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Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3
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Published in Journal of medicinal chemistry (26.10.2017)
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Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles
Wang, Yingcai, Liu, Jiwen (Jim), Dransfield, Paul J, Zhu, Liusheng, Wang, Zhongyu, Du, Xiaohui, Jiao, Xianyun, Su, Yongli, Li, An-rong, Brown, Sean P, Kasparian, Annie, Vimolratana, Marc, Yu, Ming, Pattaropong, Vatee, Houze, Jonathan B, Swaminath, Gayathri, Tran, Thanhvien, Nguyen, Khanh, Guo, Qi, Zhang, Jane, Zhuang, Run, Li, Frank, Miao, Lynn, Bartberger, Michael D, Correll, Tiffany L, Chow, David, Wong, Simon, Luo, Jian, Lin, Daniel C.-H, Medina, Julio C
Published in ACS medicinal chemistry letters (13.06.2013)
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AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies
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Published in Cancer discovery (01.12.2018)
Published in Cancer discovery (01.12.2018)
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Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease
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Published in Neuron (Cambridge, Mass.) (16.11.2022)
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Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS -Mutant Non-Small Cell Lung Cancer
Nangia, Varuna, Siddiqui, Faria M, Caenepeel, Sean, Timonina, Daria, Bilton, Samantha J, Phan, Nicole, Gomez-Caraballo, Maria, Archibald, Hannah L, Li, Chendi, Fraser, Cameron, Rigas, Diamanda, Vajda, Kristof, Ferris, Lorin A, Lanuti, Michael, Wright, Cameron D, Raskin, Kevin A, Cahill, Daniel P, Shin, John H, Keyes, Colleen, Sequist, Lecia V, Piotrowska, Zofia, Farago, Anna F, Azzoli, Christopher G, Gainor, Justin F, Sarosiek, Kristopher A, Brown, Sean P, Coxon, Angela, Benes, Cyril H, Hughes, Paul E, Hata, Aaron N
Published in Cancer discovery (01.12.2018)
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Discovery and in Vivo Evaluation of Macrocyclic Mcl‑1 Inhibitors Featuring an α‑Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere
Rescourio, Gwenaella, Gonzalez, Ana Z, Jabri, Salman, Belmontes, Brian, Moody, Gordon, Whittington, Doug, Huang, Xin, Caenepeel, Sean, Cardozo, Mario, Cheng, Alan C, Chow, David, Dou, Hannah, Jones, Adrie, Kelly, Ron C, Li, Yihong, Lizarzaburu, Mike, Lo, Mei-Chu, Mallari, Rommel, Meleza, Cesar, Rew, Yosup, Simonovich, Scott, Sun, Daqing, Turcotte, Simon, Yan, Xuelei, Wong, Simon G, Yanez, Evelyn, Zancanella, Manuel, Houze, Jonathan, Medina, Julio C, Hughes, Paul E, Brown, Sean P
Published in Journal of medicinal chemistry (27.11.2019)
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Direct and Enantioselective Organocatalytic α-Chlorination of Aldehydes
Brochu, Michael P, Brown, Sean P, MacMillan, David W. C
Published in Journal of the American Chemical Society (07.04.2004)
Published in Journal of the American Chemical Society (07.04.2004)
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The First Enantioselective Organocatalytic Mukaiyama−Michael Reaction: A Direct Method for the Synthesis of Enantioenriched γ-Butenolide Architecture
Brown, Sean P, Goodwin, Nicole C, MacMillan, David W. C
Published in Journal of the American Chemical Society (05.02.2003)
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The Direct and Enantioselective Organocatalytic α-Oxidation of Aldehydes
Brown, Sean P, Brochu, Michael P, Sinz, Christopher J, MacMillan, David W. C
Published in Journal of the American Chemical Society (10.09.2003)
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Published in Bioorganic & medicinal chemistry letters (15.02.2020)
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Brown, Sean P, Dransfield, Paul J, Vimolratana, Marc, Jiao, XianYun, Zhu, Liusheng, Pattaropong, Vatee, Sun, Ying, Liu, Jinqian, Luo, Jian, Zhang, Jane, Wong, Simon, Zhuang, Run, Guo, Qi, Li, Frank, Medina, Julio C, Swaminath, Gayathri, Lin, Daniel C.-H, Houze, Jonathan B
Published in ACS medicinal chemistry letters (13.09.2012)
Published in ACS medicinal chemistry letters (13.09.2012)
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Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates
Brown, Sean P., Dransfield, Paul, Vimolratana, Marc, Zhu, Liusheng, Luo, Jian, Zhang, Jane, Jiao, XianYun, Pattaropong, Vatee, Wong, Simon, Zhuang, Run, Swaminath, Gayathri, Houze, Jonathan B., Lin, Daniel C.-H.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Optimization of GPR40 Agonists for Type 2 Diabetes
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Published in ACS medicinal chemistry letters (08.05.2014)
Published in ACS medicinal chemistry letters (08.05.2014)
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Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists
Du, Xiaohui, Dransfield, Paul J, Lin, Daniel C.-H, Wong, Simon, Wang, Yingcai, Wang, Zhongyu, Kohn, Todd, Yu, Ming, Brown, Sean P, Vimolratana, Marc, Zhu, Liusheng, Li, An-Rong, Su, Yongli, Jiao, Xianyun, Liu, Jiwen (Jim), Swaminath, Gayathri, Tran, Thanhvien, Luo, Jian, Zhuang, Run, Zhang, Jane, Guo, Qi, Li, Frank, Connors, Richard, Medina, Julio C, Houze, Jonathan B
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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