Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer’s Disease Mouse Model
He, Feng, Chou, C. James, Scheiner, Matthias, Poeta, Eleonora, Yuan Chen, Natalia, Gunesch, Sandra, Hoffmann, Matthias, Sotriffer, Christoph, Monti, Barbara, Maurice, Tangui, Decker, Michael
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer’s Disease Mouse Model
Hoffmann, Matthias, Stiller, Carina, Endres, Erik, Scheiner, Matthias, Gunesch, Sandra, Sotriffer, Christoph, Maurice, Tangui, Decker, Michael
Published in Journal of medicinal chemistry (24.10.2019)
Published in Journal of medicinal chemistry (24.10.2019)
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Journal Article
Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer’s Disease Mouse Model
Scheiner, Matthias, Hoffmann, Matthias, He, Feng, Poeta, Eleonora, Chatonnet, Arnaud, Monti, Barbara, Maurice, Tangui, Decker, Michael
Published in Journal of medicinal chemistry (08.07.2021)
Published in Journal of medicinal chemistry (08.07.2021)
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Journal Article
Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition in Vitro and Enable Restoration of Cognition in an Alzheimer’s Disease Mouse Model upon Irradiation
Scheiner, Matthias, Sink, Alexandra, Hoffmann, Matthias, Vrigneau, Cassandre, Endres, Erik, Carles, Allison, Sotriffer, Christoph, Maurice, Tangui, Decker, Michael
Published in Journal of the American Chemical Society (23.02.2022)
Published in Journal of the American Chemical Society (23.02.2022)
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Journal Article
Sterubin: Enantioresolution and Configurational Stability, Enantiomeric Purity in Nature, and Neuroprotective Activity in Vitro and in Vivo
Hofmann, Julian, Fayez, Shaimaa, Scheiner, Matthias, Hoffmann, Matthias, Oerter, Sabrina, Appelt‐Menzel, Antje, Maher, Pamela, Maurice, Tangui, Bringmann, Gerhard, Decker, Michael
Published in Chemistry : a European journal (05.06.2020)
Published in Chemistry : a European journal (05.06.2020)
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Journal Article
Dual-Acting Cholinesterase–Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo
Scheiner, Matthias, Dolles, Dominik, Gunesch, Sandra, Hoffmann, Matthias, Nabissi, Massimo, Marinelli, Oliviero, Naldi, Marina, Bartolini, Manuela, Petralla, Sabrina, Poeta, Eleonora, Monti, Barbara, Falkeis, Christina, Vieth, Michael, Hübner, Harald, Gmeiner, Peter, Maitra, Rangan, Maurice, Tangui, Decker, Michael
Published in Journal of medicinal chemistry (24.10.2019)
Published in Journal of medicinal chemistry (24.10.2019)
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Journal Article
The selective butyrylcholinesterase inhibitor UW‐MD‐95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's disease
Carles, Allison, Hoffmann, Matthias, Scheiner, Matthias, Crouzier, Lucie, Bertrand‐Gaday, Christelle, Chatonnet, Arnaud, Decker, Michael, Maurice, Tangui
Published in CNS neuroscience & therapeutics (01.06.2024)
Published in CNS neuroscience & therapeutics (01.06.2024)
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Journal Article
Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress, and Neuroinflammation
Hofmann, Julian, Ginex, Tiziana, Espargaró, Alba, Scheiner, Matthias, Gunesch, Sandra, Aragó, Marc, Stigloher, Christian, Sabaté, Raimon, Luque, F. Javier, Decker, Michael
Published in Chemistry : a European journal (01.04.2021)
Published in Chemistry : a European journal (01.04.2021)
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Journal Article
The Structure of Cyclodecatriene Collinolactone, its Biosynthesis, and Semisynthetic Analogues: Effects of Monoastral Phenotype and Protection from Intracellular Oxidative Stress
Schmid, Julian C., Frey, Kerstin, Scheiner, Matthias, Garzón, Jaime Felipe Guerrero, Stafforst, Luise, Fricke, Jan‐Niklas, Schuppe, Michaela, Schiewe, Hajo, Zeeck, Axel, Weber, Tilmann, Usón, Isabel, Kemkemer, Ralf, Decker, Michael, Grond, Stephanie
Published in Angewandte Chemie International Edition (18.10.2021)
Published in Angewandte Chemie International Edition (18.10.2021)
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From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects
