Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer
Lücking, Ulrich, Scholz, Arne, Lienau, Philip, Siemeister, Gerhard, Kosemund, Dirk, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Meyer, Kirstin, Prelle, Katja, Denner, Karsten, Bömer, Ulf, Schäfer, Martina, Eis, Knut, Valencia, Ray, Ince, Stuart, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl, Klebl, Bert, Choidas, Axel, Nussbaumer, Peter, Baumann, Matthias, Schultz‐Fademrecht, Carsten, Rühter, Gerd, Eickhoff, Jan, Brands, Michael
Published in ChemMedChem (08.11.2017)
Published in ChemMedChem (08.11.2017)
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Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell‐based Compound Discovery and Target Prediction
Kremer, Lea, Schultz‐Fademrecht, Carsten, Baumann, Matthias, Habenberger, Peter, Choidas, Axel, Klebl, Bert, Kordes, Susanne, Schöler, Hans R., Sterneckert, Jared, Ziegler, Slava, Schneider, Gisbert, Waldmann, Herbert
Published in Angewandte Chemie International Edition (09.10.2017)
Published in Angewandte Chemie International Edition (09.10.2017)
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A PDE6δ‐KRas Inhibitor Chemotype with up to Seven H‐Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2
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Published in Angewandte Chemie International Edition (20.02.2017)
Published in Angewandte Chemie International Edition (20.02.2017)
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Identification of pyrazolopyridazinones as PDEδ inhibitors
Papke, Björn, Murarka, Sandip, Vogel, Holger A, Martín-Gago, Pablo, Kovacevic, Marija, Truxius, Dina C, Fansa, Eyad K, Ismail, Shehab, Zimmermann, Gunther, Heinelt, Kaatje, Schultz-Fademrecht, Carsten, Al Saabi, Alaa, Baumann, Matthias, Nussbaumer, Peter, Wittinghofer, Alfred, Waldmann, Herbert, Bastiaens, Philippe I.H.
Published in Nature communications (20.04.2016)
Published in Nature communications (20.04.2016)
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The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
Paolino, Magdalena, Choidas, Axel, Wallner, Stephanie, Pranjic, Blanka, Uribesalgo, Iris, Loeser, Stefanie, Jamieson, Amanda M., Langdon, Wallace Y., Ikeda, Fumiyo, Fededa, Juan Pablo, Cronin, Shane J., Nitsch, Roberto, Schultz-Fademrecht, Carsten, Eickhoff, Jan, Menninger, Sascha, Unger, Anke, Torka, Robert, Gruber, Thomas, Hinterleitner, Reinhard, Baier, Gottfried, Wolf, Dominik, Ullrich, Axel, Klebl, Bert M., Penninger, Josef M.
Published in Nature (London) (27.03.2014)
Published in Nature (London) (27.03.2014)
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Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR
Engel, Julian, Becker, Christian, Lategahn, Jonas, Keul, Marina, Ketzer, Julia, Mühlenberg, Thomas, Kollipara, Laxmikanth, Schultz-Fademrecht, Carsten, Zahedi, René P., Bauer, Sebastian, Rauh, Daniel
Published in Angewandte Chemie International Edition (26.08.2016)
Published in Angewandte Chemie International Edition (26.08.2016)
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Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor
Tomassi, Stefano, Lategahn, Jonas, Engel, Julian, Keul, Marina, Tumbrink, Hannah L, Ketzer, Julia, Mühlenberg, Thomas, Baumann, Matthias, Schultz-Fademrecht, Carsten, Bauer, Sebastian, Rauh, Daniel
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
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Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors
Jones, Philip, Altamura, Sergio, Boueres, Julia, Ferrigno, Federica, Fonsi, Massimiliano, Giomini, Claudia, Lamartina, Stefania, Monteagudo, Edith, Ontoria, Jesus M, Orsale, Maria Vittoria, Palumbi, Maria Cecilia, Pesci, Silvia, Roscilli, Giuseppe, Scarpelli, Rita, Schultz-Fademrecht, Carsten, Toniatti, Carlo, Rowley, Michael
Published in Journal of medicinal chemistry (26.11.2009)
Published in Journal of medicinal chemistry (26.11.2009)
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Cellular model system to dissect the isoform-selectivity of Akt inhibitors
Quambusch, Lena, Depta, Laura, Landel, Ina, Lubeck, Melissa, Kirschner, Tonia, Nabert, Jonas, Uhlenbrock, Niklas, Weisner, Jörn, Kostka, Michael, Levy, Laura M., Schultz-Fademrecht, Carsten, Glanemann, Franziska, Althoff, Kristina, Müller, Matthias P., Siveke, Jens T., Rauh, Daniel
Published in Nature communications (06.09.2021)
Published in Nature communications (06.09.2021)
