Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic
Lee, Youn-Bok, Chen, Han-Jou, Peres, João N., Gomez-Deza, Jorge, Attig, Jan, Štalekar, Maja, Troakes, Claire, Nishimura, Agnes L., Scotter, Emma L., Vance, Caroline, Adachi, Yoshitsugu, Sardone, Valentina, Miller, Jack W., Smith, Bradley N., Gallo, Jean-Marc, Ule, Jernej, Hirth, Frank, Rogelj, Boris, Houart, Corinne, Shaw, Christopher E.
Published in Cell reports (Cambridge) (01.12.2013)
Published in Cell reports (Cambridge) (01.12.2013)
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Journal Article
TDP-43 pathology: From noxious assembly to therapeutic removal
Keating, Sean S., San Gil, Rebecca, Swanson, Molly E.V., Scotter, Emma L., Walker, Adam K.
Published in Progress in neurobiology (01.04.2022)
Published in Progress in neurobiology (01.04.2022)
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Journal Article
Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species
Scotter, Emma L, Vance, Caroline, Nishimura, Agnes L, Lee, Youn-Bok, Chen, Han-Jou, Urwin, Hazel, Sardone, Valentina, Mitchell, Jacqueline C, Rogelj, Boris, Rubinsztein, David C, Shaw, Christopher E
Published in Journal of cell science (15.03.2014)
Published in Journal of cell science (15.03.2014)
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Journal Article
The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis
Chen, Han-Jou, Mitchell, Jacqueline C, Novoselov, Sergey, Miller, Jack, Nishimura, Agnes L, Scotter, Emma L, Vance, Caroline A, Cheetham, Michael E, Shaw, Christopher E
Published in Brain (London, England : 1878) (01.05.2016)
Published in Brain (London, England : 1878) (01.05.2016)
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Journal Article
ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules
Vance, Caroline, Scotter, Emma L, Nishimura, Agnes L, Troakes, Claire, Mitchell, Jacqueline C, Kathe, Claudia, Urwin, Hazel, Manser, Catherine, Miller, Christopher C, Hortobágyi, Tibor, Dragunow, Mike, Rogelj, Boris, Shaw, Christopher E
Published in Human molecular genetics (01.07.2013)
Published in Human molecular genetics (01.07.2013)
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Journal Article
The endocannabinoid system as a target for the treatment of neurodegenerative disease
Scotter, Emma L, Abood, Mary E, Glass, Michelle
Published in British journal of pharmacology (01.06.2010)
Published in British journal of pharmacology (01.06.2010)
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Journal Article
Altered microglia and neurovasculature in the Alzheimer's disease cerebellum
Singh-Bains, Malvindar K., Linke, Vanessa, Austria, Micah D.R., Tan, Adelie Y.S., Scotter, Emma L., Mehrabi, Nasim F., Faull, Richard L.M., Dragunow, Mike
Published in Neurobiology of disease (01.12.2019)
Published in Neurobiology of disease (01.12.2019)
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Journal Article
TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function
Rustenhoven, Justin, Aalderink, Miranda, Scotter, Emma L, Oldfield, Robyn L, Bergin, Peter S, Mee, Edward W, Graham, E Scott, Faull, Richard L M, Curtis, Maurice A, Park, Thomas I-H, Dragunow, Mike
Published in Journal of neuroinflammation (11.02.2016)
Published in Journal of neuroinflammation (11.02.2016)
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Journal Article
Cytoplasmic TDP-43 is involved in cell fate during stress recovery
Lee, Youn-Bok, Scotter, Emma L, Lee, Do-Young, Troakes, Claire, Mitchell, Jacqueline, Rogelj, Boris, Gallo, Jean-Marc, Shaw, Christopher E
Published in Human molecular genetics (27.12.2021)
Published in Human molecular genetics (27.12.2021)
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Journal Article
ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function
Wu, Josephine J., Cai, Ashley, Greenslade, Jessie E., Higgins, Nicole R., Fan, Cong, Le, Nhat T. T., Tatman, Micaela, Whiteley, Alexandra M., Prado, Miguel A., Dieriks, Birger V., Curtis, Maurice A., Shaw, Christopher E., Siddique, Teepu, Faull, Richard L. M., Scotter, Emma L., Finley, Daniel, Monteiro, Mervyn J.
