Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models
Lissa, Delphine, Takahashi, Nobuyuki, Desai, Parth, Manukyan, Irena, Schultz, Christopher W, Rajapakse, Vinodh, Velez, Moises J, Mulford, Deborah, Roper, Nitin, Nichols, Samantha, Vilimas, Rasa, Sciuto, Linda, Chen, Yuanbin, Guha, Udayan, Rajan, Arun, Atkinson, Devon, El Meskini, Rajaa, Weaver Ohler, Zoe, Thomas, Anish
Published in Nature communications (19.04.2022)
Published in Nature communications (19.04.2022)
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Journal Article
ATR inhibition augments the efficacy of lurbinectedin in small‐cell lung cancer
Schultz, Christopher W, Zhang, Yang, Elmeskini, Rajaa, Zimmermann, Astrid, Fu, Haiqing, Murai, Yasuhisa, Wangsa, Darawalee, Kumar, Suresh, Takahashi, Nobuyuki, Atkinson, Devon, Saha, Liton Kumar, Lee, Chien‐Fei, Elenbaas, Brian, Desai, Parth, Sebastian, Robin, Sharma, Ajit Kumar, Abel, Melissa, Schroeder, Brett, Krishnamurthy, Manan, Kumar, Rajesh, Roper, Nitin, Aladjem, Mirit, Zenke, Frank T, Ohler, Zoe Weaver, Pommier, Yves, Thomas, Anish
Published in EMBO molecular medicine (07.08.2023)
Published in EMBO molecular medicine (07.08.2023)
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Journal Article
Repurposing the FDA-approved anthelmintic pyrvinium pamoate for pancreatic cancer treatment: study protocol for a phase I clinical trial in early-stage pancreatic ductal adenocarcinoma
Ponzini, Francesca M, Schultz, Christopher W, Leiby, Benjamin E, Cannaday, Shawnna, Yeo, T, Posey, James, Bowne, Wilbur B, Yeo, Charles, Brody, Jonathan R, Lavu, Harish, Nevler, Avinoam
Published in BMJ open (17.10.2023)
Published in BMJ open (17.10.2023)
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Journal Article
A Novel 3DNA® Nanocarrier effectively delivers payloads to pancreatic tumors
McCarthy, Grace A., Jain, Aditi, Di Niro, Roberto, Schultz, Christopher W., Jiang, Wei, Yeo, Charles J, Bowers, Jessica, Finan, Jennifer, Rhodes, Kelly, Casta, Lou, Hou, Vivi, Stefanoni, Anthony, Brown, Samantha Z., Nevler, Avinoam, Agostini, Lebaron C., Getts, Lori, Getts, Robert, Brody, Jonathan R.
Published in Translational oncology (01.06.2023)
Published in Translational oncology (01.06.2023)
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Journal Article
CDK7 Inhibition Synergizes with Topoisomerase I Inhibition in Small Cell Lung Cancer Cells by Inducing Ubiquitin-Mediated Proteolysis of RNA Polymerase II
Sun, Yilun, Zhang, Yang, Schultz, Christopher W., Pommier, Yves, Thomas, Anish
Published in Molecular cancer therapeutics (06.09.2022)
Published in Molecular cancer therapeutics (06.09.2022)
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Journal Article
Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents
Jo, Ukhyun, Senatorov, Ilya S, Zimmermann, Astrid, Saha, Liton Kumar, Murai, Yasuhisa, Kim, Se Hyun, Rajapakse, Vinodh N, Elloumi, Fathi, Takahashi, Nobuyuki, Schultz, Christopher W, Thomas, Anish, Zenke, Frank T, Pommier, Yves
Published in Molecular cancer therapeutics (01.08.2021)
Published in Molecular cancer therapeutics (01.08.2021)
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Journal Article
Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
