Design, Synthesis, in Vitro, and in Vivo Anticancer and Antiangiogenic Activity of Novel 3‑Arylaminobenzofuran Derivatives Targeting the Colchicine Site on Tubulin
Romagnoli, Romeo, Baraldi, Pier Giovanni, Salvador, Maria Kimatrai, Prencipe, Filippo, Lopez-Cara, Carlota, Schiaffino Ortega, Santiago, Brancale, Andrea, Hamel, Ernest, Castagliuolo, Ignazio, Mitola, Stefania, Ronca, Roberto, Bortolozzi, Roberta, Porcù, Elena, Basso, Giuseppe, Viola, Giampietro
Published in Journal of medicinal chemistry (09.04.2015)
Published in Journal of medicinal chemistry (09.04.2015)
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Journal Article
2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition
Romagnoli, Romeo, Kimatrai Salvador, Maria, Schiaffino Ortega, Santiago, Baraldi, Pier Giovanni, Oliva, Paola, Baraldi, Stefania, Lopez-Cara, Luisa Carlota, Brancale, Andrea, Ferla, Salvatore, Hamel, Ernest, Balzarini, Jan, Liekens, Sandra, Mattiuzzo, Elena, Basso, Giuseppe, Viola, Giampietro
Published in European journal of medicinal chemistry (01.01.2018)
Published in European journal of medicinal chemistry (01.01.2018)
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Journal Article
Anticancer and Structure Activity Relationship of Non-Symmetrical Choline Kinase Inhibitors
Schiaffino-Ortega, Santiago, Mariotto, Elena, Luque-Navarro, Pilar María, Kimatrai-Salvador, María, Rios-Marco, Pablo, Hurtado-Guerrero, Ramon, Marco, Carmen, Carrasco-Jimenez, María Paz, Viola, Giampietro, López-Cara, Luisa Carlota
Published in Pharmaceutics (29.08.2021)
Published in Pharmaceutics (29.08.2021)
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Journal Article
1H and 13C NMR spectral assignments of 1,1′-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))-bispyridinium and -bisquinolinium bromide derivatives
Schiaffino-Ortega, Santiago, Kimatrai-Salvador, María, Baglioni, Eleonora, Gallo, Miguel Angel, Entrena Guadix, Antonio, Lopez-Cara, Luisa Carlota
Published in Magnetic resonance in chemistry (01.11.2016)
Published in Magnetic resonance in chemistry (01.11.2016)
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Journal Article
Design, Synthesis, and Biological Evaluation of 6‑Substituted Thieno[3,2‑d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors
Romagnoli, Romeo, Prencipe, Filippo, Oliva, Paola, Baraldi, Stefania, Baraldi, Pier Giovanni, Schiaffino Ortega, Santiago, Chayah, Mariem, Kimatrai Salvador, Maria, Lopez-Cara, Luisa Carlota, Brancale, Andrea, Ferla, Salvatore, Hamel, Ernest, Ronca, Roberto, Bortolozzi, Roberta, Mariotto, Elena, Mattiuzzo, Elena, Viola, Giampietro
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
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Journal Article
Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)
Schiaffino-Ortega, Santiago, Baglioni, Eleonora, Mariotto, Elena, Bortolozzi, Roberta, Serrán-Aguilera, Lucía, Ríos-Marco, Pablo, Carrasco-Jimenez, M. Paz, Gallo, Miguel A., Hurtado-Guerrero, Ramon, Marco, Carmen, Basso, Giuseppe, Viola, Giampietro, Entrena, Antonio, López-Cara, Luisa Carlota
Published in Scientific reports (31.03.2016)
Published in Scientific reports (31.03.2016)
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Journal Article
SWI/SNF proteins as targets in cancer therapy
Schiaffino-Ortega, Santiago, Balinas, Carlos, Cuadros, Marta, Medina, Pedro P
Published in Journal of hematology and oncology (13.11.2014)
Published in Journal of hematology and oncology (13.11.2014)
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Journal Article
1 H and 13 C NMR spectral assignments of 1,1′-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))-bispyridinium and -bisquinolinium bromide derivatives: NMR phenoxyethane bis-salts derivatives
