Discovery of 4-arylquinoline-2-carboxamides, highly potent and selective class of mGluR2 negative allosteric modulators: From HTS to activity in animal models
Shu, Youheng, Diamond, Tracy L., Hershey, James C., Huang, Shaei, Magliaro, Brian C., O'Brien, Julie A., Schlegel, Kelly-Ann S., Puri, Vanita, Uebele, Victor N., Uslaner, Jason M., Wang, Cheng, Converso, Antonella
Published in Bioorganic & medicinal chemistry letters (01.05.2020)
Published in Bioorganic & medicinal chemistry letters (01.05.2020)
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Discovery of 1,4-Substituted Piperidines as Potent and Selective Inhibitors of T-Type Calcium Channels
Yang, Zhi-Qiang, Barrow, James C, Shipe, William D, Schlegel, Kelly-Ann S, Shu, Youheng, Yang, F. Vivien, Lindsley, Craig W, Rittle, Kenneth E, Bock, Mark G, Hartman, George D, Uebele, Victor N, Nuss, Cindy E, Fox, Steve V, Kraus, Richard L, Doran, Scott M, Connolly, Thomas M, Tang, Cuyue, Ballard, Jeanine E, Kuo, Yuhsin, Adarayan, Emily D, Prueksaritanont, Thomayant, Zrada, Matthew M, Marino, Michael J, Graufelds, Valerie Kuzmick, DiLella, Anthony G, Reynolds, Ian J, Vargas, Hugo M, Bunting, Patricia B, Woltmann, Richard F, Magee, Michael M, Koblan, Kenneth S, Renger, John J
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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Journal Article
Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists
Schlegel, Kelly-Ann S., Yang, Zhi-Qiang, Reger, Thomas S., Shu, Youheng, Cube, Rowena, Rittle, Kenneth E., Bondiskey, Phung, Bock, Mark G., Hartman, George D., Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott M., Fox, Steven V., Garson, Susan L., Kraus, Richard L., Li, Yuxing, Uebele, Victor N., Renger, John J., Barrow, James C.
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
Pyridyl amides as potent inhibitors of T-type calcium channels
Reger, Thomas S., Yang, Zhi-Qiang, Schlegel, Kelly-Ann S., Shu, Youheng, Mattern, Christa, Cube, Rowena, Rittle, Kenneth E., McGaughey, Georgia B., Hartman, George D., Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott M., Fox, Steven V., Garson, Susan L., Li, Yuxing, Kraus, Richard L., Uebele, Victor N., Renger, John J., Barrow, James C.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists
Uebele, Victor N, Nuss, Cindy E, Fox, Steven V, Garson, Susan L, Cristescu, Razvan, Doran, Scott M, Kraus, Richard L, Santarelli, Vincent P, Li, Yuxing, Barrow, James C, Yang, Zhi-Qiang, Schlegel, Kelly-Ann S, Rittle, Kenneth E, Reger, Thomas S, Bednar, Rodney A, Lemaire, Wei, Mullen, Faith A, Ballard, Jeanine E, Tang, Cuyue, Dai, Ge, McManus, Owen B, Koblan, Kenneth S, Renger, John J
Published in Cell biochemistry and biophysics (01.11.2009)
Published in Cell biochemistry and biophysics (01.11.2009)
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Journal Article
Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators
Perkins, James J., McQuade, Paul, Bungard, Christopher J., Diamond, Tracy L., Gantert, Liza T., Gotter, Anthony L., Hanney, Barbara, Hills, Ivory D., Hurzy, Danielle M., Joshi, Aniket, Kern, Jonathan T., Schlegel, Kelly-Ann S., Manikowski, Jesse J., Meng, Zhaoyang, O’Brien, Julie A., Roecker, Anthony J., Smith, Sean M., Uslaner, Jason M., Hostetler, Eric, Meissner, Robert S.
