Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands
Ghosh, Arun K., Sean Fyvie, W., Brindisi, Margherita, Steffey, Melinda, Agniswamy, Johnson, Wang, Yuan-Fang, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
Published in Bioorganic & medicinal chemistry letters (01.11.2017)
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P2′ Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety
YEDIDI, Ravikiran S, MAEDA, Kenji, DAS, Debananda, WINGFIELD, Paul T, GHOSH, Arun K, MITSUYA, Hiroaki, SEAN FYVIE, W, STEFFEY, Melinda, DAVIS, David A, PALMER, Ira, AOKI, Manabu, KAUFMAN, Joshua D, STAHL, Stephen J, GARIMELLA, Harisha
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
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Design, Synthesis, Biological Evaluation, and X‐ray Studies of HIV‐1 Protease Inhibitors with Modified P2′ Ligands of Darunavir
Ghosh, Arun K., Fyvie, W. Sean, Brindisi, Margherita, Steffey, Melinda, Agniswamy, Johnson, Wang, Yuan‐Fang, Aoki, Manabu, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Published in ChemMedChem (07.12.2017)
Published in ChemMedChem (07.12.2017)
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A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV
YEDIDI, Ravikiran S, GARIMELLA, Harisha, DAS, Debananda, WINGFIELD, Paul T, MAEDA, Kenji, GHOSH, Arun K, MITSUYA, Hiroaki, AOKI, Manabu, AOKI-OGATA, Hiromi, DESAI, Darshan V, CHANG, Simon B, DAVIS, David A, FYVIE, W. Sean, KAUFMAN, Joshua D, SMITH, David W
Published in Antimicrobial agents and chemotherapy (01.07.2014)
Published in Antimicrobial agents and chemotherapy (01.07.2014)
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Remote induction of asymmetry in [13]-macro-dilactone topology by a single stereogenic center
Fyvie, W. Sean, Peczuh, Mark W.
Published in Chemical communications (Cambridge, England) (14.09.2008)
Published in Chemical communications (Cambridge, England) (14.09.2008)
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Computational and experimental investigations of mono-septanoside binding by Concanavalin A: correlation of ligand stereochemistry to enthalpies of binding
Duff, Michael R., Fyvie, W. Sean, Markad, Shankar D., Frankel, Alexandra E., Kumar, Challa V., Gascon, Jose A., Peczuh, Mark W.
Published in Organic & biomolecular chemistry (01.01.2011)
Published in Organic & biomolecular chemistry (01.01.2011)
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Synthesis of α-d-Idoseptanosyl Glycosides Using an S-Phenyl Septanoside Donor
Castro, Steve, Fyvie, W. Sean, Hatcher, Susan A, Peczuh, Mark W
Published in Organic letters (13.10.2005)
Published in Organic letters (13.10.2005)
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Computational and experimental investigations of mono-septanoside binding by Concanavalin A: correlation of ligand stereochemistry to enthalpies of bindingElectronic supplementary information (ESI) available: 1H and 13C NMR spectra for all newly reported compounds. Computed QM/MM structures not shown in the main text are provided. Further details on the thermodynamic cycle used in our calculations and approximations are also provided. See DOI: 10.1039/c0ob00425a
Duff Jr, Michael R, Fyvie, W. Sean, Markad, Shankar D, Frankel, Alexandra E, Kumar, Challa V, Gascón, José A, Peczuh, Mark W
Year of Publication 09.12.2010
Year of Publication 09.12.2010
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