Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Liu, Jun, Pan, Shifeng, Hsieh, Mindy H., Ng, Nicholas, Sun, Fangxian, Wang, Tao, Kasibhatla, Shailaja, Schuller, Alwin G., Li, Allen G., Cheng, Dai, Li, Jie, Tompkins, Celin, Pferdekamper, AnneMarie, Steffy, Auzon, Cheng, Jane, Kowal, Colleen, Van Phung, Guo, Guirong, Wang, Yan, Graham, Martin P., Flynn, Shannon, Brenner, J. Chad, Li, Chun, Villarroel, M. Cristina, Schultz, Peter G., Xu Wu, McNamara, Peter, Sellers, William R., Petruzzelli, Lilli, Boral, Anthony L., Seidel, H. Martin, McLaughlin, Margaret E., Che, Jianwei, Carey, Thomas E., Vanasse, Gary, Harris, Jennifer L.
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.2013)
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3-dimensional computer tomography is more accurate than traditional long-leg radiographs in the planning and evaluation of coronal alignment in total knee arthroplasty: a prospective study on 121 knees
Aunan, Eirik, Alhaug, Eivind, Schuller, Siri G, Rundfloen, Jan E
Published in Acta orthopaedica (26.10.2023)
Published in Acta orthopaedica (26.10.2023)
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Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy
Guertin, Amy D, Li, Jing, Liu, Yaping, Hurd, Melissa S, Schuller, Alwin G, Long, Brian, Hirsch, Heather A, Feldman, Igor, Benita, Yair, Toniatti, Carlo, Zawel, Leigh, Fawell, Stephen E, Gilliland, D Gary, Shumway, Stuart D
Published in Molecular cancer therapeutics (01.08.2013)
Published in Molecular cancer therapeutics (01.08.2013)
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Journal Article
Heat integration of methanol steam reformer with a high-temperature polymeric electrolyte membrane fuel cell
Ribeirinha, P., Alves, I., Vázquez, F. Vidal, Schuller, G., Boaventura, M., Mendes, A.
Published in Energy (Oxford) (01.02.2017)
Published in Energy (Oxford) (01.02.2017)
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Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
Yang, Rui, Elsaadi, Samah, Misund, Kristine, Abdollahi, Pegah, Vandsemb, Esten Nymoen, Moen, Siv Helen, Kusnierczyk, Anna, Slupphaug, Geir, Standal, Therese, Waage, Anders, Slørdahl, Tobias S, Rø, Torstein Baade, Rustad, Even, Sundan, Anders, Hay, Carl, Cooper, Zachary, Schuller, Alwin G, Woessner, Richard, Borodovsky, Alexandra, Menu, Eline, Børset, Magne, Sponaas, Anne Marit
Published in Journal for immunotherapy of cancer (01.05.2020)
Published in Journal for immunotherapy of cancer (01.05.2020)
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Stimulation of Autologous Antitumor T-Cell Responses Against Medullary Thyroid Carcinoma Using Tumor Lysate-Pulsed Dendritic Cells
Bachleitner-Hofmann, T, Stift, A, Friedl, J, Pfragner, R, Radelbauer, K, Dubsky, P, Schüller, G, Benkö, T, Niederle, B, Brostjan, C, Jakesz, R, Gnant, M
Published in The journal of clinical endocrinology and metabolism (01.03.2002)
Published in The journal of clinical endocrinology and metabolism (01.03.2002)
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Journal Article
The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models
Schuller, Alwin G, Barry, Evan R, Jones, Rhys D O, Henry, Ryan E, Frigault, Melanie M, Beran, Garry, Linsenmayer, David, Hattersley, Maureen, Smith, Aaron, Wilson, Joanne, Cairo, Stefano, Déas, Olivier, Nicolle, Delphine, Adam, Ammar, Zinda, Michael, Reimer, Corinne, Fawell, Stephen E, Clark, Edwin A, D'Cruz, Celina M
Published in Clinical cancer research (15.06.2015)
Published in Clinical cancer research (15.06.2015)
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Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
Tron, Adriana E, Belmonte, Matthew A, Adam, Ammar, Aquila, Brian M, Boise, Lawrence H, Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J, Gangl, Eric, Gibbons, Francis D, Gregory, Gareth P, Hargreaves, David, Hendricks, J Adam, Johannes, Jeffrey W, Johnstone, Ricky W, Kazmirski, Steven L, Kettle, Jason G, Lamb, Michelle L, Matulis, Shannon M, Nooka, Ajay K, Packer, Martin J, Peng, Bo, Rawlins, Philip B, Robbins, Daniel W, Schuller, Alwin G, Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J Paul, Clark, Edwin A, Wilson, David M, Fawell, Stephen E, Hird, Alexander W
Published in Nature communications (17.12.2018)
Published in Nature communications (17.12.2018)
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Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
