Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates
Foster, Donald J., Brown, Christopher R., Shaikh, Sarfraz, Trapp, Casey, Schlegel, Mark K., Qian, Kun, Sehgal, Alfica, Rajeev, Kallanthottathil G., Jadhav, Vasant, Manoharan, Muthiah, Kuchimanchi, Satya, Maier, Martin A., Milstein, Stuart
Published in Molecular therapy (07.03.2018)
Published in Molecular therapy (07.03.2018)
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Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
Janas, Maja M., Schlegel, Mark K., Harbison, Carole E., Yilmaz, Vedat O., Jiang, Yongfeng, Parmar, Rubina, Zlatev, Ivan, Castoreno, Adam, Xu, Huilei, Shulga-Morskaya, Svetlana, Rajeev, Kallanthottathil G., Manoharan, Muthiah, Keirstead, Natalie D., Maier, Martin A., Jadhav, Vasant
Published in Nature communications (19.02.2018)
Published in Nature communications (19.02.2018)
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Automated glycan assembly using the Glyconeer 2.1 synthesizer
Hahm, Heung Sik, Schlegel, Mark K., Hurevich, Mattan, Eller, Steffen, Schuhmacher, Frank, Hofmann, Johanna, Pagel, Kevin, Seeberger, Peter H.
Published in Proceedings of the National Academy of Sciences - PNAS (25.04.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (25.04.2017)
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siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs
Akabane-Nakata, Masaaki, Erande, Namrata D, Kumar, Pawan, Degaonkar, Rohan, Gilbert, Jason A, Qin, June, Mendez, Martha, Woods, Lauren Blair, Jiang, Yongfeng, Janas, Maja M, O’Flaherty, Derek K, Zlatev, Ivan, Schlegel, Mark K, Matsuda, Shigeo, Egli, Martin, Manoharan, Muthiah
Published in Nucleic acids research (18.03.2021)
Published in Nucleic acids research (18.03.2021)
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Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5′-(R)- and 5′-(S)-C-methyl-guanosine
Mikami, Atsushi, Erande, Namrata, Matsuda, Shigeo, Kel’in, Alexander, Woods, Lauren Blair, Chickering, Tyler, Pallan, Pradeep S, Schlegel, Mark K, Zlatev, Ivan, Egli, Martin, Manoharan, Muthiah
Published in Nucleic acids research (09.10.2020)
Published in Nucleic acids research (09.10.2020)
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Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA
Schlegel, Mark K, Foster, Donald J, Kel’in, Alexander V, Zlatev, Ivan, Bisbe, Anna, Jayaraman, Muthusamy, Lackey, Jeremy G, Rajeev, Kallanthottathil G, Charissé, Klaus, Harp, Joel, Pallan, Pradeep S, Maier, Martin A, Egli, Martin, Manoharan, Muthiah
Published in Journal of the American Chemical Society (28.06.2017)
Published in Journal of the American Chemical Society (28.06.2017)
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RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes
Subramanian, Megha, McIninch, James, Zlatev, Ivan, Schlegel, Mark K., Kaittanis, Charalambos, Nguyen, Tuyen, Agarwal, Saket, Racie, Timothy, Alvarado, Martha Arbaiza, Wassarman, Kelly, Collins, Thomas S., Chickering, Tyler, Brown, Christopher R., Schmidt, Karyn, Castoreno, Adam B., Shulga-Morskaya, Svetlana, Stamenova, Elena, Buckowing, Kira, Berman, Daniel, Barry, Joseph D., Bisbe, Anna, Maier, Martin A., Fitzgerald, Kevin, Jadhav, Vasant
Published in Nature communications (08.04.2023)
Published in Nature communications (08.04.2023)
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Insight into the High Duplex Stability of the Simplified Nucleic Acid GNA
Schlegel, Mark K., Xie, Xiulan, Zhang, Lilu, Meggers, Eric
Published in Angewandte Chemie International Edition (19.01.2009)
Published in Angewandte Chemie International Edition (19.01.2009)
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Metal-mediated base pairing within the simplified nucleic acid GNA
Schlegel, Mark K., Zhang, Lilu, Pagano, Nicholas, Meggers, Eric
Published in Organic & biomolecular chemistry (01.01.2009)
Published in Organic & biomolecular chemistry (01.01.2009)
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Biological Evaluation of Multivalent Lewis X-MGL-1 Interactions
Eriksson, Magdalena, Serna, Sonia, Maglinao, Maha, Schlegel, Mark K., Seeberger, Peter H., Reichardt, Niels-Christian, Lepenies, Bernd
Published in Chembiochem : a European journal of chemical biology (14.04.2014)
Published in Chembiochem : a European journal of chemical biology (14.04.2014)
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Journal Article
On the Structure and Dynamics of Duplex GNA
Johnson, Andrew T, Schlegel, Mark K, Meggers, Eric, Essen, Lars-Oliver, Wiest, Olaf
Published in Journal of organic chemistry (07.10.2011)