Schiaffino-Ortega, Santiago, Kimatrai-Salvador, María, Baglioni, Eleonora, Gallo, Miguel Angel, Entrena Guadix, Antonio, Lopez-Cara, Luisa Carlota
Published in Magnetic resonance in chemistry (01.11.2016)
Published in Magnetic resonance in chemistry (01.11.2016)
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Journal Article
New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1
Castro-Navas, Francisco Fermín, Schiaffino-Ortega, Santiago, Carrasco-Jimenez, María Paz, Ríos-Marco, Pablo, Marco, Carmen, Espinosa, Antonio, Gallo, Miguel Angel, Mariotto, Elena, Basso, Giuseppe, Viola, Giampietro, Entrena-Guadix, Antonio, López-Cara, Luisa Carlota
Published in Future medicinal chemistry (01.03.2015)
Published in Future medicinal chemistry (01.03.2015)
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Journal Article
New non-symmetrical choline kinase inhibitors
Schiaffino-Ortega, Santiago, López-Cara, Luisa Carlota, Ríos-Marco, Pablo, Carrasco-Jimenez, Maria Paz, Gallo, Miguel A., Espinosa, Antonio, Marco, Carmen, Entrena, Antonio
Published in Bioorganic & medicinal chemistry (15.11.2013)
Published in Bioorganic & medicinal chemistry (15.11.2013)
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Journal Article
1 H and 13 C NMR spectral assignments of 1,1'-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))-bispyridinium and -bisquinolinium bromide derivatives
Schiaffino-Ortega, Santiago, Kimatrai-Salvador, María, Baglioni, Eleonora, Gallo, Miguel Angel, Entrena Guadix, Antonio, Lopez-Cara, Luisa Carlota
Published in Magnetic resonance in chemistry (01.11.2016)
Published in Magnetic resonance in chemistry (01.11.2016)
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Journal Article
Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase [alpha]1 (ChoK[alpha]1)
Schiaffino-ortega, Santiago, Baglioni, Eleonora, Mariotto, Elena, Bortolozzi, Roberta, Serrán-aguilera, Lucía, Ríos-marco, Pablo, Carrasco-jimenez, M Paz, Gallo, Miguel A, Hurtado-guerrero, Ramon, Marco, Carmen, Basso, Giuseppe, Viola, Giampietro, Entrena, Antonio, López-cara, Luisa Carlota
Published in Scientific reports (01.03.2016)
Published in Scientific reports (01.03.2016)
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Journal Article
SYMMETRICAL POLAR INHIBITORS OF CHOLINE KINASE WITH ANTI-TUMOUR ACTIVITY
LÓPEZ CARA, LUISA CARLOTA, SCHIAFFINO ORTEGA, SANTIAGO, MARCO DE LA CALLE, CARMEN, CARRASCO JIMÉNEZ, MARÍA PAZ, BASSO, GIUSSEPE, BORTOLOZZI, ROBERTA, ESPINOSA UBEDA, ANTONIO, RÍOS MARCO, PABLO, VIOLA, GIAMPIETRO, ENTRENA GUADIX, ANTONIO JOSÉ
Year of Publication 10.12.2015
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Year of Publication 10.12.2015
Patent
Inhibidores polares simétricos de colina cinasa con actividad antitumoral
SCHIAFFINO ORTEGA, SANTIAGO, MARCO DE LA CALLE, CARMEN, RIOS MARCO, PABLO, BORTOLOZZI, RORBERTA, CARRASCO JIMENEZ, MARÍA PAZ, LOPEZ CARA, LUISA CARLOTA, ESPINOSA UBEDA, ANTONIO, VIOLA, GIAMPETRO, BASSO, GIUSSEPPE, ENTRENA GUADIX, ANTONIO JOSÉ
Year of Publication 19.05.2015
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Year of Publication 19.05.2015
Patent
Symmetric polar inhibitors of choline kinase with antitumor activity (Machine-translation by Google Translate, not legally binding)
SCHIAFFINO ORTEGA, SANTIAGO, MARCO DE LA CALLE, CARMEN, RIOS MARCO, PABLO, BORTOLOZZI, RORBERTA, CARRASCO JIMENEZ, MARÍA PAZ, LOPEZ CARA, LUISA CARLOTA, ESPINOSA UBEDA, ANTONIO, VIOLA, GIAMPETRO, BASSO, GIUSSEPPE, ENTRENA GUADIX, ANTONIO JOSÉ
Year of Publication 01.08.2014
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Year of Publication 01.08.2014
Patent