AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases
Arencibia, José M., Pastor-Flores, Daniel, Bauer, Angelika F., Schulze, Jörg O., Biondi, Ricardo M.
Published in Biochimica et biophysica acta (01.07.2013)
Published in Biochimica et biophysica acta (01.07.2013)
Get full text
Journal Article
Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase
Schulze, Jörg O., Saladino, Giorgio, Busschots, Katrien, Neimanis, Sonja, Süß, Evelyn, Odadzic, Dalibor, Zeuzem, Stefan, Hindie, Valerie, Herbrand, Amanda K., Lisa, María-Natalia, Alzari, Pedro M., Gervasio, Francesco L., Biondi, Ricardo M.
Published in Cell chemical biology (20.10.2016)
Published in Cell chemical biology (20.10.2016)
Get full text
Journal Article
2‑(3-Oxo-1,3-diphenylpropyl)malonic Acids as Potent Allosteric Ligands of the PIF Pocket of Phosphoinositide-Dependent Kinase-1: Development and Prodrug Concept
Wilhelm, Adriana, Lopez-Garcia, Laura A, Busschots, Katrien, Fröhner, Wolfgang, Maurer, Frauke, Boettcher, Stefan, Zhang, Hua, Schulze, Jörg O, Biondi, Ricardo M, Engel, Matthias
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
Get full text
Journal Article
An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms
Arencibia, Jose M, Fröhner, Wolfgang, Krupa, Magdalena, Pastor-Flores, Daniel, Merker, Piotr, Oellerich, Thomas, Neimanis, Sonja, Schmithals, Christian, Köberle, Verena, Süß, Evelyn, Zeuzem, Stefan, Stark, Holger, Piiper, Albrecht, Odadzic, Dalibor, Schulze, Jörg O, Biondi, Ricardo M
Published in ACS chemical biology (17.02.2017)
Published in ACS chemical biology (17.02.2017)
Get full text
Journal Article
AGC kinases, mechanisms of regulation and innovative drug development
Leroux, Alejandro E, Schulze, Jörg, Biondi, Ricardo M
Published in Seminars in cancer biology (01.02.2018)
Published in Seminars in cancer biology (01.02.2018)
Get full text
Journal Article
Molecular insights into the regulatory landscape of PKC-related kinase-2 (PRK2/PKN2) using targeted small compounds
Gross, Lissy Z.F., Winkel, Angelika F., Galceran, Facundo, Schulze, Jörg O., Fröhner, Wolfgang, Cämmerer, Simon, Zeuzem, Stefan, Engel, Matthias, Leroux, Alejandro E., Biondi, Ricardo M.
Published in The Journal of biological chemistry (01.08.2024)
Published in The Journal of biological chemistry (01.08.2024)
Get full text
Journal Article
Structural and functional characterization of human Iba proteins
Schulze, Jörg O, Quedenau, Claudia, Roske, Yvette, Adam, Thomas, Schüler, Herwig, Behlke, Joachim, Turnbull, Andrew P, Sievert, Volker, Scheich, Christoph, Mueller, Uwe, Heinemann, Udo, Büssow, Konrad
Published in The FEBS journal (01.09.2008)
Published in The FEBS journal (01.09.2008)
Get full text
Journal Article
PIF-Pocket as a Target for C. albicans Pkh Selective Inhibitors
Pastor-Flores, Daniel, Schulze, Jörg O, Bahí, Anna, Giacometti, Romina, Ferrer-Dalmau, Jofre, Passeron, Susana, Engel, Matthias, Süß, Evelyn, Casamayor, Antonio, Biondi, Ricardo M
Published in ACS chemical biology (18.10.2013)
Published in ACS chemical biology (18.10.2013)
Get full text
Journal Article
Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein
Sacerdoti, Mariana, Gross, Lissy Z F, Riley, Andrew M, Zehnder, Karin, Ghode, Abhijeet, Klinke, Sebastián, Anand, Ganesh Srinivasan, Paris, Kristina, Winkel, Angelika, Herbrand, Amanda K, Godage, H Yasmin, Cozier, Gyles E, Süß, Evelyn, Schulze, Jörg O, Pastor-Flores, Daniel, Bollini, Mariela, Cappellari, María Victoria, Svergun, Dmitri, Gräwert, Melissa A, Aramendia, Pedro F, Leroux, Alejandro E, Potter, Barry V L, Camacho, Carlos J, Biondi, Ricardo M
Published in Science signaling (13.06.2023)
Published in Science signaling (13.06.2023)
Get more information
Journal Article
Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE
Khageh Hosseini, Sabrina, Kolterer, Stefanie, Steiner, Marlene, von Manstein, Viktoria, Gerlach, Katharina, Trojan, Jörg, Waidmann, Oliver, Zeuzem, Stefan, Schulze, Jörg O., Hahn, Steffen, Steinhilber, Dieter, Gatterdam, Volker, Tampé, Robert, Biondi, Ricardo M., Proschak, Ewgenij, Zörnig, Martin
Published in Biochemical pharmacology (15.12.2017)
Published in Biochemical pharmacology (15.12.2017)
Get full text
Journal Article
Evolutionary Relationship between Initial Enzymes of Tetrapyrrole Biosynthesis
Schulze, Jörg O., Schubert, Wolf-Dieter, Moser, Jürgen, Jahn, Dieter, Heinz, Dirk W.
