A Bayesian model based computational analysis of the relationship between bisulfite accessible single-stranded DNA in chromatin and somatic hypermutation of immunoglobulin genes
Yu, Guojun, Wu, Yingru, Duan, Zhi, Tang, Catherine, Xing, Haipeng, Scharff, Matthew D, MacCarthy, Thomas
Published in PLoS computational biology (01.09.2021)
Published in PLoS computational biology (01.09.2021)
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HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function
Zhao, Ruihua, Chinai, Jordan M., Buhl, Susan, Scandiuzzi, Lisa, Ray, Anjana, Jeon, Hyungjun, Ohaegbulam, Kim C., Ghosh, Kaya, Zhao, Aimin, Scharff, Matthew D., Zang, Xingxing
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
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The biochemistry of somatic hypermutation
Peled, Jonathan U, Kuang, Fei Li, Iglesias-Ussel, Maria D, Roa, Sergio, Kalis, Susan L, Goodman, Myron F, Scharff, Matthew D
Published in Annual review of immunology (01.01.2008)
Published in Annual review of immunology (01.01.2008)
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AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes
Tang, Catherine, Bagnara, Davide, Chiorazzi, Nicholas, Scharff, Matthew D, MacCarthy, Thomas
Published in Frontiers in immunology (30.04.2020)
Published in Frontiers in immunology (30.04.2020)
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Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice
Wang, Shanzhi, Lee, Kyeryoung, Gray, Stephen, Zhang, Yongwei, Tang, Catherine, Morrish, Rikke B, Tosti, Elena, van Oers, Johanna, Amin, Mohammad Ruhul, Cohen, Paula E, MacCarthy, Thomas, Roa, Sergio, Scharff, Matthew D, Edelmann, Winfried, Chahwan, Richard
Published in Nucleic acids research (12.08.2022)
Published in Nucleic acids research (12.08.2022)
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Activation-Induced Cytidine Deaminase Deaminates Deoxycytidine on Single-Stranded DNA but Requires the Action of RNase
Bransteitter, Ronda, Pham, Phuong, Scharff, Matthew D., Goodman, Myron F.
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (01.04.2003)
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Overlapping hotspots in CDRs are critical sites for V region diversification
Wei, Lirong, Chahwan, Richard, Wang, Shanzhi, Wang, Xiaohua, Pham, Phuong T., Goodman, Myron F., Bergman, Aviv, Scharff, Matthew D., MacCarthy, Thomas
Published in Proceedings of the National Academy of Sciences - PNAS (17.02.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (17.02.2015)
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The generation of antibody diversity through somatic hypermutation and class switch recombination
Li, Ziqiang, Woo, Caroline J, Iglesias-Ussel, Maria D, Ronai, Diana, Scharff, Matthew D
Published in Genes & development (01.01.2004)
Published in Genes & development (01.01.2004)
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Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes
Schaetzlein, Sonja, Chahwan, Richard, Avdievich, Elena, Roa, Sergio, Wei, Kaichun, Eoff, Robert L, Sellers, Rani S, Clark, Alan B, Kunkel, Thomas A, Scharff, Matthew D, Edelmann, Winfried
Published in Proceedings of the National Academy of Sciences - PNAS (02.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (02.07.2013)
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Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells
Wang, Xiaohua, Duan, Zhi, Yu, Guojun, Fan, Manxia, Scharff, Matthew D
Published in mBio (17.04.2018)
Published in mBio (17.04.2018)
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Correction to: Intraclonal Complexity in Chronic Lymphocytic Leukemia: Fractions Enriched in Recently Born/Divided and Older/Quiescent Cells
Calissano, Carlo, Damle, Rajendra N, Marsilio, Sonia, Yan, Xiao-Jie, Yancopoulos, Sophia, Hayes, Gregory, Emson, Claire, Murphy, Elizabeth J, Hellerstein, Marc K, Sison, Cristina, Kaufman, Matthew S, Kolitz, Jonathan E, Allen, Steven L, Rai, Kanti R, Ivanovic, Ivana, Dozmorov, Igor M, Roa, Sergio, Scharff, Matthew D, Li, Wentian, Chiorazzi, Nicholas
Published in Molecular medicine (Cambridge, Mass.) (15.03.2022)
Published in Molecular medicine (Cambridge, Mass.) (15.03.2022)
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Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course
Bagnara, Davide, Tang, Catherine, Brown, Jennifer R, Kasar, Siddha, Fernandes, Stacey, Colombo, Monica, Vergani, Stefano, Mazzarello, Andrea N, Ghiotto, Fabio, Bruno, Silvia, Morabito, Fortunato, Rai, Kanti R, Kolitz, Jonathan E, Barrientos, Jacqueline C, Allen, Steven L, Fais, Franco, Scharff, Matthew D, MacCarthy, Thomas, Chiorazzi, Nicholas
Published in Frontiers in oncology (25.05.2021)
Published in Frontiers in oncology (25.05.2021)
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AID and Apobec3G haphazard deamination and mutational diversity
Jaszczur, Malgorzata, Bertram, Jeffrey G., Pham, Phuong, Scharff, Matthew D., Goodman, Myron F.
Published in Cellular and molecular life sciences : CMLS (01.09.2013)
Published in Cellular and molecular life sciences : CMLS (01.09.2013)
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Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
Scharff, Matthew D, Bardwell, Philip D, Woo, Caroline J, Wei, Kaichun, Li, Ziqiang, Martin, Alberto, Sack, Stephen Z, Parris, Tchaiko, Edelmann, Winfried
Published in Nature immunology (01.02.2004)
Published in Nature immunology (01.02.2004)
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Isotype switching increases efficacy of antibody protection against staphylococcal enterotoxin B-induced lethal shock and Staphylococcus aureus sepsis in mice
Varshney, Avanish K, Wang, Xiaobo, Aguilar, Jorge L, Scharff, Matthew D, Fries, Bettina C
Published in mBio (10.06.2014)
Published in mBio (10.06.2014)
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Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression
Roa, Sergio, Avdievich, Elena, Peled, Jonathan U, MacCarthy, Thomas, Werling, Uwe, Kuang, Fei Li, Kan, Rui, Zhao, Chunfang, Bergman, Aviv, Cohen, Paula E, Edelmann, Winfried, Scharff, Matthew D
Published in Proceedings of the National Academy of Sciences - PNAS (21.10.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (21.10.2008)
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RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination
Ramachandran, Shaliny, Chahwan, Richard, Nepal, Rajeev M, Frieder, Darina, Panier, Stephanie, Roa, Sergio, Zaheen, Ahmad, Durocher, Daniel, Scharff, Matthew D, Martin, Alberto
Published in Proceedings of the National Academy of Sciences - PNAS (12.01.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (12.01.2010)
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PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
van Oers, Johanna M. M., Roa, Sergio, Werling, Uwe, Liu, Yiyong, Genschel, Jochen, Hou, Harry, Sellers, Rani S., Modrich, Paul, Scharff, Matthew D., Edelmann, Winfried
Published in Proceedings of the National Academy of Sciences - PNAS (27.07.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (27.07.2010)
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