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2020)
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Journal Article
A panel of TDP-43-regulated splicing events verifies loss of TDP-43 function in amyotrophic lateral sclerosis brain tissue
Cao, Maize C., Ryan, Brigid, Wu, Jane, Curtis, Maurice A., Faull, Richard L.M., Dragunow, Mike, Scotter, Emma L.
Published in Neurobiology of disease (01.09.2023)
Published in Neurobiology of disease (01.09.2023)
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Journal Article
Serum biomarkers of neuroinflammation and blood-brain barrier leakage in amyotrophic lateral sclerosis
Cao, Maize C, Cawston, Erin E, Chen, Grace, Brooks, Collin, Douwes, Jeroen, McLean, Dave, Graham, E Scott, Dragunow, Mike, Scotter, Emma L
Published in BMC neurology (11.06.2022)
Published in BMC neurology (11.06.2022)
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Journal Article
Novel mutations support a role for Profilin 1 in the pathogenesis of ALS
Smith, Bradley N, Vance, Caroline, Scotter, Emma L, Troakes, Claire, Wong, Chun Hao, Topp, Simon, Maekawa, Satomi, King, Andrew, Mitchell, Jacqueline C, Lund, Karan, Al-Chalabi, Ammar, Ticozzi, Nicola, Silani, Vincenzo, Sapp, Peter, Brown, Robert H, Landers, John E, Al-Sarraj, Safa, Shaw, Christopher E
Published in Neurobiology of aging (01.03.2015)
Published in Neurobiology of aging (01.03.2015)
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Journal Article
Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain
Swanson, Molly E V, Mrkela, Miran, Murray, Helen C, Cao, Maize C, Turner, Clinton, Curtis, Maurice A, Faull, Richard L M, Walker, Adam K, Scotter, Emma L
Published in Acta neuropathologica communications (28.04.2023)
Published in Acta neuropathologica communications (28.04.2023)
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Journal Article
Inconsistencies in histone acetylation patterns among different HD model systems and HD post-mortem brains
Narayan, Pritika, Reid, Suzanne, Scotter, Emma L., McGregor, Ailsa L., Mehrabi, Nasim F., Singh-Bains, Malvindar K., Glass, Michelle, Faull, Richard L.M., Snell, Russell G., Dragunow, Mike
Published in Neurobiology of disease (01.12.2020)
Published in Neurobiology of disease (01.12.2020)
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Journal Article
Identification of a dysfunctional microglial population in human Alzheimer's disease cortex using novel single-cell histology image analysis
Swanson, Molly E V, Scotter, Emma L, Smyth, Leon C D, Murray, Helen C, Ryan, Brigid, Turner, Clinton, Faull, Richard L M, Dragunow, Mike, Curtis, Maurice A
Published in Acta neuropathologica communications (20.10.2020)
Published in Acta neuropathologica communications (20.10.2020)
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Journal Article
Shared Regulatory Pathways Reveal Novel Genetic Correlations Between Grip Strength and Neuromuscular Disorders
Gokuladhas, Sreemol, Schierding, William, Cameron-Smith, David, Wake, Melissa, Scotter, Emma L, O'Sullivan, Justin
Published in Frontiers in genetics (24.04.2020)
Published in Frontiers in genetics (24.04.2020)
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Journal Article
Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells
Nishimura, Agnes L, Shum, Carole, Scotter, Emma L, Abdelgany, Amr, Sardone, Valentina, Wright, Jamie, Lee, Youn-Bok, Chen, Han-Jou, Bilican, Bilada, Carrasco, Monica, Maniatis, Tom, Chandran, Siddharthan, Rogelj, Boris, Gallo, Jean-Marc, Shaw, Christopher E
Published in PloS one (20.03.2014)
Published in PloS one (20.03.2014)
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Journal Article
Single-cell image analysis reveals a protective role for microglia in glioblastoma
Woolf, Zoe, Swanson, Molly E V, Smyth, Leon C, Mee, Edward W, Schweder, Patrick, Heppner, Peter, Kim, Bernard J H, Turner, Clinton, Oldfield, Robyn L, Curtis, Maurice A, Faull, Richard L M, Scotter, Emma L, Park, Thomas I-H, Dragunow, Michael
Published in Neuro-oncology advances (01.01.2021)
Published in Neuro-oncology advances (01.01.2021)
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