PDE10A Inhibitors-Clinical Failure or Window Into Antipsychotic Drug Action?
Menniti, Frank S, Chappie, Thomas A, Schmidt, Christopher J
Published in Frontiers in neuroscience (20.01.2021)
Published in Frontiers in neuroscience (20.01.2021)
Get full text
Journal Article
Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy
Verhoest, Patrick R, Proulx-Lafrance, Caroline, Corman, Michael, Chenard, Lois, Helal, Christopher J, Hou, Xinjun, Kleiman, Robin, Liu, Shenping, Marr, Eric, Menniti, Frank S, Schmidt, Christopher J, Vanase-Frawley, Michelle, Schmidt, Anne W, Williams, Robert D, Nelson, Frederick R, Fonseca, Kari R, Liras, Spiros
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
Get full text
Journal Article
Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy
Diggle, Christine P., Sukoff Rizzo, Stacey J., Popiolek, Michael, Hinttala, Reetta, Schülke, Jan-Philip, Kurian, Manju A., Carr, Ian M., Markham, Alexander F., Bonthron, David T., Watson, Christopher, Sharif, Saghira Malik, Reinhart, Veronica, James, Larry C., Vanase-Frawley, Michelle A., Charych, Erik, Allen, Melanie, Harms, John, Schmidt, Christopher J., Ng, Joanne, Pysden, Karen, Strick, Christine, Vieira, Päivi, Mankinen, Katariina, Kokkonen, Hannaleena, Kallioinen, Matti, Sormunen, Raija, Rinne, Juha O., Johansson, Jarkko, Alakurtti, Kati, Huilaja, Laura, Hurskainen, Tiina, Tasanen, Kaisa, Anttila, Eija, Marques, Tiago Reis, Howes, Oliver, Politis, Marius, Fahiminiya, Somayyeh, Nguyen, Khanh Q., Majewski, Jacek, Uusimaa, Johanna, Sheridan, Eamonn, Brandon, Nicholas J.
Published in American journal of human genetics (07.04.2016)
Published in American journal of human genetics (07.04.2016)
Get full text
Journal Article
Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation
Threlfell, Sarah, Sammut, Stephen, Menniti, Frank S, Schmidt, Christopher J, West, Anthony R
Published in The Journal of pharmacology and experimental therapeutics (01.03.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2009)
Get full text
Journal Article
Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways
Padovan-Neto, Fernando E, Sammut, Stephen, Chakroborty, Shreaya, Dec, Alexander M, Threlfell, Sarah, Campbell, Peter W, Mudrakola, Vishnu, Harms, John F, Schmidt, Christopher J, West, Anthony R
Published in The Journal of neuroscience (08.04.2015)
Published in The Journal of neuroscience (08.04.2015)
Get full text
Journal Article
Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis
Siuciak, Judith A., Chapin, Douglas S., Harms, John F., Lebel, Lorraine A., McCarthy, Sheryl A., Chambers, Leslie, Shrikhande, Alka, Wong, Stephen, Menniti, Frank S., Schmidt, Christopher J.
Published in Neuropharmacology (01.08.2006)
Published in Neuropharmacology (01.08.2006)
Get full text
Journal Article
Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease
Kleiman, Robin J, Kimmel, Lida H, Bove, Susan E, Lanz, Thomas A, Harms, John F, Romegialli, Alison, Miller, Kenneth S, Willis, Amy, des Etages, Shelley, Kuhn, Max, Schmidt, Christopher J
Published in The Journal of pharmacology and experimental therapeutics (01.01.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2011)
Get full text
Journal Article
Immunohistochemical Localization of Phosphodiesterase 10A in Multiple Mammalian Species
Coskran, Timothy M, Morton, Daniel, Menniti, Frank S, Adamowicz, Wendy O, Kleiman, Robin J, Ryan, Anne M, Strick, Christine A, Schmidt, Christopher J, Stephenson, Diane T
Published in The journal of histochemistry and cytochemistry (01.11.2006)
Published in The journal of histochemistry and cytochemistry (01.11.2006)
Get full text
Journal Article
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor
Helal, Christopher J, Arnold, Eric P, Boyden, Tracey L, Chang, Cheng, Chappie, Thomas A, Fennell, Kimberly F, Forman, Michael D, Hajos, Mihaly, Harms, John F, Hoffman, William E, Humphrey, John M, Kang, Zhijun, Kleiman, Robin J, Kormos, Bethany L, Lee, Che-Wah, Lu, Jiemin, Maklad, Noha, McDowell, Laura, Mente, Scot, O’Connor, Rebecca E, Pandit, Jayvardhan, Piotrowski, Mary, Schmidt, Anne W, Schmidt, Christopher J, Ueno, Hirokazu, Verhoest, Patrick R, Yang, Edward X
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
Get full text
Journal Article
Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function
Siuciak, Judith A., McCarthy, Sheryl A., Chapin, Douglas S., Fujiwara, Remie A., James, Larry C., Williams, Robert D., Stock, Jeffrey L., McNeish, John D., Strick, Christine A., Menniti, Frank S., Schmidt, Christopher J.
