Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial
Dauvilliers, Yves, Prof, Bassetti, Claudio, Prof, Lammers, Gert Jan, Prof, Arnulf, Isabelle, Prof, Mayer, Geert, Prof, Rodenbeck, Andrea, Prof, Lehert, Philippe, Prof, Ding, Claire-Li, Lecomte, Jeanne-Marie, PhD, Schwartz, Jean-Charles, Prof
Published in Lancet neurology (01.11.2013)
Published in Lancet neurology (01.11.2013)
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Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial
Szakacs, Zoltan, Prof, Dauvilliers, Yves, Prof, Mikhaylov, Vladimir, MD, Poverennova, Irina, MD, Krylov, Sergei, MD, Jankovic, Slavko, Prof, Sonka, Karel, Prof, Lehert, Philippe, Prof, Lecomte, Isabelle, MD, Lecomte, Jeanne-Marie, PhD, Schwartz, Jean-Charles, Dr Prof
Published in Lancet neurology (01.03.2017)
Published in Lancet neurology (01.03.2017)
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Journal Article
Exploring occupancy of the histamine H3 receptor by pitolisant in humans using PET
Rusjan, Pablo, Sabioni, Pamela, Di Ciano, Patricia, Mansouri, Esmaeil, Boileau, Isabelle, Laveillé, Alexia, Capet, Marc, Duvauchelle, Thierry, Schwartz, Jean‐Charles, Robert, Philippe, Le Foll, Bernard
Published in British journal of pharmacology (01.08.2020)
Published in British journal of pharmacology (01.08.2020)
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Journal Article
Bioavailability and cardiovascular effects of adrenaline administered by Anapen 500 μg auto‐injector in healthy volunteers
Duvauchelle, Thierry, Robert, Philippe, Donazzolo, Yves, Loyau, Sabrina, Orlandini, Bernard, Lehert, Philippe, Lecomte, Jeanne‐Marie, Schwartz, Jean‐Charles
Published in British journal of clinical pharmacology (01.03.2023)
Published in British journal of clinical pharmacology (01.03.2023)
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Journal Article
Normal cerebrospinal fluid histamine and tele-methylhistamine levels in hypersomnia conditions
Dauvilliers, Yves, Delallée, Nathalie, Jaussent, Isabelle, Scholz, Sabine, Bayard, Sophie, Croyal, Mickael, Schwartz, Jean-Charles, Robert, Philippe
Published in Sleep (New York, N.Y.) (01.10.2012)
Published in Sleep (New York, N.Y.) (01.10.2012)
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Journal Article
Administration of oxathridine, a first‐in‐class histamine‐3 receptor partial agonist in healthy male volunteers: Central nervous system depression and pseudo‐hallucinations
Dijkstra, Francis M., Zuiker, Rob G. J. A., Heuberger, Jules A. A. C., Kanhai, Kawita M. S., De Kam, Marieke, Duvauchelle, Thierry, Lecomte, Jeanne‐Marie, Labeeuw, Olivier, Landais, Laurent, Ligneau, Xavier, Robert, Philippe, Capet, Marc, Schwartz, Jean‐Charles, Gerven, Joop M. A.
Published in British journal of clinical pharmacology (01.01.2024)
Published in British journal of clinical pharmacology (01.01.2024)
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Journal Article
An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin−/− mice and patients
Lin, Jian-Sheng, Dauvilliers, Yves, Arnulf, Isabelle, Bastuji, Hélène, Anaclet, Christelle, Parmentier, Régis, Kocher, Laurence, Yanagisawa, Masashi, Lehert, Philippe, Ligneau, Xavier, Perrin, David, Robert, Philippe, Roux, Michel, Lecomte, Jeanne-Marie, Schwartz, Jean-Charles
Published in Neurobiology of disease (01.04.2008)
Published in Neurobiology of disease (01.04.2008)
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Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro‐arrhythmia Assay initiative studies
Ligneau, Xavier, Shah, Rashmi R, Berrebi‐Bertrand, Isabelle, Mirams, Gary R, Robert, Philippe, Landais, Laurent, Maison‐Blanche, Pierre, Faivre, Jean‐François, Lecomte, Jeanne‐Marie, Schwartz, Jean‐Charles
Published in British journal of pharmacology (01.12.2017)
Published in British journal of pharmacology (01.12.2017)
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Journal Article
Cerebrospinal fluid histamine levels are decreased in patients with narcolepsy and excessive daytime sleepiness of other origin
BASSETTI, CLAUDIO L., BAUMANN, CHRISTIAN R., DAUVILLIERS, YVES, CROYAL, MICHAEL, ROBERT, PHILIPPE, SCHWARTZ, JEAN‐CHARLES
Published in Journal of sleep research (01.12.2010)
Published in Journal of sleep research (01.12.2010)
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Journal Article
Pitolisant, a wake‐promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol
Krief, Stéphane, Berrebi‐Bertrand, Isabelle, Nagmar, Isabelle, Giret, Martin, Belliard, Simon, Perrin, David, Uguen, Marilyne, Robert, Philippe, Lecomte, Jeanne‐Marie, Schwartz, Jean‐Charles, Finance, Olivier, Ligneau, Xavier
Published in Pharmacology research & perspectives (01.10.2021)
Published in Pharmacology research & perspectives (01.10.2021)
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Development of Novel 1,2,3,4-Tetrahydroisoquinoline Derivatives and Closely Related Compounds as Potent and Selective Dopamine D₃ Receptor Ligands
Mach, Ulrich R, Hackling, Anneke E, Perachon, Sylvie, Ferry, Sandrine, Wermuth, Camille G, Schwartz, Jean-Charles, Sokoloff, Pierre, Stark, Holger
Published in Chembiochem : a European journal of chemical biology (02.04.2004)
Published in Chembiochem : a European journal of chemical biology (02.04.2004)
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Journal Article
Protean agonism at histamine H3 receptors in vitro and in vivo
Gbahou, Florence, Rouleau, Agnès, Morisset, Séverine, Parmentier, Régis, Crochet, Sylvain, Lin, Jian-Sheng, Ligneau, Xavier, Tardivel-Lacombe, Joël, Stark, Holger, Schunack, Walter, Ganellin, C Robin, Schwartz, Jean-Charles, Arrang, Jean-Michel
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2003)
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Journal Article
First Metal-Containing Histamine H3 Receptor Ligands
Sander, Kerstin, Kottke, Tim, Hoffend, Claas, Walter, Miriam, Weizel, Lilia, Camelin, Jean-Claude, Ligneau, Xavier, Schneider, Erich H., Seifert, Roland, Schwartz, Jean-Charles, Stark, Holger
Published in Organic letters (04.06.2010)
Published in Organic letters (04.06.2010)
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Journal Article
The dopamine D3 receptor mediates locomotor hyperactivity induced by NMDA receptor blockade
LERICHE, Ludovic, SCHWARTZ, Jean-Charles, SOKOLOFF, Pierre
Published in Neuropharmacology (01.08.2003)
Published in Neuropharmacology (01.08.2003)
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Journal Article
Highly Potent Fluorescence-Tagged Nonimidazole Histamine H3 Receptor Ligands
Amon, Michael, Ligneau, Xavier, Camelin, Jean-Claude, Berrebi-Bertrand, Isabelle, Schwartz, Jean-Charles, Stark, Holger
Published in ChemMedChem (14.05.2007)
Published in ChemMedChem (14.05.2007)
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