Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions
Schad, Sara E, Chow, Andrew, Mangarin, Levi, Pan, Heng, Zhang, Jiajia, Ceglia, Nicholas, Caushi, Justina X, Malandro, Nicole, Zappasodi, Roberta, Gigoux, Mathieu, Hirschhorn, Daniel, Budhu, Sadna, Amisaki, Masataka, Arniella, Monica, Redmond, David, Chaft, Jamie, Forde, Patrick M, Gainor, Justin F, Hellmann, Matthew D, Balachandran, Vinod, Shah, Sohrab, Smith, Kellie N, Pardoll, Drew, Elemento, Olivier, Wolchok, Jedd D, Merghoub, Taha
Published in The Journal of experimental medicine (06.06.2022)
Published in The Journal of experimental medicine (06.06.2022)
Get full text
Journal Article
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma
Budhu, Sadna, Giese, Rachel, Gupta, Aditi, Fitzgerald, Kelly, Zappasodi, Roberta, Schad, Sara, Hirschhorn, Daniel, Campesato, Luis Felipe, De Henau, Olivier, Gigoux, Mathieu, Liu, Cailian, Mazo, Gregory, Deng, Liang, Barker, Christopher A., Wolchok, Jedd D., Merghoub, Taha
Published in Cell reports (Cambridge) (12.01.2021)
Published in Cell reports (Cambridge) (12.01.2021)
Get full text
Journal Article
968 PD-1hiFoxp3-CD4+ tumor-infiltrating T-cell lineage commitment impacts the immunotherapy outcome
Mangarin, Levi Mark, Martis, Stephen, Orlando, Andrea, Schad, Sara, Wolchok, Jedd D, Greenbaum, Benjamin, Merghoub, Taha, Zappasodi, Roberta
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
Get full text
Journal Article
TYRP1 directed CAR T cells control tumor progression in preclinical melanoma models
Hackett, Christopher S, Hirschhorn, Daniel, Tang, Meixian S, Purdon, Terence J, Marouf, Yacine, Piersigilli, Alessandra, Agaram, Narasimhan P, Liu, Cailian, Schad, Sara E, de Stanchina, Elisa, Rafiq, Sarwish, Monette, Sebastien, Wolchok, Jedd D, Merghoub, Taha, Brentjens, Renier J
Published in Molecular Therapy: Oncology (19.09.2024)
Published in Molecular Therapy: Oncology (19.09.2024)
Get full text
Journal Article
Nuclear import of the thyroid hormone receptor α1 is mediated by importin 7, importin β1, and adaptor importin α1
Roggero, Vincent R., Zhang, Jibo, Parente, Laura E., Doshi, Yazdi, Dziedzic, Rose C., McGregor, Emma L., Varjabedian, Arev D., Schad, Sara E., Bondzi, Cornelius, Allison, Lizabeth A.
Published in Molecular and cellular endocrinology (05.01.2016)
Published in Molecular and cellular endocrinology (05.01.2016)
Get full text
Journal Article
878 T cell immunotherapies recruit and activate neutrophils to eliminate tumor antigen escape variants
Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M, Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B, Li, Yanyun, Flamar, Anne-Laure, Choi, Heyjin, Cortez, Czrina A, Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Hamadene, Linda, Warner, Allison Betof, Hollmann, Travis, Arora, Arshi, Panageas, Katherine S, Duhen, Rebekka, Weinberg, Andrew D, Rizzuto, Gabrielle A, Spencer, Christine N, Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D, Merghoub, Taha
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
Get full text
Journal Article
549 Characterizing double positive T cells in the tumor microenvironment: a tale of promiscuous cell fates
Schad, Sara, Chow, Andrew, Pan, Heng, Mangarin, Levi, Zappasodi, Roberta, Gigoux, Mathieu, Redmond, David, Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Zhong, Hong, Yang, Xia, Elemento, Olivier, Wolchok, Jedd, Merghoub, Taha
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
Get full text
Journal Article
99 T cell immunotherapies trigger neutrophil activation to eliminate tumor antigen escape variants