Thomas, Anish, Takahashi, Nobuyuki, Rajapakse, Vinodh N, Zhang, Xiaohu, Sun, Yilun, Ceribelli, Michele, Wilson, Kelli M, Zhang, Yang, Beck, Erin, Sciuto, Linda, Nichols, Samantha, Elenbaas, Brian, Puc, Janusz, Dahmen, Heike, Zimmermann, Astrid, Varonin, Jillian, Schultz, Christopher W, Kim, Sehyun, Shimellis, Hirity, Desai, Parth, Klumpp-Thomas, Carleen, Chen, Lu, Travers, Jameson, McKnight, Crystal, Michael, Sam, Itkin, Zina, Lee, Sunmin, Yuno, Akira, Lee, Min-Jung, Redon, Christophe E, Kindrick, Jessica D, Peer, Cody J, Wei, Jun S, Aladjem, Mirit I, Figg, William Douglas, Steinberg, Seth M, Trepel, Jane B, Zenke, Frank T, Pommier, Yves, Khan, Javed, Thomas, Craig J
Published in Cancer cell (12.04.2021)
Published in Cancer cell (12.04.2021)
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Journal Article
Abemaciclib Is Effective Against Pancreatic Cancer Cells and Synergizes with HuR and YAP1 Inhibition
Dhir, Teena, Schultz, Christopher W, Jain, Aditi, Brown, Samantha Z, Haber, Alex, Goetz, Austin, Xi, Chunhua, Su, Gloria H, Xu, Liang, Posey, 3rd, James, Jiang, Wei, Yeo, Charles J, Golan, Talia, Pishvaian, Michael J, Brody, Jonathan R
Published in Molecular cancer research (01.10.2019)
Published in Molecular cancer research (01.10.2019)
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Journal Article
Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and Is Associated with Worse Outcomes
Pongor, Lőrinc Sándor, Schultz, Christopher W, Rinaldi, Lorenzo, Wangsa, Darawalee, Redon, Christophe E, Takahashi, Nobuyuki, Fialkoff, Gavriel, Desai, Parth, Zhang, Yang, Burkett, Sandra, Hermoni, Nadav, Vilk, Noa, Gutin, Jenia, Gergely, Rona, Zhao, Yongmei, Nichols, Samantha, Vilimas, Rasa, Sciuto, Linda, Graham, Chante, Caravaca, Juan Manuel, Turan, Sevilay, Tsai-Wei, Shen, Rajapakse, Vinodh N, Kumar, Rajesh, Upadhyay, Deep, Kumar, Suresh, Kim, Yoo Sun, Roper, Nitin, Tran, Bao, Hewitt, Stephen M, Kleiner, David E, Aladjem, Mirit I, Friedman, Nir, Hager, Gordon L, Pommier, Yves, Ried, Thomas, Thomas, Anish
Published in Cancer discovery (03.04.2023)
Published in Cancer discovery (03.04.2023)
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Journal Article
Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial
Abel, Melissa L, Takahashi, Nobuyuki, Peer, Cody, Redon, Christophe E, Nichols, Samantha, Vilimas, Rasa, Lee, Min-Jung, Lee, Sunmin, Shelat, Meenakshi, Kattappuram, Robbie, Sciuto, Linda, Pinkiert, Danielle, Graham, Chante, Butcher, Donna, Karim, Baktiar, Sharma, Ajit Kumar, Malin, Justin, Kumar, Rajesh, Schultz, Christopher W, Goyal, Shubhank, Del Rivero, Jaydira, Krishnamurthy, Manan, Upadhyay, Deep, Schroeder, Brett, Sissung, Tristan, Tyagi, Manoj, Kim, Jung, Pommier, Yves, Aladjem, Mirit, Raffeld, Mark, Figg, William Douglas, Trepel, Jane, Xi, Liqiang, Desai, Parth, Thomas, Anish
Published in Clinical cancer research (15.09.2023)
Published in Clinical cancer research (15.09.2023)
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Journal Article
Margin-Positive Pancreatic Ductal Adenocarcinoma during Pancreaticoduodenectomy: Additional Resection Does Not Improve Survival
Zheng, Richard, Nauheim, David, Bassig, Jonathan, Chadwick, Matthew, Schultz, Christopher W., Krampitz, Geoffrey, Lavu, Harish, Winter, Jordan R., Yeo, Charles J., Berger, Adam C.
