Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo
Kato, Yu, Abbott, Robert K., Freeman, Brian L., Haupt, Sonya, Groschel, Bettina, Silva, Murillo, Menis, Sergey, Irvine, Darrell J., Schief, William R., Crotty, Shane
Published in Immunity (Cambridge, Mass.) (15.09.2020)
Published in Immunity (Cambridge, Mass.) (15.09.2020)
Get full text
Journal Article
Role of nanoscale antigen organization on B-cell activation probed using DNA origami
Veneziano, Rémi, Moyer, Tyson J., Stone, Matthew B., Wamhoff, Eike-Christian, Read, Benjamin J., Mukherjee, Sayak, Shepherd, Tyson R., Das, Jayajit, Schief, William R., Irvine, Darrell J., Bathe, Mark
Published in Nature nanotechnology (01.08.2020)
Published in Nature nanotechnology (01.08.2020)
Get full text
Journal Article
RosettaAntibodyDesign (RAbD): A general framework for computational antibody design
Adolf-Bryfogle, Jared, Kalyuzhniy, Oleks, Kubitz, Michael, Weitzner, Brian D, Hu, Xiaozhen, Adachi, Yumiko, Schief, William R, Dunbrack, Jr, Roland L
Published in PLoS computational biology (01.04.2018)
Published in PLoS computational biology (01.04.2018)
Get full text
Journal Article
Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers
Tokatlian, Talar, Read, Benjamin J, Jones, Christopher A, Kulp, Daniel W, Menis, Sergey, Chang, Jason Y H, Steichen, Jon M, Kumari, Sudha, Allen, Joel D, Dane, Eric L, Liguori, Alessia, Sangesland, Maya, Lingwood, Daniel, Crispin, Max, Schief, William R, Irvine, Darrell J
Published in Science (American Association for the Advancement of Science) (08.02.2019)
Published in Science (American Association for the Advancement of Science) (08.02.2019)
Get full text
Journal Article
Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen
Jardine, Joseph G., Ota, Takayuki, Sok, Devin, Pauthner, Matthias, Kulp, Daniel W., Kalyuzhniy, Oleksandr, Skog, Patrick D., Thinnes, Theresa C., Bhullar, Deepika, Briney, Bryan, Menis, Sergey, Jones, Meaghan, Kubitz, Mike, Spencer, Skye, Adachi, Yumiko, Burton, Dennis R., Schief, William R., Nemazee, David
Published in Science (American Association for the Advancement of Science) (10.07.2015)
Published in Science (American Association for the Advancement of Science) (10.07.2015)
Get full text
Journal Article
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
Jardine, Joseph, Julien, Jean-Philippe, Menis, Sergey, Ota, Takayuki, Kalyuzhniy, Oleksandr, McGuire, Andrew, Sok, Devin, Huang, Po-Ssu, MacPherson, Skye, Jones, Meaghan, Nieusma, Travis, Mathison, John, Baker, David, Ward, Andrew B., Burton, Dennis R., Stamatatos, Leonidas, Nemazee, David, Wilson, Ian A., Schief, William R.
Published in Science (American Association for the Advancement of Science) (10.05.2013)
Published in Science (American Association for the Advancement of Science) (10.05.2013)
Get full text
Journal Article
HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies
Steichen, Jon M., Kulp, Daniel W., Tokatlian, Talar, Escolano, Amelia, Dosenovic, Pia, Stanfield, Robyn L., McCoy, Laura E., Ozorowski, Gabriel, Hu, Xiaozhen, Kalyuzhniy, Oleksandr, Briney, Bryan, Schiffner, Torben, Garces, Fernando, Freund, Natalia T., Gitlin, Alexander D., Menis, Sergey, Georgeson, Erik, Kubitz, Michael, Adachi, Yumiko, Jones, Meaghan, Mutafyan, Andrew A., Yun, Dong Soo, Mayer, Christian T., Ward, Andrew B., Burton, Dennis R., Wilson, Ian A., Irvine, Darrell J., Nussenzweig, Michel C., Schief, William R.
Published in Immunity (Cambridge, Mass.) (20.09.2016)
Published in Immunity (Cambridge, Mass.) (20.09.2016)
Get full text
Journal Article
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
Jardine, Joseph G., Kulp, Daniel W., Havenar-Daughton, Colin, Sarkar, Anita, Briney, Bryan, Sok, Devin, Sesterhenn, Fabian, Ereño-Orbea, June, Kalyuzhniy, Oleksandr, Deresa, Isaiah, Hu, Xiaozhen, Spencer, Skye, Jones, Meaghan, Georgeson, Erik, Adachi, Yumiko, Kubitz, Michael, deCamp, Allan C., Julien, Jean-Philippe, Wilson, Ian A., Burton, Dennis R., Crotty, Shane, Schief, William R.