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Development of Pyridazinone Chemotypes Targeting the PDEδ Prenyl Binding Site
Murarka, Sandip, Martín‐Gago, Pablo, Schultz‐Fademrecht, Carsten, Al Saabi, Alaa, Baumann, Matthias, Fansa, Eyad K., Ismail, Shehab, Nussbaumer, Peter, Wittinghofer, Alfred, Waldmann, Herbert
Published in Chemistry : a European journal (02.05.2017)
Published in Chemistry : a European journal (02.05.2017)
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New insights into the intracellular distribution pattern of cationic amphiphilic drugs
Vater, Magdalena, Möckl, Leonhard, Gormanns, Vanessa, Schultz Fademrecht, Carsten, Mallmann, Anna M., Ziegart-Sadowska, Karolina, Zaba, Monika, Frevert, Marie L., Bräuchle, Christoph, Holsboer, Florian, Rein, Theo, Schmidt, Ulrike, Kirmeier, Thomas
Published in Scientific reports (10.03.2017)
Published in Scientific reports (10.03.2017)
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GRK5 조절제로서3-치환된 1H-피롤로[2,3-b]피리딘
BAUMANN MATTHIAS, ZHANG JIANMIN, SCHULTZ FADEMRECHT CARSTEN, NUSSBAUMER PETER, KLEBL BERT, ENGEL JULIAN
Year of Publication 20.02.2024
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Year of Publication 20.02.2024
Patent
Discovery of a Novel Inhibitor of the Hedgehog Signaling Pathway through Cell‐based Compound Discovery and Target Prediction
Kremer, Lea, Schultz‐Fademrecht, Carsten, Baumann, Matthias, Habenberger, Peter, Choidas, Axel, Klebl, Bert, Kordes, Susanne, Schöler, Hans R., Sterneckert, Jared, Ziegler, Slava, Schneider, Gisbert, Waldmann, Herbert
Published in Angewandte Chemie (09.10.2017)
Published in Angewandte Chemie (09.10.2017)
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A PDE6δ‐KRas Inhibitor Chemotype with up to Seven H‐Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2
Martín‐Gago, Pablo, Fansa, Eyad K., Klein, Christian H., Murarka, Sandip, Janning, Petra, Schürmann, Marc, Metz , Malte, Ismail, Shehab, Schultz‐Fademrecht, Carsten, Baumann, Matthias, Bastiaens, Philippe I. H., Wittinghofer, Alfred, Waldmann, Herbert
Published in Angewandte Chemie (20.02.2017)
Published in Angewandte Chemie (20.02.2017)
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암을 치료하기에 유용한 ErbB 조절자로서의 4-치환된 피롤로[2,3-b]피리딘
DEGENHART CARSTEN, BAUMANN MATTHIAS, SCHULTZ FADEMRECHT CARSTEN, NUSSBAUMER PETER, KLEBL BERT
Year of Publication 04.05.2021
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Year of Publication 04.05.2021
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Synthesis of Enantioenriched 5-Alkylidene-2-cyclopentenones from Chiral Allenyl Carbamates: Generation of a Chiral Lithium Allenolate and Allylic Activation for a Conrotatory 4π-Electrocyclization
Schultz-Fademrecht, Carsten, Tius, Marc A., Grimme, Stefan, Wibbeling, B., Hoppe, Dieter
Published in Angewandte Chemie International Edition (03.05.2002)
Published in Angewandte Chemie International Edition (03.05.2002)
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Covalent Protein Labeling at Glutamic Acids
Martín-Gago, Pablo, Fansa, Eyad K., Winzker, Michael, Murarka, Sandip, Janning, Petra, Schultz-Fademrecht, Carsten, Baumann, Matthias, Wittinghofer, Alfred, Waldmann, Herbert
Published in Cell chemical biology (18.05.2017)
Published in Cell chemical biology (18.05.2017)
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Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS -Mutant Pancreatic and Colorectal Cancer
Weisner, Jörn, Landel, Ina, Reintjes, Christoph, Uhlenbrock, Niklas, Trajkovic-Arsic, Marija, Dienstbier, Niklas, Hardick, Julia, Ladigan, Swetlana, Lindemann, Marius, Smith, Steven, Quambusch, Lena, Scheinpflug, Rebekka, Depta, Laura, Gontla, Rajesh, Unger, Anke, Müller, Heiko, Baumann, Matthias, Schultz-Fademrecht, Carsten, Günther, Georgia, Maghnouj, Abdelouahid, Müller, Matthias P, Pohl, Michael, Teschendorf, Christian, Wolters, Heiner, Viebahn, Richard, Tannapfel, Andrea, Uhl, Waldemar, Hengstler, Jan G, Hahn, Stephan A, Siveke, Jens T, Rauh, Daniel
Published in Cancer research (Chicago, Ill.) (01.05.2019)
Published in Cancer research (Chicago, Ill.) (01.05.2019)
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TAM RTK 억제제로서 퀴놀린 유도체들
PARK DONGSIK, AHN JIYE, KIM JAESEUNG, SCHULTZ FADEMRECHT CARSTEN, JEON YEEJIN, LEE DOOHYUNG, LEE SAEYEON, AHN SEOHYUN, KIM HANA, JUNG CHUN WON, NAM KIYEAN, YANG YEONG IN, KIM JEONGJUN
Year of Publication 08.12.2017
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Year of Publication 08.12.2017
Patent