Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
Glaenzel, Ulrike, Jin, Yi, Nufer, Robert, Li, Wenkui, Schroer, Kirsten, Adam-Stitah, Sylvie, van Marle, Sjoerd Peter, Legangneux, Eric, Borell, Hubert, James, Alexander D, Meissner, Axel, Camenisch, Gian, Gardin, Anne
Published in Drug metabolism and disposition (01.07.2018)
Published in Drug metabolism and disposition (01.07.2018)
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Metabolomics: current state and evolving methodologies and tools
Oldiges, Marco, Lütz, Stephan, Pflug, Simon, Schroer, Kirsten, Stein, Nadine, Wiendahl, Christiane
Published in Applied microbiology and biotechnology (01.09.2007)
Published in Applied microbiology and biotechnology (01.09.2007)
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Evolution of Biocatalysis at Novartis over the last 40 Years
Siirola, Elina, Eggimann, Fabian, Moore, Charles, Schroer, Kirsten, Vargas, Alexandra, Peschke, Theo, Schlama, Thierry, Snajdrova, Radka
Published in Chimia (28.06.2023)
Published in Chimia (28.06.2023)
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Evolved Aliphatic Halogenases Enable Regiocomplementary C-H Functionalization of Pharmaceutically Relevant
Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Voss, Moritz, Hunziker, Jurg, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca
Published in Angewandte Chemie International Edition (16.12.2019)
Published in Angewandte Chemie International Edition (16.12.2019)
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Evolved Aliphatic Halogenases Enable Regiocomplementary C−H Functionalization of a Pharmaceutically Relevant Compound
Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Voss, Moritz, Hunziker, Jürg, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca
Published in Angewandte Chemie International Edition (16.12.2019)
Published in Angewandte Chemie International Edition (16.12.2019)
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Modulating Chemoselectivity in a Fe(II)/α-Ketoglutarate-Dependent Dioxygenase for the Oxidative Modification of a Nonproteinogenic Amino Acid
Meyer, Fabian, Frey, Raphael, Ligibel, Mathieu, Sager, Emine, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca
Published in ACS catalysis (21.05.2021)
Published in ACS catalysis (21.05.2021)
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Recombinant human cytochrome P450 monooxygenases for drug metabolite synthesis
Schroer, Kirsten, Kittelmann, Matthias, Lütz, Stephan
Published in Biotechnology and bioengineering (01.08.2010)
Published in Biotechnology and bioengineering (01.08.2010)
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Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite
Glaenzel, Ulrike, Jin, Yi, Hansen, Regine, Schroer, Kirsten, Rahmanzadeh, Gholamreza, Pfaar, Ulrike, Jaap van Lier, Jan, Borell, Hubert, Meissner, Axel, Camenisch, Gian, Zhao, Sylvia
Published in Drug metabolism and disposition (01.10.2020)
Published in Drug metabolism and disposition (01.10.2020)
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Enzyme Engineering Enables Inversion of Substrate Stereopreference of the Halogenase WelO5
Voss, Moritz, Hüppi, Sean, Schaub, Daniela, Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca
Published in ChemCatChem (20.12.2022)
Published in ChemCatChem (20.12.2022)
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Cover Picture: Evolved Aliphatic Halogenases Enable Regiocomplementary C−H Functionalization of a Pharmaceutically Relevant Compound (Angew. Chem. Int. Ed. 51/2019)
Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Voss, Moritz, Hunziker, Jürg, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca
Published in Angewandte Chemie International Edition (16.12.2019)
Published in Angewandte Chemie International Edition (16.12.2019)
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Journal Article
Front Cover: Enzyme Engineering Enables Inversion of Substrate Stereopreference of the Halogenase WelO5 (ChemCatChem 24/2022)
Voss, Moritz, Hüppi, Sean, Schaub, Daniela, Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca
Published in ChemCatChem (20.12.2022)
Published in ChemCatChem (20.12.2022)
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Biocatalytic assembly of chemically modified oligonucleotides
Mann, Greg, Stanger, Frédéric V., Peschke, Theo, Schroer, Kirsten, Trung, Nhat Quang Nguyen, Burrer, Nathalie, Grassinger, Franziska, Piccioni, Lorenzo, Erdogan, Oemer, Heimburger, Jeremy, Koehl, Hervé, Ertle, Heike, Denay, Regis, Dreier, Philippe, Schlama, Thierry
Published in Tetrahedron letters (16.03.2022)
Published in Tetrahedron letters (16.03.2022)
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A Collaborative Journey towards the Late‐Stage Functionalization of Added‐Value Chemicals Using Engineered Halogenases
Büchler, Johannes, Hegarty, Eimear, Schroer, Kirsten, Snajdrova, Radka, Turner, Nicholas J., Loiseleur, Olivier, Buller, Rebecca, Le Chapelain, Camille
Published in Helvetica chimica acta (01.01.2023)
Published in Helvetica chimica acta (01.01.2023)
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Cladosporin Derivatives Obtained by Biotransformation Provide Guidance for the Focused Derivatization of this Antimalarial Lead Compound
Fredenhagen, Andreas, Schroer, Kirsten, Schröder, Harald, Hoepfner, Dominic, Ligibel, Mathieu, Porchet Zemp, Liliane, Radoch, Caroline, Freund, Ernst, Meishammer, Aldo
Published in Chembiochem : a European journal of chemical biology (01.03.2019)
Published in Chembiochem : a European journal of chemical biology (01.03.2019)
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Journal Article
Metabolism and Disposition of Siponimod, a Novel Selective S1P 1 /S1P 5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism
Glaenzel, Ulrike, Jin, Yi, Nufer, Robert, Li, Wenkui, Schroer, Kirsten, Adam-Stitah, Sylvie, Peter van Marle, Sjoerd, Legangneux, Eric, Borell, Hubert, James, Alexander D, Meissner, Axel, Camenisch, Gian, Gardin, Anne
Published in Drug metabolism and disposition (01.07.2018)
Published in Drug metabolism and disposition (01.07.2018)
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Journal Article
Evolvierte aliphatische Halogenasen ermöglichen die regiokomplementäre C‐H‐Funktionalisierung einer hochwertigen Chemikalie
Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Voss, Moritz, Hunziker, Jürg, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca
Published in Angewandte Chemie (16.12.2019)
Published in Angewandte Chemie (16.12.2019)
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Journal Article
Titelbild: Evolvierte aliphatische Halogenasen ermöglichen die regiokomplementäre C‐H‐Funktionalisierung einer hochwertigen Chemikalie (Angew. Chem. 51/2019)
Hayashi, Takahiro, Ligibel, Mathieu, Sager, Emine, Voss, Moritz, Hunziker, Jürg, Schroer, Kirsten, Snajdrova, Radka, Buller, Rebecca
Published in Angewandte Chemie (16.12.2019)
Published in Angewandte Chemie (16.12.2019)
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