Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
Martin, Laetitia J, Koegl, Manfred, Bader, Gerd, Cockcroft, Xiao-Ling, Fedorov, Oleg, Fiegen, Dennis, Gerstberger, Thomas, Hofmann, Marco H, Hohmann, Anja F, Kessler, Dirk, Knapp, Stefan, Knesl, Petr, Kornigg, Stefan, Müller, Susanne, Nar, Herbert, Rogers, Catherine, Rumpel, Klaus, Schaaf, Otmar, Steurer, Steffen, Tallant, Cynthia, Vakoc, Christopher R, Zeeb, Markus, Zoephel, Andreas, Pearson, Mark, Boehmelt, Guido, McConnell, Darryl
Published in Journal of medicinal chemistry (26.05.2016)
Published in Journal of medicinal chemistry (26.05.2016)
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Journal Article
Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses
Zettl, Markus, Wurm, Melanie, Schaaf, Otmar, Mostböck, Sven, Tirapu, Iñigo, Apfler, Ilse, Lorenz, Ivo C., Frego, Lee, Kenny, Cynthia, Thibodeau, Michael, Oquendo Cifuentes, Elisa, Reschke, Markus, Moll, Jürgen, Kraut, Norbert, Vogt, Anne, Sedgwick, Jonathon D., Waizenegger, Irene C.
Published in Oncoimmunology (31.12.2022)
Published in Oncoimmunology (31.12.2022)
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Journal Article
Target-Induced Formation of Neuraminidase Inhibitors from in vitro Virtual Combinatorial Libraries
Hochgürtel, Matthias, Kroth, Heiko, Piecha, Dorothea, Hofmann, Michael W., Nicolau, Claude, Krause, Sonja, Schaaf, Otmar, Sonnenmoser, Gabriele, Eliseev, Alexey V.
Published in Proceedings of the National Academy of Sciences - PNAS (19.03.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (19.03.2002)
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Journal Article
Ketones as Building Blocks for Dynamic Combinatorial Libraries: Highly Active Neuraminidase Inhibitors Generated via Selection Pressure of the Biological Target
Hochgürtel, Matthias, Biesinger, Ralf, Kroth, Heiko, Piecha, Dorothea, Hofmann, Michael W, Krause, Sonja, Schaaf, Otmar, Nicolau, Claude, Eliseev, Alexey V
Published in Journal of medicinal chemistry (30.01.2003)
Published in Journal of medicinal chemistry (30.01.2003)
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Journal Article
Rapid and sensitive analysis of azadirachtin and related triterpenoids from Neem ( Azadirachta indica) by high-performance liquid chromatography–atmospheric pressure chemical ionization mass spectrometry
Schaaf, Otmar, Jarvis, Andrew P, van der Esch, S.Andrew, Giagnacovo, Germina, Oldham, Neil J
Published in Journal of Chromatography A (21.07.2000)
Published in Journal of Chromatography A (21.07.2000)
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Journal Article
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
Kim, Dongsung, Herdeis, Lorenz, Rudolph, Dorothea, Zhao, Yulei, Böttcher, Jark, Vides, Alberto, Ayala-Santos, Carlos I, Pourfarjam, Yasin, Cuevas-Navarro, Antonio, Xue, Jenny Y, Mantoulidis, Andreas, Bröker, Joachim, Wunberg, Tobias, Schaaf, Otmar, Popow, Johannes, Wolkerstorfer, Bernhard, Kropatsch, Katrin Gabriele, Qu, Rui, de Stanchina, Elisa, Sang, Ben, Li, Chuanchuan, McConnell, Darryl B, Kraut, Norbert, Lito, Piro
Published in Nature (London) (06.07.2023)
Published in Nature (London) (06.07.2023)
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Journal Article
Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer
Kuttruff, Christian A., Fleck, Martin, Carotta, Sebastian, Arnhof, Heribert, Bretschneider, Tom, Dahmann, Georg, Gremel, Gabriela, Grube, Achim, Handschuh, Sandra, Heimann, Annekatrin, Hofmann, Marco H., Impagnatiello, Maria A., Nar, Herbert, Rast, Georg, Schaaf, Otmar, Schmidt, Esther, Oost, Thorsten
