Sodium‐site in serine protease domain of human coagulation factor IXa: evidence from the crystal structure and molecular dynamics simulations study
Vadivel, Kanagasabai, Schreuder, Herman A., Liesum, Alexander, Schmidt, Amy E., Goldsmith, Gunaseelan, Bajaj, S. Paul
Published in Journal of thrombosis and haemostasis (01.04.2019)
Published in Journal of thrombosis and haemostasis (01.04.2019)
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Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders
Kannt, Aimo, Rajagopal, Sridharan, Hallur, Mahanandeesha S, Swamy, Indu, Kristam, Rajendra, Dhakshinamoorthy, Saravanakumar, Czech, Joerg, Zech, Gernot, Schreuder, Herman, Ruf, Sven
Published in Molecules (Basel, Switzerland) (13.02.2021)
Published in Molecules (Basel, Switzerland) (13.02.2021)
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A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
Kannt, Aimo, Rajagopal, Sridharan, Kadnur, Sanjay Venkatachalapathi, Suresh, Juluri, Bhamidipati, Ravi Kanth, Swaminathan, Srinivasan, Hallur, Mahanandeesha Siddappa, Kristam, Rajendra, Elvert, Ralf, Czech, Jörg, Pfenninger, Anja, Rudolph, Christine, Schreuder, Herman, Chandrasekar, Devaraj Venkatapura, Mane, Vishal Subhash, Birudukota, Swarnakumari, Shaik, Shama, Zope, Bharat Ravindra, Burri, Raghunadha Reddy, Anand, Niranjan Naranapura, Thakur, Manish Kumar, Singh, Manvi, Parveen, Reejuana, Kandan, Saravanan, Mullangi, Ramesh, Yura, Takeshi, Gosu, Ramachandraiah, Ruf, Sven, Dhakshinamoorthy, Saravanakumar
Published in Scientific reports (26.02.2018)
Published in Scientific reports (26.02.2018)
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Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin
Halland, Nis, Brönstrup, Mark, Czech, Jörg, Czechtizky, Werngard, Evers, Andreas, Follmann, Markus, Kohlmann, Markus, Schiell, Matthias, Kurz, Michael, Schreuder, Herman A, Kallus, Christopher
Published in Journal of medicinal chemistry (11.06.2015)
Published in Journal of medicinal chemistry (11.06.2015)
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Journal Article
Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa)
Halland, Nis, Czech, Jörg, Czechtizky, Werngard, Evers, Andreas, Follmann, Markus, Kohlmann, Markus, Schreuder, Herman A, Kallus, Christopher
Published in Journal of medicinal chemistry (27.10.2016)
Published in Journal of medicinal chemistry (27.10.2016)
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Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
Ruf, Sven, Rajagopal, Sridharan, Kadnur, Sanjay Venkatachalapathi, Hallur, Mahanandeesha S, Rani, Shilpa, Kristam, Rajendra, Swaminathan, Srinivasan, Zope, Bharat Ravindra, Gondrala, Pavan Kumar, Swamy, Indu, Putta, V P Rama Kishore, Kandan, Saravanan, Zech, Gernot, Schreuder, Herman, Rudolph, Christine, Elvert, Ralf, Czech, Joerg, Birudukota, Swarnakumari, Siddiqui, M Amir, Anand, Niranjan Naranapura, Mane, Vishal Subhash, Dittakavi, Sreekanth, Suresh, Juluri, Gosu, Ramachandraiah, Ramesh, Mullangi, Yura, Takeshi, Dhakshinamoorthy, Saravanakumar, Kannt, Aimo