Hirschhorn, Daniel, Budhu, Sadna, Schröder, David, kraehenbuehl, Lukas, Flammar, Anne-Laurent, Chow, Andrew, Schulze, Isabell, Schad, Sara, Ricca, Jacob, Gasmi, Billel, Henau, Olivier De, Mangarin, Levi, Redmond, David, Cortez, Czrina, Liu, Cailian, Holland, Aliya, Gigoux, Mathieu, Arora, Asrhi, Panageas, Katherine, Rizzuto, Gabrielle, Albrengues, Jean, Egeblad, Mikala, Wolchok, Jedd, Merghoub, Taha
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
Get full text
Journal Article
Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages
Guerriero, Jennifer L., Sotayo, Alaba, Ponichtera, Holly E., Castrillon, Jessica A., Pourzia, Alexandra L., Schad, Sara, Johnson, Shawn F., Carrasco, Ruben D., Lazo, Suzan, Bronson, Roderick T., Davis, Scott P., Lobera, Mercedes, Nolan, Michael A., Letai, Anthony
Published in Nature (London) (16.03.2017)
Published in Nature (London) (16.03.2017)
Get full text
Journal Article
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants
Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M., Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B., Li, Yanyun, Hamadene, Linda, Flamar, Anne-Laure, Choi, Hyejin, Cortez, Czrina A., Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Betof Warner, Allison, Hollmann, Travis J., Arora, Arshi, Panageas, Katherine S., Rizzuto, Gabrielle A., Duhen, Rebekka, Weinberg, Andrew D., Spencer, Christine N., Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D., Merghoub, Taha
Published in Cell (30.03.2023)
Published in Cell (30.03.2023)
Get full text
Journal Article
Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity
Chow, Andrew, Schad, Sara, Green, Michael D., Hellmann, Matthew D., Allaj, Viola, Ceglia, Nicholas, Zago, Giulia, Shah, Nisargbhai S., Sharma, Sai Kiran, Mattar, Marissa, Chan, Joseph, Rizvi, Hira, Zhong, Hong, Liu, Cailian, Bykov, Yonina, Zamarin, Dmitriy, Shi, Hongyu, Budhu, Sadna, Wohlhieter, Corrin, Uddin, Fathema, Gupta, Aditi, Khodos, Inna, Waninger, Jessica J., Qin, Angel, Markowitz, Geoffrey J., Mittal, Vivek, Balachandran, Vinod, Durham, Jennifer N., Le, Dung T., Zou, Weiping, Shah, Sohrab P., McPherson, Andrew, Panageas, Katherine, Lewis, Jason S., Perry, Justin S.A., de Stanchina, Elisa, Sen, Triparna, Poirier, John T., Wolchok, Jedd D., Rudin, Charles M., Merghoub, Taha
Published in Cancer cell (12.07.2021)
Published in Cancer cell (12.07.2021)
Get full text
Journal Article
Phosphatidylserine targeting antibody enhances anti-tumor activity of adoptive cell therapies in a mouse melanoma model
Schad, Sara, Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Zhong, Hong, Yang, Xia, Merghoub, Taha, Wolchok, Jedd D
Published in The Journal of immunology (1950) (01.05.2020)
Published in The Journal of immunology (1950) (01.05.2020)
Get full text
Journal Article
Abstract 3568: Phosphatidylserine targeting antibody enhances antitumor activity of CAR T cells in mouse melanoma
Schad, Sara, Hirschhorn-Cymerman, Daniel, Budhu, Sadna, Zhong, Hong, Yang, Xia, Shan, Joseph, King, Steven, Merghoub, Taha, Wolchok, Jedd
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine
Gigoux, Mathieu, Holmström, Morten O, Zappasodi, Roberta, Park, Joseph J, Pourpe, Stephane, Bozkus, Cansu Cimen, Mangarin, Levi M B, Redmond, David, Verma, Svena, Schad, Sara, George, Mariam M, Venkatesh, Divya, Ghosh, Arnab, Hoyos, David, Molvi, Zaki, Kamaz, Baransel, Marneth, Anna E, Duke, William, Leventhal, Matthew J, Jan, Max, Ho, Vincent T, Hobbs, Gabriela S, Knudsen, Trine Alma, Skov, Vibe, Kjær, Lasse, Larsen, Thomas Stauffer, Hansen, Dennis Lund, Lindsley, R Coleman, Hasselbalch, Hans, Grauslund, Jacob H, Lisle, Thomas L, Met, Özcan, Wilkinson, Patrick, Greenbaum, Benjamin, Sepulveda, Manuel A, Chan, Timothy, Rampal, Raajit, Andersen, Mads H, Abdel-Wahab, Omar, Bhardwaj, Nina, Wolchok, Jedd D, Mullally, Ann, Merghoub, Taha