Published in Neuropharmacology (01.08.2006)
Published in Neuropharmacology (01.08.2006)
Get full text
Journal Article
Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo
Kleiman, Robin J, Chapin, Douglas S, Christoffersen, Curt, Freeman, Jody, Fonseca, Kari R, Geoghegan, Kieran F, Grimwood, Sarah, Guanowsky, Victor, Hajós, Mihály, Harms, John F, Helal, Christopher J, Hoffmann, William E, Kocan, Geralyn P, Majchrzak, Mark J, McGinnis, Dina, McLean, Stafford, Menniti, Frank S, Nelson, Fredrick, Roof, Robin, Schmidt, Anne W, Seymour, Patricia A, Stephenson, Diane T, Tingley, Francis David, Vanase-Frawley, Michelle, Verhoest, Patrick R, Schmidt, Christopher J
Published in The Journal of pharmacology and experimental therapeutics (01.05.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2012)
Get full text
Journal Article
Positive Allosteric Modulation of AMPA Receptors from Efficacy to Toxicity: The Interspecies Exposure-Response Continuum of the Novel Potentiator PF-4778574
Shaffer, Christopher L., Hurst, Raymond S., Scialis, Renato J., Osgood, Sarah M., Bryce, Dianne K., Hoffmann, William E., Lazzaro, John T., Hanks, Ashley N., Lotarski, Susan, Weber, Mark L., Liu, JianHua, Menniti, Frank S., Schmidt, Christopher J., Hajós, Mihály
Published in The Journal of pharmacology and experimental therapeutics (01.10.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2013)
Get full text
Journal Article
Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels
Martina, Marzia, Gorfinkel, Yelena, Halman, Samantha, Lowe, John A., Periyalwar, Pranav, Schmidt, Christopher J., Bergeron, Richard
Published in The Journal of physiology (01.06.2004)
Published in The Journal of physiology (01.06.2004)
Get full text
Journal Article
Discovery of a Series of 6,7-Dimethoxy-4-pyrrolidylquinazoline PDE10A Inhibitors
Chappie, Thomas A., Humphrey, John M., Allen, Martin P., Estep, Kimberly G., Fox, Carol B., Lebel, Lorraine A., Liras, Spiros, Marr, Eric S., Menniti, Frank S., Pandit, Jayvardhan, Schmidt, Christopher J., Tu, Meihua, Williams, Robert D., Yang, Feng V.
Published in Journal of medicinal chemistry (25.01.2007)
Published in Journal of medicinal chemistry (25.01.2007)
Get full text
Journal Article
Immunohistochemical localization of PDE10A in the rat brain
Seeger, Thomas F, Bartlett, Brenda, Coskran, Timothy M, Culp, Jeffrey S, James, Larry C, Krull, David L, Lanfear, Jerry, Ryan, Anne M, Schmidt, Christopher J, Strick, Christine A, Varghese, Alison H, Williams, Robert D, Wylie, Patricia G, Menniti, Frank S
Published in Brain research (26.09.2003)
Published in Brain research (26.09.2003)
Get full text
Journal Article
Development and validation of a sample stabilization strategy and a UPLC–MS/MS method for the simultaneous quantitation of acetylcholine (ACh), histamine (HA), and its metabolites in rat cerebrospinal fluid (CSF)
Zhang, Yanhua, Tingley, F. David, Tseng, Elaine, Tella, Max, Yang, Xin, Groeber, Elizabeth, Liu, Jianhua, Li, Wenlin, Schmidt, Christopher J., Steenwyk, Rick
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.07.2011)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.07.2011)
Get full text
Journal Article
Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide
Harms, John F, Menniti, Frank S, Schmidt, Christopher J
Published in Frontiers in neuroscience (23.08.2019)
Published in Frontiers in neuroscience (23.08.2019)
Get full text
Journal Article
Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction
Roberts, Brooke M., Holden, Daniel E., Shaffer, Christopher L., Seymour, Patricia A., Menniti, Frank S., Schmidt, Christopher J., Williams, Graham V., Castner, Stacy A.
Published in Behavioural brain research (01.09.2010)
Published in Behavioural brain research (01.09.2010)
Get full text
Journal Article