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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Journal Article
A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation
Waizenegger, Irene C, Baum, Anke, Steurer, Steffen, Stadtmüller, Heinz, Bader, Gerd, Schaaf, Otmar, Garin-Chesa, Pilar, Schlattl, Andreas, Schweifer, Norbert, Haslinger, Christian, Colbatzky, Florian, Mousa, Sien, Kalkuhl, Arno, Kraut, Norbert, Adolf, Günther R
Published in Molecular cancer therapeutics (01.03.2016)
Published in Molecular cancer therapeutics (01.03.2016)
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Journal Article
A Novel Antagonistic CD73 Antibody for Inhibition of the Immunosuppressive Adenosine Pathway
Wurm, Melanie, Schaaf, Otmar, Reutner, Katharina, Ganesan, Rajkumar, Mostböck, Sven, Pelster, Christina, Böttcher, Jark, de Andrade Pereira, Bruna, Taubert, Christina, Alt, Isabella, Serna, Garazi, Auguste, Aurelie, Stadermann, Kai B, Delic, Denis, Han, Fei, Capdevila, Jaume, Nuciforo, Paolo G, Kroe-Barrett, Rachel, Adam, Paul J, Vogt, Anne B, Hofmann, Irmgard
Published in Molecular cancer therapeutics (01.11.2021)
Published in Molecular cancer therapeutics (01.11.2021)
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Journal Article
Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments
Martinelli, Paola, Schaaf, Otmar, Mantoulidis, Andreas, Martin, Laetitia J., Fuchs, Julian E., Bader, Gerd, Gollner, Andreas, Wolkerstorfer, Bernhard, Rogers, Catherine, Balıkçı, Esra, Lipp, Jesse J., Mischerikow, Nikolai, Doebel, Sandra, Gerstberger, Thomas, Sommergruber, Wolfgang, Huber, Kilian V. M., Böttcher, Jark
Published in ChemMedChem (14.03.2023)
Published in ChemMedChem (14.03.2023)
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Journal Article
Abstract 4522: Potent induction of a tumor-specific immune response by a cyclic dinucleotide STING agonist
Gremel, Gabriela, Impagnatiello, Maria A., Carotta, Sebastian, Schaaf, Otmar, Chetta, Paolo M., Oost, Thorsten, Zichner, Thomas, Hofmann, Marco, Blake, Sophia, Bretschneider, Tom, Fleck, Martin, Grube, Achim, Nar, Herbert, Rast, Georg, Schmidt, Esther, Klinkhardt, Ute, Arndt-Schmitz, Kirsten, Laux, Thorsten, Zinzalla, Vittoria, Sedgwick, Jonathon, Kraut, Norbert
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 4547: Characterization of the LAG-3 targeting antibody BI 754111 in monotherapy and in combination with the anti-PD-1 antibody BI 754091
Zettl, Markus, Wurm, Melanie, Schaaf, Otmar, Tirapu, Iñigo, Mostböck, Sven, Reschke, Markus, Schmidbauer, Stephan-Michael, Frego, Lee, Lorenz, Ivo C., Thibodeau, Michael, Blanset, Diann, Cifuentes, Elisa Oquendo, Moll, Jürgen, Kraut, Norbert, Borges, Eric, Vogt, Anne, Sedgwick, Jonathon, Waizenegger, Irene C.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 4558: In vitro and in vivo characterization of the PD-1 targeting antibody BI 754091
Zettl, Markus, Wurm, Melanie, Schaaf, Otmar, Tirapu, Iñigo, Mostböck, Sven, Reschke, Markus, Schmidbauer, Stephan-Michael, Frego, Lee, Lorenz, Ivo C., Thibodeau, Michael, Blanset, Diann, Cifuentes, Elisa Oquendo, Moll, Jürgen, Kraut, Norbert, Borges, Eric, Vogt, Anne, Sedgwick, Jonathon, Waizenegger, Irene C.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis
Sanderson, Michael P, Apgar, Joshua, Garin-Chesa, Pilar, Hofmann, Marco H, Kessler, Dirk, Quant, Jens, Savchenko, Alexander, Schaaf, Otmar, Treu, Matthias, Tye, Heather, Zahn, Stephan K, Zoephel, Andreas, Haaksma, Eric, Adolf, Günther R, Kraut, Norbert
