Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity
Oshima, Masaya, Pechberty, Séverine, Bellini, Lara, Göpel, Sven O., Campana, Mélanie, Rouch, Claude, Dairou, Julien, Cosentino, Cristina, Fantuzzi, Federica, Toivonen, Sanna, Marchetti, Piero, Magnan, Christophe, Cnop, Miriam, Le Stunff, Hervé, Scharfmann, Raphaël
Published in Diabetologia (01.02.2020)
Published in Diabetologia (01.02.2020)
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Reconstructing human pancreatic differentiation by mapping specific cell populations during development
Ramond, Cyrille, Glaser, Nicolas, Berthault, Claire, Ameri, Jacqueline, Kirkegaard, Jeannette Schlichting, Hansson, Mattias, Honoré, Christian, Semb, Henrik, Scharfmann, Raphaël
Published in eLife (21.07.2017)
Published in eLife (21.07.2017)
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New α- and SIN γ-retrovectors for safe transduction and specific transgene expression in pancreatic β cell lines
Albagli, Olivier, Maugein, Alicia, Huijbregts, Lukas, Bredel, Delphine, Carlier, Géraldine, Martin, Patrick, Scharfmann, Raphaël
Published in BMC biotechnology (17.06.2019)
Published in BMC biotechnology (17.06.2019)
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Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion
Ndiaye, Fatou K, Ortalli, Ana, Canouil, Mickaël, Huyvaert, Marlène, Salazar-Cardozo, Clara, Lecoeur, Cécile, Verbanck, Marie, Pawlowski, Valérie, Boutry, Raphaël, Durand, Emmanuelle, Rabearivelo, Iandry, Sand, Olivier, Marselli, Lorella, Kerr-Conte, Julie, Chandra, Vikash, Scharfmann, Raphaël, Poulain-Godefroy, Odile, Marchetti, Piero, Pattou, François, Abderrahmani, Amar, Froguel, Philippe, Bonnefond, Amélie
Published in Molecular metabolism (Germany) (01.06.2017)
Published in Molecular metabolism (Germany) (01.06.2017)
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Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling
Roberts, Geoffrey P, Larraufie, Pierre, Richards, Paul, Kay, Richard G, Galvin, Sam G, Miedzybrodzka, Emily L, Leiter, Andrew, Li, H Joyce, Glass, Leslie L, Ma, Marcella K L, Lam, Brian, Yeo, Giles S H, Scharfmann, Raphaël, Chiarugi, Davide, Hardwick, Richard H, Reimann, Frank, Gribble, Fiona M
Published in Diabetes (New York, N.Y.) (01.05.2019)
Published in Diabetes (New York, N.Y.) (01.05.2019)
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Development of a conditionally immortalized human pancreatic β cell line
Scharfmann, Raphaël, Pechberty, Severine, Hazhouz, Yasmine, von Bülow, Manon, Bricout-Neveu, Emilie, Grenier-Godard, Maud, Guez, Fanny, Rachdi, Latif, Lohmann, Matthias, Czernichow, Paul, Ravassard, Philippe
Published in The Journal of clinical investigation (01.05.2014)
Published in The Journal of clinical investigation (01.05.2014)
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Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2+ Human Pancreatic Progenitors
Ameri, Jacqueline, Borup, Rehannah, Prawiro, Christy, Ramond, Cyrille, Schachter, Karen A., Scharfmann, Raphael, Semb, Henrik
Published in Cell reports (Cambridge) (04.04.2017)
Published in Cell reports (Cambridge) (04.04.2017)
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Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets
Rachdi, Latif, Maugein, Alicia, Pechberty, Severine, Armanet, Mathieu, Hamroune, Juliette, Ravassard, Philippe, Marullo, Stefano, Albagli, Olivier, Scharfmann, Raphael
Published in Scientific reports (10.08.2020)
Published in Scientific reports (10.08.2020)
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Journal Article
Mitochondrial Protein UCP2 Controls Pancreas Development
Broche, Benjamin, Ben Fradj, Selma, Aguilar, Esther, Sancerni, Tiphaine, Bénard, Matthieu, Makaci, Fatna, Berthault, Claire, Scharfmann, Raphaël, Alves-Guerra, Marie-Clotilde, Duvillié, Bertrand
