Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers
Kim, Hoon, Nguyen, Nam-Phuong, Turner, Kristen, Wu, Sihan, Gujar, Amit D, Luebeck, Jens, Liu, Jihe, Deshpande, Viraj, Rajkumar, Utkrisht, Namburi, Sandeep, Amin, Samirkumar B, Yi, Eunhee, Menghi, Francesca, Schulte, Johannes H, Henssen, Anton G, Chang, Howard Y, Beck, Christine R, Mischel, Paul S, Bafna, Vineet, Verhaak, Roel G W
Published in Nature genetics (01.09.2020)
Published in Nature genetics (01.09.2020)
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Neuroblastoma signalling models unveil combination therapies targeting feedback-mediated resistance
Dorel, Mathurin, Klinger, Bertram, Mari, Tommaso, Toedling, Joern, Blanc, Eric, Messerschmidt, Clemens, Nadler-Holly, Michal, Ziehm, Matthias, Sieber, Anja, Hertwig, Falk, Beule, Dieter, Eggert, Angelika, Schulte, Johannes H, Selbach, Matthias, Blüthgen, Nils
Published in PLoS computational biology (01.11.2021)
Published in PLoS computational biology (01.11.2021)
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MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma
de Antonellis, Pasqualino, Medaglia, Chiara, Cusanelli, Emilio, Andolfo, Immacolata, Liguori, Lucia, De Vita, Gennaro, Carotenuto, Marianeve, Bello, Annamaria, Formiggini, Fabio, Galeone, Aldo, De Rosa, Giuseppe, Virgilio, Antonella, Scognamiglio, Immacolata, Sciro, Manuela, Basso, Giuseppe, Schulte, Johannes H, Cinalli, Giuseppe, Iolascon, Achille, Zollo, Massimo
Published in PloS one (12.09.2011)
Published in PloS one (12.09.2011)
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Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
Helmsauer, Konstantin, Valieva, Maria E, Ali, Salaheddine, Chamorro González, Rocío, Schöpflin, Robert, Röefzaad, Claudia, Bei, Yi, Dorado Garcia, Heathcliff, Rodriguez-Fos, Elias, Puiggròs, Montserrat, Kasack, Katharina, Haase, Kerstin, Keskeny, Csilla, Chen, Celine Y, Kuschel, Luis P, Euskirchen, Philipp, Heinrich, Verena, Robson, Michael I, Rosswog, Carolina, Toedling, Joern, Szymansky, Annabell, Hertwig, Falk, Fischer, Matthias, Torrents, David, Eggert, Angelika, Schulte, Johannes H, Mundlos, Stefan, Henssen, Anton G, Koche, Richard P
Published in Nature communications (16.11.2020)
Published in Nature communications (16.11.2020)
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Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma
Koche, Richard P, Rodriguez-Fos, Elias, Helmsauer, Konstantin, Burkert, Martin, MacArthur, Ian C, Maag, Jesper, Chamorro, Rocio, Munoz-Perez, Natalia, Puiggròs, Montserrat, Dorado Garcia, Heathcliff, Bei, Yi, Röefzaad, Claudia, Bardinet, Victor, Szymansky, Annabell, Winkler, Annika, Thole, Theresa, Timme, Natalie, Kasack, Katharina, Fuchs, Steffen, Klironomos, Filippos, Thiessen, Nina, Blanc, Eric, Schmelz, Karin, Künkele, Annette, Hundsdörfer, Patrick, Rosswog, Carolina, Theissen, Jessica, Beule, Dieter, Deubzer, Hedwig, Sauer, Sascha, Toedling, Joern, Fischer, Matthias, Hertwig, Falk, Schwarz, Roland F, Eggert, Angelika, Torrents, David, Schulte, Johannes H, Henssen, Anton G
Published in Nature genetics (01.01.2020)
Published in Nature genetics (01.01.2020)
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Mutational dynamics between primary and relapse neuroblastomas
Schramm, Alexander, Köster, Johannes, Assenov, Yassen, Althoff, Kristina, Peifer, Martin, Mahlow, Ellen, Odersky, Andrea, Beisser, Daniela, Ernst, Corinna, Henssen, Anton G, Stephan, Harald, Schröder, Christopher, Heukamp, Lukas, Engesser, Anne, Kahlert, Yvonne, Theissen, Jessica, Hero, Barbara, Roels, Frederik, Altmüller, Janine, Nürnberg, Peter, Astrahantseff, Kathy, Gloeckner, Christian, De Preter, Katleen, Plass, Christoph, Lee, Sangkyun, Lode, Holger N, Henrich, Kai-Oliver, Gartlgruber, Moritz, Speleman, Frank, Schmezer, Peter, Westermann, Frank, Rahmann, Sven, Fischer, Matthias, Eggert, Angelika, Schulte, Johannes H
