Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke Therapies
Rai, Ganesha, Joshi, Netra, Jung, Joo Eun, Liu, Yu, Schultz, Lena, Yasgar, Adam, Perry, Steve, Diaz, Giovanni, Zhang, Qiangli, Kenyon, Victor, Jadhav, Ajit, Simeonov, Anton, Lo, Eng H, van Leyen, Klaus, Maloney, David J, Holman, Theodore R
Published in Journal of medicinal chemistry (22.05.2014)
Published in Journal of medicinal chemistry (22.05.2014)
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Journal Article
Discovery of Potent and Selective Inhibitors of Human Reticulocyte 15-Lipoxygenase-1
Rai, Ganesha, Kenyon, Victor, Jadhav, Ajit, Schultz, Lena, Armstrong, Michelle, Jameson, J. Brian, Hoobler, Eric, Leister, William, Simeonov, Anton, Holman, Theodore R, Maloney, David J
Published in Journal of medicinal chemistry (28.10.2010)
Published in Journal of medicinal chemistry (28.10.2010)
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Rehabilitation and Return-to-Work of Patients Acquiring COVID-19 in the Workplace: A Study Protocol for an Observational Cohort Study
Müller, Katrin, Zwingmann, Katharina, Auerswald, Tina, Berger, Ivo, Thomas, Andreas, Schultz, Anna-Lena, Wilhelm, Eva, Weber, Rainer-Christian, Kolb, Franziska, Wastlhuber, Alois, Meder, Sylvia, Stegbauer, Michael
Published in Frontiers in rehabilitation sciences (31.01.2022)
Published in Frontiers in rehabilitation sciences (31.01.2022)
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Journal Article
A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2
Jameson, 2nd, J Brian, Kantz, Auric, Schultz, Lena, Kalyanaraman, Chakrapani, Jacobson, Matthew P, Maloney, David J, Jadhav, Ajit, Simeonov, Anton, Holman, Theodore R
Published in PloS one (11.08.2014)
Published in PloS one (11.08.2014)
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Journal Article
A miniaturized screen for inhibitors of Jumonji histone demethylases
Sakurai, Masaaki, Rose, Nathan R, Schultz, Lena, Quinn, Amy M, Jadhav, Ajit, Ng, Stanley S, Oppermann, Udo, Schofield, Christopher J, Simeonov, Anton
Published in Molecular bioSystems (01.01.2010)
Published in Molecular bioSystems (01.01.2010)
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796 ALG.APV-527: a 5T4 tumor directed bispecific approach utilizing ADAPTIRTM technology designed for conditional 4-1BB T cell/NK agonism against solid tumors
Nelson, Michelle, Sundstedt, Anette, Coaña, Yago Pico de, Lucas, Ashly, Nilsson, Anneli, Ljung, Lill, Chunyk, Allison, Schultz, Lena, McMahan, Catherine, Gross, Jane, Frizell, Sara, Ramos, Hilario, Ellmark, Peter
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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369 Safety and pharmacodynamic activity of ATOR-1015, a CTLA-4 x OX40 bispecific antibody, in a phase 1 dose escalation study of patients with advanced solid malignancies
Yachnin, Jeffrey, Ullenhag, Gustav, Carneiro, Ana, Nielsen, Dorte, Rohrberg, Kristoffer Staal, Kvarnhammar, Anne Månsson, Schultz, Lena, Bågeman, Erika, Wennersten, Camilla, Russell, Charlotte
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships
Niesen, Frank H, Schultz, Lena, Jadhav, Ajit, Bhatia, Chitra, Guo, Kunde, Maloney, David J, Pilka, Ewa S, Wang, Minghua, Oppermann, Udo, Heightman, Tom D, Simeonov, Anton
Published in PloS one (02.11.2010)
Published in PloS one (02.11.2010)
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Impact of Rehabilitation on Physical and Neuropsychological Health of Patients Who Acquired COVID-19 in the Workplace
Müller, Katrin, Poppele, Iris, Ottiger, Marcel, Zwingmann, Katharina, Berger, Ivo, Thomas, Andreas, Wastlhuber, Alois, Ortwein, Franziska, Schultz, Anna-Lena, Weghofer, Anna, Wilhelm, Eva, Weber, Rainer-Christian, Meder, Sylvia, Stegbauer, Michael, Schlesinger, Torsten
Published in International journal of environmental research and public health (13.01.2023)
Published in International journal of environmental research and public health (13.01.2023)
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A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells
Nguyen, Giang Huong, Dexheimer, Thomas S., Rosenthal, Andrew S., Chu, Wai Kit, Singh, Dharmendra Kumar, Mosedale, Georgina, Bachrati, Csanád Z., Schultz, Lena, Sakurai, Masaaki, Savitsky, Pavel, Abu, Mika, McHugh, Peter J., Bohr, Vilhelm A., Harris, Curtis C., Jadhav, Ajit, Gileadi, Opher, Maloney, David J., Simeonov, Anton, Hickson, Ian D.
