SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design: Application to the Discovery of Nanomolar Inhibitors of Src SH2
Lesuisse, Dominique, Lange, Gudrun, Deprez, Pierre, Bénard, Didier, Schoot, Bernard, Delettre, Georges, Marquette, Jean-Pierre, Broto, Pierre, Jean-Baptiste, Véronique, Bichet, Paulette, Sarubbi, Edoardo, Mandine, Eliane
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Vancomycin Resistance Is Associated with Serine-Containing Peptidoglycan in Enterococcus gallinarum
Grohs, P, Gutmann, L, Legrand, R, Schoot, B, Mainardi, J L
Published in Journal of Bacteriology (01.11.2000)
Published in Journal of Bacteriology (01.11.2000)
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Purification of biological molecules by continuous flow electrophoresis in the second international microgravity laboratory
Clifton, Michael J., Balmann, Hélène Roux-de, Sanchez, Victor, Bleuzen-Mariotte, Valérie, Schoot, Bernard M.
Published in Journal of biotechnology (27.06.1996)
Published in Journal of biotechnology (27.06.1996)
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Novel Mechanism of β-Lactam Resistance Due to Bypass of DD-Transpeptidation in Enterococcus faecium
Mainardi, Jean-Luc, Legrand, Raymond, Arthur, Michel, Schoot, Bernard, van Heijenoort, Jean, Gutmann, Laurent
Published in The Journal of biological chemistry (02.06.2000)
Published in The Journal of biological chemistry (02.06.2000)
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Acquisition of five high-M(r) penicillin-binding protein variants during transfer of high-level beta-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae
Hakenbeck, Regine, Konig, Andrea, Kern, Izabella, Van der Linden, Mark
Published in Journal of bacteriology (01.04.1998)
Published in Journal of bacteriology (01.04.1998)
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Acquisition of Five High- M r Penicillin-Binding Protein Variants during Transfer of High-Level β-Lactam Resistance from Streptococcus mitis to Streptococcus pneumoniae
Hakenbeck, Regine, König, Andrea, Kern, Izabella, van der Linden, Mark, Keck, Wolfgang, Billot-Klein, Danielle, Legrand, Raymond, Schoot, Bernard, Gutmann, Laurent
Published in Journal of bacteriology (01.04.1998)
Published in Journal of bacteriology (01.04.1998)
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Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors
Lange, G, Lesuisse, D, Deprez, P, Schoot, B, Loenze, P, Benard, D, Marquette, JP, Broto, P, Sarubbi, E, Mandine, E
Published in Journal of medicinal chemistry (20.11.2003)
Published in Journal of medicinal chemistry (20.11.2003)
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In Vitro Processing of Human Tumor Necrosis Factor-α(∗)
Robache-Gallea, Sylvie, Morand, Valérie, Bruneau, J. Michel, Schoot, Bernard, Tagat, Eric, Réalo, Evelyne, Chouaib, Salem, Roman-Roman, Sergio
Published in The Journal of biological chemistry (06.10.1995)
Published in The Journal of biological chemistry (06.10.1995)
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Journal Article
Requirements for Specific Binding of Low Affinity Inhibitor Fragments to the SH2 Domain of pp60Src Are Identical to Those for High Affinity Binding of Full Length Inhibitors
Lange, Gudrun, Lesuisse, Dominique, Deprez, Pierre, Schoot, Bernard, Loenze, Petra, Bénard, Didier, Marquette, Jean-Pierre, Broto, Pierre, Sarubbi, Edoardo, Mandine, Eliane
Published in Journal of medicinal chemistry (20.11.2003)
Published in Journal of medicinal chemistry (20.11.2003)
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Journal Article
Requirements for Specific Binding of Low Affinity Inhibitor Fragments to the SH2 Domain of pp60 Src Are Identical to Those for High Affinity Binding of Full Length Inhibitors
Lange, Gudrun, Lesuisse, Dominique, Deprez, Pierre, Schoot, Bernard, Loenze, Petra, Bénard, Didier, Marquette, Jean-Pierre, Broto, Pierre, Sarubbi, Edoardo, Mandine, Eliane
Published in Journal of medicinal chemistry (01.11.2003)
Published in Journal of medicinal chemistry (01.11.2003)
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Principles Governing the Binding of a Class of Non-Peptidic Inhibitors to the SH2 Domain of src Studied by X-ray Analysis
Lange, Gudrun, Lesuisse, Dominique, Deprez, Pierre, Schoot, Bernard, Loenze, Petra, Bénard, Didier, Marquette, Jean-Pierre, Broto, Pierre, Sarubbi, Edoardo, Mandine, Eliane
Published in Journal of medicinal chemistry (04.07.2002)
Published in Journal of medicinal chemistry (04.07.2002)
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Discovery of highly potent Src SH2 binders: Structure-activity studies and X-ray structures
DEPREZ, Pierre, BAHOLET, Isabelle, BURLET, Stéphane, LANGE, Gudrun, AMENGUAL, Remi, SCHOOT, Bernard, VERMOND, Annie, MANDINE, Eliane, LESUISSE, Dominique
Published in Bioorganic & medicinal chemistry letters (06.05.2002)
Published in Bioorganic & medicinal chemistry letters (06.05.2002)
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Discovery of Thioazepinone Ligands for Src SH2: From Non-specific to Specific Binding
Lesuisse, Dominique, Deprez, Pierre, Albert, Eva, Duc, Tran Thien, Sortais, Benoit, Gofflo, Dominique, Jean-Baptiste, Véronique, Marquette, Jean-Pierre, Schoot, Bernard, Sarubbi, Edoardo, Lange, Gudrun, Broto, Pierre, Mandine, Eliane
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
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Journal Article
Discovery of highly potent Src SH 2 binders: Structure–activity studies and X-ray structures
Deprez, Pierre, Baholet, Isabelle, Burlet, Stéphane, Lange, Gudrun, Amengual, Remi, Schoot, Bernard, Vermond, Annie, Mandine, Eliane, Lesuisse, Dominique
Published in Bioorganic & medicinal chemistry letters (2002)
Published in Bioorganic & medicinal chemistry letters (2002)
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Peptidoglycan structure of Lactobacillus casei, a species highly resistant to glycopeptide antibiotics
Billot-Klein, D, Legrand, R, Schoot, B, van Heijenoort, J, Gutmann, L
Published in Journal of Bacteriology (01.10.1997)
Published in Journal of Bacteriology (01.10.1997)
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Resistance to cefotaxime and peptidoglycan composition in Enterococcus faecalis are influenced by exogenous sodium chloride
Mainardi, Jean-Luc, Billot-Klein, Daniele, Coutrot, Anne, Legrand, Raymond, Schoot, Bernard, Gutmann, Laurent
Published in Microbiology (Society for General Microbiology) (01.10.1998)
Published in Microbiology (Society for General Microbiology) (01.10.1998)
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Crystallization of a recombinant form of the complete sequence of human γ-interferon: characterization by small-angle X-ray scattering, mass spectrometry and preliminary X-ray diffraction studies
Budayova-Spano, Monika, Shepard, William, Schoot, Bernard, Astier, Jean-Pierre, Veesler, Stéphane
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2001)
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2001)
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Site-directed mutagenesis and chemical modification of the two cysteine residues of the UDP- N-acetylmuramoyl: l-alanine ligase of Escherichia coli
Nosal, Florence, Masson, Anne, Legrand, Raymond, Blanot, Didier, Schoot, Bernard, van Heijenoort, Jean, Parquet, Claudine
Published in FEBS letters (24.04.1998)
Published in FEBS letters (24.04.1998)
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