Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279
Leit, Silvana, Greenwood, Jeremy, Carriero, Samantha, Mondal, Sayan, Abel, Robert, Ashwell, Mark, Blanchette, Heather, Boyles, Nicholas A., Cartwright, Mark, Collis, Alan, Feng, Shulu, Ghanakota, Phani, Harriman, Geraldine C., Hosagrahara, Vinayak, Kaila, Neelu, Kapeller, Rosanna, Rafi, Salma B., Romero, Donna L., Tarantino, Paul M., Timaniya, Jignesh, Toms, Angela V., Wester, Ronald T., Westlin, William, Srivastava, Bhaskar, Miao, Wenyan, Tummino, Peter, McElwee, Joshua J., Edmondson, Scott D., Masse, Craig E.
Published in Journal of medicinal chemistry (10.08.2023)
Published in Journal of medicinal chemistry (10.08.2023)
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Journal Article
Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder
Moyes, Christopher R, Berger, Richard, Goble, Stephen D, Harper, Bart, Shen, Dong-Ming, Wang, Liping, Bansal, Alka, Brown, Patricia N, Chen, Airu S, Dingley, Karen H, Di Salvo, Jerry, Fitzmaurice, Aileen, Gichuru, Loise N, Hurley, Amanda L, Jochnowitz, Nina, Miller, Randall R, Mistry, Shruty, Nagabukuro, Hiroshi, Salituro, Gino M, Sanfiz, Anthony, Stevenson, Andra S, Villa, Katherine, Zamlynny, Beata, Struthers, Mary, Weber, Ann E, Edmondson, Scott D
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Journal Article
Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity
Scapin, Giovanna, Patel, Sangita B, Chung, Christine, Varnerin, Jeffrey P, Edmondson, Scott D, Mastracchio, Anthony, Parmee, Emma R, Singh, Suresh B, Becker, Joseph W, Van der Ploeg, Lex H. T, Tota, Michael R
Published in Biochemistry (Easton) (25.05.2004)
Published in Biochemistry (Easton) (25.05.2004)
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Journal Article
Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase
Degorce, Sébastien L, Tavana, Omid, Banks, Erica, Crafter, Claire, Gingipalli, Lakshmaiah, Kouvchinov, David, Mao, Yumeng, Pachl, Fiona, Solanki, Anisha, Valge-Archer, Viia, Yang, Bin, Edmondson, Scott D
Published in Journal of medicinal chemistry (24.09.2020)
Published in Journal of medicinal chemistry (24.09.2020)
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Journal Article
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs
Johannes, Jeffrey W., Balazs, Amber, Barratt, Derek, Bista, Michal, Chuba, Matthew D., Cosulich, Sabina, Critchlow, Susan E., Degorce, Sebastien L., Di Fruscia, Paolo, Edmondson, Scott D., Embrey, Kevin, Fawell, Stephen, Ghosh, Avipsa, Gill, Sonja J., Gunnarsson, Anders, Hande, Sudhir M., Heightman, Tom D., Hemsley, Paul, Illuzzi, Giuditta, Lane, Jordan, Larner, Carrie, Leo, Elisabetta, Liu, Lina, Madin, Andrew, Martin, Scott, McWilliams, Lisa, O'Connor, Mark J., Orme, Jonathan P., Pachl, Fiona, Packer, Martin J., Pei, Xiaohui, Pike, Andrew, Schimpl, Marianne, She, Hongyao, Staniszewska, Anna D., Talbot, Verity, Underwood, Elizabeth, Varnes, Jeffrey G., Xue, Lin, Yao, Tieguang, Zhang, Ke, Zhang, Andrew X., Zheng, Xiaolan
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Journal Article
Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis
Leit, Silvana, Greenwood, Jeremy R., Mondal, Sayan, Carriero, Samantha, Dahlgren, Markus, Harriman, Geraldine C., Kennedy-Smith, Joshua J., Kapeller, Rosana, Lawson, Jon P., Romero, Donna L., Toms, Angela V., Shelley, Mee, Wester, Ronald T., Westlin, William, McElwee, Joshua J., Miao, Wenyan, Edmondson, Scott D., Masse, Craig E.