Published in Chemistry & biology (24.01.2013)
Published in Chemistry & biology (24.01.2013)
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ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1
Enell Smith, Karin, Fritzell, Sara, Nilsson, Anneli, Barchan, Karin, Rosén, Anna, Schultz, Lena, Varas, Laura, Säll, Anna, Rose, Nadia, Håkansson, Maria, von Schantz, Laura, Ellmark, Peter
Published in Cancer Immunology, Immunotherapy (01.12.2023)
Published in Cancer Immunology, Immunotherapy (01.12.2023)
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Initial findings from a first-in-human, multicenter, open-label study of ATOR-1017, a 4-1BB antibody, in patients with advanced solid malignancies
Ullenhag, Gustav J., Carneiro, Ana, Enell Smith, Karin, Schultz, Lena, Ambarkhane, Sumeet Vijay, Landstrom, Tova, Yachnin, Jeffrey
Published in JOURNAL OF CLINICAL ONCOLOGY (01.06.2022)
Published in JOURNAL OF CLINICAL ONCOLOGY (01.06.2022)
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Conference Proceeding
The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies
Nelson, Michelle H, Fritzell, Sara, Miller, Robert, Werchau, Doreen, Van Citters, Danielle, Nilsson, Anneli, Misher, Lynda, Ljung, Lill, Bader, Robert, Deronic, Adnan, Chunyk, Allison G, Schultz, Lena, Varas, Laura A, Rose, Nadia, Håkansson, Maria, Gross, Jane, Furebring, Christina, Pavlik, Peter, Sundstedt, Anette, Veitonmäki, Niina, Ramos, Hilario J, Säll, Anna, Dahlman, Anna, Bienvenue, David, von Schantz, Laura, McMahan, Catherine J, Askmyr, Maria, Hernandez-Hoyos, Gabriela, Ellmark, Peter
Published in Molecular cancer therapeutics (03.01.2023)
Published in Molecular cancer therapeutics (03.01.2023)
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Synthesis and Structure–Activity Relationship Studies of 4‑((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase
Luci, Diane K., Jameson, J. Brian, Yasgar, Adam, Diaz, Giovanni, Joshi, Netra, Kantz, Auric, Markham, Kate, Perry, Steve, Kuhn, Norine, Yeung, Jennifer, Kerns, Edward H., Schultz, Lena, Holinstat, Michael, Nadler, Jerry L., Taylor-Fishwick, David A., Jadhav, Ajit, Simeonov, Anton, Holman, Theodore R., Maloney, David J.
Published in Journal of medicinal chemistry (23.01.2014)
Published in Journal of medicinal chemistry (23.01.2014)
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A first-in-human phase I study in patients with advanced and/or refractory solid malignancies to evaluate the safety of ATOR-1015, a CTLA-4 x OX40 bispecific antibody
Yachnin, Jeffrey, Ullenhag, Gustav J., Carneiro, Ana, Nielsen, Dorte, Rohrberg, Kristoffer Staal, Kvarnhammar, Anne Månsson, Schultz, Lena, Bågeman, Erika, Wennersten, Camilla, Russell, Charlotte Astrid
Published in JOURNAL OF CLINICAL ONCOLOGY (20.05.2020)
Published in JOURNAL OF CLINICAL ONCOLOGY (20.05.2020)
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Journal Article
Conference Proceeding
Discovery of Potent and Selective Inhibitors of Human Platelet-Type 12- Lipoxygenase
Kenyon, Victor, Rai, Ganesha, Jadhav, Ajit, Schultz, Lena, Armstrong, Michelle, Jameson, J. Brian, Perry, Steven, Joshi, Netra, Bougie, James M, Leister, William, Taylor-Fishwick, David A, Nadler, Jerry L, Holinstat, Michael, Simeonov, Anton, Maloney, David J, Holman, Theodore R
Published in Journal of medicinal chemistry (11.08.2011)
Published in Journal of medicinal chemistry (11.08.2011)
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Abstract A018: Mitazalimab (CD40 agonist) in combination with mFOLFIRINOX in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC): Safety data and recommended dose for phase 2 (RP2D) from OPTIMIZE-1, a phase 1b/2 study
Van Laethem, Jean-Luc, Borbath, Ivan, Prenen, Hans, Lambert, Aurélien, Geboes, Karen, Blanc, Jean-Frédéric, de Coaña, Yago Pico, Enell-Smith, Karin, Schultz, Lena, Nordbladh, Karin, Ellmark, Peter, Ambarkhane, Sumeet, Carlsson, Malin, Cassier, Philippe
Published in Cancer research (Chicago, Ill.) (15.11.2022)
Published in Cancer research (Chicago, Ill.) (15.11.2022)
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Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay
Prast-Nielsen, Stefanie, Dexheimer, Thomas S., Schultz, Lena, Stafford, William C., Cheng, Qing, Xu, Jianqiang, Jadhav, Ajit, Arnér, Elias S.J., Simeonov, Anton
Published in Free radical biology & medicine (01.05.2011)
Published in Free radical biology & medicine (01.05.2011)
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Journal Article
High-Affinity Inhibitors of Human NAD.sup.+-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships
Niesen, Frank H, Schultz, Lena, Jadhav, Ajit, Bhatia, Chitra, Guo, Kunde, Maloney, David J, Pilka, Ewa S, Wang, Minghua, Oppermann, Udo, Heightman, Tom D, Simeonov, Anton
Published in PloS one (02.11.2010)
Published in PloS one (02.11.2010)
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Journal Article
NOVEL POLYPEPTIDES AND USE THEREOF
CORNELIS VAN KESSEL, CHRISTINA FUREBRING, ERIKA GUSTAFSSON, HARALDSSON KARIN, LENA SCHULTZ, JOHANNES VAN STRIJP, ANNA ROSEN, HAAS PETRUS JOHANNES ANDREAS
Year of Publication 09.01.2014
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Year of Publication 09.01.2014
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