TGF‐β as a driver of fibrosis: physiological roles and therapeutic opportunities
Budi, Erine H, Schaub, Johanna R, Decaris, Martin, Turner, Scott, Derynck, Rik
Published in The Journal of pathology (01.07.2021)
Published in The Journal of pathology (01.07.2021)
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Journal Article
De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation
Schaub, Johanna R., Huppert, Kari A., Kurial, Simone N. T., Hsu, Bernadette Y., Cast, Ashley E., Donnelly, Bryan, Karns, Rebekah A., Chen, Feng, Rezvani, Milad, Luu, Hubert Y., Mattis, Aras N., Rougemont, Anne-Laure, Rosenthal, Philip, Huppert, Stacey S., Willenbring, Holger
Published in Nature (London) (10.05.2018)
Published in Nature (London) (10.05.2018)
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Journal Article
Integrins in biliary injury and fibrosis
Schaub, Johanna R, Chen, Jennifer Y, Turner, Scott M
Published in Current opinion in gastroenterology (01.03.2024)
Published in Current opinion in gastroenterology (01.03.2024)
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Journal Article
Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Decaris, Martin L., Schaub, Johanna R., Chen, Chun, Cha, Jacob, Lee, Gail G., Rexhepaj, Megi, Ho, Steve S., Rao, Vikram, Marlow, Megan M., Kotak, Prerna, Budi, Erine H., Hooi, Lisa, Wu, Jianfeng, Fridlib, Marina, Martin, Shamra P., Huang, Shaoyi, Chen, Ming, Muñoz, Manuel, Hom, Timothy F., Wolters, Paul J., Desai, Tushar J., Rock, Fernando, Leftheris, Katerina, Morgans, David J., Lepist, Eve-Irene, Andre, Patrick, Lefebvre, Eric A., Turner, Scott M.
Published in Respiratory research (19.10.2021)
Published in Respiratory research (19.10.2021)
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Journal Article
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
Alsamman, Sarah, Christenson, Stephanie A, Yu, Amy, Ayad, Nadia M E, Mooring, Meghan S, Segal, Joe M, Hu, Jimmy Kuang-Hsien, Schaub, Johanna R, Ho, Steve S, Rao, Vikram, Marlow, Megan M, Turner, Scott M, Sedki, Mai, Pantano, Lorena, Ghoshal, Sarani, Ferreira, Diego Dos Santos, Ma, Hsiao-Yen, Duwaerts, Caroline C, Espanol-Suner, Regina, Wei, Lan, Newcomb, Benjamin, Mileva, Izolda, Canals, Daniel, Hannun, Yusuf A, Chung, Raymond T, Mattis, Aras N, Fuchs, Bryan C, Tager, Andrew M, Yimlamai, Dean, Weaver, Valerie M, Mullen, Alan C, Sheppard, Dean, Chen, Jennifer Y
Published in Science translational medicine (19.08.2020)
Published in Science translational medicine (19.08.2020)
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Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I
Schaub, Johanna R, Lu, Xiaobing, Doneske, Blair, Shin, Yeon-Kyun, McNew, James A
Published in Nature structural & molecular biology (01.08.2006)
Published in Nature structural & molecular biology (01.08.2006)
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Journal Article
The West coast regional safety pharmacology society meeting update: Filling translational gaps in safety assessment
Abi-Gerges, Najah, McMahon, Carrie, Vargas, Hugo, Sager, Philip, Chui, Ray, Stevens, Dale, Davila, Jonathan, Schaub, Johanna R., Wu, Joseph C., del Rio, Carlos, Mathes, Chris, Miller, Paul E., Burns-Naas, Leigh Ann, Ghetti, Andre
Published in Journal of pharmacological and toxicological methods (01.07.2019)
Published in Journal of pharmacological and toxicological methods (01.07.2019)
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Journal Article
The Polybasic Juxtamembrane Region of Sso1p Is Required for SNARE Function In Vivo
Van Komen, Jeffrey S, Bai, Xiaoyang, Rodkey, Travis L, Schaub, Johanna, McNew, James A
Published in Eukaryotic Cell (01.12.2005)
Published in Eukaryotic Cell (01.12.2005)
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Journal Article
TOP-564 Dual alpha-v/beta-6 and alpha-v/beta-1 integrin inhibitor bexotegrast targets TGF-beta inhibition to specific cell types in human liver explant tissue with biliary fibrosis