Pont, Caterina, Ginex, Tiziana, Griñán-Ferré, Christian, Scheiner, Matthias, Mattellone, Alexia, Martínez, Noemí, Arce, Elsa M., Soriano-Fernández, Yolanda, Naldi, Marina, De Simone, Angela, Barenys, Marta, Gómez-Catalán, Jesús, Pérez, Belén, Sabate, Raimon, Andrisano, Vincenza, Loza, María Isabel, Brea, José, Bartolini, Manuela, Bolognesi, Maria Laura, Decker, Michael, Pallàs, Mercè, Luque, F. Javier, Muñoz-Torrero, Diego
Published in European journal of medicinal chemistry (05.12.2021)
Published in European journal of medicinal chemistry (05.12.2021)
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Journal Article
Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB(2)R Ligands To Combat Neurodegenerative Disorders
Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmueller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios, Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea, Decker, Michael
Published in ChemMedChem (20.06.2016)
Published in ChemMedChem (20.06.2016)
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Journal Article
Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2R Ligands To Combat Neurodegenerative Disorders
Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmüller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios, Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea, Decker, Michael
Published in ChemMedChem (20.06.2016)
Published in ChemMedChem (20.06.2016)
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Cover Picture: Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2R Ligands To Combat Neurodegenerative Disorders (ChemMedChem 12/2016)
Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmüller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios, Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea, Decker, Michael
Published in ChemMedChem (20.06.2016)
Published in ChemMedChem (20.06.2016)
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Journal Article
Cover Picture: Aminobenzimidazoles and Structural Isomers as Templates for Dual‐Acting Butyrylcholinesterase Inhibitors and h CB 2 R Ligands To Combat Neurodegenerative Disorders (ChemMedChem 12/2016)
Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmüller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios, Sotriffer, Christoph, Wittmann, Hans‐Joachim, Strasser, Andrea, Decker, Michael
Published in ChemMedChem (20.06.2016)
Published in ChemMedChem (20.06.2016)
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Journal Article
Aminobenzimidazoles and Structural Isomers as Templates for Dual‐Acting Butyrylcholinesterase Inhibitors and h CB 2 R Ligands To Combat Neurodegenerative Disorders
Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmüller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios, Sotriffer, Christoph, Wittmann, Hans‐Joachim, Strasser, Andrea, Decker, Michael
Published in ChemMedChem (20.06.2016)
Published in ChemMedChem (20.06.2016)
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Journal Article
Cover Picture: Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB sub(2)R Ligands To Combat Neurodegenerative Disorders (ChemMedChem 12/2016)
Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmueller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios, Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea, Decker, Michael
Published in ChemMedChem (01.06.2016)
Published in ChemMedChem (01.06.2016)
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Journal Article
Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB sub(2)R Ligands To Combat Neurodegenerative Disorders
Dolles, Dominik, Nimczick, Martin, Scheiner, Matthias, Ramler, Jacqueline, Stadtmueller, Patricia, Sawatzky, Edgar, Drakopoulos, Antonios, Sotriffer, Christoph, Wittmann, Hans-Joachim, Strasser, Andrea, Decker, Michael
Published in ChemMedChem (01.06.2016)
Published in ChemMedChem (01.06.2016)
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Journal Article
Die Struktur des Cyclodecatriens Collinolacton, seine Biosynthese und semisynthetische Derivate: monopolare Spindeln und Schutz vor intrazellulärem oxidativem Stress
Schmid, Julian C., Frey, Kerstin, Scheiner, Matthias, Garzón, Jaime Felipe Guerrero, Stafforst, Luise, Fricke, Jan‐Niklas, Schuppe, Michaela, Schiewe, Hajo, Zeeck, Axel, Weber, Tilmann, Usón, Isabel, Kemkemer, Ralf, Decker, Michael, Grond, Stephanie
Published in Angewandte Chemie (18.10.2021)
Published in Angewandte Chemie (18.10.2021)
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Journal Article