Published in Science (American Association for the Advancement of Science) (25.03.2016)
Published in Science (American Association for the Advancement of Science) (25.03.2016)
Get full text
Journal Article
Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches
Pauthner, Matthias, Havenar-Daughton, Colin, Sok, Devin, Nkolola, Joseph P., Bastidas, Raiza, Boopathy, Archana V., Carnathan, Diane G., Chandrashekar, Abishek, Cirelli, Kimberly M., Cottrell, Christopher A., Eroshkin, Alexey M., Guenaga, Javier, Kaushik, Kirti, Kulp, Daniel W., Liu, Jinyan, McCoy, Laura E., Oom, Aaron L., Ozorowski, Gabriel, Post, Kai W., Sharma, Shailendra K., Steichen, Jon M., de Taeye, Steven W., Tokatlian, Talar, Torrents de la Peña, Alba, Butera, Salvatore T., LaBranche, Celia C., Montefiori, David C., Silvestri, Guido, Wilson, Ian A., Irvine, Darrell J., Sanders, Rogier W., Schief, William R., Ward, Andrew B., Wyatt, Richard T., Barouch, Dan H., Crotty, Shane, Burton, Dennis R.
Published in Immunity (Cambridge, Mass.) (20.06.2017)
Published in Immunity (Cambridge, Mass.) (20.06.2017)
Get full text
Journal Article
HIV-1 neutralizing antibodies induced by native-like envelope trimers
Sanders, Rogier W., van Gils, Marit J., Derking, Ronald, Sok, Devin, Ketas, Thomas J., Burger, Judith A., Ozorowski, Gabriel, Cupo, Albert, Simonich, Cassandra, Goo, Leslie, Arendt, Heather, Kim, Helen J., Lee, Jeong Hyun, Pugach, Pavel, Williams, Melissa, Debnath, Gargi, Moldt, Brian, van Breemen, Mariëlle J., Isik, Gözde, Medina-Ramírez, Max, Back, Jaap Willem, Koff, Wayne C., Julien, Jean-Philippe, Rakasz, Eva G., Seaman, Michael S., Guttman, Miklos, Lee, Kelly K., Klasse, Per Johan, LaBranche, Celia, Schief, William R., Wilson, Ian A., Overbaugh, Julie, Burton, Dennis R., Ward, Andrew B., Montefiori, David C., Dean, Hansi, Moore, John P.
Published in Science (American Association for the Advancement of Science) (10.07.2015)
Published in Science (American Association for the Advancement of Science) (10.07.2015)
Get full text
Journal Article
Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies
McCoy, Laura E., van Gils, Marit J., Ozorowski, Gabriel, Messmer, Terrence, Briney, Bryan, Voss, James E., Kulp, Daniel W., Macauley, Matthew S., Sok, Devin, Pauthner, Matthias, Menis, Sergey, Cottrell, Christopher A., Torres, Jonathan L., Hsueh, Jessica, Schief, William R., Wilson, Ian A., Ward, Andrew B., Sanders, Rogier W., Burton, Dennis R.
Published in Cell reports (Cambridge) (30.08.2016)
Published in Cell reports (Cambridge) (30.08.2016)
Get full text
Journal Article
Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies
Briney, Bryan, Sok, Devin, Jardine, Joseph G., Kulp, Daniel W., Skog, Patrick, Menis, Sergey, Jacak, Ronald, Kalyuzhniy, Oleksandr, de Val, Natalia, Sesterhenn, Fabian, Le, Khoa M., Ramos, Alejandra, Jones, Meaghan, Saye-Francisco, Karen L., Blane, Tanya R., Spencer, Skye, Georgeson, Erik, Hu, Xiaozhen, Ozorowski, Gabriel, Adachi, Yumiko, Kubitz, Michael, Sarkar, Anita, Wilson, Ian A., Ward, Andrew B., Nemazee, David, Burton, Dennis R., Schief, William R.
Published in Cell (08.09.2016)
Published in Cell (08.09.2016)
Get full text
Journal Article
Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
McGuire, Andrew T, Hoot, Sam, Dreyer, Anita M, Lippy, Adriana, Stuart, Andrew, Cohen, Kristen W, Jardine, Joseph, Menis, Sergey, Scheid, Johannes F, West, Anthony P, Schief, William R, Stamatatos, Leonidas
Published in The Journal of experimental medicine (08.04.2013)
Published in The Journal of experimental medicine (08.04.2013)
Get full text
Journal Article
Global site-specific N-glycosylation analysis of HIV envelope glycoprotein
Cao, Liwei, Diedrich, Jolene K., Kulp, Daniel W., Pauthner, Matthias, He, Lin, Park, Sung-Kyu Robin, Sok, Devin, Su, Ching Yao, Delahunty, Claire M., Menis, Sergey, Andrabi, Raiees, Guenaga, Javier, Georgeson, Erik, Kubitz, Michael, Adachi, Yumiko, Burton, Dennis R., Schief, William R., Yates III, John R., Paulson, James C.