Published in ACS medicinal chemistry letters (13.07.2023)
Published in ACS medicinal chemistry letters (13.07.2023)
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Journal Article
Short-Acting T-Type Calcium Channel Antagonists Significantly Modify Sleep Architecture in Rodents
Yang, Zhi-Qiang, Schlegel, Kelly-Ann S, Shu, Youheng, Reger, Thomas S, Cube, Rowena, Mattern, Christa, Coleman, Paul J, Small, Jim, Hartman, George D, Ballard, Jeanine, Tang, Cuyue, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E, Doran, Scott, Fox, Steve V, Garson, Susan L, Li, Yuxing, Kraus, Richard L, Uebele, Victor N, Taylor, Adekemi B, Zeng, Wei, Fang, Wei, Chavez-Eng, Cynthia, Troyer, Matthew D, Luk, Julie Ann, Laethem, Tine, Cook, William O, Renger, John J, Barrow, James C
Published in ACS medicinal chemistry letters (09.12.2010)
Published in ACS medicinal chemistry letters (09.12.2010)
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Journal Article
Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure–Activity Relationships
Plotkin, Michael A., Labroli, Marc, Schubert, Jeffrey, Shaw, Anthony, Schlegel, Kelly-Ann S., Berger, Richard, Cooke, Andrew J., Hayes, Robert P., Armacost, Kira A., Kinek, Keith, Krosky, Paula, Burlein, Christine, Meng, Shi, DiNunzio, Edward, Murray, Edward M., Agrawal, Sony, Madeira, Maria, Flattery, Amy, Yao, Huifang, Leithead, Andrew, Rose, William A, Cox, Christopher, Tellers, David M., McKenna, Philip M., Raheem, Izzat
Published in ACS medicinal chemistry letters (08.08.2024)
Published in ACS medicinal chemistry letters (08.08.2024)
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Identification of potent inhibitors of the sortilin-progranulin interaction
Stachel, Shawn J., Ginnetti, Anthony T., Johnson, Scott A., Cramer, Paige, Wang, Yi, Bukhtiyarova, Marina, Krosky, Daniel, Stump, Craig, Hurzy, Danielle M., Schlegel, Kelly-Ann, Cooke, Andrew J., Allen, Samantha, O'Donnell, Gregory, Ziebell, Michael, Parthasarathy, Gopal, Getty, Krista L., Ho, Thu, Ou, Yangsi, Jovanovska, Aneta, Carroll, Steve S., Pausch, Mark, Lumb, Kevin, Mosser, Scott D., Voleti, Bhavya, Klein, Daniel J., Soisson, Stephen M., Zerbinatti, Celina, Coleman, Paul J.
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
Published in Bioorganic & medicinal chemistry letters (01.09.2020)
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Journal Article
Discovery of [ 11 C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR 2 Negative Allosteric Modulators
Perkins, James J, McQuade, Paul, Bungard, Christopher J, Diamond, Tracy L, Gantert, Liza T, Gotter, Anthony L, Hanney, Barbara, Hills, Ivory D, Hurzy, Danielle M, Joshi, Aniket, Kern, Jonathan T, Schlegel, Kelly-Ann S, Manikowski, Jesse J, Meng, Zhaoyang, O'Brien, Julie A, Roecker, Anthony J, Smith, Sean M, Uslaner, Jason M, Hostetler, Eric, Meissner, Robert S
Published in ACS medicinal chemistry letters (13.07.2023)
Published in ACS medicinal chemistry letters (13.07.2023)
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Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca(2+) channel antagonist
Shipe, William D., Barrow, James C., Yang, Zhi-Qiang, Lindsley, Craig W., Yang, F. Vivien, Schlegel, Kelly-Ann S., Shu, Youheng, Rittle, Kenneth E., Bock, Mark G., Hartman, George D., Tang, Cuyue, Ballard, Jeanine E., Kuo, Yuhsin, Adarayan, Emily D., Prueksaritanont, Thomayant, Zrada, Matthew M., Uebele, Victor N., Nuss, Cindy E., Connolly, Thomas M., Doran, Scott M., Fox, Steven V., Kraus, Richard L., Marino, Michael J., Gratifelds, Valerie Kuzmick, Vargas, Hugo M., Bunting, Patricia B., Hasbun-Manning, Martha, Evans, Rose M., Koblan, Kenneth S., Renger, John J.
