Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation
Ma, Lei, Seager, Matthew, Wittmann, Marion, Jacobson, Marlene, Bickel, Denise, Burno, Maryann, Jones, Keith, Graufelds, Valerie Kuzmick, Xu, Guangping, Pearson, Michelle, McCampbell, Alexander, Gaspar, Renee, Shughrue, Paul, Danziger, Andrew, Regan, Christopher, Flick, Rose, Pascarella, Danette, Garson, Susan, Doran, Scott, Kreatsoulas, Constantine, Veng, Lone, Lindsley, Craig W, Shipe, William, Kuduk, Scott, Sur, Cyrille, Kinney, Gene, Seabrook, Guy R, Ray, William J
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2009)
Get full text
Journal Article
Group III Metabotropic Glutamate-Receptor-Mediated Modulation of Excitatory Transmission in Rodent Substantia Nigra Pars Compacta Dopamine Neurons
Valenti, Ornella, Mannaioni, Guido, Seabrook, Guy R, Conn, P Jeffrey, Marino, Michael J
Published in The Journal of pharmacology and experimental therapeutics (01.06.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2005)
Get full text
Journal Article
LRRTM3 Promotes Processing of Amyloid-Precursor Protein by BACE1 and Is a Positional Candidate Gene for Late-Onset Alzheimer's Disease
Majercak, John, Ray, William J., Espeseth, Amy, Simon, Adam, Shi, Xiao-Ping, Wolffe, Carrie, Getty, Krista, Marine, Shane, Stec, Erica, Ferrer, Marc, Strulovici, Berta, Bartz, Steven, Gates, Adam, Xu, Min, Huang, Qian, Ma, Lei, Shughrue, Paul, Burchard, Julja, Colussi, Dennis, Pietrak, Beth, Kahana, Jason, Beher, Dirk, Rosahl, Thomas, Shearman, Mark, Hazuda, Daria, Sachs, Alan B., Koblan, Kenneth S., Seabrook, Guy R., Stone, David J.
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2006)
Get full text
Journal Article
Functional Properties of the High-Affinity TRPV1 (VR1) Vanilloid Receptor Antagonist (4-Hydroxy-5-iodo-3-methoxyphenylacetate ester) Iodo-Resiniferatoxin
Seabrook, Guy R, Sutton, Kathy G, Jarolimek, Wolfgang, Hollingworth, Gregory J, Teague, Simon, Webb, Janine, Clark, Natalie, Boyce, Susan, Kerby, Julie, Ali, Zahid, Chou, Margaret, Middleton, Richard, Kaczorowski, Gregory, Jones, A Brian
Published in The Journal of pharmacology and experimental therapeutics (01.12.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2002)
Get full text
Journal Article
Discrete expression of TRPV2 within the hypothalamo-neurohypophysial system: Implications for regulatory activity within the hypothalamic-pituitary-adrenal axis
Wainwright, Anna, Rutter, A. Richard, Seabrook, Guy R., Reilly, Kathryn, Oliver, Kevin R.
Published in Journal of comparative neurology (1911) (14.06.2004)
Published in Journal of comparative neurology (1911) (14.06.2004)
Get full text
Journal Article
Comprehensive Real-World Assessment of Marketed Medications to Guide Parkinson’s Drug Discovery
Cepeda, M. Soledad, Kern, David M., Seabrook, Guy R., Lovestone, Simon
Published in Clinical drug investigation (01.11.2019)
Published in Clinical drug investigation (01.11.2019)
Get full text
Journal Article
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors
Lindsley, Stacey R., Moore, Keith P., Rajapakse, Hemaka A., Selnick, Harold G., Young, Mary Beth, Zhu, Hong, Munshi, Sanjeev, Kuo, Lawrence, McGaughey, Georgia B., Colussi, Dennis, Crouthamel, Ming-Chih, Lai, Ming-Tain, Pietrak, Beth, Price, Eric A., Sankaranarayanan, Sethu, Simon, Adam J., Seabrook, Guy R., Hazuda, Daria J., Pudvah, Nicole T., Hochman, Jerome H., Graham, Samuel L., Vacca, Joseph P., Nantermet, Philippe G.
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Get full text
Journal Article
Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein
Zerbinatti, Celina V, Cordy, Joanna M, Chen, Ci-Di, Guillily, Maria, Suon, Sokreine, Ray, William J, Seabrook, Guy R, Abraham, Carmela R, Wolozin, Benjamin
Published in Molecular neurodegeneration (18.03.2008)
Published in Molecular neurodegeneration (18.03.2008)
Get full text
Journal Article
Clozapine Potentiation of N-Methyl-d-aspartate Receptor Currents in the Nucleus Accumbens: Role of NR2B and Protein Kinase A/Src Kinases
Wittmann, Marion, Marino, Michael J, Henze, Darrell A, Seabrook, Guy R, Conn, P Jeffrey
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
Get full text
Journal Article
Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists
Layton, Mark E., Kelly, Michael J., Rodzinak, Kevin J., Sanderson, Philip E., Young, Steven D., Bednar, Rodney A., DiLella, Anthony G., Mcdonald, Terrence P., Wang, Hao, Mosser, Scott D., Fay, John F., Cunningham, Michael E., Reiss, Duane R., Fandozzi, Christine, Trainor, Nicole, Liang, Annie, Lis, Edward V., Seabrook, Guy R., Urban, Mark O., Yergey, James, Koblan, Kenneth S.
Published in ACS chemical neuroscience (20.07.2011)
Published in ACS chemical neuroscience (20.07.2011)
Get full text
Journal Article
A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1
Fitzjohn, Stephen M, Kuenzi, Frederick, Morton, Robin A, Rosahl, Thomas W, Lewis, Huw, Smith, David, Seabrook, Guy R, Collingridge, Graham L
Published in Molecular brain (14.07.2010)
Published in Molecular brain (14.07.2010)
Get full text
Journal Article
Aiding the discovery of new treatments for dementia by uncovering unknown benefits of existing medications
Kern, David M., Cepeda, M. Soledad, Lovestone, Simon, Seabrook, Guy R.
Published in Alzheimer's & dementia : translational research & clinical interventions (2019)
Published in Alzheimer's & dementia : translational research & clinical interventions (2019)
Get full text
Journal Article
Human D2 and D4 dopamine receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system : Selective antagonism by L-741,626 and L-745,870 respectively
PILLAI, G, BROWN, N. A, MCALLISTER, G, MILLIGAN, G, SEABROOK, G. R
Published in Neuropharmacology (01.08.1998)
Published in Neuropharmacology (01.08.1998)
Get full text
Journal Article
Genome-Wide Microarray Analysis of the Differential Neuroprotective Effects of Antioxidants in Neuroblastoma Cells Overexpressing the Familial Parkinson’s Disease α-Synuclein A53T Mutation
Ma, Lei, Cao, Tracy T., Kandpal, Geeta, Warren, Lee, Fred Hess, J., Seabrook, Guy R., Ray, William J.
Published in Neurochemical research (2010)
Published in Neurochemical research (2010)
Get full text
Journal Article
Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein
Fitzjohn, Stephen M, Morton, Robin A, Kuenzi, Frederick, Rosahl, Thomas W, Shearman, Mark, Lewis, Huw, Smith, David, Reynolds, David S, Davies, Ceri H, Collingridge, Graham L, Seabrook, Guy R
Published in The Journal of neuroscience (01.07.2001)
Published in The Journal of neuroscience (01.07.2001)
Get full text
Journal Article