Evidence for Seeding of beta -Amyloid by Intracerebral Infusion of Alzheimer Brain Extracts in beta -Amyloid Precursor Protein-Transgenic Mice
Kane, Michael D, Lipinski, William J, Callahan, Michael J, Bian, Feng, Durham, Robert A, Schwarz, Roy D, Roher, Alex E, Walker, Lary C
Published in The Journal of neuroscience (15.05.2000)
Published in The Journal of neuroscience (15.05.2000)
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Journal Article
Synthesis and SAR of 2-aryl pyrido[2,3- d]pyrimidines as potent mGlu5 receptor antagonists
Wendt, John A., Deeter, Susan D., Bove, Susan E., Knauer, Christopher S., Brooker, Rachel M., Augelli-Szafran, Corinne E., Schwarz, Roy D., Kinsora, Jack J., Kilgore, Kenneth S.
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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Journal Article
Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists
Galatsis, Paul, Yamagata, Koji, Wendt, John A., Connolly, Cleo J., Mickelson, John W., Milbank, Jared B.J., Bove, Susan E., Knauer, Christopher S., Brooker, Rachel M., Augelli-Szafran, Corinne E., Schwarz, Roy D., Kinsora, Jack J., Kilgore, Kenneth S.
Published in Bioorganic & medicinal chemistry (01.12.2007)
Published in Bioorganic & medicinal chemistry (01.12.2007)
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Journal Article
A Structure−Activity Relationship Study of Novel Phenylacetamides Which Are Sodium Channel Blockers
Roufos, Ioannis, Hays, Sheryl, Schwarz, Roy D
Published in Journal of medicinal chemistry (29.03.1996)
Published in Journal of medicinal chemistry (29.03.1996)
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Journal Article
Identification and Characterization of m1 Selective Muscarinic Receptor Antagonists
Augelli-Szafran, Corinne E, Blankley, C. John, Jaen, Juan C, Moreland, David W, Nelson, Carrie B, Penvose-Yi, Jan R, Schwarz, Roy D, Thomas, Anthony J
Published in Journal of medicinal chemistry (11.02.1999)
Published in Journal of medicinal chemistry (11.02.1999)
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The M1 Muscarinic Agonist CI-1017 Facilitates Trace Eyeblink Conditioning in Aging Rabbits and Increases the Excitability of CA1 Pyramidal Neurons
Weiss, Craig, Preston, Alison R, Oh, M. Matthew, Schwarz, Roy D, Welty, Devin, Disterhoft, John F
Published in The Journal of neuroscience (15.01.2000)
Published in The Journal of neuroscience (15.01.2000)
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Journal Article
Muscarinic receptors: it's a knockout
Birdsall, Nigel J.M, Nathanson, Neil M, Schwarz, Roy D
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2001)
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2001)
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Journal Article
Milameline (CI-979/RU35926): A Muscarinic Receptor Agonist with Cognition-Activating Properties: Biochemical and In Vivo Characterization
Schwarz, R D, Callahan, M J, Coughenour, L L, Dickerson, M R, Kinsora, J J, Lipinski, W J, Raby, C A, Spencer, C J, Tecle, H
Published in The Journal of pharmacology and experimental therapeutics (01.11.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.11.1999)
Journal Article
Design and Synthesis of m1-Selective Muscarinic Agonists: (R)-(−)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3‘-Methoxyphenyl)-2-propynyl)- oxime Maleate (CI-1017), a Functionally m1-Selective Muscarinic Agonist
Tecle, Haile, Barrett, Stephen D, Lauffer, David J, Augelli-Szafran, Corinne, Brann, Mark R, Callahan, Michael J, Caprathe, Bradley. W, Davis, Robert E, Doyle, Patricia D, Eubanks, David, Lipiniski, William, Mirzadegan, Tara, Moos, Walter H, Moreland, D. W, Nelson, Carrie B, Pavia, Michael R, Raby, Charlotte, Schwarz, Roy D, Spencer, Carolyn J, Thomas, Anthony J, Jaen, Juan C
Published in Journal of medicinal chemistry (02.07.1998)
Published in Journal of medicinal chemistry (02.07.1998)
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Journal Article
Cognition activators
Moos, W H, Davis, R E, Schwarz, R D, Gamzu, E R
Published in Medicinal research reviews (01.07.1988)
Published in Medicinal research reviews (01.07.1988)
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Journal Article
Design and Synthesis of Novel Quinoxaline-2,3-dione AMPA/GlyN Receptor Antagonists: Amino Acid Derivatives
Nikam, Sham S, Cordon, John J, Ortwine, Daniel F, Heimbach, Tycho H, Blackburn, Anthony C, Vartanian, Mark G, Nelson, Carrie B, Schwarz, Roy D, Boxer, Peter A, Rafferty, Michael F
Published in Journal of medicinal chemistry (17.06.1999)
Published in Journal of medicinal chemistry (17.06.1999)
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Journal Article
Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake
Pavia, Michael R, Lobbestael, Sandra J, Nugiel, David, Mayhugh, Daniel R, Gregor, Vlad E, Taylor, Charles P, Schwarz, Roy D, Brahce, Laura, Vartanian, Mark G
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Journal Article
Mutations of aspartate 103 in the Hm2 receptor and alterations in receptor binding properties of muscarinic agonists
Schwarz, Roy D., Spencer, Carolyn J., Jaen, Juan C., Mirzadegan, Tara, Moreland, David, Tecle, Haile, Thomas, Anthony J.
Published in Life sciences (1973) (1995)
Published in Life sciences (1973) (1995)
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Journal Article
Synthesis and pharmacology of benzoxazines as highly selective antagonists at M-4 muscarinic receptors
Bohme, TM, Augelli-Szafran, CE, Hallak, H, Pugsley, T, Serpa, K, Schwarz, RD
Published in Journal of medicinal chemistry (04.07.2002)
Published in Journal of medicinal chemistry (04.07.2002)
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Journal Article
Design and synthesis of novel quinoxaline-2,3-dione AMPA/Gly(N) receptor antagonists: Amino acid derivatives
Nikam, SS, Cordon, JJ, Ortwine, DF, Heimbach, TH, Blackburn, AC, Vartanian, MG, Nelson, CB, Schwarz, RD, Boxer, PA, Rafferty, MF
Published in Journal of medicinal chemistry (17.06.1999)
Published in Journal of medicinal chemistry (17.06.1999)
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Journal Article
Substituted 2-benzothiazolamines as sodium flux inhibitors: quantitative structure-activity relationships and anticonvulsant activity
Hays, S J, Rice, M J, Ortwine, D F, Johnson, G, Schwarz, R D, Boyd, D K, Copeland, L F, Vartanian, M G, Boxer, P A
Published in Journal of pharmaceutical sciences (01.10.1994)
Published in Journal of pharmaceutical sciences (01.10.1994)
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