The Mechanism-Based Inactivation of CYP3A4 by Ritonavir: What Mechanism?
Loos, Nancy H. C., Beijnen, Jos H., Schinkel, Alfred H.
Published in International journal of molecular sciences (01.09.2022)
Published in International journal of molecular sciences (01.09.2022)
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Journal Article
Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar
Chuan Tang, Seng, Nguyen, Luan N., Sparidans, Rolf W., Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.
Published in International journal of cancer (15.03.2014)
Published in International journal of cancer (15.03.2014)
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Journal Article
Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions
Ciarimboli, Giuliano, Deuster, Dirk, Knief, Arne, Sperling, Michael, Holtkamp, Michael, Edemir, Bayram, Pavenstädt, Hermann, Lanvers-Kaminsky, Claudia, am Zehnhoff-Dinnesen, Antoinette, Schinkel, Alfred H, Koepsell, Hermann, Jürgens, Heribert, Schlatter, Eberhard
Published in The American journal of pathology (01.03.2010)
Published in The American journal of pathology (01.03.2010)
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Journal Article
Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2)
Kort, Anita, Sparidans, Rolf W., Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.
Published in Pharmacological research (01.12.2015)
Published in Pharmacological research (01.12.2015)
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Journal Article
Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1)
Kort, Anita, Durmus, Selvi, Sparidans, Rolf W., Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.
Published in Pharmaceutical research (01.07.2015)
Published in Pharmaceutical research (01.07.2015)
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Journal Article
Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation
van Hoppe, Stéphanie, Sparidans, Rolf W., Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.
Published in Pharmacological research (01.06.2017)
Published in Pharmacological research (01.06.2017)
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Journal Article
Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice
Slijepcevic, Davor, Roscam Abbing, Reinout L.P., Katafuchi, Takeshi, Blank, Antje, Donkers, Joanne M., van Hoppe, Stéphanie, de Waart, Dirk. R., Tolenaars, Dagmar, van der Meer, Jonathan H.M., Wildenberg, Manon, Beuers, Ulrich, Oude Elferink, Ronald P.J., Schinkel, Alfred H., van de Graaf, Stan F.J.
Published in Hepatology (Baltimore, Md.) (01.11.2017)
Published in Hepatology (Baltimore, Md.) (01.11.2017)
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Journal Article
Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein)
van Hoppe, Stéphanie, Jamalpoor, Amer, Rood, Johannes J.M., Wagenaar, Els, Sparidans, Rolf W., Beijnen, Jos H., Schinkel, Alfred H.
Published in Pharmacological research (01.08.2019)
Published in Pharmacological research (01.08.2019)
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Journal Article
Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) Restrict Oral Availability and Brain Accumulation of the PARP Inhibitor Rucaparib (AG-014699)
Durmus, Selvi, Sparidans, Rolf W., van Esch, Anita, Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.
Published in Pharmaceutical research (01.01.2015)
Published in Pharmaceutical research (01.01.2015)
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Journal Article
Influence of Human OATP1B1, OATP1B3, and OATP1A2 on the Pharmacokinetics of Methotrexate and Paclitaxel in Humanized Transgenic Mice
DE STEEG, Evita Van, ESCH, Anita Van, WAGENAAR, Els, KENWORTHY, Kathryn E, SCHINKEL, Alfred H
Published in Clinical cancer research (15.02.2013)
Published in Clinical cancer research (15.02.2013)
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Journal Article
Apical ABC Transporters and Cancer Chemotherapeutic Drug Disposition
Durmus, Selvi, Hendrikx, Jeroen J M A, Schinkel, Alfred H
Published in ABC Transporters and Cancer (2015)
Published in ABC Transporters and Cancer (2015)
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Book Chapter
Journal Article
Ochratoxin A transport by the human breast cancer resistance protein (BCRP), multidrug resistance protein 2 (MRP2), and organic anion-transporting polypeptides 1A2, 1B1 and 2B1
Qi, Xiaozhe, Wagenaar, Els, Xu, Wentao, Huang, Kunlun, Schinkel, Alfred H.
Published in Toxicology and applied pharmacology (15.08.2017)
Published in Toxicology and applied pharmacology (15.08.2017)
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Journal Article
Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b
Vasilyeva, Aksana, Durmus, Selvi, Li, Lie, Wagenaar, Els, Hu, Shuiying, Gibson, Alice A, Panetta, John C, Mani, Sridhar, Sparreboom, Alex, Baker, Sharyn D, Schinkel, Alfred H
Published in Cancer research (Chicago, Ill.) (01.07.2015)
Published in Cancer research (Chicago, Ill.) (01.07.2015)
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Journal Article
Functions of OATP1A and 1B transporters in vivo: insights from mouse models
Iusuf, Dilek, van de Steeg, Evita, Schinkel, Alfred H
Published in Trends in pharmacological sciences (Regular ed.) (01.02.2012)
Published in Trends in pharmacological sciences (Regular ed.) (01.02.2012)
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Journal Article
ABCB1 attenuates brain exposure to the KRASG12C inhibitor opnurasib whereas binding to mouse carboxylesterase 1c influences its plasma exposure
Rijmers, Jamie, Retmana, Irene A., Bui, Viët, Arguedas, Davinia, Lebre, Maria C., Sparidans, Rolf W., Beijnen, Jos H., Schinkel, Alfred H.
Published in Biomedicine & pharmacotherapy (01.06.2024)
Published in Biomedicine & pharmacotherapy (01.06.2024)
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Journal Article