Published in Nature communications (28.03.2017)
Published in Nature communications (28.03.2017)
Get full text
Journal Article
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
Wu, Xueling, Yang, Zhi-Yong, Li, Yuxing, Hogerkorp, Carl-Magnus, Schief, William R, Seaman, Michael S, Zhou, Tongqing, Schmidt, Stephen D, Wu, Lan, Xu, Ling, Longo, Nancy S, McKee, Krisha, O'Dell, Sijy, Louder, Mark K, Wycuff, Diane L, Feng, Yu, Nason, Martha, Doria-Rose, Nicole, Connors, Mark, Kwong, Peter D, Roederer, Mario, Wyatt, Richard T, Nabel, Gary J, Mascola, John R
Published in Science (American Association for the Advancement of Science) (13.08.2010)
Published in Science (American Association for the Advancement of Science) (13.08.2010)
Get full text
Journal Article
RosettaRemodel: a generalized framework for flexible backbone protein design
Huang, Po-Ssu, Ban, Yih-En Andrew, Richter, Florian, Andre, Ingemar, Vernon, Robert, Schief, William R, Baker, David
Published in PloS one (31.08.2011)
Published in PloS one (31.08.2011)
Get full text
Journal Article
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
Sok, Devin, Briney, Bryan, Jardine, Joseph G., Kulp, Daniel W., Menis, Sergey, Pauthner, Matthias, Wood, Andrew, Lee, E-Chiang, Le, Khoa M., Jones, Meaghan, Ramos, Alejandra, Kalyuzhniy, Oleksandr, Adachi, Yumiko, Kuhitz, Michael, MacPherson, Skye, Bradley, Allan, Friedrich, Glenn A., Schief, William R., Burton, Dennis R.
Published in Science (American Association for the Advancement of Science) (30.09.2016)
Published in Science (American Association for the Advancement of Science) (30.09.2016)
Get full text
Journal Article
Proof of principle for epitope-focused vaccine design
Correia, Bruno E., Bates, John T., Loomis, Rebecca J., Baneyx, Gretchen, Carrico, Chris, Jardine, Joseph G., Rupert, Peter, Correnti, Colin, Kalyuzhniy, Oleksandr, Vittal, Vinayak, Connell, Mary J., Stevens, Eric, Schroeter, Alexandria, Chen, Man, MacPherson, Skye, Serra, Andreia M., Adachi, Yumiko, Holmes, Margaret A., Li, Yuxing, Klevit, Rachel E., Graham, Barney S., Wyatt, Richard T., Baker, David, Strong, Roland K., Crowe, James E., Johnson, Philip R., Schief, William R.
Published in Nature (London) (13.03.2014)
Published in Nature (London) (13.03.2014)
Get full text
Journal Article
Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers
Pauthner, Matthias G., Nkolola, Joseph P., Havenar-Daughton, Colin, Murrell, Ben, Reiss, Samantha M., Bastidas, Raiza, Prévost, Jérémie, Nedellec, Rebecca, von Bredow, Benjamin, Abbink, Peter, Cottrell, Christopher A., Kulp, Daniel W., Tokatlian, Talar, Nogal, Bartek, Bianchi, Matteo, Li, Hui, Lee, Jeong Hyun, Butera, Salvatore T., Evans, David T., Hangartner, Lars, Finzi, Andrés, Wilson, Ian A., Wyatt, Richard T., Irvine, Darrell J., Schief, William R., Ward, Andrew B., Sanders, Rogier W., Crotty, Shane, Shaw, George M., Barouch, Dan H., Burton, Dennis R.
Published in Immunity (Cambridge, Mass.) (15.01.2019)
Published in Immunity (Cambridge, Mass.) (15.01.2019)
Get full text
Journal Article
Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
Cao, Liwei, Pauthner, Matthias, Andrabi, Raiees, Rantalainen, Kimmo, Berndsen, Zachary, Diedrich, Jolene K., Menis, Sergey, Sok, Devin, Bastidas, Raiza, Park, Sung-Kyu Robin, Delahunty, Claire M., He, Lin, Guenaga, Javier, Wyatt, Richard T., Schief, William R., Ward, Andrew B., Yates, John R., Burton, Dennis R., Paulson, James C.
Published in Nature communications (12.09.2018)
Published in Nature communications (12.09.2018)
Get full text
Journal Article