Published in Annals of surgical oncology (01.03.2021)
Published in Annals of surgical oncology (01.03.2021)
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Journal Article
The FDA-Approved Anthelmintic Pyrvinium Pamoate Inhibits Pancreatic Cancer Cells in Nutrient-Depleted Conditions by Targeting the Mitochondria
Schultz, Christopher W, McCarthy, Grace A, Nerwal, Teena, Nevler, Avinoam, DuHadaway, James B, McCoy, Matthew D, Jiang, Wei, Brown, Samantha Z, Goetz, Austin, Jain, Aditi, Calvert, Valerie S, Vishwakarma, Vikalp, Wang, Dezhen, Preet, Ranjan, Cassel, Joel, Summer, Ross, Shaghaghi, Hoora, Pommier, Yves, Baechler, Simone A, Pishvaian, Michael J, Golan, Talia, Yeo, Charles J, Petricoin, Emanuel F, Prendergast, George C, Salvino, Joseph, Singh, Pankaj K, Dixon, Dan A, Brody, Jonathan R
Published in Molecular cancer therapeutics (01.11.2021)
Published in Molecular cancer therapeutics (01.11.2021)
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Journal Article
Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial
Abel, Melissa L, Takahashi, Nobuyuki, Peer, Cody, Redon, Christophe E, Nichols, Samantha, Vilimas, Rasa, Lee, Min-Jung, Lee, Sunmin, Shelat, Meenakshi, Kattapuram, Robbie, Sciuto, Linda, Pinkiert, Danielle, Graham, Chante, Butcher, Donna, Karim, Baktiar, Sharma, Ajit Kumar, Malin, Justin, Kumar, Rajesh, Schultz, Christopher W, Goyal, Shubhank, Del Rivero, Jaydira, Krishnamurthy, Manan, Upadhyay, Deep, Schroeder, Brett, Sissung, Tristan, Tyagi, Manoj, Kim, Jung, Pommier, Yves, Aladjem, Mirit, Raffeld, Mark, Figg, William Douglas, Trepel, Jane, Xi, Liqiang, Desai, Parth, Thomas, Anish
Published in Clinical cancer research (15.09.2023)
Published in Clinical cancer research (15.09.2023)
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Journal Article
Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer
Jain, Aditi, Agostini, Lebaron C, McCarthy, Grace A, Chand, Saswati N, Ramirez, AnnJosette, Nevler, Avinoam, Cozzitorto, Joseph, Schultz, Christopher W, Lowder, Cinthya Yabar, Smith, Kate M, Waddell, Ian D, Raitses-Gurevich, Maria, Stossel, Chani, Gorman, Yulia Glick, Atias, Dikla, Yeo, Charles J, Winter, Jordan M, Olive, Kenneth P, Golan, Talia, Pishvaian, Michael J, Ogilvie, Donald, James, Dominic I, Jordan, Allan M, Brody, Jonathan R
Published in Cancer research (Chicago, Ill.) (01.09.2019)
Published in Cancer research (Chicago, Ill.) (01.09.2019)
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Journal Article
ASO Author Reflections: Margin-Positive Pancreatic Ductal Adenocarcinoma During Pancreaticoduodenectomy: Additional Resection Does Not Improve Survival
Zheng, Richard, Nauheim, David, Bassig, Jonathan, Chadwick, Matthew, Schultz, Christopher W., Krampitz, Geoffrey, Lavu, Harish, Winter, Jordan R., Yeo, Charles J., Berger, Adam C.
Published in Annals of surgical oncology (01.12.2020)
Published in Annals of surgical oncology (01.12.2020)
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Journal Article
The RNA-Binding Protein HuR Posttranscriptionally Regulates the Protumorigenic Activator YAP1 in Pancreatic Ductal Adenocarcinoma
Brown, Samantha Z., McCarthy, Grace A., Carroll, James R., Di Niro, Roberto, Pelz, Carl, Jain, Aditi, Sutton, Thomas L., Holly, Hannah D., Nevler, Avinoam, Schultz, Christopher W., McCoy, Matthew D., Cozzitorto, Joseph A., Jiang, Wei, Yeo, Charles J., Dixon, Dan A., Sears, Rosalie C., Brody, Jonathan R.
Published in Molecular and cellular biology (21.07.2022)
Published in Molecular and cellular biology (21.07.2022)
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Journal Article
Selecting the optimal parameters for sonoporation of pancreatic cancer in a pre-clinical model
Schultz, Christopher W., Ruiz de Garibay, Gorka, Langer, Anika, Liu, Ji-Bin, Dhir, Teena, Leitch, Calum, Wessner, Corinne E., Mayoral, Mireia, Zhang, Bo, Popa, Mihaela, Huang, Chunwang, Kotopoulis, Spiros, Luo, Xianghong, Zhen, Yanhua, Niu, Sihua, Torkzaban, Mehnoosh, Wallace, Kirk, Eisenbrey, John R., Brody, Jonathan R., McCormack, Emmet, Forsberg, Flemming
Published in Cancer biology & therapy (04.03.2021)
Published in Cancer biology & therapy (04.03.2021)
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Journal Article
Effect of Hypercapnia, an Element of Obstructive Respiratory Disorder, on Pancreatic Cancer Chemoresistance and Progression
Nevler, Avinoam, Brown, Samantha Z., Nauheim, David, Portocarrero, Carla, Rodeck, Ulrich, Bassig, Jonathan, Schultz, Christopher W., McCarthy, Grace A., Lavu, Harish, Yeo, Theresa P., Yeo, Charles J., Brody, Jonathan R.
Published in Journal of the American College of Surgeons (01.04.2020)
Published in Journal of the American College of Surgeons (01.04.2020)
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