Search Results - "Schlachter, Stephen, T" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

3‑[(1S,2S,3R)‑2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma

3‑[(1S,2S,3R)‑2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma

by Xu, Rui, Wang, Keshi, Rizzi, James P, Huang, Heli, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Wehn, Paul M, Yang, Hanbiao, Dixon, Darryl D, Czerwinski, Robert M, Du, Xinlin, Ged, Emily L, Han, Guangzhou, Tan, Huiling, Wong, Tai, Xie, Shanhai, Josey, John A, Wallace, Eli M
Published in Journal of medicinal chemistry (08.08.2019)

Get full text

Journal Article

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

by Wallace, Eli M, Rizzi, James P, Han, Guangzhou, Wehn, Paul M, Cao, Zhaodan, Du, Xinlin, Cheng, Tzuling, Czerwinski, Robert M, Dixon, Darryl D, Goggin, Barry S, Grina, Jonas A, Halfmann, Megan M, Maddie, Melissa A, Olive, Sarah R, Schlachter, Stephen T, Tan, Huiling, Wang, Bin, Wang, Keshi, Xie, Shanhai, Xu, Rui, Yang, Hanbiao, Josey, John A
Published in Cancer research (Chicago, Ill.) (15.09.2016)

Get full text

Journal Article

DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer

DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer

by Kashishian, Adam, Douangpanya, Heather, Clark, Darcey, Schlachter, Stephen T, Eary, C Todd, Schiro, Justin G, Huang, Hongmei, Burgess, Larry E, Kesicki, Edward A, Halbrook, James
Published in Molecular cancer therapeutics (01.12.2003)

Get full text

Journal Article

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)‑3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro‑1H‑inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)‑3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro‑1H‑inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

by Wehn, Paul M, Rizzi, James P, Dixon, Darryl D, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Cao, Zhaodan, Cheng, Tzuling, Czerwinski, Robert M, Goggin, Barry S, Huang, Heli, Halfmann, Megan M, Maddie, Melissa A, Morton, Emily L, Olive, Sarah R, Tan, Huiling, Xie, Shanhai, Wong, Tai, Josey, John A, Wallace, Eli M
Published in Journal of medicinal chemistry (08.11.2018)

Get full text

Journal Article

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

by Wehn, Paul M, Rizzi, James P, Dixon, Darryl D, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Cao, Zhaodan, Cheng, Tzuling, Czerwinski, Robert M, Goggin, Barry S, Huang, Heli, Halfmann, Megan M, Maddie, Melissa A, Morton, Emily L, Olive, Sarah R, Tan, Huiling, Xie, Shanhai, Wong, Tai, Josey, John A, Wallace, Eli M
Published in Journal of medicinal chemistry (08.11.2018)

Get full text

Journal Article

Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an Olp→πAr interaction

Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an Olp→πAr interaction

by Wehn, Paul M., Yang, Song, Grina, Jonas A., Rizzi, James P., Schlachter, Stephen T., Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Czerwinski, Robert M., Ged, Emily L., Huang, Heli, Halfmann, Megan M., Maddie, Melissa A., Morton, Emily R., Olive, Sarah R., Tan, Huiling, Xie, Shanhai, Josey, John A., Wallace, Eli M.
Published in Medicinal chemistry research (01.07.2023)

Get full text

Journal Article

Discovery of a Novel Class of Imidazo[1,2‑a]Pyridines with Potent PDGFR Activity and Oral Bioavailability

Discovery of a Novel Class of Imidazo[1,2‑a]Pyridines with Potent PDGFR Activity and Oral Bioavailability

by Hicken, Erik J, Marmsater, Fred P, Munson, Mark C, Schlachter, Stephen T, Robinson, John E, Allen, Shelley, Burgess, Laurence E, DeLisle, Robert Kirk, Rizzi, James P, Topalov, George T, Zhao, Qian, Hicks, Julie M, Kallan, Nicholas C, Tarlton, Eugene, Allen, Andrew, Callejo, Michele, Cox, April, Rana, Sumeet, Klopfenstein, Nathalie, Woessner, Richard, Lyssikatos, Joseph P
Published in ACS medicinal chemistry letters (09.01.2014)

Get full text

Journal Article

Carbonyl-Containing Bisphosphonate Esters as Novel Antiinflammatory and Antiarthritic Agents

Carbonyl-Containing Bisphosphonate Esters as Novel Antiinflammatory and Antiarthritic Agents

by Nugent, Richard A, Schlachter, Stephen T, Murphy, Megan, Dunn, Colin J, Staite, Nigel D, Galinet, Louise A, Shields, Sharon K, Wu, Haiyan, Aspar, Danielle G, Richard, Karen A
Published in Journal of medicinal chemistry (01.12.1994)

Get full text

Journal Article

Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

by Nugent, Richard A, Schlachter, Stephen T, Murphy, Michael J, Cleek, Gary J, Poel, Toni J, Wishka, Donn G, Graber, David R, Yagi, Yoshihiko, Keiser, Barbara J, Olmsted, Robert A, Kopta, Laurie A, Swaney, Steven M, Poppe, Susan M, Morris, Joel, Tarpley, W. Gary, Thomas, Richard C
Published in Journal of medicinal chemistry (24.09.1998)

Get full text

Journal Article

Pyrazoline bisphosphonate esters as novel antiinflammatory and antiarthritic agents

Pyrazoline bisphosphonate esters as novel antiinflammatory and antiarthritic agents

by Nugent, Richard A., Murphy, Megan, Schlachter, Stephen T., Dunn, Colin J., Smith, Robert J., Staite, Nigel D., Galinet, Louise A., Shields, Sharon K., Aspar, Danielle G., Richard, Karen A., Rohloff, Norman A.
Published in Journal of medicinal chemistry (1993)

