Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists
Mantlo, Nathan B, Chakravarty, Prasun K, Ondeyka, Debra L, Siegl, Peter K. S, Chang, Raymond S, Lotti, Victor J, Faust, Kristie A, Schorn, Terry W, Chen, Tsing Bau
Published in Journal of medicinal chemistry (01.09.1991)
Published in Journal of medicinal chemistry (01.09.1991)
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Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analog inhibitors containing a novel analog of statine
Boger, Joshua, Payne, Linda S, Perlow, Debra S, Lohr, Nancy S, Poe, Martin, Blaine, Edward H, Ulm, Edgar H, Schorn, Terry W, LaMont, Bruce I
Published in Journal of medicinal chemistry (01.12.1985)
Published in Journal of medicinal chemistry (01.12.1985)
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Design and Synthesis of Novel α1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia
Nagarathnam, Dhanapalan, Wetzel, John M, Miao, Shou Wu, Marzabadi, Mohammad R, Chiu, George, Wong, Wai C, Hong, Xingfang, Fang, James, Forray, Carlos, Branchek, Theresa A, Heydorn, William E, Chang, Raymond S. L, Broten, Theodore, Schorn, Terry W, Gluchowski, Charles
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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Renin inhibitors containing C-termini derived from mercaptoheterocycles
Ashton, Wallace T, Cantone, Christine L, Meurer, Laura C, Tolman, Richard L, Greenlee, William J, Patchett, Arthur A, Lynch, Robert J, Schorn, Terry W, Strouse, John F, Siegl, Peter K. S
Published in Journal of medicinal chemistry (01.05.1992)
Published in Journal of medicinal chemistry (01.05.1992)
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De Novo Design of a Novel Oxazolidinone Analogue as a Potent and Selective α1A Adrenergic Receptor Antagonist with High Oral Bioavailability
Lagu, Bharat, Tian, Dake, Jeon, Yoon, Li, Chao, Wetzel, John M, Nagarathnam, Dhanapalan, Shen, Quanrong, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Ransom, Richard W, Chan, Tsing-Bao, O'Malley, Stacey S, Schorn, Terry W, Rodrigues, A. David, Kassahun, Kelem, Pettibone, Douglas J, Freidinger, Roger, Gluchowski, Charles
Published in Journal of medicinal chemistry (27.07.2000)
Published in Journal of medicinal chemistry (27.07.2000)
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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 2. Approaches To Eliminate Opioid Agonist Metabolites via Modification of Linker and 4-Methoxycarbonyl-4-phenylpiperidine Moiety
Murali Dhar, T. G, Nagarathnam, Dhanapalan, Marzabadi, Mohammad R, Lagu, Bharat, Wong, Wai C, Chiu, George, Tyagarajan, Sriram, Miao, Shou Wu, Zhang, Fengqi, Sun, Wanying, Tian, Dake, Shen, Quanrong, Zhang, Jack, Wetzel, John M, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Schorn, Terry W, Chen, Tsing Bao, O'Malley, Stacy, Ransom, Richard, Schneck, Kathryn, Bendesky, Robert, Harrell, Charles M, Vyas, Kamlesh P, Zhang, Kanyin, Gilbert, John, Pettibone, Douglas J, Patane, Michael A, Bock, Mark G, Freidinger, Roger M, Gluchowski, Charles
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 1. Structure−Activity Relationship in Dihydropyrimidinones
Nagarathnam, Dhanapalan, Miao, Shou Wu, Lagu, Bharat, Chiu, George, Fang, James, Murali Dhar, T. G, Zhang, Jack, Tyagarajan, Sriram, Marzabadi, Mohammad R, Zhang, Fengqi, Wong, Wai C, Sun, Wanying, Tian, Dake, Wetzel, John M, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Ransom, Richard W, Schorn, Terry W, Chen, Tsing B, O'Malley, Stacey, Kling, Paul, Schneck, Kathryn, Bendesky, Robert, Harrell, Charles M, Vyas, Kamlesh P, Gluchowski, Charles
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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Novel renin inhibitors containing the amino acid statine
Boger, J, Lohr, N S, Ulm, E H, Poe, M, Blaine, E H, Fanelli, G M, Lin, T Y, Payne, L S, Schorn, T W, LaMont, B I, Vassil, T C, Stabilito, I I, Veber, D F, Rich, D H, Bopari, A S
Published in Nature (London) (05.05.1983)
Published in Nature (London) (05.05.1983)
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Highly potent, orally active diester macrocyclic human renin inhibitors
Weber, Ann E, Steiner, Mark G, Krieter, Philip A, Colletti, Adria E, Tata, James R, Halgren, Thomas A, Ball, Richard G, Doyle, John J, Schorn, Terry W
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics
Williams, Peter D, Perlow, Debra S, Payne, Linda S, Holloway, M. Katherine, Siegl, Peter K. S, Schorn, Terry W, Lynch, Robert J, Doyle, John J, Strouse, John F
Published in Journal of medicinal chemistry (01.03.1991)
Published in Journal of medicinal chemistry (01.03.1991)