Published in Nature genetics (01.08.2015)
Published in Nature genetics (01.08.2015)
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Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition
Henssen, Anton, Althoff, Kristina, Odersky, Andrea, Beckers, Anneleen, Koche, Richard, Speleman, Frank, Schäfers, Simon, Bell, Emma, Nortmeyer, Maike, Westermann, Frank, De Preter, Katleen, Florin, Alexandra, Heukamp, Lukas, Spruessel, Annika, Astrahanseff, Kathy, Lindner, Sven, Sadowski, Natalie, Schramm, Alexander, Astorgues-Xerri, Lucile, Riveiro, Maria E, Eggert, Angelika, Cvitkovic, Esteban, Schulte, Johannes H
Published in Clinical cancer research (15.05.2016)
Published in Clinical cancer research (15.05.2016)
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BET bromodomain protein inhibition is a therapeutic option for medulloblastoma
Henssen, Anton, Thor, Theresa, Odersky, Andrea, Heukamp, Lukas, El-Hindy, Nicolai, Beckers, Anneleen, Speleman, Frank, Althoff, Kristina, Schäfers, Simon, Schramm, Alexander, Sure, Ulrich, Fleischhack, Gudrun, Eggert, Angelika, Schulte, Johannes H
Published in Oncotarget (01.11.2013)
Published in Oncotarget (01.11.2013)
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Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions
Schmelz, Karin, Toedling, Joern, Huska, Matt, Cwikla, Maja C, Kruetzfeldt, Louisa-Marie, Proba, Jutta, Ambros, Peter F, Ambros, Inge M, Boral, Sengül, Lodrini, Marco, Chen, Celine Y, Burkert, Martin, Guergen, Dennis, Szymansky, Annabell, Astrahantseff, Kathy, Kuenkele, Annette, Haase, Kerstin, Fischer, Matthias, Deubzer, Hedwig E, Hertwig, Falk, Hundsdoerfer, Patrick, Henssen, Anton G, Schwarz, Roland F, Schulte, Johannes H, Eggert, Angelika
Published in Nature communications (23.11.2021)
Published in Nature communications (23.11.2021)
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Ceritinib in paediatric patients with anaplastic lymphoma kinase-positive malignancies: an open-label, multicentre, phase 1, dose-escalation and dose-expansion study
Fischer, Matthias, Moreno, Lucas, Ziegler, David S, Marshall, Lynley V, Zwaan, C Michel, Irwin, Meredith S, Casanova, Michela, Sabado, Constantino, Wulff, Beate, Stegert, Mario, Wang, Luojun, Hurtado, Felipe K, Branle, Fabrice, Geoerger, Birgit, Schulte, Johannes H
Published in The lancet oncology (01.12.2021)
Published in The lancet oncology (01.12.2021)
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Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy
SCHULTE, Johannes H, LIM, Soyoung, METZGER, Eric, SCHÜLE, Roland, EGGERT, Angelika, BUETTNER, Reinhard, KIRFEL, Jutta, SCHRAMM, Alexander, FRIEDRICHS, Nicolaus, KOSTER, Jan, VERSTEEG, Rogier, ORA, Ingrid, PAJTIER, Kristian, KLEIN-HITPASS, Ludger, KUHFITTIG-KULLE, Steffi
Published in Cancer research (Chicago, Ill.) (01.03.2009)
Published in Cancer research (Chicago, Ill.) (01.03.2009)
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Histone deacetylase 10 promotes autophagy-mediated cell survival
Oehme, Ina, Linke, Jan-Peter, Böck, Barbara C, Milde, Till, Lodrini, Marco, Hartenstein, Bettina, Wiegand, Inga, Eckert, Christian, Roth, Wilfried, Kool, Marcel, Kaden, Sylvia, Gröne, Hermann-Josef, Schulte, Johannes H, Lindner, Sven, Hamacher-Brady, Anne, Brady, Nathan R, Deubzer, Hedwig E, Witt, Olaf
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2013)
