Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics
Dans, Madeline G, Piirainen, Henni, Nguyen, William, Khurana, Sachin, Mehra, Somya, Razook, Zahra, Geoghegan, Niall D, Dawson, Aurelie T, Das, Sujaan, Parkyn Schneider, Molly, Jonsdottir, Thorey K, Gabriela, Mikha, Gancheva, Maria R, Tonkin, Christopher J, Mollard, Vanessa, Goodman, Christopher Dean, McFadden, Geoffrey I, Wilson, Danny W, Rogers, Kelly L, Barry, Alyssa E, Crabb, Brendan S, de Koning-Ward, Tania F, Sleebs, Brad E, Kursula, Inari, Gilson, Paul R
Published in PLoS biology (13.04.2023)
Published in PLoS biology (13.04.2023)
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Journal Article
Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development
Parkyn Schneider, Molly, Liu, Boyin, Glock, Philipp, Suttie, Annika, McHugh, Emma, Andrew, Dean, Batinovic, Steven, Williamson, Nicholas, Hanssen, Eric, McMillan, Paul, Hliscs, Marion, Tilley, Leann, Dixon, Matthew W A
Published in PLoS pathogens (01.10.2017)
Published in PLoS pathogens (01.10.2017)
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Journal Article
The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture
Bullen, Hayley E., Sanders, Paul R., Dans, Madeline G., Jonsdottir, Thorey K., Riglar, David T., Looker, Oliver, Palmer, Catherine S., Kouskousis, Betty, Charnaud, Sarah C., Triglia, Tony, Gabriela, Mikha, Parkyn Schneider, Molly, Chan, Jo‐Anne, Koning‐Ward, Tania F., Baum, Jake, Kazura, James W., Beeson, James G., Cowman, Alan F., Gilson, Paul R., Crabb, Brendan S.
Published in Molecular microbiology (01.05.2022)
Published in Molecular microbiology (01.05.2022)
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Journal Article
The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts
Parkyn Schneider, Molly, Looker, Oliver, Rebelo, Maria, Khoury, David S, Dixon, Matthew W A, Oeuvray, Claude, Crabb, Brendan S, McCarthy, James, Gilson, Paul R
Published in Frontiers in cellular and infection microbiology (29.06.2023)
Published in Frontiers in cellular and infection microbiology (29.06.2023)
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Journal Article
PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum
Jonsdottir, Thorey K, Elsworth, Brendan, Cobbold, Simon, Gabriela, Mikha, Ploeger, Ellen, Parkyn Schneider, Molly, Charnaud, Sarah C, Dans, Madeline G, McConville, Malcolm, Bullen, Hayley E, Crabb, Brendan S, Gilson, Paul R
Published in PLoS pathogens (31.07.2023)
Published in PLoS pathogens (31.07.2023)
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Journal Article
An exported protein-interacting complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes
Batinovic, Steven, McHugh, Emma, Chisholm, Scott A., Matthews, Kathryn, Liu, Boiyin, Dumont, Laure, Charnaud, Sarah C., Schneider, Molly Parkyn, Gilson, Paul R., de Koning-Ward, Tania F., Dixon, Matthew W. A., Tilley, Leann
Published in Nature communications (10.07.2017)
Published in Nature communications (10.07.2017)
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Journal Article
Sequence elements within the PEXEL motif and its downstream region modulate PTEX‐dependent protein export in Plasmodium falciparum
Gabriela, Mikha, Barnes, Claudia B. G., Leong, Dickson, Sleebs, Brad E., Schneider, Molly Parkyn, Littler, Dene R., Crabb, Brendan S., Koning‐Ward, Tania F., Gilson, Paul R.
Published in Traffic (Copenhagen, Denmark) (01.01.2024)
Published in Traffic (Copenhagen, Denmark) (01.01.2024)
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Journal Article
Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity
Ashton, Trent D., Ngo, Anna, Favuzza, Paola, Bullen, Hayley E., Gancheva, Maria R., Romeo, Ornella, Parkyn Schneider, Molly, Nguyen, Nghi, Steel, Ryan W.J., Duffy, Sandra, Lowes, Kym N., Sabroux, Helene Jousset, Avery, Vicky M., Boddey, Justin A., Wilson, Danny W., Cowman, Alan F., Gilson, Paul R., Sleebs, Brad E.
Published in Bioorganic chemistry (01.12.2021)
Published in Bioorganic chemistry (01.12.2021)
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Journal Article
PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum
Jonsdottir, Thorey K, Elsworth, Brendan, Cobbold, Simon, Mikha Gabriela, Charnaud, Sarah C, Dans, Madeline G, Molly Parkyn Schneider, Mcconville, Malcolm, Bullen, Hayley E, Crabb, Brendan S, Gilson, Paul R
Published in bioRxiv (15.11.2022)
Published in bioRxiv (15.11.2022)
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Paper
The sulfonylpiperazine MMV020291 prevents red blood cell invasion by the malaria parasite Plasmodium falciparum through interference with actin-1/profilin dynamics
Dans, Madeline G, Piirainen, Henni, Nguyen, William, Khurana, Sachin, Mehra, Somya, Razook, Zahra, Das, Sujaan, Molly Parkyn Schneider, Jonsdottir, Thorey K, Mikha Gabriela, Gancheva, Maria R, Tonkin, Christopher J, Mollard, Vanessa, Goodman, Christopher Dean, Mcfadden, Geoffrey I, Wilson, Danny W, Barry, Alyssa E, Crabb, Brendan S, De Koning-Ward, Tania F, Sleebs, Brad E, Kursula, Inari, Gilson, Paul R
Published in bioRxiv (30.09.2022)
Published in bioRxiv (30.09.2022)
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Paper