Published in Journal of molecular biology (19.05.2006)
Published in Journal of molecular biology (19.05.2006)
Get full text
Journal Article
Allosteric Regulation of Protein Kinase PKCζ by the N-Terminal C1 Domain and Small Compounds to the PIF-Pocket
Lopez-Garcia, Laura A., Schulze, Jörg O., Fröhner, Wolfgang, Zhang, Hua, Süß, Evelyn, Weber, Nadja, Navratil, Jeanette, Amon, Sabine, Hindie, Valerie, Zeuzem, Stefan, Jørgensen, Thomas J.D., Alzari, Pedro M., Neimanis, Sonja, Engel, Matthias, Biondi, Ricardo M.
Published in Chemistry & biology (23.11.2011)
Published in Chemistry & biology (23.11.2011)
Get full text
Journal Article
Crystal Structure of a Non-discriminating Glutamyl-tRNA Synthetase
Schulze, Jörg O., Masoumi, Ava, Nickel, Daniel, Jahn, Martina, Jahn, Dieter, Schubert, Wolf-Dieter, Heinz, Dirk W.
Published in Journal of molecular biology (01.09.2006)
Published in Journal of molecular biology (01.09.2006)
Get full text
Journal Article
Molecular Mechanism of Regulation of the Atypical Protein Kinase C by N-terminal Domains and an Allosteric Small Compound
Zhang, Hua, Neimanis, Sonja, Lopez-Garcia, Laura A., Arencibia, José M., Amon, Sabine, Stroba, Adriana, Zeuzem, Stefan, Proschak, Ewgen, Stark, Holger, Bauer, Angelika F., Busschots, Katrien, Jørgensen, Thomas J.D., Engel, Matthias, Schulze, Jörg O., Biondi, Ricardo M.
Published in Chemistry & biology (19.06.2014)
Published in Chemistry & biology (19.06.2014)
Get full text
Journal Article
Substrate-Selective Inhibition of Protein Kinase PDK1 by Small Compounds that Bind to the PIF-Pocket Allosteric Docking Site
Busschots, Katrien, Lopez-Garcia, Laura A., Lammi, Carmen, Stroba, Adriana, Zeuzem, Stefan, Piiper, Albrecht, Alzari, Pedro M., Neimanis, Sonja, Arencibia, Jose M., Engel, Matthias, Schulze, Jörg O., Biondi, Ricardo M.
Published in Chemistry & biology (21.09.2012)
Published in Chemistry & biology (21.09.2012)
Get full text
Journal Article
Chemical biology and structural studies on the mechanism of regulation of phosphoinositide-dependent protein kinase 1 (PDK1)
Gross, Lissy Z. F., Sacerdoti, Mariana, Leroux, Alejandro E., Ghode, Abhijeet, Anand, Ganesh S., Schulze, Jörg O., Graewert, Melissa A., Svergun, Dmitri I., Klinke, Sebastian, Biondi, Ricardo M.
Published in Acta crystallographica. Section A, Foundations and advances (14.08.2021)
Published in Acta crystallographica. Section A, Foundations and advances (14.08.2021)
Get full text
Journal Article