Published in Scientific reports (14.09.2022)
Published in Scientific reports (14.09.2022)
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Journal Article
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase
Ruf, Sven, Hallur, Mahanandeesha Siddappa, Anchan, Nisha K., Swamy, Indu N., Murugesan, Karthikai Raj, Sarkar, Sayantani, Narasimhulu, Lokesh Kananti, Putta, V.P. Rama Kishore, Shaik, Shama, Chandrasekar, Devaraj Venkatapura, Mane, Vishal Subhash, Kadnur, Sanjay Venkatachalapathi, Suresh, Juluri, Bhamidipati, Ravi Kanth, Singh, Manvi, Burri, Raghunadha Reddy, Kristam, Rajendra, Schreuder, Herman, Czech, Joerg, Rudolph, Christine, Marker, Alexander, Langer, Thomas, Mullangi, Ramesh, Yura, Takeshi, Gosu, Ramachandraiah, Kannt, Aimo, Dhakshinamoorthy, Saravanakumar, Rajagopal, Sridharan
Published in Bioorganic & medicinal chemistry letters (01.03.2018)
Published in Bioorganic & medicinal chemistry letters (01.03.2018)
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Journal Article
Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases
Schreuder, Herman A., Liesum, Alexander, Kroll, Katja, Böhnisch, Britta, Buning, Christian, Ruf, Sven, Sadowski, Thorsten
Published in Biochemical and biophysical research communications (07.03.2014)
Published in Biochemical and biophysical research communications (07.03.2014)
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A Combination of Spin Diffusion Methods for the Determination of Protein-Ligand Complex Structural Ensembles
Pilger, Jens, Mazur, Adam, Monecke, Peter, Schreuder, Herman, Elshorst, Bettina, Bartoschek, Stefan, Langer, Thomas, Schiffer, Alexander, Krimm, Isabelle, Wegstroth, Melanie, Lee, Donghan, Hessler, Gerhard, Wendt, K.-Ulrich, Becker, Stefan, Griesinger, Christian
Published in Angewandte Chemie (26.05.2015)
Published in Angewandte Chemie (26.05.2015)
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5‑Chlorothiophene-2-carboxylic Acid [(S)‑2-[2-Methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a Selective and Potent Orally Active Dual Thrombin and Factor Xa Inhibitor
Meneyrol, Jerome, Follmann, Markus, Lassalle, Gilbert, Wehner, Volkmar, Barre, Guillaume, Rousseaux, Tristan, Altenburger, Jean-Michel, Petit, Frederic, Bocskei, Zsolt, Schreuder, Herman, Alet, Nathalie, Herault, Jean-Pascal, Millet, Laurence, Dol, Frederique, Florian, Peter, Schaeffer, Paul, Sadoun, Freddy, Klieber, Sylvie, Briot, Christophe, Bono, Françoise, Herbert, Jean-Marc
Published in Journal of medicinal chemistry (12.12.2013)
Published in Journal of medicinal chemistry (12.12.2013)
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The Crystal Structure of Thrombin-activable Fibrinolysis Inhibitor (TAFI) Provides the Structural Basis for Its Intrinsic Activity and the Short Half-life of TAFIa
Anand, Kanchan, Pallares, Irantzu, Valnickova, Zuzana, Christensen, Trine, Vendrell, Josep, Wendt, K. Ulrich, Schreuder, Herman A., Enghild, Jan J., Avilés, Francesc X.
