Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816
Hutchinson, J. H, Riendeau, D, Brideau, C, Chan, C, Delorme, D, Denis, D, Falgueyret, J. P, Fortin, R, Guay, J
Published in Journal of medicinal chemistry (01.09.1993)
Published in Journal of medicinal chemistry (01.09.1993)
Get full text
Journal Article
Thiopyrano[2,3,4-cd]indoles as 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Resolution of 2-[2-[1-(4-Chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic Acid
Hutchinson, J. H, Riendeau, D, Brideau, C, Chan, C, Falgueyret, J.-P, Guay, J, Jones, T. R, Lepine, C, Macdonald, D
Published in Journal of medicinal chemistry (01.04.1994)
Published in Journal of medicinal chemistry (01.04.1994)
Get full text
Journal Article
L-656,224 (7-chloro-2-[(4-methoxyphenyl)methyl]-3- methyl-5-propyl-4-benzofuranol): a novel, selective, orally active 5-lipoxygenase inhibitor
Belanger, P, Maycock, A, Guindon, Y, Bach, T, Dollob, A L, Dufresne, C, Ford-Hutchinson, A W, Gale, P H, Hopple, S, Lau, C K
Published in Canadian journal of physiology and pharmacology (01.12.1987)
Published in Canadian journal of physiology and pharmacology (01.12.1987)
Get more information
Journal Article
AN IMPROVED SYNTHESIS OF ETHYL 4-HYDROXY-3-METHYLBENZOFURAN-2-CARBOXYLATE
BELANGER, PC, DUFRESNE, C, LAU, CK, SCHEIGETZ, J
Published in Organic preparations and procedures international (01.06.1988)
Published in Organic preparations and procedures international (01.06.1988)
Get more information
Journal Article
β-Substituted Cyclohexanecarboxamide: A Nonpeptidic Framework for the Design of Potent Inhibitors of Cathepsin K
Crane, Sheldon N, Black, W. Cameron, Palmer, James T, Davis, Dana E, Setti, Eduardo, Robichaud, Joel, Paquet, Julie, Oballa, Renata M, Bayly, Christopher I, McKay, Daniel J, Somoza, John R, Chauret, Natalie, Seto, Carmai, Scheigetz, John, Wesolowski, Greg, Massé, Frederic, Desmarais, Sylvie, Ouellet, Marc
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
Get full text
Journal Article
Process Development and Large-Scale Synthesis of a PDE4 Inhibitor
Conlon, David A, Drahus-Paone, Antoinette, Ho, Guo-Jie, Pipik, Brenda, Helmy, Roy, McNamara, James M, Shi, Yao-Jun, Williams, J. Michael, Macdonald, Dwight, Deschênes, Denis, Gallant, Michel, Mastracchio, Anthony, Roy, Bruno, Scheigetz, John
Published in Organic process research & development (01.01.2006)
Published in Organic process research & development (01.01.2006)
Get full text
Journal Article
Identification of an indole series of prostaglandin D 2 receptor antagonists
Sturino, Claudio F., Lachance, Nicolas, Boyd, Michael, Berthelette, Carl, Labelle, Marc, Li, Lianhai, Roy, Bruno, Scheigetz, John, Tsou, Nancy, Brideau, Christine, Cauchon, Elizabeth, Carriere, Marie-Claude, Denis, Danielle, Greig, Gillian, Kargman, Stacia, Lamontagne, Sonia, Mathieu, Marie-Claude, Sawyer, Nicole, Slipetz, Deborah, O’Neill, Gary, Wang, Zhaoyin, Zamboni, Robert, Metters, Kathleen M., Young, Robert N.
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
Get full text
Journal Article
Discovery of a Potent and Selective Prostaglandin D sub(2) Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl) -1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)
Sturino, C F, O'Neill, G, Lachance, N, Boyd, M, Berthelette, C, Labelle, M, Li, L, Roy, B, Scheigetz, J, Tsou, N, Aubin, Y, Bateman, K P, Chauret, N, Day, SH
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
Get full text
Journal Article
Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor
Macdonald, Dwight, Mastracchio, Anthony, Perrier, Hélène, Dubé, Daniel, Gallant, Michel, Lacombe, Patrick, Deschênes, Denis, Roy, Bruno, Scheigetz, John, Bateman, Kevin, Li, Chun, Trimble, Laird A., Day, Stephen, Chauret, Nathalie, Nicoll-Griffith, Deborah A., Silva, Jose M., Huang, Zheng, Laliberté, France, Liu, Susana, Ethier, Diane, Pon, Doug, Muise, Eric, Boulet, Louise, Chan, Chi Chung, Styhler, Angela, Charleson, Stella, Mancini, Joseph, Masson, Paul, Claveau, David, Nicholson, Donald, Turner, Mervyn, Young, Robert N., Girard, Yves
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Get full text
Journal Article
Preparation and stereochemistry of 8- and 9-hydroxy-2,5-ethano-3-benzazocines
Bélanger, Patrice C, Scheigetz, John, Young, Robert N
Published in Canadian journal of chemistry (01.09.1983)
Published in Canadian journal of chemistry (01.09.1983)
Get full text
Journal Article
Base-catalyzed deuterium and tritium labeling of aryl methyl sulfones
Scheigetz, John, Berthelette, Carl, Li, Chun, Zamboni, Robert J.
Published in Journal of labelled compounds & radiopharmaceuticals (30.10.2004)
Published in Journal of labelled compounds & radiopharmaceuticals (30.10.2004)
Get full text
Journal Article
Urinary metabolites of timolol from humans and laboratory animals. Syntheses and .beta.-adrenergic blocking activities
Wasson, B. K, Scheigetz, J, Rooney, C. S, Hall, R. A, Share, N. N, VandenHeuvel, W. J. A, Arison, B. H, Hensens, O. D, Ellsworth, R. L, Tocco, D. J
Published in Journal of medicinal chemistry (01.11.1980)
Published in Journal of medicinal chemistry (01.11.1980)
Get full text
Journal Article
3,6-Fluorescein Diphosphate: A Sensitive Fluorogenic and Chromogenic Substrate for Protein Tyrosine Phosphatases
Huang, Z, Wang, Q, Ly, HD, Gorvindarajan, A, Scheigetz, J, Zamboni, R, Desmarais, S, Ramachandran, C
Published in Journal of biomolecular screening (01.12.1999)
Published in Journal of biomolecular screening (01.12.1999)
Get full text
Journal Article
THIOPYRANOL[2,3,4-C,D] INDOLES AS INHIBITORS OF 5-LIPOXYGENASE, 5-LIPOXYGENASE-ACTIVATING PROTEIN, AND LEUKOTRIENE C-4 SYNTHASE
HUTCHINSON, JH, CHARLESON, S, EVANS, JF, FALGUEYRET, JP, HOOGSTEEN, K, JONES, TR, KARGMAN, S, MACDONALD, D, MCFARLANE, CS, NICHOLSON, DW, PIECHUTA, H, RIENDEAU, D, SCHEIGETZ, J, THERIEN, M, GIRARD, Y
Published in Journal of medicinal chemistry (27.10.1995)
Published in Journal of medicinal chemistry (27.10.1995)
Get full text
Journal Article