Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
Scheuner, D, Eckman, C, Jensen, M, Song, X, Citron, M, Suzuki, N, Bird, T D, Hardy, J, Hutton, M, Kukull, W, Larson, E, Levy-Lahad, E, Viitanen, M, Peskind, E, Poorkaj, P, Schellenberg, G, Tanzi, R, Wasco, W, Lannfelt, L, Selkoe, D, Younkin, S
Published in Nature medicine (01.08.1996)
Published in Nature medicine (01.08.1996)
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A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress
Boyce, Michael, Bryant, Kevin F., Jousse, Céline, Long, Kai, Harding, Heather P., Scheuner, Donalyn, Kaufman, Randal J., Ma, Dawei, Coen, Donald M., Ron, David, Yuan, Junying
Published in Science (American Association for the Advancement of Science) (11.02.2005)
Published in Science (American Association for the Advancement of Science) (11.02.2005)
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Stress granules and processing bodies are dynamically linked sites of mRNP remodeling
Kedersha, Nancy, Stoecklin, Georg, Ayodele, Maranatha, Yacono, Patrick, Lykke-Andersen, Jens, Fitzler, Marvin J, Scheuner, Donalyn, Kaufman, Randal J, Golan, David E, Anderson, Paul
Published in The Journal of cell biology (20.06.2005)
Published in The Journal of cell biology (20.06.2005)
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ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
Bi, Meixia, Naczki, Christine, Koritzinsky, Marianne, Fels, Diane, Blais, Jaime, Hu, Nianping, Harding, Heather, Novoa, Isabelle, Varia, Mahesh, Raleigh, James, Scheuner, Donalyn, Kaufman, Randal J, Bell, John, Ron, David, Wouters, Bradly G, Koumenis, Constantinos
Published in The EMBO journal (05.10.2005)
Published in The EMBO journal (05.10.2005)
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Journal Article
Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2
Deng, Jing, Lu, Phoebe D., Zhang, Yuhong, Scheuner, Donalyn, Kaufman, Randal J., Sonenberg, Nahum, Harding, Heather P., Ron, David
Published in Molecular and Cellular Biology (01.12.2004)
Published in Molecular and Cellular Biology (01.12.2004)
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Heme-regulated Inhibitor Kinase-mediated Phosphorylation of Eukaryotic Translation Initiation Factor 2 Inhibits Translation, Induces Stress Granule Formation, and Mediates Survival upon Arsenite Exposure
McEwen, Edward, Kedersha, Nancy, Song, Benbo, Scheuner, Donalyn, Gilks, Natalie, Han, Anping, Chen, Jane-Jane, Anderson, Paul, Kaufman, Randal J.
Published in The Journal of biological chemistry (29.04.2005)
Published in The Journal of biological chemistry (29.04.2005)
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Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis
Schuit, Frans C, Kaufman, Randal J, Scheuner, Donalyn, Mierde, Dirk Vander, Song, Benbo, Flamez, Daisy, Creemers, John W M, Tsukamoto, Katsura, Ribick, Mark
Published in Nature medicine (01.07.2005)
Published in Nature medicine (01.07.2005)
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Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses
Jiang, Hao-Yuan, Wek, Sheree A., McGrath, Barbara C., Scheuner, Donalyn, Kaufman, Randal J., Cavener, Douglas R., Wek, Ronald C.
Published in Molecular and Cellular Biology (01.08.2003)
Published in Molecular and Cellular Biology (01.08.2003)
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Journal Article
Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis
Scheuner, Donalyn, Song, Benbo, McEwen, Edward, Liu, Chuan, Laybutt, Ross, Gillespie, Patrick, Saunders, Thom, Bonner-Weir, Susan, Kaufman, Randal J
Published in Molecular cell (01.06.2001)
Published in Molecular cell (01.06.2001)
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Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway
Talloczy, Z, Jiang, W, Virgin IV, HW, Leib, DA, Scheuner, D, Kaufman, R J, Eskelinen, E, Levine, B
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2002)
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Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2
Lu, Phoebe D, Jousse, Céline, Marciniak, Stefan J, Zhang, Yuhong, Novoa, Isabel, Scheuner, Donalyn, Kaufman, Randal J, Ron, David, Harding, Heather P
Published in The EMBO journal (14.01.2004)
Published in The EMBO journal (14.01.2004)
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Ultraviolet Light Activates NFκB through Translational Inhibition of IκBα Synthesis
Wu, Shiyong, Tan, Mingjia, Hu, Yuanyuan, Wang, Ju-Lin, Scheuner, Donalyn, Kaufman, Randal J.
Published in The Journal of biological chemistry (13.08.2004)
Published in The Journal of biological chemistry (13.08.2004)
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Journal Article
Activation of GCN2 in UV-Irradiated Cells Inhibits Translation
Deng, Jing, Harding, Heather P., Raught, Brian, Gingras, Anne-Claude, Berlanga, Juan Jose, Scheuner, Donalyn, Kaufman, Randal J., Ron, David, Sonenberg, Nahum
Published in Current biology (06.08.2002)
Published in Current biology (06.08.2002)
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Journal Article
The Zipper Model of Translational Control: A Small Upstream ORF Is the Switch that Controls Structural Remodeling of an mRNA Leader
Yaman, Ibrahim, Fernandez, James, Liu, Haiyan, Caprara, Mark, Komar, Anton A., Koromilas, Antonis E., Zhou, Lingyin, Snider, Martin D., Scheuner, Donalyn, Kaufman, Randal J., Hatzoglou, Maria
Published in Cell (16.05.2003)
Published in Cell (16.05.2003)
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Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression
Harding, Heather P., Zhang, Yuhong, Khersonsky, Sonya, Marciniak, Stefan, Scheuner, Donalyn, Kaufman, Randal J., Javitt, Norman, Chang, Young-Tae, Ron, David
Published in Cell metabolism (01.12.2005)
Published in Cell metabolism (01.12.2005)
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Journal Article
Nucleotide sequence of a cDNA for bovine cytochrome c oxidase subunit VIIa
SATHIAGANA SEELAN, R, SCHEUNER, D, LOMAX, M. I, GROSSMAN, L. I
Published in Nucleic acids research (11.08.1989)
Published in Nucleic acids research (11.08.1989)
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Potential role of PKR in double-stranded RNA-induced macrophage activation
Maggi Jr, Leonard B., Heitmeier, Monique R., Scheuner, Donalyn, Kaufman, Randal J., Buller, R.Mark L., Corbett, John A.
Published in The EMBO journal (17.07.2000)
Published in The EMBO journal (17.07.2000)
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Mechanisms of β-cell death in response to double-stranded (ds) RNA and interferon-γ dsrna-dependent protein kinase apoptosis and nitric oxide-dependent necrosis
SCARIM, Anna L, ARNUSH, Marc, BLAIR, Libby A, CONCEPCION, Josephine, HEITMEIER, Monique R, SCHEUNER, Donalyn, KAUFMAN, T. Randal J, RYERSE, Jan, BULLER, R. Mark, CORBETT, John A
Published in The American journal of pathology (01.07.2001)
Published in The American journal of pathology (01.07.2001)
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