Published in The Journal of biological chemistry (24.10.2008)
Published in The Journal of biological chemistry (24.10.2008)
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Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-ray Crystallography
Nazaré, Marc, Will, David W, Matter, Hans, Schreuder, Herman, Ritter, Kurt, Urmann, Matthias, Essrich, Melanie, Bauer, Armin, Wagner, Michael, Czech, Jörg, Lorenz, Martin, Laux, Volker, Wehner, Volkmar
Published in Journal of medicinal chemistry (14.07.2005)
Published in Journal of medicinal chemistry (14.07.2005)
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Quantitative Structure−Activity Relationship of Human Neutrophil Collagenase (MMP-8) Inhibitors Using Comparative Molecular Field Analysis and X-ray Structure Analysis
Matter, Hans, Schwab, Wilfried, Barbier, Denis, Billen, Günter, Haase, Burkhard, Neises, Bernhard, Schudok, Manfred, Thorwart, Werner, Schreuder, Herman, Brachvogel, Volker, Lönze, Petra, Weithmann, Klaus Ulrich
Published in Journal of medicinal chemistry (03.06.1999)
Published in Journal of medicinal chemistry (03.06.1999)
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Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa
Dickopf, Stefan, Frank, Michael, Junker, Hans-Dieter, Maier, Sabine, Metz, Günther, Ottleben, Holger, Rau, Harald, Schellhaas, Nathalie, Schmidt, Kristina, Sekul, Renate, Vanier, Cecile, Vetter, Dirk, Czech, Jörg, Lorenz, Martin, Matter, Hans, Schudok, Manfred, Schreuder, Herman, Will, David W., Nestler, Hans Peter
Published in Analytical biochemistry (01.12.2004)
Published in Analytical biochemistry (01.12.2004)
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Journal Article
Identification and Characterization of a Single High‐Affinity Fatty Acid Binding Site in Human Serum Albumin
Wenskowsky, Lea, Schreuder, Herman, Derdau, Volker, Matter, Hans, Volkmar, Julia, Nazaré, Marc, Opatz, Till, Petry, Stefan
Published in Angewandte Chemie International Edition (22.01.2018)
Published in Angewandte Chemie International Edition (22.01.2018)
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Journal Article
Resolving Binding Events on the Multifunctional Human Serum Albumin
Wenskowsky, Lea, Wagner, Michael, Reusch, Johannes, Schreuder, Herman, Matter, Hans, Opatz, Till, Petry, Stefan Matthias
Published in ChemMedChem (06.05.2020)
Published in ChemMedChem (06.05.2020)
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Journal Article
Inhibition of Human Neutrophil Elastase. 4. Design, Synthesis, X-ray Crystallographic Analysis, and Structure−Activity Relationships for a Series of P2-Modified, Orally Active Peptidyl Pentafluoroethyl Ketones
Cregge, Robert J, Durham, Sherrie L, Farr, Robert A, Gallion, Steven L, Hare, C. Michelle, Hoffman, Robert V, Janusz, Michael J, Kim, Hwa-Ok, Koehl, Jack R, Mehdi, Shujaath, Metz, William A, Peet, Norton P, Pelton, John T, Schreuder, Herman A, Sunder, Shyam, Tardif, Chantal
Published in Journal of medicinal chemistry (02.07.1998)
Published in Journal of medicinal chemistry (02.07.1998)
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Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations
Evers, Andreas, Bossart, Martin, Pfeiffer-Marek, Stefania, Elvert, Ralf, Schreuder, Herman, Kurz, Michael, Stengelin, Siegfried, Lorenz, Martin, Herling, Andreas, Konkar, Anish, Lukasczyk, Ulrike, Pfenninger, Anja, Lorenz, Katrin, Haack, Torsten, Kadereit, Dieter, Wagner, Michael
Published in Journal of medicinal chemistry (12.07.2018)
Published in Journal of medicinal chemistry (12.07.2018)
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Crystal Structures of Wild-Type p-Hydroxybenzoate Hydroxylase Complexed with 4-Aminobenzoate, 2,4-Dihydroxybenzoate, and 2-Hydroxy-4-aminobenzoate and of the Tyr222Ala Mutant Complexed with 2-Hydroxy-4-aminobenzoate. Evidence for a Proton Channel and a New Binding Mode of the Flavin Ring
Schreuder, Herman A, Mattevi, Andrea, Obmolova, Galina, Kalk, Kor H, Hol, Wim G. J, van der Bolt, Frank J. T, van Berkel, Willem J. H
Published in Biochemistry (Easton) (01.08.1994)
Published in Biochemistry (Easton) (01.08.1994)
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