Schaub, Johanna, Ahn, Richard, Her, Chris, Ho, Steve, Rao, Vikram, Lau, Jessie, An, Mahru, Yuzon, Jennifer, Turner, Scott, Decaris, Martin
Published in Journal of hepatology (01.06.2024)
Published in Journal of hepatology (01.06.2024)
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Journal Article
Non-invasive imaging method demonstrates anti-fibrotic efficacy of a dual integrin alpha-v/beta-6 and alpha-v/beta-1 inhibitor in a rat model of biliary fibrosis
Schaub, Johanna, Ning, Yingying, Zhou, Iris Y., Rotile, Nicholas, Boice, Avery, Lau, Jessie, Caravan, Peter, Turner, Scott
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
WED-215 - Dual alpha-v/beta-6 and alpha-v/beta-1 integrin inhibitor bexotegrast attenuates profibrogenic gene expression of myofibroblasts in human liver explant tissue with biliary fibrosis
Ho, Steve, Her, Chris, Ahn, Richard, Rao, Vikram, Lau, Jessie, An, Mahru, Turner, Scott, Decaris, Martin, Schaub, Johanna
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
Dual alpha-v/beta-6 and alpha-v/beta-1 integrin inhibitor bexotegrast attenuates profibrogenic gene expression of myofibroblasts in human liver explant tissue with biliary fibrosis
Ho, Steve, Her, Chris, Ahn, Richard, Rao, Vikram, Lau, Jessie, An, Mahru, Turner, Scott, Decaris, Martin, Schaub, Johanna
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
FRI-335 - Non-invasive imaging method demonstrates anti-fibrotic efficacy of a dual integrin alpha-v/beta-6 and alpha-v/beta-1 inhibitor in a rat model of biliary fibrosis
Schaub, Johanna, Ning, Yingying, Zhou, Iris Y., Rotile, Nicholas, Boice, Avery, Lau, Jessie, Caravan, Peter, Turner, Scott
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
Rationale for evaluation of PLN-74809 treatment in participants with primary sclerosing cholangitis in Phase 2a study INTEGRIS-PSC
Lefebvre, Eric, Cosgrove, Greg, Wong, Simon, Park, Erica, Cilli, Fiona, Thuener, Theresa, Jurek, Marzena, Turner, Scott, Decaris, Martin, Schaub, Johanna
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
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Journal Article
Dual inhibition of integrins alpha-v/beta-6 and alpha-v/beta-1 decreases portal pressure and liver fibrosis in rats with biliary cirrhosis
Königshofer, Philipp, Schaub, Johanna, Brusilovskaya, Ksenia, Hofer, Benedikt, Simbrunner, Benedikt, Petrenko, Oleksandr, Scharnagl, Hubert, Stojakovic, Tatjana, Schwabl, Philipp, Lefebvre, Eric, Turner, Scott, Reiberger, Thomas
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
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Journal Article
LBP-039 Oral alpha-v/beta-6 and alpha-v/beta-1 integrin inhibitor bexotegrast in primary sclerosing cholangitis: updated 12-week interim safety and efficacy analysis of the INTEGRIS-PSC phase 2a trial
Trauner, Michael, Kowdley, Kris V., Hirschfield, Gideon M., Lefebvre, Eric, Decaris, Martin, Schaub, Johanna, Clark, Annie, Lin, Mandy, An, Mahru, Balasubramanyam, Aarthi, Barnes, Chris N., Pencek, Richard, Thorburn, Douglas, Montano-Loza, Aldo J., Bowlus, Christopher L., Schramm, Christoph, Levy, Cynthia, Trivedi, Palak J.
Published in Journal of hepatology (01.06.2024)
Published in Journal of hepatology (01.06.2024)
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Journal Article
Reduction in types I and III collagen gene expression by an alphavbeta1 integrin inhibitor correlates with a decrease in PRO-C1 and PRO-C3 levels in precision-cut liver tissue slices from cirrhotic non-alcoholic steatohepatitis patients
Schaub, Johanna, Ho, Steve, Rao, Vikram, Marlow, Megan, Lefebvre, Eric, Leeming, Diana, Nielsen, Mette Juul, Gudmann, Natasja, Karsdal, Morten, Turner, Scott
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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