Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X‑ray Cocrystal Structures
Schwertz, Geoffrey, Witschel, Matthias C, Rottmann, Matthias, Bonnert, Roger, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Jaruwat, Aritsara, Ittarat, Wanwipa, Schäfer, Anja, Aponte, Raphael A, Charman, Susan A, White, Karen L, Kundu, Abhijit, Sadhukhan, Surajit, Lloyd, Mel, Freiberg, Gail M, Srikumaran, Myron, Siggel, Marc, Zwyssig, Adrian, Chaiyen, Pimchai, Diederich, François
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
Get full text
Journal Article
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
Chan, Eunice H Y, Nousiainen, Marjaana, Chalamalasetty, Ravindra B, Schäfer, Anja, Nigg, Erich A, Silljé, Herman H W
Published in Oncogene (17.03.2005)
Published in Oncogene (17.03.2005)
Get full text
Journal Article
The essential malaria protein PfCyRPA targets glycans to invade erythrocytes
Day, Christopher J., Favuzza, Paola, Bielfeld, Sabrina, Haselhorst, Thomas, Seefeldt, Leonie, Hauser, Julia, Shewell, Lucy K., Flueck, Christian, Poole, Jessica, Jen, Freda E.-C., Schäfer, Anja, Dangy, Jean-Pierre, Gilberger, Tim-W., França, Camila Tenorio, Duraisingh, Manoj T., Tamborrini, Marco, Brancucci, Nicolas M.B., Grüring, Christof, Filarsky, Michael, Jennings, Michael P., Pluschke, Gerd
Published in Cell reports (Cambridge) (23.04.2024)
Published in Cell reports (Cambridge) (23.04.2024)
Get full text
Journal Article
Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans
Warryn, Louisa, Dangy, Jean-Pierre, Gersbach, Philipp, Gehringer, Matthias, Schäfer, Anja, Ruf, Marie-Thérèse, Ruggli, Nicolas, Altmann, Karl-Heinz, Pluschke, Gerd
Published in PLoS neglected tropical diseases (01.06.2020)
Published in PLoS neglected tropical diseases (01.06.2020)
Get full text
Journal Article
Influence of Chlorine or Fluorine Substitution on the Estrogenic Properties of 1‑Alkyl-2,3,5-tris(4-hydroxyphenyl)‑1H‑pyrroles
Schäfer, Anja, Wellner, Anja, Strauss, Martin, Schäfer, Andreas, Wolber, Gerhard, Gust, Ronald
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
Get full text
Journal Article
Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion
Zick, Michael, Duvezin-Caubet, Stéphane, Schäfer, Anja, Vogel, Frank, Neupert, Walter, Reichert, Andreas S.
Published in FEBS letters (07.07.2009)
Published in FEBS letters (07.07.2009)
Get full text
Journal Article
Scalable Process for High-Yield Production of PfCyRPA Using Insect Cells for Inclusion in a Malaria Virosome-Based Vaccine Candidate
Fernandes, Bárbara, Sousa, Marcos, Castro, Rute, Schäfer, Anja, Hauser, Julia, Schulze, Kai, Amacker, Mario, Tamborrini, Marco, Pluschke, Gerd, Alves, Paula M, Fleury, Sylvain, Roldão, António
Published in Frontiers in bioengineering and biotechnology (20.05.2022)
Published in Frontiers in bioengineering and biotechnology (20.05.2022)
Get full text
Journal Article
Deep-crustal magma reservoirs beneath the Nicaraguan volcanic arc, revealed by 2-D and semi 3-D inversion of magnetotelluric data
Brasse, Heinrich, Schäfer, Anja, Díaz, Daniel, Alvarado, Guillermo E., Muñoz, Angélica, Mütschard, Lutz
Published in Physics of the earth and planetary interiors (01.11.2015)
Published in Physics of the earth and planetary interiors (01.11.2015)
Get full text
Journal Article
Intramembrane Proteolysis of Mgm1 by the Mitochondrial Rhomboid Protease Is Highly Promiscuous Regarding the Sequence of the Cleaved Hydrophobic Segment
Schäfer, Anja, Zick, Michael, Kief, Jan, Steger, Mirco, Heide, Heinrich, Duvezin-Caubet, Stéphane, Neupert, Walter, Reichert, Andreas S.
Published in Journal of molecular biology (13.08.2010)
Published in Journal of molecular biology (13.08.2010)
Get full text
Journal Article
Stabilization of protein–protein interactions by small molecules
Giordanetto, Fabrizio, Schäfer, Anja, Ottmann, Christian
Published in Drug discovery today (01.11.2014)
Published in Drug discovery today (01.11.2014)
Get full text
Journal Article
The malaria blood stage antigen PfCyRPA formulated with the TLR-4 agonist adjuvant GLA-SE elicits parasite growth inhibitory antibodies in experimental animals
Tamborrini, Marco, Schäfer, Anja, Hauser, Julia, Zou, Linghui, Paris, Daniel H, Pluschke, Gerd
Published in Malaria journal (15.07.2023)
Published in Malaria journal (15.07.2023)
Get full text
Journal Article
An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery
Najer, Adrian, Wu, Dalin, Nussbaumer, Martin G, Schwertz, Geoffrey, Schwab, Anatol, Witschel, Matthias C, Schäfer, Anja, Diederich, François, Rottmann, Matthias, Palivan, Cornelia G, Beck, Hans-Peter, Meier, Wolfgang
Published in Nanoscale (21.08.2016)
Published in Nanoscale (21.08.2016)
Get full text
Journal Article
Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor–Nuclear Receptor Related 1 Protein Dimer Activation
Sundén, Henrik, Schäfer, Anja, Scheepstra, Marcel, Leysen, Seppe, Malo, Marcus, Ma, Jian-Nong, Burstein, Ethan S, Ottmann, Christian, Brunsveld, Luc, Olsson, Roger
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
Get full text
Journal Article
Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold
Schwertz, Geoffrey, Witschel, Matthias C., Rottmann, Matthias, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Jaruwat, Aritsara, Amornwatcharapong, Watcharee, Ittarat, Wanwipa, Schäfer, Anja, Aponte, Raphael A., Trapp, Nils, Chaiyen, Pimchai, Diederich, François
Published in ChemMedChem (08.05.2018)
Published in ChemMedChem (08.05.2018)
Get full text
Journal Article
Vaccination with virosomally formulated recombinant CyRPA elicits protective antibodies against Plasmodium falciparum parasites in preclinical in vitro and in vivo models
Tamborrini, Marco, Hauser, Julia, Schäfer, Anja, Amacker, Mario, Favuzza, Paola, Kyungtak, Kwak, Fleury, Sylvain, Pluschke, Gerd
Published in npj vaccines (2020)
Published in npj vaccines (2020)
Get full text
Journal Article
Bexarotene prodrugs: Targeting through cleavage by NQO1 (DT-diaphorase)
Schafer, Anja, Burstein, Ethan S., Olsson, Roger
Published in Bioorganic & medicinal chemistry letters (15.04.2014)
Published in Bioorganic & medicinal chemistry letters (15.04.2014)
Get full text
Journal Article
Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs
Schwertz, Geoffrey, Frei, Michelle S., Witschel, Matthias C., Rottmann, Matthias, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Jaruwat, Aritsara, Ittarat, Wanwipa, Schäfer, Anja, Aponte, Raphael A., Trapp, Nils, Mark, Kerstin, Chaiyen, Pimchai, Diederich, François
Published in Chemistry : a European journal (12.10.2017)
Published in Chemistry : a European journal (12.10.2017)
Get full text
Journal Article