Glyco- and Peptidomimetics from Three-Component Joullié−Ugi Coupling Show Selective Antiviral Activity
Chapman, Timothy M, Davies, Ieuan G, Gu, Baohua, Block, Timothy M, Scopes, David I. C, Hay, Philip A, Courtney, Stephen M, McNeill, Luke A, Schofield, Christopher J, Davis, Benjamin G
Published in Journal of the American Chemical Society (19.01.2005)
Published in Journal of the American Chemical Society (19.01.2005)
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RS-0406 Arrests Amyloid-β Oligomer-Induced Behavioural Deterioration In Vivo
O’Hare, Eugene, Scopes, David I.C., Treherne, J. Mark, Norwood, Kelly, Spanswick, David, Kim, Eun-Mee
Published in Behavioural brain research (26.06.2010)
Published in Behavioural brain research (26.06.2010)
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Orally bioavailable small molecule drug protects memory in Alzheimer's disease models
O'Hare, Eugene, Scopes, David I.C, Kim, Eun-Mee, Palmer, Philip, Jones, Martyn, Whyment, Andrew D, Spanswick, David, Amijee, Hozefa, Nerou, Edmund, McMahon, Bridgeen, Treherne, J. Mark, Jeggo, Ross
Published in Neurobiology of aging (01.04.2013)
Published in Neurobiology of aging (01.04.2013)
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Novel 5-aryloxypyrimidine SEN1576 as a candidate for the treatment of Alzheimer's disease
O'Hare, Eugene, Scopes, David I.C., Kim, Eun-Mee, Palmer, Philip, Spanswick, David, McMahon, Bridgeen, Amijee, Hozefa, Nerou, Edmund, Treherne, J. Mark, Jeggo, Ross
Published in The international journal of neuropsychopharmacology (01.01.2014)
Published in The international journal of neuropsychopharmacology (01.01.2014)
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The N‑Methylated Peptide SEN304 Powerfully Inhibits Aβ(1–42) Toxicity by Perturbing Oligomer Formation
Amijee, Hozefa, Bate, Clive, Williams, Alun, Virdee, Jasmeet, Jeggo, Ross, Spanswick, David, Scopes, David I.C, Treherne, J. Mark, Mazzitelli, Sonia, Chawner, Ross, Eyers, Claire E, Doig, Andrew J
Published in Biochemistry (Easton) (23.10.2012)
Published in Biochemistry (Easton) (23.10.2012)
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Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500
Lo, Adrian C., Tesseur, Ina, Scopes, David I.C., Nerou, Edmund, Callaerts-Vegh, Zsuzsanna, Vermaercke, Ben, Treherne, J. Mark, De Strooper, Bart, D'Hooge, Rudi
Published in Neuropharmacology (01.12.2013)
Published in Neuropharmacology (01.12.2013)
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Novel anti-inflammatory compound SEN1176 alleviates behavioral deficits induced following bilateral intrahippocampal injection of aggregated amyloid-β
O'Hare, Eugene, Scopes, David I C, Treherne, J Mark, Monaghan, John, Palmer, Philip M, Amijee, Hozefa, Kim, Eun-Mee
Published in Journal of Alzheimer's disease (2011)
Published in Journal of Alzheimer's disease (2011)
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Rhodanine-3-acetic acid derivatives as inhibitors of fungal protein mannosyl transferase 1 (PMT1)
Orchard, Michael G, Neuss, Judi C, Galley, Carl M.S, Carr, Andrew, Porter, David W, Smith, Phillip, Scopes, David I.C, Haydon, David, Vousden, Katherine, Stubberfield, Colin R, Young, Kate, Page, Martin
Published in Bioorganic & medicinal chemistry letters (02.08.2004)
Published in Bioorganic & medicinal chemistry letters (02.08.2004)
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Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor
Courtney, Stephen M., Hay, Philip A., Buck, Richard T., Colville, Claire S., Phillips, David J., Scopes, David I.C., Pollard, Faye C., Page, Martin J., Bennett, James M., Hircock, Margaret L., McKenzie, Edward A., Bhaman, Maina, Felix, Robert, Stubberfield, Colin R., Turner, Paul R.
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
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2,3-Dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid derivatives: a novel class of small molecule heparanase inhibitors
COURTNEY, Stephen M, HAY, Philip A, MCKENZIE, Edward A, STUBBERFIELD, Colin R, TURNER, Paul R, BUCK, Richard T, COLVILLE, Claire S, PORTER, David W, SCOPES, David I. C, POLLARD, Faye C, PAGE, Martin J, BENNETT, James M, HIRCOCK, Margaret L
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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New .kappa.-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus
Scopes, David I. C, Hayes, Norman F, Bays, David E, Belton, David, Brain, John, Brown, Dearg S, Judd, Duncan B, McElroy, Andrew B, Meerholz, Clive A
Published in Journal of medicinal chemistry (01.02.1992)
Published in Journal of medicinal chemistry (01.02.1992)
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Evolution of a Novel Series of [(N,N-Dimethylamino)propyl]- and Piperazinylbenzanilides as the First Selective 5-HT1D Antagonists
Clitherow, John W, Scopes, David I. C, Skingle, Malcolm, Jordan, Christopher C, Feniuk, Wasyl, Campbell, Ian B, Carter, Malcolm C, Collington, Eric W, Connor, Helen E
Published in Journal of medicinal chemistry (01.07.1994)
Published in Journal of medicinal chemistry (01.07.1994)
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Bromobenzofuran-Based Non-peptide Antagonists of Angiotensin II: GR138950, a Potent Antihypertensive Agent with High Oral Bioavailability
Judd, Duncan B, Dowle, Michael D, Middlemiss, David, Scopes, David I. C, Ross, Barry C, Jack, Torquil I, Pass, Martin, Tranquillini, Elvira, Hobson, Julie E
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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A synthetic approach to the indole alkaloid apparicine. Synthesis of the ring skeleton
Scopes, David I. C., Allen, Malcolm S., Hignett, Geoffrey J., Wilson, Nigel D. V., Harris, Martin, Joule, John A.
Published in Journal of the Chemical Society, Perkin Transactions 1 (1977)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1977)
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Synthesis, antinociceptive activity and opioid receptor profiles of substituted trans-3-(decahydro- and octahydro-4a-isoquinolinyl)phenols
Judd, Duncan B, Brown, Dearg S, Lloyd, Jane E, McElroy, Andrew B, Scopes, David I. C, Birch, Phillip J, Hayes, Ann G, Sheehan, Michael J
Published in Journal of medicinal chemistry (01.01.1992)
Published in Journal of medicinal chemistry (01.01.1992)
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