Ettenberg, Seth A., Charlat, Olga, Daley, Michael P., Liu, Shanming, Vincent, Karen J., Stuart, Darrin D., Schuller, Alwin G., Yuan, Jing, Ospina, Beatriz, Green, John, Yu, Qunyan, Walsh, Renee, Li, Sharon, Schmitz, Rita, Heine, Holger, Bilic, Sanela, Ostrom, Lance, Mosher, Rebecca, Hartlepp, K. Felix, Zhu, Zhenping, Fawell, Stephen, Yao, Yung-Mae, Stover, David, Finan, Peter M., Porter, Jeffery A., Sellers, William R., Klagge, Ingo M., Cong, Feng, Nusse, Roeland
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
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Diminished Growth and Enhanced Glucose Metabolism in Triple Knockout Mice Containing Mutations of Insulin-Like Growth Factor Binding Protein-3, -4, and -5
Ning, Yun, Schuller, Alwin G. P, Bradshaw, Sheri, Rotwein, Peter, Ludwig, Thomas, Frystyk, Jan, Pintar, John E
Published in Molecular endocrinology (Baltimore, Md.) (01.09.2006)
Published in Molecular endocrinology (Baltimore, Md.) (01.09.2006)
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MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis
Booher, Robert N, Hatch, Harold, Dolinski, Brian M, Nguyen, Thi, Harmonay, Lauren, Al-Assaad, Ali-Samer, Ayers, Mark, Nebozhyn, Michael, Loboda, Andrey, Hirsch, Heather A, Zhang, Theresa, Shi, Bin, Merkel, Carrie E, Angagaw, Minilik H, Wang, Yaolin, Long, Brian J, Lennon, Xianlu Q, Miselis, Nathan, Pucci, Vincenzo, Monahan, James W, Lee, Junghoon, Kondic, Anna Georgieva, Im, Eun Kyung, Mauro, David, Blanchard, Rebecca, Gilliland, Gary, Fawell, Stephen E, Zawel, Leigh, Schuller, Alwin G, Strack, Peter
Published in PloS one (07.10.2014)
Published in PloS one (07.10.2014)
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Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
Graziano, Vincenzo, Dannhorn, Andreas, Hulme, Heather, Williamson, Kate, Buckley, Hannah, Karim, Saadia A, Wilson, Matthew, Lee, Sheng Y, Kaistha, Brajesh P, Islam, Sabita, Thaventhiran, James E D, Richards, Frances M, Goodwin, Richard, Brais, Rebecca, Morton, Jennifer P, Dovedi, Simon J, Schuller, Alwin G, Eyles, Jim, Jodrell, Duncan I
Published in Journal for immunotherapy of cancer (01.08.2023)
Published in Journal for immunotherapy of cancer (01.08.2023)
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Journal Article
H mode of the W 7-AS stellarator
Erckmann, V, V, Wagner, F, Baldzuhn, J, Brakel, R, Burhenn, R, Gasparino, U, Grigull, P, Hartfuss, HJ, Hofmann, JV, Jaenicke, R, Niedermeyer, H, Ohlendorf, W, Rudyj, A, Weller, A, Bogdanov, SD, Bomba, B, Borschegovsky, AA, Cattanei, G, Dodhy, A, Dorst, D, Elsner, A, Endler, M, Geist, T, Giannone, L, Hacker, H, Heinrich, O, Herre, G, Hildebrandt, D, Hiznyak, VI, VI, Il'in, VI, VI, Kasparek, W, Karger, F, Kick, M, Kubo, S, Kuftin, AN, Kurbatov, VI, VI, Lazaros, A, Malygin, SA, Malygin, VI, VI, McCormick, K, Müller, GA, Orlov, VB, Pech, P, Roi, IN, Sardei, F, Sattler, S, Schneider, F, Schneider, U, Schüller, PG, Siller, G, Stroth, U, Tutter, M, Unger, E, Wolff, H, Würsching, E, Zöpfel, S
Published in Physical review letters (05.04.1993)
Published in Physical review letters (05.04.1993)
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Journal Article
Delayed Mammary Gland Involution in Mice with Mutation of the Insulin-Like Growth Factor Binding Protein 5 Gene
Ning, Yun, Hoang, Bao, Schuller, Alwin G. P, Cominski, Tara P, Hsu, Ming-Sing, Wood, Teresa L, Pintar, John E
Published in Endocrinology (Philadelphia) (01.05.2007)
Published in Endocrinology (Philadelphia) (01.05.2007)
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Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy
Patterson, Claire M., Balachander, Srividya B., Grant, Iain, Pop-Damkov, Petar, Kelly, Brian, McCoull, William, Parker, Jeremy, Giannis, Michael, Hill, Kathryn J., Gibbons, Francis D., Hennessy, Edward J., Kemmitt, Paul, Harmer, Alexander R., Gales, Sonya, Purbrick, Stuart, Redmond, Sean, Skinner, Matthew, Graham, Lorraine, Secrist, J. Paul, Schuller, Alwin G., Wen, Shenghua, Adam, Ammar, Reimer, Corinne, Cidado, Justin, Wild, Martin, Gangl, Eric, Fawell, Stephen E., Saeh, Jamal, Davies, Barry R., Owen, David J., Ashford, Marianne B.
Published in Communications biology (25.01.2021)
Published in Communications biology (25.01.2021)
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Genetic Dissociation of Opiate Tolerance and Physical Dependence in delta -Opioid Receptor-1 and Preproenkephalin Knock-Out Mice
Nitsche, Joshua F, Schuller, Alwin G. P, King, Michael A, Zengh, Min, Pasternak, Gavril W, Pintar, John E
Published in The Journal of neuroscience (15.12.2002)
Published in The Journal of neuroscience (15.12.2002)
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