Get full text

Journal Article

ARYL ETHERS AND USES THEREOF

ARYL ETHERS AND USES THEREOF

by JOSEY JOHN A, DIXON DARRYL DAVID, YANG HANBIAO, GRINA JONAS, SCHLACHTER STEPHEN T, XU RUI, WALLACE ELI M, WEHN PAUL, RIZZI JAMES P, WANG BIN
Year of Publication 17.05.2016

Get full text

Patent

PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

by HENTEMANN MARTIN F, SCHLACHTER STEPHEN T, XIAO DENGMING, LIANG JUN, GRAHAM JAMES M, BLAKE JAMES F, SPENCER KEITH L, BENCSIK JOSEF, MITCHELL IAN S, XU RUI, SAFINA BRIAN S, WELCH MIKE, KALLAN NICHOLAS C
Year of Publication 04.08.2015

Get full text

Patent

5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES

5,7-SUBSTITUTED-IMIDAZO[1,2-C]PYRIMIDINES

by MORENO DAVID A, SCHLACHTER STEPHEN T, HARVEY DARREN, BOYS MARK LAURENCE, GRONEBERG ROBERT, KRASER CHRISTOPHER F, HACHE BRUNO P, HICKEN ERIK JAMES, ROBINSON JOHN E, REN LI, LAIRD ELLEN, MUNSON MARK C, BURGESS LAURENCE E, EARY C. TODD
Year of Publication 20.06.2014

Get full text

Patent

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

by SCHLACHTER STEPHEN T, XIAO DENGMING, SAFINA BRIAN, BENCSIK JOSEF R, LIANG JUN, BANKA ANNA L, BLAKE JAMES F, MITCHELL IAN S, XU RUI, CHABOT CHRISTINE, ZHANG BIRONG, DO STEVEN, WALLACE ELI M, SPENCER KEITH LEE, KALLAN NICHOLAS C
Year of Publication 11.05.2015

Get full text

Patent

AKT-PROTEIN KINASE INHIBITOR HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINE

AKT-PROTEIN KINASE INHIBITOR HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINE

by SCHLACHTER STEPHEN T, XIAO DENGMING, SAFINA BRIAN, BENCSIK JOSEF R, LIANG JUN, BANKA ANNA L, BLAKE JAMES F, MITCHELL IAN S, CHABOT CHRISTINE, ZHANG BIRONG, DO STEVEN, SPENCER KEITH LEE, RUI XU, WALLACE ELI W, KALLEN NICHOLAS C
Year of Publication 11.12.2014

Get full text

Patent

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

by SCHLACHTER STEPHEN T, XIAO DENGMING, SAFINA BRIAN, BENCSIK JOSEF R, LIANG JUN, BANKA ANNA L, BLAKE JAMES F, MITCHELL IAN S, XU RUI, CHABOT CHRISTINE, ZHANG BIRONG, DO STEVEN, WALLACE ELI M, SPENCER KEITH LEE, KALLAN NICHOLAS C
Year of Publication 25.07.2014

Get full text

Patent

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

by SCHLACHTER STEPHEN T, XIAO DENGMING, SAFINA BRIAN, BENCSIK JOSEF R, LIANG JUN, BANKA ANNA L, BLAKE JAMES F, MITCHELL IAN S, XU RUI, CHABOT CHRISTINE, ZHANG BIRONG, DO STEVEN, WALLACE ELI M, SPENCER KEITH LEE, KALLAN NICHOLAS C
Year of Publication 26.12.2013

Get full text

Patent

Abstract B140: PT2977, a novel HIF-2a antagonist, has potent antitumor activity and remodels the immunosuppressive tumor microenvironment in clear cell renal cell cancer

Abstract B140: PT2977, a novel HIF-2a antagonist, has potent antitumor activity and remodels the immunosuppressive tumor microenvironment in clear cell renal cell cancer

by Wong, Tai W., Shrimali, Rajeev, Contreras, Cristina, Cheng, Tzuling, Czerwinski, Robert M., Dixon, Daryl D., Du, Xinlin, Fett, Craig, Goree, Jessica, Grina, Jonas A., Han, Guangzhou, Huang, Heli, Rizzi, Jim, Schlachter, Stephen T., Wang, Bin, Wang, Keshi, Wehn, Paul M., Xie, Shanhai, Xu, Rui, Yang, Hanbiao, Josey, John A., Wallace, Eli M.
Published in Molecular cancer therapeutics (01.01.2018)

Get full text

Journal Article

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

by SCHLACHTER STEPHEN T, XIAO DENGMING, SAFINA BRIAN, BENCSIK JOSEF R, LIANG JUN, BANKA ANNA L, BLAKE JAMES F, MITCHELL IAN S, XU RUI, CHABOT CHRISTINE, ZHANG BIRONG, DO STEVEN, WALLACE ELI M, SPENCER KEITH LEE, KALLAN NICHOLAS C
Year of Publication 22.03.2013

Get full text

Patent

PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

by HENTEMANN MARTIN F, SCHLACHTER STEPHEN T, XIAO DENGMING, LIANG JUN, GRAHAM JAMES M, BLAKE JAMES F, SPENCER KEITH L, BENCSIK JOSEF, MITCHELL IAN S, XU RUI, SAFINA BRIAN S, WELCH MIKE, KALLAN NICHOLAS C
Year of Publication 30.04.2010

Get full text

Patent

1
2
3
4
5
6
7
8
9
10
11
Next
[20]