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
An allometric pharmacokinetic/pharmacodynamics model for BI 893923, a novel IGF-1 receptor inhibitor
Titze, Melanie I., Schaaf, Otmar, Hofmann, Marco H., Sanderson, Michael P., Zahn, Stephan K., Quant, Jens, Lehr, Thorsten
Published in Cancer chemotherapy and pharmacology (01.03.2017)
Published in Cancer chemotherapy and pharmacology (01.03.2017)
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Journal Article
Abstract B103: Development and characterisation of KRASmulti inhibitors for the treatment of KRAS mutant pancreatic ductal adenocarcinoma
Tedeschi, Antonio, Schaaf, Otmar, Gmachl, Michael, Herdeis, Lorenz, Rocchetti, Francesca, Popow, Johannes, Schischlik, Fiorella, Gerlach, Daniel, Lipp, Jesse, Bröker, Joachim, Mantoulidis, Andreas, Smethurst, Chris, Kessler, Dirk, Boettcher, Jark, Wunberg, Tobias, Santoro, Valeria, Waterson, Alex, Phan, Jason, Little, Andrew, Abbott, Jason, Sun, Qi, Fesik, Stephen, Mcconnell, Darryl, Pearson, Mark A., Kraut, Norbert, Rudolph, Dorothea
Published in Cancer research (Chicago, Ill.) (16.01.2024)
Published in Cancer research (Chicago, Ill.) (16.01.2024)
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Journal Article
Abstract 3321: KRASmulti inhibitor BI 3706674, an orally bioavailable, direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRASG12V-driven preclinical models
Peng, David Hwa, Tedeschi, Antonio, Herdeis, Lorenz, Schaaf, Otmar, Savarese, Fabio, Rocchetti, Francesca, Popow, Johannes, Huber, Heinrich J., Wilding, Birgit, Treu, Matthias, Fuchs, Julian, Bröeker, Joachim, Wunberg, Tobias, Schischlik, Firoella, Lipp, Jesse, Williams, Mariah, Chandler, Vaness, Deckard, Charles E., Ramamoorthy, Vandhana, Daniele, Joseph R., Kopetz, Scott, Kim, Michael, Gibbons, Don L., Vellano, Christopher P., Marszalek, Joseph R., Heffernan, TImothy P., McConnell, Darryl, Pearson, Mark, Kraut, Norbert, Rudolph, Dorothea
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
A comprehensive pharmacokinetic/pharmacodynamics analysis of the novel IGF1R/INSR inhibitor BI 893923 applying in vitro, in vivo and in silico modeling techniques
Titze, Melanie I., Schaaf, Otmar, Hofmann, Marco H., Sanderson, Michael P., Zahn, Stephan K., Quant, Jens, Lehr, Thorsten
Published in Cancer chemotherapy and pharmacology (01.06.2016)
Published in Cancer chemotherapy and pharmacology (01.06.2016)
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Journal Article
Abstract 3317: KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harbouring KRASG12V mutations and KRAS wild-type amplifications
Tedeschi, Antonio, Peng, David H., Schischlik, Fiorella, Herdeis, Lorenz, Schaaf, Otmar, Santoro, Valeria, Gerlach, Daniel, Savarese, Fabio, Lipp, Jesse, Haslinger, Christian, Rocchetti, Francesca, Popow, Johannes, Huber, Heinrich J., Wilding, Birgit, Treu, Matthias, Fuchs, Julian, Broeker, Joachim, Wunber, Tobias, Gmachl, Michael, Rumpel, Klaus, Rees, Matthew, Ron, Melissa, Roth, Jennifer, Williams, Mariah, Deckard, Charles, Ramamoorthy, Vandhana, Daniele, Joseph R., Ajani, Jaffer A., Meric-Bernstam, Funda, Kopetz, Scott, Kim, Michael, Gibbons, Don L., Vellano, Christopher P., Marszalek, Joseph R., Heffernan, Timothy P., McConnell, Darryl, Pearson, Mark, Kraut, Norbert, Rudolph, Dorothea
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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