The landscape of chromothripsis across adult cancer types
Voronina, Natalia, Wong, John K. L., Hübschmann, Daniel, Hlevnjak, Mario, Uhrig, Sebastian, Heilig, Christoph E., Horak, Peter, Kreutzfeldt, Simon, Mock, Andreas, Stenzinger, Albrecht, Hutter, Barbara, Fröhlich, Martina, Brors, Benedikt, Jahn, Arne, Klink, Barbara, Gieldon, Laura, Sieverling, Lina, Feuerbach, Lars, Chudasama, Priya, Beck, Katja, Kroiss, Matthias, Heining, Christoph, Möhrmann, Lino, Fischer, Andrea, Schröck, Evelin, Glimm, Hanno, Zapatka, Marc, Lichter, Peter, Fröhling, Stefan, Ernst, Aurélie
Published in Nature communications (08.05.2020)
Published in Nature communications (08.05.2020)
Get full text
Journal Article
Haploinsufficiency of ARID1B, a Member of the SWI/SNF-A Chromatin-Remodeling Complex, Is a Frequent Cause of Intellectual Disability
Hoyer, Juliane, Ekici, Arif B., Endele, Sabine, Popp, Bernt, Zweier, Christiane, Wiesener, Antje, Wohlleber, Eva, Dufke, Andreas, Rossier, Eva, Petsch, Corinna, Zweier, Markus, Göhring, Ina, Zink, Alexander M., Rappold, Gudrun, Schröck, Evelin, Wieczorek, Dagmar, Riess, Olaf, Engels, Hartmut, Rauch, Anita, Reis, André
Published in American journal of human genetics (09.03.2012)
Published in American journal of human genetics (09.03.2012)
Get full text
Journal Article
Guidelines for the Li-Fraumeni and heritable TP53-related cancer syndromes
Frebourg, Thierry, Bajalica Lagercrantz, Svetlana, Oliveira, Carla, Magenheim, Rita, Evans, D Gareth
Published in European journal of human genetics : EJHG (01.10.2020)
Published in European journal of human genetics : EJHG (01.10.2020)
Get full text
Journal Article
Web Resource
ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage
Perkhofer, Lukas, Schmitt, Anna, Romero Carrasco, Maria Carolina, Ihle, Michaela, Hampp, Stephanie, Ruess, Dietrich Alexander, Hessmann, Elisabeth, Russell, Ronan, Lechel, André, Azoitei, Ninel, Lin, Qiong, Liebau, Stefan, Hohwieler, Meike, Bohnenberger, Hanibal, Lesina, Marina, Algül, Hana, Gieldon, Laura, Schröck, Evelin, Gaedcke, Jochen, Wagner, Martin, Wiesmüller, Lisa, Sipos, Bence, Seufferlein, Thomas, Reinhardt, Hans Christian, Frappart, Pierre-Olivier, Kleger, Alexander
Published in Cancer research (Chicago, Ill.) (15.10.2017)
Published in Cancer research (Chicago, Ill.) (15.10.2017)
Get full text
Journal Article
Integrative genomic and transcriptomic analysis of leiomyosarcoma
Chudasama, Priya, Mughal, Sadaf S., Sanders, Mathijs A., Hübschmann, Daniel, Chung, Inn, Deeg, Katharina I., Wong, Siao-Han, Rabe, Sophie, Hlevnjak, Mario, Zapatka, Marc, Ernst, Aurélie, Kleinheinz, Kortine, Schlesner, Matthias, Sieverling, Lina, Klink, Barbara, Schröck, Evelin, Hoogenboezem, Remco M., Kasper, Bernd, Heilig, Christoph E., Egerer, Gerlinde, Wolf, Stephan, von Kalle, Christof, Eils, Roland, Stenzinger, Albrecht, Weichert, Wilko, Glimm, Hanno, Gröschel, Stefan, Kopp, Hans-Georg, Omlor, Georg, Lehner, Burkhard, Bauer, Sebastian, Schimmack, Simon, Ulrich, Alexis, Mechtersheimer, Gunhild, Rippe, Karsten, Brors, Benedikt, Hutter, Barbara, Renner, Marcus, Hohenberger, Peter, Scholl, Claudia, Fröhling, Stefan