Published in Science translational medicine (15.06.2022)
Published in Science translational medicine (15.06.2022)
Get more information
Journal Article
Abstract 978: Tim-4+ tissue-resident macrophages impair antitumor T-cell immunity
Chow, Andrew, Schad, Sara, Sharma, Sai K., Budhu, Sadna, Gupta, Aditi, Pimentel, Corrin, Zhong, Hong, Lewis, Jason S., Poirier, John T., Wolchok, Jedd D., Rudin, Charles M., Merghoub, Taha
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Abstract 1651: Targeting phosphatidylserine in combination with adoptive T cell transfer eliminates advanced tumors without off-target toxicities in a melanoma preclinical model
Hirschhorn-Cymerman, Daniel, Schad, Sara Sara, Budhu, Sadna, Hong, Zhong, Yang, Xia, Jeff, Hutchins T., Freimark, Bruce D., Gray, Michael J., Wolchok, Jedd, Merghoub, Taha
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
Heteroclitic peptide cancer vaccine counters MHC-I skewing in mutant calreticulin-positive myeloproliferative neoplasms
Gigoux, Mathieu, Zappasodi, Roberta, Park, Joseph J, Pourpe, Stephane, Ghosh, Arnab, Bozkus, Cansu Cimen, Mangarin, Levi M.B., Redmond, David, Verma, Svena, Schad, Sara, Duke, William, Leventhal, Matthew, Jan, Max, Ho, Vincent, Hobbs, Gabriella, Knudsen, Trine Alma, Skov, Vibe, Kjær, Lasse, Larsen, Thomas Stauffer, Hansen, Dennis Lund, Lindsley, R Coleman, Hasselbalch, Hans, Grauslund, Jacob H, Andersen, Mads H, Holmström, Morten O, Chan, Timothy, Rampal, Raajit, Abdel-Wahab, Omar, Bhardwaj, Nina, Wolchok, Jedd D, Mullally, Ann, Merghoub, Taha
Published in The Journal of immunology (1950) (01.05.2020)
Published in The Journal of immunology (1950) (01.05.2020)
Get full text
Journal Article
Class IIa HDAC inhibition reduces breast tumors and metastases via anti-tumor macrophages
Guerriero, Jennifer L., Sotayo, Alaba, Ponichtera, Holly E., Castrillon, Jessica A., Pourzia, Alexandra L., Schad, Sara, Johnson, Shawn F., Carrasco, Ruben D., Lazo, Suzan, Bronson, Roderick T., Davis, Scott P., Lobera, Mercedes, Nolan, Michael A., Letai, Anthony
Published in Nature (London) (08.03.2017)
Published in Nature (London) (08.03.2017)
Get full text
Journal Article
997 T cell immunotherapies trigger neutrophils to eliminates heterogenous tumors
Budhu, Sadna, Redmond, David, Ricca, Jacob, Gasmi, Billel, Gigoux, Mathieu, Liu, Cailian, Li, Yanyun, Cortez, Czrina, Schroder, David, Arora, Arshi, Hollman, Travis, Kraehenbuehl, Lukas, Choi, Hyejin, Schad, Sara, Schulze, Isabell, Duhen, Rebekka, Weinberg, Andrew, Chow, Andrew, Egeblad, Mikala, Panageas, Katherine, Rizzuto, Gabrielle, de Henau, Olivier, Holland, Aliya, Albrengues, Jean, Hamadane, Linda, Ng, David, Xue-Yan, He, Wolchok, Jedd, Taha Merghoub, Hirschhorn, Daniel
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
Get full text
Journal Article
444 MHC-I skewing in mutant calreticulin-positive myeloproliferative neoplasms is countered by heteroclitic peptide cancer vaccination
Gigoux, Mathieu, Zappasodi, Roberta, Park, Joseph, Pourpe, Stephane, Ghosh, Arnab, Bozkus, Cansu Cimen, Mangarin, Levi, Redmond, David, Verma, Svena, Schad, Sara, Duke, William, Jan, Max, Leventhal, Matthew, Ho, Vincent, Hobbs, Gabriela, Knudsen, Trine Alma, Skov, Vibe, Kjær, Lasse, Larsen, Thomas Stauffer, Hansen, Dennis Lund, Coleman Lindsley, R, Hasselbalch, Hans, Grauslund, Jacob, Andersen, Mads, Holmström, Morten, Chan, Timothy, Rampal, Raajit, Abdel-Wahab, Omar, Bhardwaj, Nina, Wolchok, Jedd, Mullally, Ann, Merghoub, Taha
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
Get full text
Journal Article