Selective Cannabinoid Receptor Type 2 (CB2) Agonists: Optimization of a Series of Purines Leading to the Identification of a Clinical Candidate for the Treatment of Osteoarthritic Pain
Hollinshead, Sean P, Tidwell, Michael W, Palmer, John, Guidetti, Rossella, Sanderson, Adam, Johnson, Michael P, Chambers, Mark G, Oskins, Jennifer, Stratford, Robert, Astles, Peter C
Published in Journal of medicinal chemistry (25.07.2013)
Published in Journal of medicinal chemistry (25.07.2013)
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Identification and Pharmacological Profile of a New Class of Selective Nicotinic Acetylcholine Receptor Potentiators
Broad, Lisa M, Zwart, Ruud, Pearson, Kathy H, Lee, Martin, Wallace, Louise, McPhie, Gordon I, Emkey, Renee, Hollinshead, Sean P, Dell, Colin P, Baker, S Richard, Sher, Emanuele
Published in The Journal of pharmacology and experimental therapeutics (01.09.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2006)
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Discovery of the First α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ‑8
Gardinier, Kevin M, Gernert, Douglas L, Porter, Warren J, Reel, Jon K, Ornstein, Paul L, Spinazze, Patrick, Stevens, F. Craig, Hahn, Patric, Hollinshead, Sean P, Mayhugh, Daniel, Schkeryantz, Jeff, Khilevich, Albert, De Frutos, Oscar, Gleason, Scott D, Kato, Akihiko S, Luffer-Atlas, Debra, Desai, Prashant V, Swanson, Steven, Burris, Kevin D, Ding, Chunjin, Heinz, Beverly A, Need, Anne B, Barth, Vanessa N, Stephenson, Gregory A, Diseroad, Benjamin A, Woods, Tim A, Yu, Hong, Bredt, David, Witkin, Jeffrey M
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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The SAR development of substituted purine derivatives as selective CB2 agonists for the treatment of chronic pain
Guidetti, Rossella, Astles, Peter C., Sanderson, Adam J., Hollinshead, Sean P., Johnson, Michael P., Chambers, Mark G.
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
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Two Practical Syntheses of Sterically Congested Benzophenones
Hollinshead, Sean P, Nichols, Jeffrey B, Wilson, Joseph W
Published in Journal of organic chemistry (01.11.1994)
Published in Journal of organic chemistry (01.11.1994)
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3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity
Fisher, Matthew J., Backer, Ryan T., Barth, Vanessa N., Garbison, Kim E., Gruber, Joseph M., Heinz, Beverly A., Iyengar, Smriti, Hollinshead, Sean P., Kingston, Anne, Kuklish, Steven L., Li, Linglin, Nisenbaum, Eric S., Peters, Steven C., Phebus, Lee, Simmons, Rosa Maria A., van der Aar, Ellen
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
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Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator
Hao, Junliang, Dehlinger, Veronique, Fivush, Adam M., Rudyk, Helene C.E., Britton, Thomas C., Hollinshead, Sean P., Vokits, Benjamin P., Clark, Barry P., Henry, Steven S., Massey, Steven M., Peng, Langu, Dressman, Bruce A., Heinz, Beverly A., Roberts, Edda F., Bracey-Walker, Mallorie R., Swanson, Steven, Catlow, John T., Love, Patrick L., Tepool, Anita D., Peters, Steven C., Simmons, Rosa Maria A., Iyengar, Smriti, McKinzie, David L., Monn, James A.
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1)
NORMAN, Bryan H, GRUBER, Joseph M, WAGNER, Margaret M, DANTZIG, Anne H, HOLLINSHEAD, Sean P, WILSON, Joseph W, STARLING, James J, LAW, Kevin L, SELF, Tracy D, TABAS, Linda B, WILLIAMS, Daniel C, PAUL, Donald C
Published in Bioorganic & medicinal chemistry letters (25.03.2002)
Published in Bioorganic & medicinal chemistry letters (25.03.2002)
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Journal Article
Diastereo- and enantio-selectivity in the Pictet-Spengler reaction
BAILEY, P. D, HOLLINSHEAD, S. P, MCLAY, N. R, MORGAN, K, PALMER, S. J, PRINCE, S. N, REYNOLDS, C. D, WOOD, S. D
Published in J. Chem. Soc., Perkin Trans. 1 (1993)
Published in J. Chem. Soc., Perkin Trans. 1 (1993)
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Synthesis and Protein Kinase Inhibitory Activity of Balanol Analogues with Modified Benzophenone Subunits
Lampe, John W, Biggers, Christopher K, Defauw, Jean M, Foglesong, Robert J, Hall, Steven E, Heerding, Julia M, Hollinshead, Sean P, Hu, Hong, Hughes, Philip F, Jagdmann, G. Erik, Johnson, Mary George, Lai, Yen-Shi, Lowden, Christopher T, Lynch, Michael P, Mendoza, José S, Murphy, Marcia M, Wilson, Joseph W, Ballas, Lawrence M, Carter, Kiyomi, Darges, James W, Davis, Jefferson E, Hubbard, Frederick R, Stamper, Mark L
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogs of 6-(benzyloxy)-4-(methoxymethyl)-.beta.-carboline-3-carboxylic acid ethyl ester
Hollinshead, Sean P, Trudell, Mark L, Skolnick, Phil, Cook, James M
Published in Journal of medicinal chemistry (01.03.1990)
Published in Journal of medicinal chemistry (01.03.1990)
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Pictet-Spengler reactions in aprotic media. Stereospecificity in the Pictet-Spengler reaction
Sandrin, Joseph, Hollinshead, Sean P, Cook, James M
Published in Journal of organic chemistry (01.11.1989)
Published in Journal of organic chemistry (01.11.1989)
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Journal Article
Identifying Novel Leads Using Combinatorial Libraries: Issues and Successes
Michael R. Pavia, Sean P. Hollinshead, Harold V. Meyers, Steven P. Hall
Published in Chimia (01.11.1997)
Published in Chimia (01.11.1997)
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[3,3]-Sigmatropic rearrangements in indoloazabicyclo[3.3.1]nonene systems. Reversal of the stereofacial selectivity in the Claisen vs. the ortho ester Claisen rearrangement
Zhang, Lin Hua, Trudell, Mark L, Hollinshead, Sean P, Cook, James M
Published in Journal of the American Chemical Society (01.10.1989)
Published in Journal of the American Chemical Society (01.10.1989)
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AN ASYMMETRIC ROUTE TO THE DEMETHOXY-FUMITREMORGINS
BAILEY, PD, HOLLINSHEAD, SP, MCLAY, NR, EVERETT, JH, REYNOLDS, CD, WOOD, SD, GIORDANO, F
Published in Journal of the Chemical Society, Perkin Transactions 1 (1993)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1993)
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