Published in Diabetes (New York, N.Y.) (01.01.2018)
Published in Diabetes (New York, N.Y.) (01.01.2018)
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A 3D atlas of the human developing pancreas to explore progenitor proliferation and differentiation
Villalba, Adrian, Gitton, Yorick, Inoue, Megumi, Aiello, Virginie, Blain, Raphaël, Toupin, Maryne, Mazaud-Guittot, Séverine, Rachdi, Latif, Semb, Henrik, Chédotal, Alain, Scharfmann, Raphaël
Published in Diabetologia (01.06.2024)
Published in Diabetologia (01.06.2024)
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Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function
Meulebrouck, Sarah, Merrheim, Judith, Queniat, Gurvan, Bourouh, Cyril, Derhourhi, Mehdi, Boissel, Mathilde, Yi, Xiaoyan, Badreddine, Alaa, Boutry, Raphaël, Leloire, Audrey, Toussaint, Bénédicte, Amanzougarene, Souhila, Vaillant, Emmanuel, Durand, Emmanuelle, Loiselle, Hélène, Huyvaert, Marlène, Dechaume, Aurélie, Scherrer, Victoria, Marchetti, Piero, Balkau, Beverley, Charpentier, Guillaume, Franc, Sylvia, Marre, Michel, Roussel, Ronan, Scharfmann, Raphaël, Cnop, Miriam, Canouil, Mickaël, Baron, Morgane, Froguel, Philippe, Bonnefond, Amélie
Published in Nature communications (05.08.2024)
Published in Nature communications (05.08.2024)
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Mutations in BOREALIN cause thyroid dysgenesis
Carré, Aurore, Stoupa, Athanasia, Kariyawasam, Dulanjalee, Gueriouz, Manelle, Ramond, Cyrille, Monus, Taylor, Léger, Juliane, Gaujoux, Sébastien, Sebag, Frédéric, Glaser, Nicolas, Zenaty, Delphine, Nitschke, Patrick, Bole-Feysot, Christine, Hubert, Laurence, Lyonnet, Stanislas, Scharfmann, Raphaël, Munnich, Arnold, Besmond, Claude, Taylor, William, Polak, Michel
Published in Human molecular genetics (01.02.2017)
Published in Human molecular genetics (01.02.2017)
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Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants
Thomsen, Soren K, Ceroni, Alessandro, van de Bunt, Martijn, Burrows, Carla, Barrett, Amy, Scharfmann, Raphael, Ebner, Daniel, McCarthy, Mark I, Gloyn, Anna L
Published in Diabetes (New York, N.Y.) (01.12.2016)
Published in Diabetes (New York, N.Y.) (01.12.2016)
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Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension
Baron, Morgane, Maillet, Julie, Huyvaert, Marlène, Dechaume, Aurélie, Boutry, Raphaël, Loiselle, Hélène, Durand, Emmanuelle, Toussaint, Bénédicte, Vaillant, Emmanuel, Philippe, Julien, Thomas, Jérémy, Ghulam, Amjad, Franc, Sylvia, Charpentier, Guillaume, Borys, Jean-Michel, Lévy-Marchal, Claire, Tauber, Maïthé, Scharfmann, Raphaël, Weill, Jacques, Aubert, Cécile, Kerr-Conte, Julie, Pattou, François, Roussel, Ronan, Balkau, Beverley, Marre, Michel, Boissel, Mathilde, Derhourhi, Mehdi, Gaget, Stefan, Canouil, Mickaël, Froguel, Philippe, Bonnefond, Amélie
Published in Nature Medicine (01.11.2019)
Published in Nature Medicine (01.11.2019)
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The RB gene family controls the maturation state of the EndoC-βH2 human pancreatic β-cells
Maugein, Alicia, Diedisheim, Marc, Bailly, Karine, Scharfmann, Raphaël, Albagli, Olivier
Published in Differentiation (London) (01.05.2020)
Published in Differentiation (London) (01.05.2020)
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Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling
Ramond, Cyrille, Beydag-Tasöz, Belin Selcen, Azad, Ajuna, van de Bunt, Martijn, Petersen, Maja Borup Kjær, Beer, Nicola L, Glaser, Nicolas, Berthault, Claire, Gloyn, Anna L, Hansson, Mattias, McCarthy, Mark I, Honoré, Christian, Grapin-Botton, Anne, Scharfmann, Raphael
Published in Development (Cambridge) (15.08.2018)
Published in Development (Cambridge) (15.08.2018)
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