LINCS Data Portal 2.0: next generation access point for perturbation-response signatures
Stathias, Vasileios, Turner, John, Koleti, Amar, Vidovic, Dusica, Cooper, Daniel, Fazel-Najafabadi, Mehdi, Pilarczyk, Marcin, Terryn, Raymond, Chung, Caty, Umeano, Afoma, Clarke, Daniel J B, Lachmann, Alexander, Evangelista, John Erol, Ma’ayan, Avi, Medvedovic, Mario, Schürer, Stephan C
Published in Nucleic acids research (08.01.2020)
Published in Nucleic acids research (08.01.2020)
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SigCom LINCS: data and metadata search engine for a million gene expression signatures
Evangelista, John Erol, Clarke, Daniel J B, Xie, Zhuorui, Lachmann, Alexander, Jeon, Minji, Chen, Kerwin, Jagodnik, Kathleen M, Jenkins, Sherry L, Kuleshov, Maxim V, Wojciechowicz, Megan L, Schürer, Stephan C, Medvedovic, Mario, Ma’ayan, Avi
Published in Nucleic acids research (05.07.2022)
Published in Nucleic acids research (05.07.2022)
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Pharos 2023: an integrated resource for the understudied human proteome
Kelleher, Keith J, Sheils, Timothy K, Mathias, Stephen L, Yang, Jeremy J, Metzger, Vincent T, Siramshetty, Vishal B, Nguyen, Dac-Trung, Jensen, Lars Juhl, Vidović, Dušica, Schürer, Stephan C, Holmes, Jayme, Sharma, Karlie R, Pillai, Ajay, Bologa, Cristian G, Edwards, Jeremy S, Mathé, Ewy A, Oprea, Tudor I
Published in Nucleic acids research (06.01.2023)
Published in Nucleic acids research (06.01.2023)
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Drug and disease signature integration identifies synergistic combinations in glioblastoma
Stathias, Vasileios, Jermakowicz, Anna M, Maloof, Marie E, Forlin, Michele, Walters, Winston, Suter, Robert K, Durante, Michael A, Williams, Sion L, Harbour, J William, Volmar, Claude-Henry, Lyons, Nicholas J, Wahlestedt, Claes, Graham, Regina M, Ivan, Michael E, Komotar, Ricardo J, Sarkaria, Jann N, Subramanian, Aravind, Golub, Todd R, Schürer, Stephan C, Ayad, Nagi G
Published in Nature communications (14.12.2018)
Published in Nature communications (14.12.2018)
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Journal Article
Kinome-Wide Virtual Screening by Multi-Task Deep Learning
Hu, Jiaming, Allen, Bryce K, Stathias, Vasileios, Ayad, Nagi G, Schürer, Stephan C
Published in International journal of molecular sciences (22.02.2024)
Published in International journal of molecular sciences (22.02.2024)
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Journal Article
TCRD and Pharos 2021: mining the human proteome for disease biology
Sheils, Timothy K, Mathias, Stephen L, Kelleher, Keith J, Siramshetty, Vishal B, Nguyen, Dac-Trung, Bologa, Cristian G, Jensen, Lars Juhl, Vidović, Dušica, Koleti, Amar, Schürer, Stephan C, Waller, Anna, Yang, Jeremy J, Holmes, Jayme, Bocci, Giovanni, Southall, Noel, Dharkar, Poorva, Mathé, Ewy, Simeonov, Anton, Oprea, Tudor I
Published in Nucleic Acids Research (08.01.2021)
Published in Nucleic Acids Research (08.01.2021)
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Web Resource
Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data
Koleti, Amar, Terryn, Raymond, Stathias, Vasileios, Chung, Caty, Cooper, Daniel J, Turner, John P, Vidović, Dušica, Forlin, Michele, Kelley, Tanya T, D'Urso, Alessandro, Allen, Bryce K, Torre, Denis, Jagodnik, Kathleen M, Wang, Lily, Jenkins, Sherry L, Mader, Christopher, Niu, Wen, Fazel, Mehdi, Mahi, Naim, Pilarczyk, Marcin, Clark, Nicholas, Shamsaei, Behrouz, Meller, Jarek, Vasiliauskas, Juozas, Reichard, John, Medvedovic, Mario, Ma'ayan, Avi, Pillai, Ajay, Schürer, Stephan C
Published in Nucleic acids research (04.01.2018)
Published in Nucleic acids research (04.01.2018)
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Journal Article
Connecting omics signatures and revealing biological mechanisms with iLINCS
Pilarczyk, Marcin, Fazel-Najafabadi, Mehdi, Kouril, Michal, Shamsaei, Behrouz, Vasiliauskas, Juozas, Niu, Wen, Mahi, Naim, Zhang, Lixia, Clark, Nicholas A, Ren, Yan, White, Shana, Karim, Rashid, Xu, Huan, Biesiada, Jacek, Bennett, Mark F, Davidson, Sarah E, Reichard, John F, Roberts, Kurt, Stathias, Vasileios, Koleti, Amar, Vidovic, Dusica, Clarke, Daniel J B, Schürer, Stephan C, Ma'ayan, Avi, Meller, Jarek, Medvedovic, Mario
Published in Nature communications (09.08.2022)
Published in Nature communications (09.08.2022)
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Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress
Ghosh, Rajarshi, Wang, Likun, Wang, Eric S., Perera, B. Gayani K., Igbaria, Aeid, Morita, Shuhei, Prado, Kris, Thamsen, Maike, Caswell, Deborah, Macias, Hector, Weiberth, Kurt F., Gliedt, Micah J., Alavi, Marcel V., Hari, Sanjay B., Mitra, Arinjay K., Bhhatarai, Barun, Schürer, Stephan C., Snapp, Erik L., Gould, Douglas B., German, Michael S., Backes, Bradley J., Maly, Dustin J., Oakes, Scott A., Papa, Feroz R.