Published in Nature communications (10.01.2018)
Published in Nature communications (10.01.2018)
Get full text
Journal Article
NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer
Heining, Christoph, Horak, Peter, Uhrig, Sebastian, Codo, Paula L, Klink, Barbara, Hutter, Barbara, Fröhlich, Martina, Bonekamp, David, Richter, Daniela, Steiger, Katja, Penzel, Roland, Endris, Volker, Ehrenberg, Karl Roland, Frank, Stephanie, Kleinheinz, Kortine, Toprak, Umut H, Schlesner, Matthias, Mandal, Ranadip, Schulz, Lothar, Lambertz, Helmut, Fetscher, Sebastian, Bitzer, Michael, Malek, Nisar P, Horger, Marius, Giese, Nathalia A, Strobel, Oliver, Hackert, Thilo, Springfeld, Christoph, Feuerbach, Lars, Bergmann, Frank, Schröck, Evelin, von Kalle, Christof, Weichert, Wilko, Scholl, Claudia, Ball, Claudia R, Stenzinger, Albrecht, Brors, Benedikt, Fröhling, Stefan, Glimm, Hanno
Published in Cancer discovery (01.09.2018)
Published in Cancer discovery (01.09.2018)
Get full text
Journal Article
Precision oncology based on omics data: The NCT Heidelberg experience
Horak, Peter, Klink, Barbara, Heining, Christoph, Gröschel, Stefan, Hutter, Barbara, Fröhlich, Martina, Uhrig, Sebastian, Hübschmann, Daniel, Schlesner, Matthias, Eils, Roland, Richter, Daniela, Pfütze, Katrin, Geörg, Christina, Meißburger, Bettina, Wolf, Stephan, Schulz, Angela, Penzel, Roland, Herpel, Esther, Kirchner, Martina, Lier, Amelie, Endris, Volker, Singer, Stephan, Schirmacher, Peter, Weichert, Wilko, Stenzinger, Albrecht, Schlenk, Richard F., Schröck, Evelin, Brors, Benedikt, von Kalle, Christof, Glimm, Hanno, Fröhling, Stefan
Published in International journal of cancer (01.09.2017)
Published in International journal of cancer (01.09.2017)
Get full text
Journal Article
Range of genetic mutations associated with severe non-syndromic sporadic intellectual disability: an exome sequencing study
Rauch, Anita, Prof, Wieczorek, Dagmar, MD, Graf, Elisabeth, MSc, Wieland, Thomas, MSc, Endele, Sabine, PhD, Schwarzmayr, Thomas, MSc, Albrecht, Beate, MD, Bartholdi, Deborah, MD, Beygo, Jasmin, MSc, Di Donato, Nataliya, MD, Dufke, Andreas, MD, Cremer, Kirsten, MD, Hempel, Maja, MD, Horn, Denise, MD, Hoyer, Juliane, MD, Joset, Pascal, PhD, Röpke, Albrecht, PhD, Moog, Ute, MD, Riess, Angelika, MD, Thiel, Christian T, MD, Tzschach, Andreas, MD, Wiesener, Antje, MD, Wohlleber, Eva, MD, Zweier, Christiane, MD, Ekici, Arif B, PhD, Zink, Alexander M, MSc, Rump, Andreas, PhD, Meisinger, Christa, MD, Grallert, Harald, PhD, Sticht, Heinrich, PhD, Schenck, Annette, PhD, Engels, Hartmut, PhD, Rappold, Gudrun, Prof, Schröck, Evelin, Prof, Wieacker, Peter, Prof, Riess, Olaf, Prof, Meitinger, Thomas, Prof, Reis, André, Prof, Strom, Tim M, Dr
Published in The Lancet (British edition) (10.11.2012)
Published in The Lancet (British edition) (10.11.2012)
Get full text
Journal Article
Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome
Tischkowitz, Marc, Colas, Chrystelle, Pouwels, Sjaak, Hoogerbrugge, Nicoline
Published in European journal of human genetics : EJHG (01.10.2020)