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
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Journal Article
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors
Barlaam, Bernard, Boiko, Scott, Boyd, Scott, Dry, Hannah, Gingipalli, Lakshmaiah, Ikeda, Timothy, Johnson, Tony, Kawatkar, Sameer, Lorthioir, Olivier, Pike, Andy, Pollard, Hannah, Read, Jon, Su, Qibin, Wang, Haiyun, Wang, Huimin, Wang, Lianghe, Wang, Peng, Edmondson, Scott D.
Published in Bioorganic & medicinal chemistry letters (15.11.2020)
Published in Bioorganic & medicinal chemistry letters (15.11.2020)
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Journal Article
Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors
Xu, Jinyou, Wei, Lan, Mathvink, Robert J., Edmondson, Scott D., Eiermann, George J., He, Huaibing, Leone, Joseph F., Leiting, Barbara, Lyons, Kathryn A., Marsilio, Frank, Patel, Reshma A., Patel, Sangita B., Petrov, Aleksandr, Scapin, Giovanna, Wu, Joseph K., Thornberry, Nancy A., Weber, Ann E.
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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Journal Article
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors
Grimster, Neil P., Gingipalli, Lakshmaiah, Balazs, Amber, Barlaam, Bernard, Boiko, Scott, Boyd, Scott, Dry, Hannah, Goldberg, Frederick W., Ikeda, Tim, Johnson, Tony, Kawatkar, Sameer, Kemmitt, Paul, Lamont, Scott, Lorthioir, Olivier, Mfuh, Adelphe, Patel, Joe, Pike, Andy, Read, Jon, Romero, Romulo, Sarkar, Ujjal, Sha, Li, Simpson, Iain, Song, Kun, Su, Qibin, Wang, Haixia, Watson, David, Wu, Allan, Zehnder, Troy E., Zheng, XiaoLan, Li, Shaolu, Dong, Zhiqiang, Yang, Dejian, Song, Yanwei, Wang, Peng, Liu, Xuemei, Dowling, James E., Edmondson, Scott D.
Published in Bioorganic & medicinal chemistry letters (15.07.2023)
Published in Bioorganic & medicinal chemistry letters (15.07.2023)
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Journal Article
Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants
Hussain, Zahid, Cooke, Andrew J., Neelamkavil, Santhosh, Brown, Lindsay, Carswell, Emma, Geissler, Wayne M., Guo, Zhuyan, Hawes, Brian, Kelly, Terri M., Kiyoi, Yasuko, Lai, KehDih, Lesburg, Charles, Pow, Eleanor, Zang, Yi, Wood, Harold B., Edmondson, Scott D., Liu, Weiguo
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
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Journal Article
Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase
Kawatkar, Sameer P., Barlaam, Bernard, Kemmitt, Paul, Simpson, Iain, Watson, David, Wang, Peng, Lamont, Scott, Su, Qibin, Boiko, Scott, Ikeda, Timothy, Patel, Joe, Pike, Andy, Pollard, Hannah, Read, Jon, Sarkar, Ujjal, Wang, Haiyun, Wen, Quanshan, Yan, Zhiyuan, Dowling, James E., Dry, Hannah, Edmondson, Scott D.
Published in Bioorganic & medicinal chemistry letters (15.09.2020)
Published in Bioorganic & medicinal chemistry letters (15.09.2020)
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Journal Article
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors
Grimster, Neil P., Gingipalli, Lakshmaiah, Barlaam, Bernard, Su, Qibin, Zheng, XiaoLan, Watson, David, Wang, Haixia, Simpson, Iain, Pike, Andy, Balazs, Amber, Boiko, Scott, Ikeda, Timothy P., Impastato, Anna C., Jones, Natalie H., Kawatkar, Sameer, Kemmitt, Paul, Lamont, Scott, Patel, Joe, Read, Jon, Sarkar, Ujjal, Sha, Li, Tomlinson, Ronald C., Wang, Haiyun, Wilson, David M., Zehnder, Troy E., Wang, Lianghe, Wang, Peng, Goldberg, Frederick W., Shao, Wenlin, Fawell, Stephen, Dry, Hannah, Dowling, James E., Edmondson, Scott D.