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Next-generation personalised medicine for high-risk paediatric cancer patients – The INFORM pilot study
Worst, Barbara C, van Tilburg, Cornelis M, Balasubramanian, Gnana Prakash, Fiesel, Petra, Witt, Ruth, Freitag, Angelika, Boudalil, Miream, Previti, Christopher, Wolf, Stephan, Schmidt, Sabine, Chotewutmontri, Sasithorn, Bewerunge-Hudler, Melanie, Schick, Matthias, Schlesner, Matthias, Hutter, Barbara, Taylor, Lenka, Borst, Tobias, Sutter, Christian, Bartram, Claus R, Milde, Till, Pfaff, Elke, Kulozik, Andreas E, von Stackelberg, Arend, Meisel, Roland, Borkhardt, Arndt, Reinhardt, Dirk, Klusmann, Jan-Henning, Fleischhack, Gudrun, Tippelt, Stephan, Dirksen, Uta, Jürgens, Heribert, Kramm, Christof M, von Bueren, Andre O, Westermann, Frank, Fischer, Matthias, Burkhardt, Birgit, Wößmann, Wilhelm, Nathrath, Michaela, Bielack, Stefan S, Frühwald, Michael C, Fulda, Simone, Klingebiel, Thomas, Koscielniak, Ewa, Schwab, Matthias, Tremmel, Roman, Driever, Pablo Hernáiz, Schulte, Johannes H, Brors, Benedikt, von Deimling, Andreas, Lichter, Peter, Eggert, Angelika, Capper, David, Pfister, Stefan M, Jones, David T.W, Witt, Olaf
Published in European journal of cancer (1990) (01.09.2016)
Published in European journal of cancer (1990) (01.09.2016)
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IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression
Hagemann, Sven, Misiak, Danny, Bell, Jessica L, Fuchs, Tommy, Lederer, Marcell I, Bley, Nadine, Hämmerle, Monika, Ghazy, Ehab, Sippl, Wolfgang, Schulte, Johannes H, Hüttelmaier, Stefan
Published in Molecular cancer (29.05.2023)
Published in Molecular cancer (29.05.2023)
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Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma
Schulte, Johannes H, Marschall, Tobias, Martin, Marcel, Rosenstiel, Philipp, Mestdagh, Pieter, Schlierf, Stefanie, Thor, Theresa, Vandesompele, Jo, Eggert, Angelika, Schreiber, Stefan, Rahmann, Sven, Schramm, Alexander
Published in Nucleic acids research (01.09.2010)
Published in Nucleic acids research (01.09.2010)
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Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
Eleveld, Thomas F, Oldridge, Derek A, Bernard, Virginie, Koster, Jan, Colmet Daage, Léo, Diskin, Sharon J, Schild, Linda, Bentahar, Nadia Bessoltane, Bellini, Angela, Chicard, Mathieu, Lapouble, Eve, Combaret, Valérie, Legoix-Né, Patricia, Michon, Jean, Pugh, Trevor J, Hart, Lori S, Rader, JulieAnn, Attiyeh, Edward F, Wei, Jun S, Zhang, Shile, Naranjo, Arlene, Gastier-Foster, Julie M, Hogarty, Michael D, Asgharzadeh, Shahab, Smith, Malcolm A, Guidry Auvil, Jaime M, Watkins, Thomas B K, Zwijnenburg, Danny A, Ebus, Marli E, van Sluis, Peter, Hakkert, Anne, van Wezel, Esther, van der Schoot, C Ellen, Westerhout, Ellen M, Schulte, Johannes H, Tytgat, Godelieve A, Dolman, M Emmy M, Janoueix-Lerosey, Isabelle, Gerhard, Daniela S, Caron, Huib N, Delattre, Olivier, Khan, Javed, Versteeg, Rogier, Schleiermacher, Gudrun, Molenaar, Jan J, Maris, John M
Published in Nature genetics (01.08.2015)
Published in Nature genetics (01.08.2015)
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CD171- and GD2-specific CAR-T cells potently target retinoblastoma cells in preclinical in vitro testing
Andersch, Lena, Radke, Josefine, Klaus, Anika, Schwiebert, Silke, Winkler, Annika, Schumann, Elisa, Grunewald, Laura, Zirngibl, Felix, Flemmig, Carina, Jensen, Michael C, Rossig, Claudia, Joussen, Antonia, Henssen, Anton, Eggert, Angelika, Schulte, Johannes H, Künkele, Annette
Published in BMC cancer (09.09.2019)
Published in BMC cancer (09.09.2019)
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