Published in European journal of human genetics : EJHG (01.10.2020)
Get full text
Journal Article
Web Resource
Janus face-like effects of Aurora B inhibition: antitumoral mode of action versus induction of aneuploid progeny
Wiedemuth, Ralf, Klink, Barbara, Fujiwara, Mamoru, Schröck, Evelin, Tatsuka, Masaaki, Schackert, Gabriele, Temme, Achim
Published in Carcinogenesis (New York) (01.10.2016)
Published in Carcinogenesis (New York) (01.10.2016)
Get full text
Journal Article
Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
Gröschel, Stefan, Hübschmann, Daniel, Raimondi, Francesco, Horak, Peter, Warsow, Gregor, Fröhlich, Martina, Klink, Barbara, Gieldon, Laura, Hutter, Barbara, Kleinheinz, Kortine, Bonekamp, David, Marschal, Oliver, Chudasama, Priya, Mika, Jagoda, Groth, Marie, Uhrig, Sebastian, Krämer, Stephen, Heining, Christoph, Heilig, Christoph E., Richter, Daniela, Reisinger, Eva, Pfütze, Katrin, Eils, Roland, Wolf, Stephan, von Kalle, Christof, Brandts, Christian, Scholl, Claudia, Weichert, Wilko, Richter, Stephan, Bauer, Sebastian, Penzel, Roland, Schröck, Evelin, Stenzinger, Albrecht, Schlenk, Richard F., Brors, Benedikt, Russell, Robert B., Glimm, Hanno, Schlesner, Matthias, Fröhling, Stefan
Published in Nature communications (09.04.2019)
Published in Nature communications (09.04.2019)
Get full text
Journal Article
Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity
Möhrmann, Lino, Werner, Maximilian, Oleś, Małgorzata, Mock, Andreas, Uhrig, Sebastian, Jahn, Arne, Kreutzfeldt, Simon, Fröhlich, Martina, Hutter, Barbara, Paramasivam, Nagarajan, Richter, Daniela, Beck, Katja, Winter, Ulrike, Pfütze, Katrin, Heilig, Christoph E., Teleanu, Veronica, Lipka, Daniel B., Zapatka, Marc, Hanf, Dorothea, List, Catrin, Allgäuer, Michael, Penzel, Roland, Rüter, Gina, Jelas, Ivan, Hamacher, Rainer, Falkenhorst, Johanna, Wagner, Sebastian, Brandts, Christian H., Boerries, Melanie, Illert, Anna L., Metzeler, Klaus H., Westphalen, C. Benedikt, Desuki, Alexander, Kindler, Thomas, Folprecht, Gunnar, Weichert, Wilko, Brors, Benedikt, Stenzinger, Albrecht, Schröck, Evelin, Hübschmann, Daniel, Horak, Peter, Heining, Christoph, Fröhling, Stefan, Glimm, Hanno
Published in Nature communications (02.08.2022)
Published in Nature communications (02.08.2022)
Get full text
Journal Article
Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
Tretter, Celina, de Andrade Krätzig, Niklas, Pecoraro, Matteo, Lange, Sebastian, Seifert, Philipp, von Frankenberg, Clara, Untch, Johannes, Zuleger, Gabriela, Wilhelm, Mathias, Zolg, Daniel P., Dreyer, Florian S., Bräunlein, Eva, Engleitner, Thomas, Uhrig, Sebastian, Boxberg, Melanie, Steiger, Katja, Slotta-Huspenina, Julia, Ochsenreither, Sebastian, von Bubnoff, Nikolas, Bauer, Sebastian, Boerries, Melanie, Jost, Philipp J., Schenck, Kristina, Dresing, Iska, Bassermann, Florian, Friess, Helmut, Reim, Daniel, Grützmann, Konrad, Pfütze, Katrin, Klink, Barbara, Schröck, Evelin, Haller, Bernhard, Kuster, Bernhard, Mann, Matthias, Weichert, Wilko, Fröhling, Stefan, Rad, Roland, Hiltensperger, Michael, Krackhardt, Angela M.