Published in Cell (31.07.2014)
Published in Cell (31.07.2014)
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Drug Repositioning in Glioblastoma: A Pathway Perspective
Tan, Sze Kiat, Jermakowicz, Anna, Mookhtiar, Adnan K, Nemeroff, Charles B, Schürer, Stephan C, Ayad, Nagi G
Published in Frontiers in pharmacology (16.03.2018)
Published in Frontiers in pharmacology (16.03.2018)
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Targeted degrader technologies as prospective SARS-CoV-2 therapies
Khurshid, Rabia, Schulz, Joseph M., Hu, Jiaming, Snowden, Timothy S., Reynolds, Robert C., Schürer, Stephan C.
Published in Drug discovery today (01.01.2024)
Published in Drug discovery today (01.01.2024)
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Potent, Selective, and Orally Bioavailable Quinazoline-Based STK17A/B Dual Inhibitors
Chaudhry, Sana, Castro, Jesus R., Totiger, Tulasigeri M., Afaghani, Jumana, Khurshid, Rabia, Nicholls, Miah, Zhang, Ziming, Schürer, Stephan C., Shah, Ashish, Taylor, Justin, Feng, Yangbo
Published in ACS medicinal chemistry letters (13.06.2024)
Published in ACS medicinal chemistry letters (13.06.2024)
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Predicting COVID-19 cases using SARS-CoV-2 RNA in air, surface swab and wastewater samples
Solo-Gabriele, Helena M., Kumar, Shelja, Abelson, Samantha, Penso, Johnathon, Contreras, Julio, Babler, Kristina M., Sharkey, Mark E., Mantero, Alejandro M.A., Lamar, Walter E., Tallon, John J., Kobetz, Erin, Solle, Natasha Schaefer, Shukla, Bhavarth S., Kenney, Richard J., Mason, Christopher E., Schürer, Stephan C., Vidovic, Dusica, Williams, Sion L., Grills, George S., Jayaweera, Dushyantha T., Mirsaeidi, Mehdi, Kumar, Naresh
Published in The Science of the total environment (20.01.2023)
Published in The Science of the total environment (20.01.2023)
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Relationships between SARS-CoV‑2 in Wastewater and COVID-19 Clinical Cases and Hospitalizations, with and without Normalization against Indicators of Human Waste
Zhan, Qingyu, Babler, Kristina M., Sharkey, Mark E., Amirali, Ayaaz, Beaver, Cynthia C., Boone, Melinda M., Comerford, Samuel, Cooper, Daniel, Cortizas, Elena M., Currall, Benjamin B., Foox, Jonathan, Grills, George S., Kobetz, Erin, Kumar, Naresh, Laine, Jennifer, Lamar, Walter E., Mantero, Alejandro M.A., Mason, Christopher E., Reding, Brian D., Robertson, Maria, Roca, Matthew A., Ryon, Krista, Schürer, Stephan C., Shukla, Bhavarth S., Solle, Natasha Schaefer, Stevenson, Mario, Tallon Jr, John J., Thomas, Collette, Thomas, Tori, Vidović, Dušica, Williams, Sion L., Yin, Xue, Solo-Gabriele, Helena M.
Published in ACS ES&T water (11.11.2022)
Published in ACS ES&T water (11.11.2022)
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Lessons learned from SARS-CoV-2 measurements in wastewater
Sharkey, Mark E., Kumar, Naresh, Mantero, Alejandro M.A., Babler, Kristina M., Boone, Melinda M., Cardentey, Yoslayma, Cortizas, Elena M., Grills, George S., Herrin, James, Kemper, Jenny M., Kenney, Richard, Kobetz, Erin, Laine, Jennifer, Lamar, Walter E., Mader, Christopher C., Mason, Christopher E., Quintero, Anda Z., Reding, Brian D., Roca, Matthew A., Ryon, Krista, Solle, Natasha Schaefer, Schürer, Stephan C., Shukla, Bhavarth, Stevenson, Mario, Stone, Thomas, Tallon, John J., Venkatapuram, Sreeharsha S., Vidovic, Dusica, Williams, Sion L., Young, Benjamin, Solo-Gabriele, Helena M.
Published in The Science of the total environment (01.12.2021)
Published in The Science of the total environment (01.12.2021)
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Journal Article
Degradation rates influence the ability of composite samples to represent 24-hourly means of SARS-CoV-2 and other microbiological target measures in wastewater
Babler, Kristina M., Sharkey, Mark E., Abelson, Samantha, Amirali, Ayaaz, Benitez, Aymara, Cosculluela, Gabriella A., Grills, George S., Kumar, Naresh, Laine, Jennifer, Lamar, Walter, Lamm, Erik D., Lyu, Jiangnan, Mason, Christopher E., McCabe, Philip M., Raghavender, Joshi, Reding, Brian D., Roca, Matthew A., Schürer, Stephan C., Stevenson, Mario, Szeto, Angela, Tallon, John J., Vidović, Dusica, Zarnegarnia, Yalda, Solo-Gabriele, Helena M.
Published in The Science of the total environment (01.04.2023)
Published in The Science of the total environment (01.04.2023)
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