Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics
Schmid, Cullen L., Kennedy, Nicole M., Ross, Nicolette C., Lovell, Kimberly M., Yue, Zhizhou, Morgenweck, Jenny, Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.
Published in Cell (16.11.2017)
Published in Cell (16.11.2017)
Get full text
Journal Article
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
Brust, Tarsis F, Morgenweck, Jenny, Kim, Susy A, Rose, Jamie H, Locke, Jason L, Schmid, Cullen L, Zhou, Lei, Stahl, Edward L, Cameron, Michael D, Scarry, Sarah M, Aubé, Jeffrey, Jones, Sara R, Martin, Thomas J, Bohn, Laura M
Published in Science signaling (29.11.2016)
Published in Science signaling (29.11.2016)
Get more information
Journal Article
Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors
Zhou, Lei, Lovell, Kimberly M., Frankowski, Kevin J., Slauson, Stephen R., Phillips, Angela M., Streicher, John M., Stahl, Edward, Schmid, Cullen L., Hodder, Peter, Madoux, Franck, Cameron, Michael D., Prisinzano, Thomas E., Aubé, Jeffrey, Bohn, Laura M.
Published in The Journal of biological chemistry (20.12.2013)
Published in The Journal of biological chemistry (20.12.2013)
Get full text
Journal Article
Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine
Acevedo-Canabal, Agnes, Grim, Travis W, Schmid, Cullen L, McFague, Nina, Stahl, Edward L, Kennedy, Nicole M, Bannister, Thomas D, Bohn, Laura M
Published in Biomolecules (Basel, Switzerland) (01.06.2023)
Published in Biomolecules (Basel, Switzerland) (01.06.2023)
Get full text
Journal Article
Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ‑OR Agonist
Roach, Jeremy J, Sasano, Yusuke, Schmid, Cullen L, Zaidi, Saheem, Katritch, Vsevolod, Stevens, Raymond C, Bohn, Laura M, Shenvi, Ryan A
Published in ACS central science (27.12.2017)
Published in ACS central science (27.12.2017)
Get full text
Journal Article
Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse
Fei, Guijun, Raehal, Kirsten, Liu, Sumei, Qu, Mei-Hua, Sun, Xiaohong, Wang, Guo-Du, Wang, Xi-Yu, Xia, Yun, Schmid, Cullen L, Bohn, Laura M, Wood, Jackie D
Published in The Journal of pharmacology and experimental therapeutics (01.07.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2010)
Get full text
Journal Article
Intermolecular Interactions between Retroviral Gag Proteins in the Nucleus
Kenney, Scott P, Lochmann, Timothy L, Schmid, Cullen L, Parent, Leslie J
Published in Journal of Virology (01.01.2008)
Published in Journal of Virology (01.01.2008)
Get full text
Journal Article
Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6
Raehal, Kirsten M, Schmid, Cullen L, Medvedev, Ivan O, Gainetdinov, Raul R, Premont, Richard T, Bohn, Laura M
Published in Drug and alcohol dependence (01.10.2009)
Published in Drug and alcohol dependence (01.10.2009)
Get full text
Journal Article
G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists
Stahl, Edward L, Schmid, Cullen L, Acevedo-Canabal, Agnes, Read, Cai, Grim, Travis W, Kennedy, Nicole M, Bannister, Thomas D, Bohn, Laura M
Published in Proceedings of the National Academy of Sciences - PNAS (30.11.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (30.11.2021)
Get full text
Journal Article
A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal
Grim, Travis W, Schmid, Cullen L, Stahl, Edward L, Pantouli, Fani, Ho, Jo-Hao, Acevedo-Canabal, Agnes, Kennedy, Nicole M, Cameron, Michael D, Bannister, Thomas D, Bohn, Laura M
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2020)
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2020)
Get full text
Journal Article
Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain
Pantouli, Fani, Grim, Travis W., Schmid, Cullen L., Acevedo-Canabal, Agnes, Kennedy, Nicole M., Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.
Published in Neuropharmacology (01.03.2021)
Published in Neuropharmacology (01.03.2021)
Get full text
Journal Article
Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias
Kennedy, Nicole M, Schmid, Cullen L, Ross, Nicolette C, Lovell, Kimberly M, Yue, Zhizhou, Chen, Yen Ting, Cameron, Michael D, Bohn, Laura M, Bannister, Thomas D
Published in Journal of medicinal chemistry (11.10.2018)
Published in Journal of medicinal chemistry (11.10.2018)
Get full text
Journal Article
Recruitment of β-Arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization
Green, Jill A., Schmid, Cullen L., Bley, Elizabeth, Monsma, Paula C., Brown, Anthony, Bohn, Laura M., Mykytyn, Kirk
Published in Molecular and cellular biology (01.01.2016)
Published in Molecular and cellular biology (01.01.2016)
Get full text
Journal Article
Clozapine Acts as an Agonist at Serotonin 2A Receptors to Counter MK-801-Induced Behaviors through a βArrestin2-Independent Activation of Akt
SCHMID, Cullen L, STREICHER, John M, MELTZER, Herbert Y, BOHN, Laura M
Published in Neuropsychopharmacology (New York, N.Y.) (01.07.2014)
Published in Neuropsychopharmacology (New York, N.Y.) (01.07.2014)
Get full text
Journal Article
Irreversible and noncompetitive mu opioid receptor agonists
Stahl, Edward, Schmid, Cullen L, Acevedo-Canabal, Agnes, Read, Cai, Grim, Travis, Kennedy, Nicole M, Bannister, Thomas D, Bohn, Laura M
Published in The FASEB journal (01.05.2022)
Published in The FASEB journal (01.05.2022)
Get more information
Journal Article