MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition
Fell, Matthew J, Mirescu, Christian, Basu, Kallol, Cheewatrakoolpong, Boonlert, DeMong, Duane E, Ellis, J Michael, Hyde, Lynn A, Lin, Yinghui, Markgraf, Carrie G, Mei, Hong, Miller, Michael, Poulet, Frederique M, Scott, Jack D, Smith, Michelle D, Yin, Zhizhang, Zhou, Xiaoping, Parker, Eric M, Kennedy, Matthew E, Morrow, John A
Published in The Journal of pharmacology and experimental therapeutics (01.12.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2015)
Get full text
Journal Article
Synthesis of DNA-Encoded Macrocyclic Peptides via Nitrile-Aminothiol Click Reaction
Fan, Lijun, Yu, Yang, Jayne, Charles, Frost, John R., Scott, Jack D.
Published in Organic letters (10.11.2023)
Published in Organic letters (10.11.2023)
Get full text
Journal Article
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients
Kennedy, Matthew E, Stamford, Andrew W, Chen, Xia, Cox, Kathleen, Cumming, Jared N, Dockendorf, Marissa F, Egan, Michael, Ereshefsky, Larry, Hodgson, Robert A, Hyde, Lynn A, Jhee, Stanford, Kleijn, Huub J, Kuvelkar, Reshma, Li, Wei, Mattson, Britta A, Mei, Hong, Palcza, John, Scott, Jack D, Tanen, Michael, Troyer, Matthew D, Tseng, Jack L, Stone, Julie A, Parker, Eric M, Forman, Mark S
Published in Science translational medicine (02.11.2016)
Published in Science translational medicine (02.11.2016)
Get more information
Journal Article
Discovery of the 3‑Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease
Scott, Jack D, Li, Sarah W, Brunskill, Andrew P. J, Chen, Xia, Cox, Kathleen, Cumming, Jared N, Forman, Mark, Gilbert, Eric J, Hodgson, Robert A, Hyde, Lynn A, Jiang, Qin, Iserloh, Ulrich, Kazakevich, Irina, Kuvelkar, Reshma, Mei, Hong, Meredith, John, Misiaszek, Jeffrey, Orth, Peter, Rossiter, Lana M, Slater, Meagan, Stone, Julie, Strickland, Corey O, Voigt, Johannes H, Wang, Ganfeng, Wang, Hongwu, Wu, Yusheng, Greenlee, William J, Parker, Eric M, Kennedy, Matthew E, Stamford, Andrew W
Published in Journal of medicinal chemistry (08.12.2016)
Published in Journal of medicinal chemistry (08.12.2016)
Get full text
Journal Article
Development of DNA-compatible hydroxycarbonylation reactions using chloroform as a source of carbon monoxide
Liu, Wentao, Huang, Wei, Lin, Qian, Tsai, Mei-Hsuan, Zhang, Rui, Fan, Lijun, Scott, Jack D., Liu, Guansai, Wan, Jinqiao
Published in Bioorganic & medicinal chemistry (15.05.2021)
Published in Bioorganic & medicinal chemistry (15.05.2021)
Get full text
Journal Article
Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration
Dong, Shuzhi, Zhao, Zhiqiang, Tang, Haiqun, Li, Guoqing, Pan, Jianping, Gu, Xin, Jiang, Jinlong, Xiao, Li, Scapin, Giovanna, Hunter, David N., Yang, Dexi, Huang, Yuhua, Bennett, Frank, Yang, Shu-Wei, Mandal, Mihirbaran, Tang, Haifeng, Su, Jing, Tudge, Clare, deJesus, Reynalda Keh, Ding, Fa-Xiang, Lombardo, Matthew, Hicks, Jacqueline D., Fischmann, Thierry, Mirza, Asra, Dayananth, Priya, Painter, Ronald E., Villafania, Artjohn, Garlisi, Charles G., Zhang, Rumin, Mayhood, Todd W., Si, Qian, Li, Nianyu, Amin, Rupesh P., Bhatt, Bhavana, Chen, Feifei, Regan, Christopher P., Regan, Hillary, Lin, Xinjie, Wu, Jin, Leithead, Andrew, Pollack, Scott R., Scott, Jack D., Nargund, Ravi P., Therien, Alex G., Black, Todd, Young, Katherine, Pasternak, Alexander
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
Get full text
Journal Article
Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors
Gulati, Anmol, Yeung, Charles S, Lapointe, Blair, Kattar, Solomon D, Gunaydin, Hakan, Scott, Jack D, Childers, Kaleen K, Methot, Joey L, Simov, Vladimir, Kurukulasuriya, Ravi, Pio, Barbara, Morriello, Greg J, Liu, Ping, Tang, Haiqun, Neelamkavil, Santhosh, Wood, Harold B, Rada, Vanessa L, Ardolino, Michael J, Yan, Xin Cindy, Palte, Rachel, Otte, Karin, Faltus, Robert, Woodhouse, Janice, Hegde, Laxminarayan G, Ciaccio, Paul, Minnihan, Ellen C, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H, Ellis, J. Michael
Published in MedChemComm (21.07.2021)
Published in MedChemComm (21.07.2021)
Get full text
Journal Article
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction
Stamford, Andrew W, Scott, Jack D, Li, Sarah W, Babu, Suresh, Tadesse, Dawit, Hunter, Rachael, Wu, Yusheng, Misiaszek, Jeffrey, Cumming, Jared N, Gilbert, Eric J, Huang, Chunli, McKittrick, Brian A, Hong, Liwu, Guo, Tao, Zhu, Zhaoning, Strickland, Corey, Orth, Peter, Voigt, Johannes H, Kennedy, Matthew E, Chen, Xia, Kuvelkar, Reshma, Hodgson, Robert, Hyde, Lynn A, Cox, Kathleen, Favreau, Leonard, Parker, Eric M, Greenlee, William J
Published in ACS medicinal chemistry letters (08.11.2012)
Published in ACS medicinal chemistry letters (08.11.2012)
Get full text
Journal Article
Tetrahydroquinoline sulfonamides as vasopressin 1b receptor anatgonists
Scott, Jack D., Miller, Michael W., Li, Sarah W., Lin, Sue-Ing, Vaccaro, Henry A., Hong, Liwu, Mullins, Deborra E., Guzzi, Mario, Weinstein, Jay, Hodgson, Robert A., Varty, Geoffrey B., Stamford, Andrew W., Chan, Tin-Yau, McKittrick, Brian A., Greenlee, William J., Priestley, Tony, Parker, Eric M.
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
Get full text
Journal Article
Diaryl piperidines as CB1 receptor antagonists
SCOTT, Jack D, LI, Sarah W, STAMFORD, Andrew W, CHACKALAMANNIL, Samuel, LACHOWICZ, Jean E, GREENLEE, William J, HONGWU WANG, YAN XIA, JAYNE, Charles L, MILLER, Michael W, DUFFY, Ruth A, BOYKOW, George C, KOWALSKI, Timothy J, SPAR, Brian D
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Get full text
Journal Article
메탈로-베타-락타마제 억제제로서의 3-테트라졸릴-벤젠-1,2-디술폰아미드 유도체
PASTERNAK ALEXANDER, ZHAO ZHIQIANG, YANG DEXI, HUANG YUHUA, ZHANG ZHIBO, YOUNG KATHERINE, JIANG JINLONG, GU XIN, TANG HAIQUN, XIAO LI, FU JIANMIN, DONG SHUZHI, SCOTT JACK D, BENNETT FRANK
Year of Publication 12.02.2018
Get full text
Year of Publication 12.02.2018
Patent
IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
CUMMING JARED N, STAMFORD ANDREW W, LI GUOQING, GILBERT ERIC J, SCOTT JACK D, MISIASZEK JEFFREY A, ISERLOH ULRICH
Year of Publication 10.08.2016
Get full text
Year of Publication 10.08.2016
Patent
2-SPIRO-SUBSTITUTED IMINOTHIAZINES AND THEIR MONO- AND DIOXIDES AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE
BENNETT CHAD, WU WEN LIAN, BURNETT DUANE A, CUMMING JARED N, SASISKUMAR THAVALAKULAMGARA K, STAMFORD ANDREW, SCOTT JACK D, ASBEROM THEODROS
Year of Publication 08.05.2014
Get full text
Year of Publication 08.05.2014
Patent
IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
CUMMING JARED N, STAMFORD ANDREW W, LI GUOQING, GILBERT ERIC J, SCOTT JACK D, MISIASZEK JEFFREY A, ISERLOH ULRICH
Year of Publication 24.03.2014
Get full text
Year of Publication 24.03.2014
Patent
IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
CUMMING JARED N, STAMFORD ANDREW W, LI GUOQING, GILBERT ERIC J, SCOTT JACK D, MISIASZEK JEFFREY A, ISERLOH ULRICH
Year of Publication 17.08.2012
Get full text
Year of Publication 17.08.2012
Patent
SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS
GREENLEE WILLIAM J, DEMONG DUANE EUGENE, CELLY CHANDER SHEKHER, GILBERT ERIC J, MILLER MICHAEL W, STAMFORD ANDREW, SCOTT JACK D
Year of Publication 17.05.2010
Get full text
Year of Publication 17.05.2010
Patent