Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design
Pang, Yuan-Ping, Vummenthala, Anuradha, Mishra, Rajesh K, Park, Jewn Giew, Wang, Shaohua, Davis, Jon, Millard, Charles B, Schmidt, James J
Published in PloS one (10.11.2009)
Published in PloS one (10.11.2009)
Get full text
Journal Article
Inhibition of Metalloprotease Botulinum Serotype A from a Pseudo-peptide Binding Mode to a Small Molecule That Is Active in Primary Neurons
Burnett, James C., Ruthel, Gordon, Stegmann, Christian M., Panchal, Rekha G., Nguyen, Tam L., Hermone, Ann R., Stafford, Robert G., Lane, Douglas J., Kenny, Tara A., McGrath, Connor F., Wipf, Peter, Stahl, Andrea M., Schmidt, James J., Gussio, Rick, Brunger, Axel T., Bavari, Sina
Published in The Journal of biological chemistry (16.02.2007)
Published in The Journal of biological chemistry (16.02.2007)
Get full text
Journal Article
Fluorigenic Substrates for the Protease Activities of Botulinum Neurotoxins, Serotypes A, B, and F
SCHMIDT, James J, STAFFORD, Robert G
Published in Applied and Environmental Microbiology (01.01.2003)
Published in Applied and Environmental Microbiology (01.01.2003)
Get full text
Journal Article
Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A
Park, Jewn Giew, Sill, Peter C., Makiyi, Edward F., Garcia-Sosa, Alfonso T., Millard, Charles B., Schmidt, James J., Pang, Yuan-Ping
Published in Bioorganic & medicinal chemistry (15.01.2006)
Published in Bioorganic & medicinal chemistry (15.01.2006)
Get full text
Journal Article
Use of a Recombinant Fluorescent Substrate with Cleavage Sites for All Botulinum Neurotoxins in High-Throughput Screening of Natural Product Extracts for Inhibitors of Serotypes A, B, and E
Hines, Harry B, Kim, Alexander D, Stafford, Robert G, Badie, Shirin S, Brueggeman, Ernst E, Newman, David J, Schmidt, James J
Published in Applied and Environmental Microbiology (01.02.2008)
Published in Applied and Environmental Microbiology (01.02.2008)
Get full text
Journal Article
Three‐Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three‐Zone Pharmacophore
Hermone, Ann R., Burnett, James C., Nuss, Jonathan E., Tressler, Lyal E., Nguyen, Tam L., Šolaja, Bogdan A., Vennerstrom, Jonathan L., Schmidt, James J., Wipf, Peter, Bavari, Sina, Gussio, Rick
Published in ChemMedChem (15.12.2008)
Published in ChemMedChem (15.12.2008)
Get full text
Journal Article
Targeted delivery into motor nerve terminals of inhibitors for SNARE‐cleaving proteases via liposomes coupled to an atoxic botulinum neurotoxin
Edupuganti, Om P., Ovsepian, Saak V., Wang, Jiafu, Zurawski, Tomas H., Schmidt, James J., Smith, Leonard, Lawrence, Gary W., Dolly, J. Oliver
Published in The FEBS journal (01.07.2012)
Published in The FEBS journal (01.07.2012)
Get full text
Journal Article
A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate
Zuniga, Jorge E., Schmidt, James J., Fenn, Timothy, Burnett, James C., Araç, Demet, Gussio, Rick, Stafford, Robert G., Badie, Shirin S., Bavari, Sina, Brunger, Axel T.
Published in Structure (London) (08.10.2008)
Published in Structure (London) (08.10.2008)
Get full text
Journal Article
A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease
Burnett, James C, Opsenica, Dejan, Sriraghavan, Kamaraj, Panchal, Rekha G, Ruthel, Gordon, Hermone, Ann R, Nguyen, Tam L, Kenny, Tara A, Lane, Douglas J, McGrath, Connor F, Schmidt, James J, Vennerstrom, Jonathan L, Gussio, Rick, Šolaja, Bogdan A, Bavari, Sina
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
Get full text
Journal Article
Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity
Burnett, James C, Schmidt, James J, Stafford, Robert G, Panchal, Rekha G, Nguyen, Tam L, Hermone, Ann R, Vennerstrom, Jonathan L, McGrath, Connor F, Lane, Douglas J, Sausville, Edward A, Zaharevitz, Daniel W, Gussio, Rick, Bavari, Sina
Published in Biochemical and biophysical research communications (10.10.2003)
Published in Biochemical and biophysical research communications (10.10.2003)
Get full text
Journal Article
High-Throughput Assays for Botulinum Neurotoxin Proteolytic Activity: Serotypes A, B, D, and F
Schmidt, James J., Stafford, Robert G., Millard, Charles B.
Published in Analytical biochemistry (01.09.2001)
Published in Analytical biochemistry (01.09.2001)
Get full text
Journal Article
Peptide-Toxin Tools for Probing the Expression and Function of Fetal and Adult Subtypes of the Nicotinic Acetylcholine Receptor
Teichert, Russell W., Garcia, Carmen C., Potian, Joseph G., Schmidt, James J., Witzemann, Veit, Olivera, Baldomero M., McArdle, Joseph J.
Published in Annals of the New York Academy of Sciences (01.06.2008)
Published in Annals of the New York Academy of Sciences (01.06.2008)
Get full text
Journal Article
Conformational sampling of the botulinum neurotoxin serotype a light chain: implications for inhibitor binding
Burnett, James C., Schmidt, James J., McGrath, Connor F., Nguyen, Tam L., Hermone, Ann R., Panchal, Rekha G., Vennerstrom, Jonathan L., Kodukula, Krishna, Zaharevitz, Daniel W., Gussio, Rick, Bavari, Sina
Published in Bioorganic & medicinal chemistry (17.01.2005)
Published in Bioorganic & medicinal chemistry (17.01.2005)
Get full text
Journal Article