics characterization implicates PTK7 in ovarian cancer EMT and cell plasticity and offers strategies for therapeutic intervention
Raivola, Juuli, Dini, Alice, Karvonen, Hanna, Piki, Emilia, Salokas, Kari, Niininen, Wilhelmiina, Kaleva, Laura, Zhang, Kaiyang, Arjama, Mariliina, Gudoityte, Greta, Seashore-Ludlow, Brinton, Varjosalo, Markku, Kallioniemi, Olli, Hautaniemi, Sampsa, Murumägi, Astrid, Ungureanu, Daniela
Published in Cell death & disease (17.08.2022)
Published in Cell death & disease (17.08.2022)
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Journal Article
Targeting SAMHD1 with hydroxyurea in first‐line cytarabine‐based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT‐AML trial
Jädersten, Martin, Lilienthal, Ingrid, Tsesmetzis, Nikolaos, Lourda, Magda, Bengtzén, Sofia, Bohlin, Anna, Arnroth, Cornelia, Erkers, Tom, Seashore‐Ludlow, Brinton, Giraud, Géraldine, Barkhordar, Giti S., Tao, Sijia, Fogelstrand, Linda, Saft, Leonie, Östling, Päivi, Schinazi, Raymond F., Kim, Baek, Schaller, Torsten, Juliusson, Gunnar, Deneberg, Stefan, Lehmann, Sören, Rassidakis, Georgios Z., Höglund, Martin, Henter, Jan‐Inge, Herold, Nikolas
Published in Journal of internal medicine (01.12.2022)
Published in Journal of internal medicine (01.12.2022)
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Journal Article
Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine
Howard, Thomas P, Oberlick, Elaine M, Rees, Matthew G, Arnoff, Taylor E, Pham, Minh-Tam, Brenan, Lisa, DoCarmo, Mariana, Hong, Andrew L, Kugener, Guillaume, Chou, Hsien-Chao, Drosos, Yiannis, Mathias, Kaeli M, Ramos, Pilar, Seashore-Ludlow, Brinton, Giacomelli, Andrew O, Wang, Xiaofeng, Freeman, 3rd, Burgess B, Blankenship, Kaley, Hoffmann, Lauren, Tiv, Hong L, Gokhale, Prafulla C, Johannessen, Cory M, Stewart, Elizabeth A, Schreiber, Stuart L, Hahn, William C, Roberts, Charles W M
Published in Clinical cancer research (15.09.2020)
Published in Clinical cancer research (15.09.2020)
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Journal Article
SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis
Murga, Matilde, Lopez-Pernas, Gema, Soliva, Robert, Fueyo-Marcos, Elena, Amor, Corina, Faustino, Ignacio, Serna, Marina, Serrano, Alicia G., Díaz, Lucía, Martínez, Sonia, Blanco-Aparicio, Carmen, Antón, Marta Elena, Seashore-Ludlow, Brinton, Pastor, Joaquín, Jafari, Rozbeh, Lafarga, Miguel, Llorca, Oscar, Orozco, Modesto, Fernández-Capetillo, Oscar
Published in Cell death & disease (28.09.2024)
Published in Cell death & disease (28.09.2024)
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Journal Article
Addition of Azomethine Ylides to Aldehydes: Mechanistic Dichotomy of Differentially Substituted α-Imino Esters
Seashore-Ludlow, Brinton, Torssell, Staffan, Somfai, Peter
Published in European Journal of Organic Chemistry (01.07.2010)
Published in European Journal of Organic Chemistry (01.07.2010)
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Book Review
Journal Article
Discovery of a Small-Molecule Probe for V‑ATPase Function
Aldrich, Leslie N, Kuo, Szu-Yu, Castoreno, Adam B, Goel, Gautam, Kuballa, Petric, Rees, Matthew G, Seashore-Ludlow, Brinton A, Cheah, Jaime H, Latorre, Isabel J, Schreiber, Stuart L, Shamji, Alykhan F, Xavier, Ramnik J
Published in Journal of the American Chemical Society (29.04.2015)
Published in Journal of the American Chemical Society (29.04.2015)
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Journal Article
Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
Oberlick, Elaine M., Rees, Matthew G., Seashore-Ludlow, Brinton, Vazquez, Francisca, Nelson, Geoffrey M., Dharia, Neekesh V., Weir, Barbara A., Tsherniak, Aviad, Ghandi, Mahmoud, Krill-Burger, John M., Meyers, Robin M., Wang, Xiaofeng, Montgomery, Phil, Root, David E., Bieber, Jake M., Radko, Sandi, Cheah, Jaime H., Hon, C. Suk-Yee, Shamji, Alykhan F., Clemons, Paul A., Park, Peter J., Dyer, Michael A., Golub, Todd R., Stegmaier, Kimberly, Hahn, William C., Stewart, Elizabeth A., Schreiber, Stuart L., Roberts, Charles W.M.
Published in Cell reports (Cambridge) (27.08.2019)
Published in Cell reports (Cambridge) (27.08.2019)
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Journal Article