Published in Journal of organic chemistry (07.10.2011)
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Journal Article
Duplex Formation of the Simplified Nucleic Acid GNA
Schlegel, Mark K., Peritz, Adam E., Kittigowittana, Krisada, Zhang, Lilu, Meggers, Eric
Published in Chembiochem : a European journal of chemical biology (25.05.2007)
Published in Chembiochem : a European journal of chemical biology (25.05.2007)
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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates
Brown, Kirk M., Nair, Jayaprakash K., Janas, Maja M., Anglero-Rodriguez, Yesseinia I., Dang, Lan T. H., Peng, Haiyan, Theile, Christopher S., Castellanos-Rizaldos, Elena, Brown, Christopher, Foster, Donald, Kurz, Jeffrey, Allen, Jeffrey, Maganti, Rajanikanth, Li, Jing, Matsuda, Shigeo, Stricos, Matthew, Chickering, Tyler, Jung, Michelle, Wassarman, Kelly, Rollins, Jeff, Woods, Lauren, Kelin, Alex, Guenther, Dale C., Mobley, Melissa W., Petrulis, John, McDougall, Robin, Racie, Timothy, Bombardier, Jessica, Cha, Diana, Agarwal, Saket, Johnson, Lei, Jiang, Yongfeng, Lentini, Scott, Gilbert, Jason, Nguyen, Tuyen, Chigas, Samantha, LeBlanc, Sarah, Poreci, Urjana, Kasper, Anne, Rogers, Arlin B., Chong, Saeho, Davis, Wendell, Sutherland, Jessica E., Castoreno, Adam, Milstein, Stuart, Schlegel, Mark K., Zlatev, Ivan, Charisse, Klaus, Keating, Mark, Manoharan, Muthiah, Fitzgerald, Kevin, Wu, Jing-Tao, Maier, Martin A., Jadhav, Vasant
Published in Nature biotechnology (01.10.2022)
Published in Nature biotechnology (01.10.2022)
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Journal Article
Reversal of siRNA-mediated gene silencing in vivo
Zlatev, Ivan, Castoreno, Adam, Brown, Christopher R, Qin, June, Waldron, Scott, Schlegel, Mark K, Degaonkar, Rohan, Shulga-Morskaya, Svetlana, Xu, Huilei, Gupta, Swati, Matsuda, Shigeo, Akinc, Akin, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Maier, Martin A, Jadhav, Vasant
Published in Nature biotechnology (01.07.2018)
Published in Nature biotechnology (01.07.2018)
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RNAs Containing Carbocyclic Ribonucleotides
Akabane-Nakata, Masaaki, Chickering, Tyler, Harp, Joel M, Schlegel, Mark K, Matsuda, Shigeo, Egli, Martin, Manoharan, Muthiah
Published in Organic letters (21.01.2022)
Published in Organic letters (21.01.2022)
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From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization
Schlegel, Mark K, Janas, Maja M, Jiang, Yongfeng, Barry, Joseph D, Davis, Wendell, Agarwal, Saket, Berman, Daniel, Brown, Christopher R, Castoreno, Adam, LeBlanc, Sarah, Liebow, Abigail, Mayo, Tara, Milstein, Stuart, Nguyen, Tuyen, Shulga-Morskaya, Svetlana, Hyde, Sarah, Schofield, Sally, Szeto, John, Woods, Lauren Blair, Yilmaz, Vedat O, Manoharan, Muthiah, Egli, Martin, Charissé, Klaus, Sepp-Lorenzino, Laura, Haslett, Patrick, Fitzgerald, Kevin, Jadhav, Vasant, Maier, Martin A
Published in Nucleic acids research (08.07.2022)
Published in Nucleic acids research (08.07.2022)
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Journal Article
Duplex Structure of a Minimal Nucleic Acid
Schlegel, Mark K, Essen, Lars-Oliver, Meggers, Eric
Published in Journal of the American Chemical Society (02.07.2008)
Published in Journal of the American Chemical Society (02.07.2008)
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Journal Article
Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates
Janas, Maja M, Zlatev, Ivan, Liu, Ju, Jiang, Yongfeng, Barros, Scott A, Sutherland, Jessica E, Davis, Wendell P, Liu, Jingxuan, Brown, Christopher R, Liu, Xiumin, Schlegel, Mark K, Blair, Lauren, Zhang, Xuemei, Das, Biplab, Tran, Chris, Aluri, Krishna, Li, Jing, Agarwal, Saket, Indrakanti, Ramesh, Charisse, Klaus, Nair, Jayaprakash, Matsuda, Shigeo, Rajeev, Kallanthottathil G, Zimmermann, Tracy, Sepp-Lorenzino, Laura, Xu, Yuanxin, Akinc, Akin, Fitzgerald, Kevin, Vaishnaw, Akshay K, Smith, Peter F, Manoharan, Muthiah, Jadhav, Vasant, Wu, Jing-Tao, Maier, Martin A
Published in Nucleic acids research (23.04.2019)
Published in Nucleic acids research (23.04.2019)
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A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation
Maglinao, Maha, Eriksson, Magdalena, Schlegel, Mark K., Zimmermann, Stephanie, Johannssen, Timo, Götze, Sebastian, Seeberger, Peter H., Lepenies, Bernd
Published in Journal of controlled release (10.02.2014)
Published in Journal of controlled release (10.02.2014)
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