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
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Journal Article
Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc‑1 Inhibitors Distinct from Traditional High Throughput Screening
Kutchukian, Peter S, Warren, Lee, Magliaro, Brian C, Amoss, Adam, Cassaday, Jason A, O’Donnell, Gregory, Squadroni, Brian, Zuck, Paul, Pascarella, Danette, Culberson, J. Chris, Cooke, Andrew J, Hurzy, Danielle, Schlegel, Kelly-Ann Sondra, Thomson, Fiona, Johnson, Eric N, Uebele, Victor N, Hermes, Jeffrey D, Parmentier-Batteur, Sophie, Finley, Michael
Published in ACS chemical biology (17.02.2017)
Published in ACS chemical biology (17.02.2017)
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Journal Article
Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+ Channel Antagonist
Shipe, William D, Barrow, James C, Yang, Zhi-Qiang, Lindsley, Craig W, Yang, F. Vivien, Schlegel, Kelly-Ann S, Shu, Youheng, Rittle, Kenneth E, Bock, Mark G, Hartman, George D, Tang, Cuyue, Ballard, Jeanine E, Kuo, Yuhsin, Adarayan, Emily D, Prueksaritanont, Thomayant, Zrada, Matthew M, Uebele, Victor N, Nuss, Cindy E, Connolly, Thomas M, Doran, Scott M, Fox, Steven V, Kraus, Richard L, Marino, Michael J, Graufelds, Valerie Kuzmick, Vargas, Hugo M, Bunting, Patricia B, Hasbun-Manning, Martha, Evans, Rose M, Koblan, Kenneth S, Renger, John J
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
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Journal Article
Discovery of 11CMK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators
Perkins, James J, McQuade, Paul, Bungard, Christopher J, Diamond, Tracy L, Gantert, Liza T, Gotter, Anthony L, Hanney, Barbara, Hills, Ivory D, Hurzy, Danielle M, Joshi, Aniket, Kern, Jonathan T, Schlegel, Kelly-Ann S, Manikowski, Jesse J, Meng, Zhaoyang, O'Brien, Julie A, Roecker, Anthony J, Smith, Sean M, Uslaner, Jason M, Hostetler, Eric, Meissner, Robert S
Published in ACS medicinal chemistry letters (13.07.2023)
Published in ACS medicinal chemistry letters (13.07.2023)
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Journal Article
Discovery of [C-11]MK-8056: A Selective PET Imaging Agent for the Study of mGluR(2) Negative Allosteric Modulators
Perkins, James J. J., McQuade, Paul, Bungard, Christopher J. J., Diamond, Tracy L. L., Gantert, Liza T. T., Gotter, Anthony L. L., Hanney, Barbara, Hills, Ivory D. D., Hurzy, Danielle M. M., Joshi, Aniket, Kern, Jonathan T. T., Schlegel, Kelly-Ann S., Manikowski, Jesse J. J., Meng, Zhaoyang, O'Brien, Julie A. A., Roecker, Anthony J. J., Smith, Sean M. M., Uslaner, Jason M. M., Hostetler, Eric, Meissner, Robert S. S.
Published in ACS medicinal chemistry letters (13.06.2023)
Published in ACS medicinal chemistry letters (13.06.2023)
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Journal Article
HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS
BARROW JAMES C, COLEMAN PAUL J, YANG ZHI QIANG, SHU YOUHENG, REGER THOMAS S, SCHLEGEL KELLY ANN S
Year of Publication 30.06.2010
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Year of Publication 30.06.2010
Patent
Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca 2+ Channel Antagonist
Shipe, William D., Barrow, James C., Yang, Zhi-Qiang, Lindsley, Craig W., Yang, F. Vivien, Schlegel, Kelly-Ann S., Shu, Youheng, Rittle, Kenneth E., Bock, Mark G., Hartman, George D., Tang, Cuyue, Ballard, Jeanine E., Kuo, Yuhsin, Adarayan, Emily D., Prueksaritanont, Thomayant, Zrada, Matthew M., Uebele, Victor N., Nuss, Cindy E., Connolly, Thomas M., Doran, Scott M., Fox, Steven V., Kraus, Richard L., Marino, Michael J., Graufelds, Valerie Kuzmick, Vargas, Hugo M., Bunting, Patricia B., Hasbun-Manning, Martha, Evans, Rose M., Koblan, Kenneth S., Renger, John J.
Published in Journal of medicinal chemistry (01.07.2008)
Published in Journal of medicinal chemistry (01.07.2008)
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Journal Article
3-ARYL AND HETEROARYL SUBSTITUTED 5-TRIFLUOROMETHYL OXADIAZOLES AS HISTONE DEACETYLASE 6 (HDAC6) INHIBITORS
WALJI, Abbas, WANG, Deping, MULHEARN, James, J, JONES, Kristen, G, STUMP, Craig, A, FRALEY, Mark, E, BERGER, Richard, SCHLEGEL, Kelly Ann, S, GRESHOCK, Thomas, J
Year of Publication 10.04.2024
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Year of Publication 10.04.2024
Patent