Published in Nature communications (02.08.2023)
Published in Nature communications (02.08.2023)
Get full text
Journal Article
A clinical screening tool to detect genetic cancer predisposition in pediatric oncology shows high sensitivity but can miss a substantial percentage of affected children
Friedrich, Ulrike A., Bienias, Marc, Zinke, Claudia, Prazenicova, Maria, Lohse, Judith, Jahn, Arne, Menzel, Maria, Langanke, Jonas, Walter, Carolin, Wagener, Rabea, Brozou, Triantafyllia, Varghese, Julian, Dugas, Martin, Erlacher, Miriam, Schröck, Evelin, Suttorp, Meinolf, Borkhardt, Arndt, Hauer, Julia, Auer, Franziska
Published in Genetics in medicine (01.08.2023)
Published in Genetics in medicine (01.08.2023)
Get full text
Journal Article
Evaluating the performance of the breast cancer genetic risk models BOADICEA, IBIS, BRCAPRO and Claus for predicting BRCA1/2 mutation carrier probabilities: a study based on 7352 families from the German Hereditary Breast and Ovarian Cancer Consortium
Fischer, Christine, Kuchenbäcker, Karoline, Engel, Christoph, Zachariae, Silke, Rhiem, Kerstin, Meindl, Alfons, Rahner, Nils, Dikow, Nicola, Plendl, Hansjörg, Debatin, Irmgard, Grimm, Tiemo, Gadzicki, Dorothea, Flöttmann, Ricarda, Horvath, Judit, Schröck, Evelin, Stock, Friedrich, Schäfer, Dieter, Schwaab, Ira, Kartsonaki, Christiana, Mavaddat, Nasim, Schlegelberger, Brigitte, Antoniou, Antonis C, Schmutzler, Rita
Published in Journal of medical genetics (01.06.2013)
Published in Journal of medical genetics (01.06.2013)
Get full text
Journal Article
Targetable ERBB2 mutations identified in neurofibroma/schwannoma hybrid nerve sheath tumors
Ronellenfitsch, Michael W, Harter, Patrick N, Kirchner, Martina, Heining, Christoph, Hutter, Barbara, Gieldon, Laura, Schittenhelm, Jens, Schuhmann, Martin U, Tatagiba, Marcos, Marquardt, Gerhard, Wagner, Marlies, Endris, Volker, Brandts, Christian H, Mautner, Victor-Felix, Schröck, Evelin, Weichert, Wilko, Brors, Benedikt, von Deimling, Andreas, Mittelbronn, Michel, Steinbach, Joachim P, Reuss, David E, Glimm, Hanno, Stenzinger, Albrecht, Fröhling, Stefan
Published in The Journal of clinical investigation (01.05.2020)
Published in The Journal of clinical investigation (01.05.2020)
Get full text
Journal Article
Survivin safeguards chromosome numbers and protects from aneuploidy independently from p53
Wiedemuth, Ralf, Klink, Barbara, Töpfer, Katrin, Schröck, Evelin, Schackert, Gabriele, Tatsuka, Masaaki, Temme, Achim
Published in Molecular cancer (09.05.2014)
Published in Molecular cancer (09.05.2014)
Get full text
Journal Article
Targeted capture-based NGS is superior to multiplex PCR-based NGS for hereditary BRCA1 and BRCA2 gene analysis in FFPE tumor samples
Zakrzewski, Falk, Gieldon, Laura, Rump, Andreas, Seifert, Michael, Grützmann, Konrad, Krüger, Alexander, Loos, Sina, Zeugner, Silke, Hackmann, Karl, Porrmann, Joseph, Wagner, Johannes, Kast, Karin, Wimberger, Pauline, Baretton, Gustavo, Schröck, Evelin, Aust, Daniela, Klink, Barbara
Published in BMC cancer (27.04.2019)
Published in BMC cancer (27.04.2019)
Get full text
Journal Article
Highly significant antiviral activity of HIV-1 LTR-specific tre-recombinase in humanized mice
Hauber, Ilona, Hofmann-Sieber, Helga, Chemnitz, Jan, Dubrau, Danilo, Chusainow, Janet, Stucka, Rolf, Hartjen, Philip, Schambach, Axel, Ziegler, Patrick, Hackmann, Karl, Schröck, Evelin, Schumacher, Udo, Lindner, Christoph, Grundhoff, Adam, Baum, Christopher, Manz, Markus G, Buchholz, Frank, Hauber, Joachim
Published in PLoS pathogens (01.09.2013)
Published in PLoS pathogens (01.09.2013)
Get full text
Journal Article