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In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia
Barrow, JC, Nantermet, PG, Selnick, HG, Glass, KL, Rittle, KE, Gilbert, KF, Steele, TG, Homnick, CF, Freidinger, RM, Ransom, RW, Kling, P, Reiss, D, Broten, TP, Schorn, TW, Chang, RSL, O'Malley, SS, Olah, TV, Ellis, JD, Barrish, A, Kassahun, K, Leppert, P, Nagarathnam, D, Forray, C
Published in Journal of medicinal chemistry (13.07.2000)
Published in Journal of medicinal chemistry (13.07.2000)
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Inhibitors of human renin with C-termini derived from amides and esters of .alpha.-mercaptoalkanoic acids
Ashton, Wallace T, Cantone, Christine L, Tolman, Richard L, Greenlee, William J, Lynch, Robert J, Schorn, Terry W, Strouse, John F, Siegl, Peter K. S
Published in Journal of medicinal chemistry (01.07.1992)
Published in Journal of medicinal chemistry (01.07.1992)
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Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones
Nagarathnam, D, Miao, SW, Lagu, B, Chiu, G, Fang, J, Dhar, TGM, Zhang, J, Tyagarajan, S, Marzabadi, MR, Zhang, FQ, Wong, WC, Sun, WY, Tian, D, Wetzel, JM, Forray, C, Chang, RSL, Broten, TP, Ransom, RW, Schorn, TW, Chen, TB, O'Malley, S, Kling, P, Schneck, K, Bendesky, R, Harrell, CM, Vyas, KP, Gluchowski, C
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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Comparison of Renin and Converting Enzyme Inhibition in Sodium-Deficient Dogs
BLAINE, EDWARD H, NELSON, BARBARA J, SEYMOUR, ANDREA A, SCHORN, TERRY W, SWEET, CHARLES S, SLATER, EVE E, NUSSBERGER, JURGE, BOGER, JOSHUA
Published in Hypertension (Dallas, Tex. 1979) (01.05.1985)
Published in Hypertension (Dallas, Tex. 1979) (01.05.1985)
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Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety
Dhar, TGM, Nagarathnam, D, Marzabadi, MR, Lagu, B, Wong, WC, Chiu, G, Tyagarajan, S, Miao, SW, Zhang, FQ, Sun, WY, Tian, D, Shen, QR, Zhang, J, Wetzel, JM, Forray, C, Chang, RSL, Broten, TP, Schorn, TW, Chen, TB, O'Malley, S, Ransom, R, Schneck, K, Bendesky, R, Harrell, CM, Vyas, KP, Zhang, KY, Gilbert, J, Pettibone, DJ, Patane, MA, Bock, MG, Freidinger, RM, Gluchowski, C
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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Journal Article
Design and synthesis of novel alpha(1a) adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia
Nagarathnam, D, Wetzel, JM, Miao, SW, Marzabadi, MR, Chiu, G, Wong, WC, Hong, XF, Fang, J, Forray, C, Branchek, TA, Heydorn, WE, Chang, RSL, Broten, T, Schorn, TW, Gluchowski, C
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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Journal Article
De novo design of a novel oxazolidinone analogue as a potent and selective alpha(1A) adrenergic receptor antagonist with high oral bioavailability
Lagu, B, Tian, D, Jeon, Y, Li, C, Wetzel, JM, Nagarathnam, D, Shen, QR, Forray, C, Chang, RSL, Broten, TP, Ransom, RW, Chan, TB, O'Malley, SS, Schorn, TW, Rodrigues, AD, Kassahun, K, Pettibone, DJ, Freidinger, R, Gluchowski, C
Published in Journal of medicinal chemistry (27.07.2000)
Published in Journal of medicinal chemistry (27.07.2000)
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A highly potent, orally active imidazo-[4,5-b]pyridine biphenylacylsulfonamide (MK-996;L-159,282) : a new AT1-selective angiotensin II receptor antagonist
CHAKRAVARTY, P. K, NAYLOR, E. M, SCHORN, T. W, SCHAFFER, L. W, BROTEN, T. P, SIEGL, P. K. S, PATCHETT, A. A, GREENLEE, W. J, CHEN, A, CHANG, R. S. L, TSING-BAU CHEN, FAUST, K. A, LOTTI, V. J, KIVLIGHN, S. D, GABLE, R. A, ZINGARO, G. J
Published in Journal of medicinal chemistry (25.11.1994)
Published in Journal of medicinal chemistry (25.11.1994)
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Journal Article
In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α 1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia
Barrow, James C., Nantermet, Philippe G., Selnick, Harold G., Glass, Kristen L., Rittle, Kenneth E., Gilbert, Kevin F., Steele, Thomas G., Homnick, Carl F., Freidinger, Roger M., Ransom, Rick W., Kling, Paul, Reiss, Duane, Broten, Theodore P., Schorn, Terry W., Chang, Raymond S. L., O'Malley, Stacey S., Olah, Timothy V., Ellis, Joan D., Barrish, Andrea, Kassahun, Kelem, Leppert, Paula, Nagarathnam, Dhanapalan, Forray, Carlos
Published in Journal of medicinal chemistry (01.07.2000)
Published in Journal of medicinal chemistry (01.07.2000)
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