Published in Bioorganic & medicinal chemistry letters (01.10.2020)
Published in Bioorganic & medicinal chemistry letters (01.10.2020)
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Journal Article
Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder
Edmondson, Scott D, Zhu, Cheng, Kar, Nam Fung, Di Salvo, Jerry, Nagabukuro, Hiroshi, Sacre-Salem, Beatrice, Dingley, Karen, Berger, Richard, Goble, Stephen D, Morriello, Gregori, Harper, Bart, Moyes, Christopher R, Shen, Dong-Ming, Wang, Liping, Ball, Richard, Fitzmaurice, Aileen, Frenkl, Tara, Gichuru, Loise N, Ha, Sookhee, Hurley, Amanda L, Jochnowitz, Nina, Levorse, Dorothy, Mistry, Shruty, Miller, Randy R, Ormes, James, Salituro, Gino M, Sanfiz, Anthony, Stevenson, Andra S, Villa, Katherine, Zamlynny, Beata, Green, Stuart, Struthers, Mary, Weber, Ann E
Published in Journal of medicinal chemistry (28.01.2016)
Published in Journal of medicinal chemistry (28.01.2016)
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Journal Article
Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents
Adams, Gregory L, Velazquez, Francisco, Jayne, Charles, Shah, Unmesh, Miao, Shouwu, Ashley, Eric R, Madeira, Maria, Akiyama, Taro E, Di Salvo, Jerry, Suzuki, Takao, Wang, Nengxue, Truong, Quang, Gilbert, Eric, Zhou, Dan, Verras, Andreas, Kirkland, Melissa, Pachanski, Michele, Powles, Maryann, Yin, Wu, Ujjainwalla, Feroze, Venkatraman, Srikanth, Edmondson, Scott D
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
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Journal Article
Discovery of phenyl acetamides as potent and selective GPR119 agonists
Zhu, Cheng, Wang, Liping, Zhu, Yuping, Guo, Zack Zhiqiang, Liu, Ping, Hu, Zhiyong, Szewczyk, Jason W., Kang, Ling, Chicchi, Gary, Ehrhardt, Anka, Woods, Andrea, Seo, Toru, Woods, Morgan, van Heek, Margaret, Dingley, Karen H., Pang, Jianmei, Salituro, Gino M., Powell, Joyce, Terebetski, Jenna L., Hornak, Viktor, Campeau, Louis-Charles, Orr, Robert K., Ujjainwalla, Feroze, Miller, Michael, Stamford, Andrew, Wood, Harold B., Kowalski, Timothy, Nargund, Ravi P., Edmondson, Scott D.
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
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Journal Article
Discovery of benzamides as potent human β3 adrenergic receptor agonists
Zhu, Cheng, Kar, Nam F., Li, Bing, Costa, Melissa, Dingley, Karen H., Di Salvo, Jerry, Ha, Sookhee N., Hurley, Amanda L., Li, Xiaofang, Miller, Randy R., Salituro, Gino M., Struthers, Mary, Weber, Ann E., Hale, Jeffrey J., Edmondson, Scott D.
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
Published in Bioorganic & medicinal chemistry letters (01.01.2016)
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Journal Article
Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder
Harper, Bart H., Wang, Liping, Zhu, Cheng, Kar, Nam F., Li, Bing, Moyes, Christopher R., Goble, Stephen D., Costa, Melissa, Dingley, Karen, Di Salvo, Jerry, Ha, Sookhee N., Hurley, Amanda, Li, Xiaofang, Miller, Randy R., Nagabukuro, Hiroshi, Salituro, Gino M., Smith, Sean, Struthers, Mary, Hale, Jeffrey J., Edmondson, Scott D., Berger, Richard
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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Journal Article
Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors
Edmondson, Scott D., Wei, Lan, Xu, Jinyou, Shang, Jackie, Xu, Shiyao, Pang, Jianmei, Chaudhary, Ashok, Dean, Dennis C., He, Huaibing, Leiting, Barbara, Lyons, Kathryn A., Patel, Reshma A., Patel, Sangita B., Scapin, Giovanna, Wu, Joseph K., Beconi, Maria G., Thornberry, Nancy A., Weber, Ann E.
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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